2026-10-30T05:34:14Zhttps://munzur-rdlopen.rawdatalibrary.net/oai/request

oai:munzur-rdlopen.rawdatalibrary.net:munzur/29282026-10-28T15:30:13Zopenairedrivercom_munzur_1col_munzur_2com_munzur_11col_munzur_162

Synthesis, structural characterizations and in vitro cytotoxic activities of new sulfonamide-based Schiff base derivativesŞahal, HakanÖz, SametTekin, SuatCanpolat, Erdalcancer cell linescytotoxic activityDNA damageSchiff basespectroscopicSulfonamide derivativeSynthesis of five different new compounds (1-5) were carried out. Their structures were characterized by spectroscopic methods such as Fourier transform infrared, Proton nuclear magnetic resonance, Carbon-13 nuclear magnetic resonance and Elemental analysis. Cytotoxic activities of five new sulfonamide based-Schiff base compounds were determined by MTT assay using A-2780 (human ovarian cancer) and MCF-7 (breast cancer) cell lines. LogIC50 values of the sulfonamide derivates compounds were calculated by Graphpad Prism 12 programme after a 24-hour treatment for A2780 and MCF-7 cells. Comet assay experiments were performed to determine DNA damage using LogIC50 concentrations of all compounds in A2780 and MCF-7 cells. All compounds significantly reduced A2780 and MCF-7 cell viability compared to control groups (p < 0.05). In addition, all compounds caused DNA damage in A2780 and MCF-7 cells (p < 0.05). These results show that the synthesized compounds exhibit cytotoxic effects against cancer cells and that the cause of cell death is due to DNA damage. Communicated by Ramaswamy H. Sarma.Taylor and Francis Ltd.2023Articlehttps://rdlopen.rawdatalibrary.net/r/munzur/2928https://doi.org/10.1080/07391102.2022.20672370739-1102enJournal of Biomolecular Structure and Dynamicsinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://munzur-rdlopen.rawdatalibrary.net/tr/items/munzur/2928