2026-10-30T03:26:56Zhttps://munzur-rdlopen.rawdatalibrary.net/oai/request

oai:munzur-rdlopen.rawdatalibrary.net:munzur/37522026-10-28T15:31:01Zopenairedrivercom_munzur_1col_munzur_2com_munzur_8col_munzur_154

Ghanaian Mangrove Wetland Endophytic Fungus, Penicillium herquei strain BRS2A-AR produces (9Z, 11E)-13-oxooctadeca-9,11-dienoic acid with activity against Trichomonas mobilensisHayibor, KennedyKwain, SamuelOsei, EnochNartey, Adwoa PadikiTetevi, Gilbert MawuliOwusu, Kofi Baffour-AwuahCamas, MustafaCamas, Anil SazakKyeremeh, KwakuAntiprasiticLeishmaniaOxylipinPlasmodiumTrichomonasTrypanosomeSub-Sahara Africa is burdened with a high incidence of parasitic infections, including schistosomiasis, trypanosomiasis, trichomoniasis, and leishmaniasis. Currently, there is a rapid widespread development of resistance to prescription drugs for these neglected diseases. Microbes provide the largest chemical and biological diversity in drug discovery screening programs; therefore, our project seeks to explore microbes in the sub-region for new drugs. The oxylipin (9Z,11E)-13-oxooctadeca-9,11-dienoic acid (1) was isolated from the Ghanaian endophytic fungus, Penicillium herquei strain BRS2A-AR obtained from the leaves of a Laguncularia racemosa tree growing on the banks of the River Butre in the Western Regional wetlands of Ghana. Compound 1 was isolated on reverse phase HPLC at tR of 34.3 minutes. The structure of compound 1 was confirmed by a combination of mass spectrometry, 1D and 2D-NMR techniques. Compound 1 showed minimal antiparasitic activity when tested against Plasmodium falciparum 3d7 (IC50>100µM; aretesunate, IC50 36nm), Trypanosoma brucei brucei (IC50>100µM; Coptis japonica, IC50 8.20µM), Leishmani donovani (IC50>100µM; amphotericin B, IC50 0.32µM) and Leishmania major (IC50>100µM; amphotericin B, IC50 0.31µM). Compound 1 produced IC50 of 44.47µM when tested against Trichomonas mobilensis with metronidazole (IC50 5.20µM) as standard. These results show the potential to further engineer the structure of compound 1 into a potent anti-Trichomonas scaffold.International Formulae Group (IFG)2019Articlehttps://rdlopen.rawdatalibrary.net/r/munzur/3752https://doi.org/10.4314/ijbcs.v13i4.21991-8631enInternational Journal of Biological and Chemical Sciencesinfo:eu-repo/semantics/openAccessinfo:eu-repo/semantics/articlehttps://munzur-rdlopen.rawdatalibrary.net/tr/items/munzur/3752