İdil, Önder; Şahal, Hakan; Canpolat, Erdal; Özkan, Mustafa

Synthesis of three Schiff bases of 5-bromo-3-nitro salicylaldehyde containing different sulfonamide group antibiotic compounds and their Cu(II) complexes was carried out. Structures of all compounds were characterized with spectroscopic methods, including Fourier transform infrared, proton nuclear magnetic resonance, and elemental analysis. The in vitro antimicrobial activity of ligands and complexes against Gramnegative and Gram-positive bacteria and the yeast Candida albicans was evaluated. It was determined that the ligand and complexes showed outstanding antimicrobial activity against almost all of the microorganisms tested. It has been observed that the newly synthesized complexes have more antimicrobial effects than the corresponding ligands. It has been determined that the newly synthesized complexes have more antimicrobial effects than the others (E. coli, L. monocytogenes, and C. albicans), especially on Staphylococcus aureus and Pseudomonas aeruginosa.

AtıfScopus4·WoS3·OpenAlex2

İncele

Şahal, Hakan; İdil, Önder; Canpolat, Erdal; Özkan, Mustafa

Abstract: Synthesis of three different new sulfonamide compounds (L1–L3) and their Cu(II) complexes were carried out. Their structures were characterized by spectroscopic methods such as Fourier transform infrared, Proton nuclear magnetic resonance and elemental analysis. Cu(II) complexes were screened for Gram-positive, Gram-negative bacteria and against yeast using the microdilution method. In particular, CuL2 was found to have significant antimicrobial effects on Gram (–), Gram (+) and eukaryotic yeast. The results showed that CuL2 exhibited better antimicrobial activity than other complexes. Depending on the antimicrobial activity results, time killing experiments of CuL2, the most effective complex, were performed.

AtıfScopus3·WoS2·OpenAlex2

İncele