2026-10-29T21:48:21Zhttps://munzur-rdlopen.rawdatalibrary.net/oai/requestoai:munzur-rdlopen.rawdatalibrary.net:munzur/58072026-10-28T15:10:58Zopenairecom_munzur_1col_munzur_2Effect of Lutein/Zeaxanthin Isomers on the Musclin Signaling PathwaySahin, KazimEr, BesirErten, FusunTıbbi Araştırmalar DeneyselFizyolojiBiyokimya ve Moleküler BiyolojiSpor BilimleriVeterinerlikLutein (L) and zeaxanthin (Zi) are plant origin carotenoids. They have anti-inflammatory and\rantioxidant effects. Musclin is a myokine induced by physical activity. The aim of this study was to\rinvestigate the effect of L/Zi supplementation on serum and skeletal muscle musclin levels in rats\rsubjected to physical exercise. For this purpose, the rats were divided into four groups, each\rconsisting of seven rats, as the control group, no exercise, L/Zi treated and no exercise group\r(L/Zi), exercise group (E), and L/Zi treated and exercise group (E + L/Zi treatment). L/Zi was\radministered daily for eight weeks as an oral supplement by gavage at a dose level of 100 mg/kg\rBW. When compared with control, E, L/Zi and E + L/Zi decreased muscle triglyceride level by\r30.8%, 28.3% and 57.4%, respectively and increased serum and muscle musclin levels by 58.03%,\r67.4%, 136.5% and 49.4%, 50.1%, 85.6% respectively. In conclusion, it was determined that\rskeletal muscle and systemic musclin levels were stimulated by L/Zi combination in rats subjected\rto chronic exercise2022Articlehttps://rdlopen.rawdatalibrary.net/r/munzur/58071308-9323trFırat Üniversitesi Sağlık Bilimleri Veteriner Dergisiinfo:eu-repo/semantics/closedAccessinfo:eu-repo/semantics/articlehttps://munzur-rdlopen.rawdatalibrary.net/tr/items/munzur/5807