Korkmaz, N.; Korkmaz, Ş.A.; Ceylan, Y.; İmamoğlu, R.; Bülbül, A.S.; Karadağ, A.

In this study, the cyanido complexes given by the formula [Ni(Abut)Ni(CN)4 ]·8H2 O (C1), [Cu(Abut)2 Ni(CN)4 ]·7H2 O (C2), [Zn(Abut)Ni(CN)4 ]·8H2 O (C3) and [Cd(Abut)Ni(CN)4 ]·7H2 O (C4) were ob-tained by microwave synthesis method. The powder forms of the complexes were characterized by elemental, FT-IR spectroscopy, and thermal analysis. And also antibacterial, antibiofilm and anticancer activities were investigated. The splitting stretching bands of cyanido groups in the FT-IR spectra of C1-C4 indicated the assets of terminal and end cyanido groups. The antibacterial activities of C1-C4 were tested with nine Gram negative and six Gram positive bacteria. The most efficient antibacterial activity of complexes was observed at 1000 µg/ml-1 concentration. Anticancer activity was tested using HeLa cell line and MTT test. The studied cyanide complexes have been shown to decrease the viability of HeLa cells with IC50 values 14.86, 6.5, 7.2 and 19.2 µg/ml for C1, C2, C3 and C4 complex, respectively.

İncele

Korkmaz, S. Aslan; Karadag, A.; Korkmaz, N.; Andaç, O.; Gürbüz, N.; Özdemir, I.; Topkaya, R.

Five cyanide complexes, [Ni(N-bishydeten)Pd(CN)(4)] (1), [Cu(N-bishydeten)Pd(-CN)(2)(CN)(2)](n) (2), [Cu(N-bishydeten)(2)][Pd(CN)(4)] (3), [Zn(N-bishydeten)Pd(CN)(4)] (4), and [Cd(N-bishydeten)(2)][Pd(CN)(4)] (5) (N-bishydeten = N,N-bis(2-hydroxyethyl)-ethylenediamine), have been synthesized and characterized using various techniques. Different structures were formed when the M:L ratio was varied in copper complexes. The single-crystal X-ray diffraction analysis reveals that 2, a 1-D cyanide-bridged complex with 2,2-CT-type zigzag chain, was obtained by using 1:1M:L ratio whereas 3 was formed as a complex salt in a molar ratio of 1:2. The thermal stabilities determined from DTG(max) values of the first decomposition stages change in the order 1>5>4>3>2. Although an EPR signal was not observed for 1, the g parameters obtained from the EPR spectra of 2 and 3 indicate that Cu-II ions are located in tetragonally distorted octahedral sites (D-4h), and the ground state of the unpaired electron is (B-2(1g)). The magnetic behavior indicates a very small antiferromagnetic interaction below 10K for 1-3. In 3, there is a temperature-independent paramagnetism () due to the orbital moments of the d electrons. 1-3 were tested as catalysts in Suzuki and Heck coupling reactions.

AtıfWoS16·OpenAlex15

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