Sürdürülebilir Kalkınma Amaçları

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• Derleme MakaleYalnız künye2025Scopus SJRQ2/r/munzur/1222
  Revolutionizing biomedicine with rare earth element nanoparticles: physical properties and biotechnological potential

  Şahal, Hakan

  Rare earth elements (REEs) are used in the creation of many promising technologies that have the potential to revolutionize many medical and biotechnological fields such as medical imaging, cancer treatment and diagnosis, biosensors and diagnostic kits, tissue engineering and regenerative medicine, cosmetics and dermatology, gene therapy and molecular biology, pharmacology, and drug delivery systems today and in the future. Their use as targeted treatment approaches, biocompatible materials and imaging agents with anticancer, antimicrobial, antibacterial, and antioxidant properties enables revolutionary developments in modern medicine and biotechnology. The versatile uses of these elements may contribute to the development of more effective and sensitive methods in medical treatment and diagnosis in the future. For this reason, they are intensively researched worldwide. The focus of this research is that rare earth elements and their derivatives can provide innovative solutions for diagnosis and treatment at the molecular level. Doping with rare earth elements, which are considered as vitamins of industries, redefines the properties of materials and increases their efficiency. For this reason, research is aimed at obtaining new properties and applications by creating hybrid structures of rare earth elements with different components. In recent years, scientific interest in investigating the molecular interactions of REEs with biomolecules has increased. These studies aim to activate drug-specific molecules in target cells, reduce their side effects, and provide more effective treatment methods. These studies aim to create potential structures in gene therapy, biosensor technologies, and cancer research with modifications performed using REEs. This study investigates the transformative potential of REE nanoparticles in various biotechnological and biomedical applications and emphasizes their promise as versatile tools for innovation in multiple disciplines by highlighting their roles in advancing targeted therapies, reducing side effects and addressing critical challenges in modern healthcare.

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  AtıfScopus2·WoS1·OpenAlex2

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• DüzeltmeAçık Erişim2024Scopus SJRQ2/r/munzur/1810
  Correction: Genotoxic effects of copper nanoparticles on Vicia pannonica Crantz. root meristem cells (Journal of Nanoparticle Research, (2024), 26, 8, (185), 10.1007/s11051-024-06096-y)

  Tasar, Neslihan

  The original version of this article unfortunately contained incorrect Figs. 2, 3, and 4. Lastly, Open access cancellation shall be initiated. The approval manager initially approved the article by mistake, and they approved it above their maximum article threshold by accident. (Figure presented.) (Figure presented.) (Figure presented.) A Adhesion in prophase, B distorted prophase, C metaphase, D distorted metaphase, E non-collection in metaphase plaque, F lagging chromosome in metaphase, G adhesion in metaphase, H chromosome loss in metaphase, I chromosome breakage in metaphase, J asynchronous division in anaphase, K distorted anaphase, L lagging chromosome in anaphase, M polar deviation in anaphase, N chromosome bridges in anaphase, O advance in anaphase, P polar deviation in telophase, R bridge in telophase, S lagging chromosome in telophase, T distorted telophase, U adhesion in telophase (magnification = × 100) A The scanning electron microscopy (SEM) image of the control group, EDS characteristic spectrum, and mapping image. B The scanning electron microscopy (SEM) image of the sample that was prepared with 50 ppm Cu NPs, EDS characteristic spectrum, and mapping image. C The scanning electron microscopy (SEM) image of the sample that was prepared with 150 ppm Cu NPs, EDS characteristic spectrum, and mapping image. D The scanning electron microscopy (SEM) image of the sample that was prepared with 300 ppm Cu NPs, EDS characteristic spectrum, and mapping image The XRD plots of the samples that were obtained from V. pannonica plant grown with Cu (40–60 nm) NP

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• MakaleAçık Erişim2024Scopus SJRQ2/r/munzur/1593
  Genotoxic effects of copper nanoparticles on Vicia pannonica Crantz. root meristem cells

  Tasar, Neslihan

  With the increasing use of metal nanoparticles, their access to the food chain has become the main concern for scientists. The present study sheds light on the copper nanoparticles (Cu NPs), which are widely used in many industries today. For this purpose, Vicia pannonica Crantz., a common fodder plant, was used and exposed to metal-based Cu NPs. To determine the genotoxic effects on root meristem cells, total of 3 different concentrations (50 ppm, 150 ppm, and 300 ppm) of Cu NPs and the control in deionized water solutions were prepared. The determination of the accumulation and elimination of Cu NPs in Vicia pannonica used in the study was carried out using with X-ray diffraction (XRD), scanning electron microscopy (SEM), SEM element mapping, and energy dispersive X-ray diffraction (EDS) characteristic spectrum analysis. All doses of Cu NPs caused significant decreases in the Mitotic index of V. pannonica meristem cells compared to the control. Multiple analyzes carried out in the study showed that Cu NPs caused abnormalities in cell division such as C-metaphase, polar aberration, deconstructed anaphase, chromosome breakage, loss of genetic material, failure to assemble in the metaphase plate, deconstructed metaphase, asynchronous division remaining chromosome in metaphase, adhesion, deconstructed prophase, advanced chromosomes, and chromosome bridges in anaphase. Results support that Cu NPs have a genotoxic effect on V. pannonica.

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  AtıfScopus5·WoS2·OpenAlex6

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