Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2026Seasonal changes in oxidant and antioxidant biomarkers in liver and muscle of common carp (Cyprinus carpio) in Atatürk Dam Lake
Benzer, Fulya; Tepe, Rıdvan; Erisir, Mine; Turkoglu, Semra; Fırat, Özgür; Şahin, Ayse Gül; Sünbül, Muhammet Raşit; Örnekci, Gürel Nedim; Küçükyılmaz, Mehmet; Öz, Özden Barım
Seasonal investigations were conducted on 640 Cyprinus carpio specimens obtained through commercial fishing at four different stations (Gerger, Sitilce, Hosirge, and Samsat) in the Atatürk Dam Lake. MDA (malondialdehyde) levels were measured in the liver and muscle tissues of male and female fish; the results revealed a significant increase in MDA levels at stations exposed to point-source discharge. This indicates that pollution-induced oxidative stress in fish varies significantly across seasonal and regional scales. Among the stations compared, the lowest MDA values were detected in fish tissues from the Gerger station, while the highest values were recorded at the Sitilce and Hosirge stations. Analysis of SOD, GSH-Px, and GSH values across all stations showed that these parameters fluctuated in correlation with MDA levels thereby maintaining the oxidant-antioxidant balance. This study investigated seasonal and spatial variations in oxidative stress biomarkers in common carp (Cyprinus carpio) collected from four stations in Atatürk Dam Lake. A total of 640 specimens were analyzed for malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) levels in liver and muscle tissues. Results showed that MDA levels were significantly higher in fish collected from Sitilce and Hosirge stations, indicating elevated lipid peroxidation associated with point-source pollution. In contrast, the lowest MDA levels were observed at the reference station, Gerger. Antioxidant enzyme activities (SOD, GSH-Px, and GSH) exhibited tissue-, season-, and site-dependent variations, suggesting adaptive responses to oxidative stress. Overall, the findings demonstrate that anthropogenic pressures in Atatürk Dam Lake significantly alter the oxidant–antioxidant balance in fish, highlighting the usefulness of these biomarkers for environmental monitoring.
- MakaleAçık Erişim2014The investigation of some bioactive compounds and antioxidant properties of hawthorn (Crataegus monogyna subsp. monogyna Jacq)
Keser, Serhat; Celik, Sait; Turkoglu, Semra; Yilmaz, Okkes; Turkoglu, Ismail
The antioxidant and pharmacological effects of hawthorn have mainly been attributed to the polyphenolic contents. The aim of this research is to determine some bioactive compounds and antioxidant properties of hawthorn aqueous and ethanol extracts of leaves, flowers, and ripened fruits. Materials and Methods: For this purpose, antioxidant activities of extracts were assessed on DPPH center dot, ABTS center dot +, superoxide scavenging, reducing power and ferrous metal chelating activity assays and phenolic content of extracts was determined by Folin-Cioacalteu's reagent. Results: The flavonoids including rutin, apigenin, myricetin, quercetin, naringenin and kaempferol, were identified by high- performance liquid chromatography in the hawthorn extract. Conclusion: It was observed the aqueous and ethanol extracts of Crataegus monogyna subsp. monogyna fruits showed the highest activity in reducing power and metal chelating activity assays. In addition, it was determined that the aqueous flower extract showed higher flavonoid content than aqueous leaves extract. The antioxidant and pharmacological effects of hawthorn have mainly been attributed to the polyphenolic contents.
AtıfWoS47OpenAlex58
İncele - MakaleYalnız künye2014Scopus SJRQ2THE EFFECTS HYDROXYUREA DERIVATIVE SCHIFF BASES ON FATTY ACIDS AND LYPOPHILIC VITAMINS IN LIVER OF RATS
Turkoglu, Semra; Parlak, Akif E.; Yildirim, Isil; Karagozoglu, Yusuf; Alayunt, Naci O.
Schiff bases and their metal complexes have antiviral, antimicrobial, antitumoral, radical scavenging and antioxidant activities. In this study, effects of Schiff base ligand and its metal complexes on the fatty acids and lyphophlilic vitamins of the liver of rats were investigated. The fatty acids of the liver were determined by GC and lyphophlilic vitamins of the liver determined by HPLC. The amounts of stearic acid (18:0), oleic acid (18:1) and monounsaturated fatty acids (MUFA) considerably decreased in the Mn, Ni and Zn complexes groups, whereas the amount of linolenic acid (18:3) and eicosatrienoic acid (20:3) considerably increased in the Ni an Zn complexes groups compared to the control group (P<0.01). However, there was no significant difference (P>0.05) in the amounts of arachidonic acid (20:4), docosahexaenoic acid (22:6), total saturated fatty acids (SFA) and polyunsaturated fatty acids (PUFA), total omega-3 and omega-6 fatty acids between groups. The amounts of vitamin K-1, vitamin D-2 considerably increased (P<0.05) in the Mn and Ni complexes groups as compared to the control. It was observed that the amount of a-tocopherol increased both in the Ni and Co complexes groups when compared to the control group but this increase was parallel to the amount in the same groups (P<0.05). As a result, it can be think that with the application of toxic metals such as manganese, cupper, nickel, cobalt, and zinc unsaturated fatty acids affected the activities of enzymes which are in the liver tissue and in charge in the fatty acid chain elongation.
AtıfWoS1İncele - MakaleAçık Erişim2013Scopus SJRQ2Total phenolic contents and free-radical scavenging activities of grape (Vitis vinifera L.) and grape products
Keser, Serhat; Celik, Sait; Turkoglu, Semra
Grape is one of the world's largest fruit crops, with an approximate annual production of 58 million metric tons, and it is well known that the grape skins, seeds and stems, waste products generated during wine and grape juice processing, are rich sources of polyphenols. It contains flavonoids, phenolic acids and stilbenes. In this study, we tried to determine antioxidant properties and phenolic contents of grape and grape products (fresh fruit, seed, dried fruit, molasses, pestil, vinegar) of ethanol and water extracts. Antioxidant properties of extracts were investigated by DPPH center dot, ABTS(center dot+), superoxide, H2O2 scavenging, reducing power, metal chelating activity and determination of total phenolic contents. The seed extracts revealed highest ABTS(center dot+), DPPH center dot, H2O2 scavenging and reducing power activities. Furthermore, these extracts showed higher total phenolic contents than other grape product extracts.
AtıfWoS41OpenAlex45
İncele - MakaleYalnız künye2012Scopus SJRQ2ANTIOXIDANT PROPERTIES OF WILD EDIBLE MUSHROOM PLEUROTUS ERYNGII COLLECTED FROM TUNCELI PROVINCE OF TURKEY
Yildirim, Nuran Cikcikoglu; Turkoglu, Semra; Yildirim, Numan; Ince, Olcay Kaplan
Antioxidants are our first line of defense against free radical damage, and are critical for maintaining health. The need for antioxidants becomes even more critical with increased exposure to free radicals. In the past few years there has been an increasing interest in determining relevant dietary sources of antioxidant phenolics. Mushrooms have been not only used as food materials with their unique flavor and texture, but also recognized as an important source of biologically active compound of medicinal value. In our study, to determine the antioxidant properties of the methanolic extracts of Pleurotus eryngii strains collected from different region of Tunceli, radical scavenging activity, total phenolic contents, reducing power, metal chelating activity and total antioxidant status (TAS) were analyzed. The analysis of phenolic compounds was performed by HPLC. In particular, the methanolic extract of P. eryngii collected from city center revealed the highest DPPH radical scavenging activity and reducing power, while the highest total phenolics and total antioxidant status was determined in P. eryngii collected from Pulumur. P. eryngii collected from Ovacik showed the highest chelating effects. Concentration of phenolic compounds found in three wild edible mushrooms. Kaempferol and catechin were not determined in musrooms species. The highest rutin levels were determined in ovacik. Resveratrol was determined only in Pulumur. The studied wild mushrooms might be beneficial to protect human body against oxidative damage.
AtıfWoS40İncele - MakaleYalnız künye2012Scopus SJRQ4Determination of Antioxidant Capacities of Phlomis pungens Wild. var. hispida Hub.-Mor.
Keser, Serhat; Turkoglu, Semra; Celik, Sait; Turkoglu, Ismail
The genus Phlomis L. belongs to the Lamiaceae family and encompasses 100 species native to Turkey, North Africa, Europe and Asia. It is a popular herbal tea enjoyed for its taste and aroma. Phlomis species are used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. In this study, ethanol and water extracts were prepared from powdered P pungens flowers and leaves. Antioxidant activities were measured by 2,2-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS(center dot+)) radical scavenging, 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH center dot) scavenging, superoxide anion (02) radical scavenging, reducing activity and ferrous metal chelating activity assays. In conclusion, P. pungens flowers and leaves had effective ABTS(center dot+) and DPPH center dot radical scavenging, superoxide anion radical scavenging, reducing power and metal chelating activities when compared with BHA, BHT and alpha-tocopherol as reference antioxidants.
AtıfWoS13İncele
