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oai:munzur-rdlopen.rawdatalibrary.net:munzur/36872026-10-28T15:39:33Zopenairecom_munzur_1col_munzur_2com_munzur_8col_munzur_159

Regulation of signaling pathways by β-elemene in cancer progression and metastasisQureshi, Muhammad Z.Attar, RuksetRomero, Mirna A.Sabitaliyevich, Uteuliyev Y.Nurmurzayevich, Sadykov B.Ozturk, OzlemWakim, Lara H.Lin, XiukunOzbey, UlkuYelekenova, Armida BakhytbekovnaFarooqi, Ammad A.apoptosiscancerelemenesignalingEntry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how β-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by β-elemene. Last, we will discuss the results of clinical trials of β-elemene and how effectively we can use these findings to stratify patients who can benefit most from β-elemene.Wiley-Liss Inc.2019Articlehttps://rdlopen.rawdatalibrary.net/r/munzur/3687https://doi.org/10.1002/jcb.286240730-2312enJournal of Cellular Biochemistryinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://munzur-rdlopen.rawdatalibrary.net/tr/items/munzur/3687