Yazarlar
- Gul, Muhammet(35)
- Erten, Fusun(23)
- Zengin, Gokhan(23)
- Benzer, Fulya(22)
- Dal, Nursel Alp(20)
- Sahin, Kazim(20)
- Orhan, Cemal(19)
- Yeşiltepe, Akgün(17)
- Topal, Murat(15)
- Yucesan, Melih(15)
- Yildirim, Ozal(13)
- Öbek, Erdal(13)
- Aksakal, B.(12)
- Gürarslan Baş, Nazan(12)
- Alp Dal, Nursel(11)
- Baloglu, Ulas Baran(11)
- Cakilcioglu, Ugur(11)
- Kandemir, Fatih Mehmet(11)
- Paksoy, Mehmet Yavuz(11)
- Talo, Muhammed(11)
- Celik, Erkan(10)
- Er, Besir(10)
- Say, Yakup(10)
- Yaman, Mine(10)
- Yüksekol, Özlem Doğan(10)
- Aksu, Önder(9)
- Aslan, N.(9)
- Aslan, Naim(9)
- Baş, Kazım(9)
- Erişir, Mine(9)
- Mahomoodally, Mohamad Fawzi(9)
- Acharya, U. Rajendra(8)
- Caprioli, Giovanni(8)
- Karatay, Gülnaz(8)
- Kocabaş, Mehmet(8)
- Macit, Arife(8)
- Parlak Ak, Tuba(8)
- İpek, Yeliz(8)
- Beydağ, Kerime Derya(7)
- Camas, Mustafa(7)
Yayınlar
- MakaleAçık Erişim2026The association between perceived bullying in physical education classes and school satisfaction among middle school students: the mediating roles of physical activity enjoyment and physical education class happiness
Güllü, M; Akarsu, M; Tan, H; Karakaş, E; Günata, GP; Akçınar, S
- MakaleAçık Erişim2026The relationship between sport competition rumination and sport-specific achievement motivation levels among professional athletes in Turkey
Bulut, M; Yildiz, M; Kizilkoca, M; Tokgöz, G; Can, B
- MakaleAçık Erişim2026Tek Ebeveynli Ailede Kadın Olmak: Güçlükler, Başa Etme Stratejileri, İhtiyaç ve Beklentiler
Akgül, Ceylan Sülü
Bu çalışma; tek ebeveynli ailede yaşayan kadınların yaşadığı güçlükler, baş etme stratejileri, ihtiyaç ve beklentilerini incelemek amacıyla kaleme alınmıştır. Kadının ve çocuğun güçlenmesinin aileyi ve toplumu güçlendireceği anlayışıyla, sosyal hizmetlere yönelik politika önerilerinin sunulması da diğer amaçlar arasında yer almaktadır. Nitel araştırma yöntemiyle kaleme alınan çalışma üç ana temaya ayrılarak incelenmiştir. Elde edilen bulgular MAXQDA 2024 programı kullanılarak betimsel analizler yoluyla deşifre edilmiştir. Tunceli ili sınırları içerinde yaşayan 10 kadın çalışmanın örneklem grubunu oluşturmuştur. Buna göre hem çocuğun bakımını hem evin geçimini üstlenen kadınların ekonomik, psikolojik ve sosyal açıdan çok yönlü zorluklar yaşadığı tespit edilmiştir. Katılımcıların baş etme sürecinde çocuklarının varlığı, kişisel motivasyonları ve sosyal destek ağlarının önemli rol oynadığı görülmüştür. Kadınlar başta çocuklarının bakımı için uygun destek koşulları sağlandığında istihdam hayatına katılma ve ekonomik bağımsızlığını sağlama konusunda oldukça istekli olmakta bu minvalde çeşitli beklenti ve önerilerini paylaşmaktadır.
AtıfOpenAlex1
İncele - MakaleAçık Erişim2026The Effect of Nurse-Parent Support on Coping with Anxiety, and Caregiver Burden Among Parents of Hospitalized Infants: A Cross-Sectional Study
Kaya, Ayla; Kemer, Duygu
Objective: This study aimed to evaluate the effect of nurse-parent support on coping with anxiety and caregiver burden among parents of hospitalized infants. Materials and Methods: This cross-sectional study included 214 parents of hospitalized infants from a comprehensive hospital in southern Türkiye. Data were collected between August 2023 and March 2024 using the “Nurse-Parent Support Tool,” “State Anxiety Inventory,” and “Burden Interview Scale.” The STROBE checklist was used for reporting. Results: In this study, 38.3% of the parents were 25 years of age or younger. Parents' perceptions of nurse-parent support were above average; anxiety was high, and caregiver burden was medium. Female parents with lower education levels, whose infants were seven months or older, perceived nurse-parent support as high, and had lower anxiety. In addition, caregiver burden was higher among parents aged 31 or older. There was a negative relationship between nurse-parent support and anxiety level, and a positive relationship between nurse-parent support and caregiver burden. A negative relationship was also observed between anxiety level and caregiver burden. Conclusion: Nurse-parent support was found to reduce parents' anxiety and increase caregiver burden. To improve the quality of care, pediatric nurses should consider parents’ anxiety and caregiver burden and prioritize providing appropriate support.
- MakaleAçık Erişim2026Food Literacy, Sustainable Eating Behaviors, and Healthy Eating Index in University Students
Yeşiltepe, Akgün; Haznedar, Nagihan Kırcalı; Macit, Arife
Objective: This study aims to examine the relationships among food literacy, sustainable and healthy eating behaviors, and Healthy Eating Index (HEI) scores among university students. Materials and Methods: This cross-sectional study was conducted with 301 volunteer university students using a structured questionnaire which included questions about general information, a sustainable and healthy eating behaviors scale (SHEB), a food literacy scale (FOODLIT), and a 24-hour dietary recall. HEI (2015) scores were calculated for all participants using 24-hour data. The statistical analysis of the data was performed using the JASP and SPSS (version 26.0) software. Results: The mean SHEB, FOODLIT, and HEI scores of the participants were 2.93±0.82, 33.13±12.55, and 41.22±11.44, respectively. A positive and significant relationship was found between FOODLIT and SHEB scores (r=0.418; p<0.05), and FOODLIT scores were found to explain 17.5% of the variance in SHEB scores (R2=0.175). In dimension analyses, environmentally safe and selection-planning skills stood out as variables associated with HEI scores, while no significant relationship was found between HEI scores and other variables. Conclusion: In conclusion, it is considered that food literacy is associated with sustainable eating behaviors, but this relationship may not directly reflect diet quality.
- MakaleAçık Erişim2026Pohlia wahlenbergii (Bryophyta)’nin Biyoaktif Potansiyeli: Antioksidan, Antidiyabetik ve Antimikrobiyal Aktiviteleri
Alataş, Mevlüt; Erdem, Belgin; Çöteli, Ebru
Briyofitler, biyolojik aktiviteleri yeterince incelenmemiş önemli bir bitki grubunu oluşturmaktadır. Yapılarındaki çok sayıda biyoaktif bileşik, onları önemli kılmaktadır. Bu çalışmada, Pohlia wahlenbergii karayosununun aseton ve metanol özütlerinin in vitro antioksidan, antidiyabetik ve antimikrobiyal aktiviteleri değerlendirilmiştir. Antioksidan aktivitenin belirlenmesinde, bu özütlerin iki farklı radikale, DPPH. ve ABTS.+'ya karşı inhibitör güçleri ölçülmüştür. Sonuçlar, standart askorbik asit sonuçlarıyla karşılaştırıldı. Ayrıca bu ekstraktların antidiyabetik aktivitesini belirlemek için, α-amilaz enzim inhibisyonu ölçüldü. Sonuçları karşılaştırmak için akarboz ilacı kullanıldı. En yüksek DPPH. ve ABTS.+ radikal temizleme aktivitesi sırasıyla 1.509 ve 1.301 mg/mL IC₅₀ değerleriyle aseton ekstraktında gözlendi. ABTS.⁺ radikal temizleme aktivitesinin daha güçlü olduğu bulundu. Antidiyabetik aktivitenin belirlenmesinde, α-amilaz enzim inhibisyonu kullanıldı ve metanol ekstraktında en yüksek seviyede olduğu görüldü (1.792 mg/mL). Ekstraktların antioksidan ve antidiyabetik aktivitelere sahip olduğu belirlendi. Ayrıca, Pohlia wahlenbergii'den elde edilen özütlerin çeşitli patojen mikroorganizmalara karşı in vitro antimikrobiyal potansiyeli değerlendirilmiştir. Sonuçlar, güçlü antifungal aktivite göstermiştir; aseton özütü, standart ilaç Flukonazol'den daha iyi performans göstererek Candida albicans'a karşı 25 mm'lik bir inhibisyon bölgesi ve 16 µg/mL'lik bir MIC sergilemiştir. Metanol özütü de geniş spektrumlu antibakteriyel etkiler göstermiş, özellikle Bacillus cereus ve Salmonella typhimurium'a karşı 20 mm'lik bir inhibisyon bölgesi göstermiştir. Pohlia wahlenbergii'nin seçici antimikrobiyal özellikleri, yeni doğal antibiyotikler ve antifungal ajanlar geliştirmek için potansiyel bir kaynak olduğunu göstermektedir.
- Derleme MakaleAçık Erişim2026Scopus SJRQ3Afet Direnci Kavramını Anlamak: Direnç Göstergeleri Üzerine PRISMA Yöntemiyle Sistematik Bir İnceleme
Peker, İskender; Ozbey, Sümeyye
Doğal ve beşerî faktörlerin bir araya gelmesiyle oluşan afetler, toplumların güvenliği, sürdürülebilir kalkınması ve yaşam kalitesi üzerinde ciddi tehditler oluşturmaktadır. Afetlerin önlenebilmesi veya etkilerinin azaltılabilmesi, toplumların ve kurumların afet direncinin artırılmasıyla doğrudan ilişkilidir. Afetlere dirençli toplumlar, afetlerle karşı karşıya kaldıklarında daha az kayıp yaşamakta, daha hızlı toparlanabilmekte ve yeniden işlevsel hale gelebilmektedir. Afetlerin etkilerinin azaltılması ve toplumsal hazırlığın artırılması amacıyla toplumsal afet direnci kavramına literatürde yer verilmiş olmasına rağmen bu kavrama ilişkin teorik çerçeve sınırlıdır. Kavramın tanımlanması, etkileyen faktörlerin belirlenmesi, hangi yöntemlerle değerlendirilebileceği açık değildir. Bu çalışma, söz konusu kavramsal boşluğu doldurmak amacıyla PRISMA yöntemi kullanılarak kapsamlı bir literatür analizi gerçekleştirmekte ve toplumsal afet direncine dair metodolojik bir çerçeve sunmaktadır. Analiz sonucunda, afetlere karşı kırılganlığın azaltılması için dirençlilikle ilişkili mevcut çalışmalar sistematik biçimde değerlendirilmiş, ayrıca bu kavramın ölçülebilmesi için kullanılabilecek bir dizi ilke ve gösterge sunulmuştur. Sonuç olarak çalışma, afetlere karşı kırılganlığı azaltmaya ve sürdürülebilir bir afet yönetimi yaklaşımı geliştirmeye katkı sunacak kavramsal ve pratik öneriler ortaya koymaktadır.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Yaşlılarda Telesağlık ve Teletıp Uygulamalarının Sistematik İncelenmesi
Baş, Kazım
Bu araştırmanın amacı, 1998-2024 yılları arasında yayınlanmış eserlerden yararlanılarak yaşlı bireylerde telesağlık ve teletıp uygulamalarının sistematik olarak incelenmesidir. Sistematik derleme türü olan bu çalışmada, evrenden örneklem grubuna dahil edilen kaynakların belirlenmesinde PRISMA-ScR raporlama kılavuzu temel alınmıştır. Araştırma kapsamında, yaşlı bireylerde telesağlık ve teletıp uygulamalarını ele alan ve araştırmanın modeli ile amacına uygunluk gösteren 230 eserden 60 tanesi örneklem grubunu oluşturmuştur. Dijitalleşme uzaktan sağlık hizmetlerinin sunumunu mümkün hale getirmiştir. Dijitalleşmenin sağlık hizmetlerindeki örnekleri arasında elektronik sağlık kayıtları, web ve mobil uygulamalar, teletıp, yapay zeka teknolojileri, giyilebilir cihazlar, otomatik sağlık iş akışları, öngörücü analizler ve dijital hasta etkileşimi gibi yenilikçi çözümler yer almaktadır. Bu kapsamda telesağlık ve teletıp uygulamalarının hastaların tıbbi bakımında yaygın bir şekilde kullanıldığı görülmektedir. Özellikle kronik ve yaşlı hastaların izlenmesi, hastalara danışmanlık ve bakım verilmesi gibi durumlarda teletıp uygulamalarına başvurulmaktadır. Yaşlılar için teletıp uygulamaları; yaşam bulgularının ölçümü ve izlenmesi, etkileşimli sistemler ve sağlık personeliyle doğrudan iletişimi sağlayan uygulamaları kapsamaktadır. Son yıllarda, yaşlı nüfusun artan sağlık sorunlarının çözümünde telesağlık ve teletıp uygulamaları sağlık politikalarının önemli bir bileşeni haline gelmiştir. Bu hizmetler maliyet etkinliği, sağlık ve sosyal bakım hizmetlerine erişim kolaylığı nedeniyle yaşlı sağlığının desteklenmesinde önerilmektedir. Bu hizmetlerin, etkili ve verimli yürütülebilmesi için sağlık politika yapıcıları, devlet ve geniş toplum kesimleri, sağlık hizmeti sunan kurumlar, sağlık çalışanları ve sosyal güvenlik ile sigorta kurumlarının iş birliği içinde hareket etmeleri önemlidir.
AtıfOpenAlex1İncele - MakaleAçık Erişim2026Development of the intention to be physically active scale: A validity and reliability study in the context of physical education and sport
Şahin, Aykut; Öner, Burak
The aim of this study is to develop a scale for the intention to be physically active within the context of physical education and sports, and to examine its psychometric properties. The scale development process began with the creation of an item pool based on a theoretical foundation and establishing content validity through expert opinions. The research was conducted with data obtained from 439 middle school students. To determine the construct validity of the scale, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were performed. The Kaiser-Meyer-Olkin (KMO) value (0.91) and the results of the Bartlett’s Test of Sphericity showed that the data were suitable for factor analysis. In the first stage, during the factor extraction process of the EFA conducted with data from 154 students, the eigenvalue rule (>1), scree plot, and parallel analysis results were evaluated together. As a result of the EFA, it was determined that the scale had a single-factor structure with 13 items in a 5-point Likert type format, and this single factor explained 47.07% of the total variance. In the second stage, the CFA conducted with data from 285 students revealed that the model had acceptable fit indices (x2/df=2.40, CFI=.94, GFI=.92, TLI=.93, RMSEA=.07, SRMR=.04). To prove construct validity, the CR value was calculated as 0.91 and the AVE value as 0.44. The CR value being well above the threshold supported the convergent validity evidence for the AVE value. Reliability analyses of the scale indicated that Cronbach’s Alpha was 0.90 and McDonald’s Omega was 0.91, demonstrating high internal consistency coefficients. Higher scores on the scale indicate that students have a greater intention to be physically active in the future. As a result, it was determined that the intention to be physically active scale is a valid and reliable measurement tool for physical education settings.
- MakaleAçık Erişim2026Leisure time loneliness: A study on youth offices
Yıldız, Metin
This study aims to examine university students’ perceptions of loneliness experienced during their free time within the framework of social isolation, difficulties in forming bonds, social access difficulties, and emotional deprivation. The research was conducted to determine the levels of leisure loneliness among students participating in Munzur University Youth Office activities and to analyze whether these levels differed according to various demographic variables. The research group consists of 301 university students (158 women, 143 men) who volunteered to participate in activities during the 2024–2025 academic year. The “Personal Information Form” and the “Leisure Time Loneliness Scale” were used in the data collection process. The data obtained were analyzed using the SPSS 26.0 program; frequency, percentage, t-test, One-Way ANOVA, and Tukey HSD tests. The findings indicate that students’ levels of leisure loneliness are generally low to moderate; although they participate in social interactions, they experience limitations in forming deep and sustainable bonds. Although gender and age were found to have no significant effect on overall loneliness levels, men were found to be more prone to emotional deprivation, while students aged 24 and above were found to be more prone to isolation. Additionally, it was determined that first-year students experience greater difficulty in forming social bonds, students who participate more frequently in youth office activities have lower levels of leisure loneliness, and students in the high-income group experience greater difficulty in terms of emotional fulfillment. In conclusion, it was found that levels of leisure loneliness did not show a significant difference according to demographic variables such as gender, age, and educational status. However, it was determined that variables such as frequency of participation in youth office activities, social bonding processes, and emotional deprivation were more closely related to leisure loneliness
- MakaleAçık Erişim2026Dindarlık Eğilimi ve Aile İçi Şiddet Farkındalığı Arasındaki İlişkide Toplumsal Cinsiyet Algısının Aracılık Rolü
Öztürk, Meral; Türk, Ahmet; Tire, Olcay
Bu araştırma dindarlık eğilimi ve aile içi şiddet farkındalığı arasındaki ilişkide toplumsal cinsiyet algısının aracılık rolünü incelemek amacıyla gerçekleştirilmiştir. Araştırmanın amacına uygun olarak tarama modeli kullanılmıştır. Araştırmaya 18-70 yaş aralığında 463’ü (%68,9) kadın ve 209’u (%31,1) erkek olmak üzere 672 kişi katılmıştır. Katılımcıların yaş ortalaması x̄=28,70±10,02’dir. Araştırmada veriler Kişisel Bilgi Formu, Dindarlık Eğilimi Ölçeği, Aile İçi Şiddet Farkındalığı Ölçeği ve Toplumsal Cinsiyet Algısı Ölçeği kullanılarak toplanmıştır. Verilerin analizinde Pearson korelasyon analizi ile PROCESS Makro regresyon analizleri kullanılmıştır. Bulgular, katılımcıların olumlu bir toplumsal cinsiyet algısına, yüksek düzeyde dindarlık eğilimi ve aile içi şiddet farkındalığına sahip olduğunu ortaya koymaktadır. Dindarlık eğilimi ile aile içi şiddet farkındalığı ve toplumsal cinsiyet algısı arasında pozitif yönlü, toplumsal cinsiyet algısı ile aile içi şiddet farkındalığı arasında negatif yönlü anlamlı bir ilişki olduğu tespit edilmiştir. Aracılık analizi sonucunda dindarlık eğilimi ve aile içi şiddet farkındalığı arasındaki ilişkide toplumsal cinsiyet algısının kısmi aracılık etkisine sahip olduğu saptanmıştır.
- MakaleAçık Erişim2026Beden Eğitiminde Yenilik İhtiyacı Tatmini ve Engellenmesinin Değerlendirilmesi: Bir Ölçek Uyarlama Çalışması
Şahin, Aykut; Öner, Burak
Bu araştırmada “Beden Eğitiminde Yenilik İhtiyacı Tatmini ve Engellenmesi Ölçeği”nin (BEYİTEÖ) Türk kültürüne uyarlanması ve psikometrik özelliklerinin ortaya konulması amaçlanmıştır. Bu kapsamda öğrencilerin beden eğitimi ve spor (BES) derslerinde hissettikleri yenilik ihtiyacı deneyimlerini hem yenilik ihtiyaç tatmini (YİT) hem de yenilik ihtiyaç engellenmesi (YİE) boyutlarıyla ölçebilecek geçerli ve güvenilir bir ölçeğin Türkiye’de kullanılabilirliği test edilmiştir. Araştırmaya Elazığ ilinde bulunan ve devlet ortaokullarında eğitim gören 446 öğrenci katılmıştır. Uyarlama sürecinin ilk aşamasında dil geçerliği, geri çeviri ve uzman paneli aşamalarından oluşan sistematik bir yol izlenmiştir. Verilerin analizinde yapı geçerliliği için açımlayıcı faktör analizi (AFA) ve doğrulayıcı faktör analizi (DFA) gerçekleştirilmiş, ölçeğin güvenirliğine yönelik kanıt elde etmek için Cronbach alfa (α) ve McDonald’s Omega (ω) katsayıları hesaplanmıştır. Ek olarak, yakınsak ve ıraksak geçerlilik AVE, CR, MSV değerleri ve HTMT oranları üzerinden değerlendirilmiştir. AFA sonuçları, ölçeğin toplam varyansın %68’ini açıklayan iki faktörlü bir yapı sergilediğini ortaya koymuştur. DFA sonuçları, modelin verilerle iyi uyum sağladığını (x2 /df=2,65; CFI= 0,96; GFI= 0,94; TLI= 0,95; RMSEA= 0,07; SRMR= 0,05) doğrulamıştır. Cronbach alfa iç tutarlılık katsayıları YİT boyutu için 0,92 ve YİE boyutu için 0,83 olarak saptanmıştır. Yakınsak geçerlilik için YİT boyutunda AVE değeri 0,68, CR değeri 0,91 olarak belirlenirken, YİE boyutunda AVE değeri 0,52, CR değeri 0,83 olarak hesaplanmıştır. Iraksak geçerlilik için her iki faktörün AVE değerinin MSV değerinden büyük olduğu görülmüş, ayrıca HTMT oranının (0,387) istenilen düzeyde olduğu tespit edilmiştir. Her iki boyutun yeterli yapı geçerliği ve güvenirlik ölçütlerini sağladığı belirlenmiştir. Sonuç olarak, Türk kültürüne uyarlaması yapılan BEYİTEÖ’nün, BES derslerinde ortaokul öğrencilerinin yenilik algılarını ölçmek amacıyla kullanılabilecek geçerli ve güvenilir bir ölçme aracı olduğu belirlenmiştir.
- MakaleAçık Erişim2026Application of machine learning techniques for multi-class classification performance on mental disorders
Can, Umit
The contemporary social framework is predicated on a fiercely competitive system, which amplifies individual pressure and subsequently elevates the incidence of mental diseases, significantly affecting public health. Consequently, governmental and non-governmental groups allocate considerable resources to tackle these concerns. The precise identification of such illnesses via artificial intelligence techniques has become critically significant. These methodologies, widely used across several healthcare sectors, have been increasingly adopted in psychiatry. Evaluating psychiatric data to forecast disease accurately enables doctors to make better decisions and establishes a robust decision-support framework. This work employed prevalent machine learning techniques to identify mental illnesses utilizing a dataset with labels for seven distinct mental states—six disorders and one normative condition. The approaches were initially evaluated on an imbalanced dataset and subsequently on a balanced dataset, facilitating comparison of the outcomes. Among Categorical Boosting, Gradient Boosting, Extreme Gradient Boosting, Support Vector Machine, and Logistic Regression, the Support Vector Machine method demonstrated superior performance on both balanced and imbalanced datasets.
- MakaleYalnız künye2026Scopus SJRQ2From assistance to dependence: The nexus between AI dependence and workplace cognitive engagement
Uyan, Umut; Ibin, Adil
Background The increasing integration of artificial intelligence (AI) tools into workplace practices has reshaped how employees process information and perform cognitive tasks. While these systems are often associated with superior efficiency, their excessive use may entail significant cognitive costs. Objective Grounded in automation complacency perspective and the growing literature on technology addiction, this study investigates how dependence on artificial intelligence is associated with cognitive engagement in the workplace, with particular attention to the mediating role of cognitive fatigue. Methods Adopting quantitative research design, data were collected from 246 academic and administrative staff who actively use AI tools in their daily work routines. Partial Least Squares Structural Equation Modeling (PLS-SEM) was used to test the theoretical model proposed. Results The findings indicate that dependence on AI was positively associated with cognitive fatigue (beta = 0.569; t = 13.468; p = 0.000) and negatively with cognitive engagement (beta = -0.174; t = 2.503; p = 0.012). In addition, the relationship between cognitive fatigue and cognitive engagement was found to be negative and statistically significant (beta = -0.207; t = 2.773; p = 0.006). Mediation analysis further revealed that cognitive fatigue partially mediates the relationship between dependence on AI and cognitive engagement (indirect effect beta = -0.118, t = 2.724, p < .01; VAF = 40.5%). Conclusion These results suggest that higher levels of dependence on AI correspond to higher employee cognitive fatigue, which in turn relates to lower cognitive engagement at work. By empirically demonstrating the cognitive costs of AI reliance, this study contributes to the emerging literature on workplace AI and technology addiction.
- MakaleAçık Erişim2026Scopus SJRQ3Ten-Year Trends in Kidney Transplantation by Donor Type, Age, Dialysis, and Sex/Gender Inequality in Turkiye
Ordin, Yaprak Sarigol; Kankaya, Eda Ayten; Celik, Buket
Introduction: Gender disparity remains a global issue in access to renal replacement therapy and kidney transplantation among patients with end-stage kidney disease. Aim: This study examined trends in donor type, recipient age, and dialysis modality in kidney transplantation in T & uuml;rkiye from 2013 to 2022. A secondary aim was to explore gender disparities in kidney transplantation and treatment modalities for end-stage kidney disease using registry data. Methods: This descriptive and cross-sectional study analyzed the distribution and trends of kidney transplants in T & uuml;rkiye between 2013 and 2022. The data were obtained from the publicly accessible Registry of Nephrology, Dialysis, and Transplantation reports in Turkiye. Per million population increase/decrease rate, chi(2) linear trend, and chi(2) R by C were used. Results: Overtime, transplants from living donors increased, while deceased donor transplants decreased. The highest rates of living donor transplants were in 2022, 2021, and 2019. Transplants in high-risk age groups increased significantly. There were differences in donor type among patients receiving hemodialysis, peritoneal dialysis, or preemptive transplantation (p < .001). Preemptive transplants showed the most significant increase, especially from living donors in 2022. Between 2013 and 2022, kidney transplantation increased by 24.67% in men and 19.94% in women. Female transplant rates were lowest in 2016, 2020, and 2021, indicating a persistent gender gap. There was no significant gender difference in the incidence of hemodialysis or peritoneal dialysis. Conclusion: Living donor transplants, especially preemptive ones, increased markedly over the past decade. Gender disparities persist, and efforts should focus on improving access for women and promoting deceased donor programs to ensure equity.
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İncele - MakaleYayıncıda açık erişim2026Scopus SJRQ1Effects of 8-week plyometric training program on balance, reaction time, and attention on elite adolescent female taekwondo athletes
Genç, Harun; Türkmen, Mustafa; Tekin, Irem; Cigerci, Ali Erdem; Gürses, Veli Volkan; Kizar, Oktay; Ökmen, Mehmet Serif; Polatcan, Ismail; Gündogdu, Serhat Dogu
Introduction: Taekwondo is a complex combat sport requiring high levels of strength, balance, reaction time, attention, agility, and endurance for effective performance under rapid offensive and defensive conditions. This study aimed to investigate the effects of an 8-week plyometric training program on static balance (SB), dynamic balance (DB), reaction time (RT), and attention (AT) in adolescent female taekwondo athletes. Methods: Twenty female athletes (age: 14.85 +/- 1.53 years; height: 162.27 +/- 7.12 cm; body mass: 56.69 +/- 6.45 kg) voluntarily participated in the study at Mardin Halit Demir Martial Arts Club. Participants were randomly assigned to either an experimental group (EG, n = 10) or a control group (CG, n = 10). The EG performed plyometric training twice weekly for 8 weeks in addition to regular taekwondo training, while the CG continued only taekwondo training. Static balance was defined as the primary outcome, whereas dynamic balance, reaction time, and attention were considered secondary outcomes. A 2 & times; 2 repeated-measures analysis of variance (group & times; time) was used to examine intervention effects. Results: Significant group & times; time interactions were observed for static balance and dynamic balance (p < 0.05), favoring the experimental group. However, no significant group & times; time interactions were found for reaction time or attention (p > 0.05). Discussion: These findings suggest that plyometric training may effectively improve balance performance in adolescent female taekwondo athletes, particularly static and dynamic balance. However, no significant effects were observed for reaction time or attention. Further studies with larger sample sizes are needed to clarify the potential effects of plyometric training on cognitive performance.
- MakaleAçık Erişim2026Scopus SJRQ1Ellagic Acid Mitigates Lead (Pb)-Induced Toxicity in Cyprinus carpio: A Multi-Biomarker Assessment of Hematological, Immunological, and Oxidative Stress Responses Supported by Molecular Docking
Eroglu, Mucahit; Cakmak, Mehmet Nuri; Pala, Aysegul; Uslu, Harun; Yonar, Serpil Mise; Ispir, Unal; Orhan, Cemal; Yonar, Muhammet Enis
Lead (Pb) is a widespread environmental pollutant that induces systemic toxicity in aquatic organisms primarily through oxidative stress, hematological disruption, and immune dysfunction. This study investigated the protective effects of ellagic acid (EA) against Pb-induced toxicity in common carp (Cyprinus carpio) using a multi-biomarker approach and molecular docking. Fish were assigned to six experimental groups: control, EA-treated, Pb-I, Pb-I + EA, Pb-II, and Pb-II + EA. Fish in the Pb-I and Pb-II groups were exposed to 2.5 and 5 mg/L Pb, respectively, while EA was administered via diet at 100 mg/kg for 14 days. At the end of the exposure period, hematological indices, innate immune parameters, and oxidative stress biomarkers were assessed in blood, liver, kidney, and gill tissues. Pb exposure caused marked hematological impairment, suppressed immune responses, increased malondialdehyde levels, and disrupted antioxidant defense by reducing SOD, CAT, GSH-Px, and GSH levels while increasing GST activity. In contrast, dietary EA supplementation significantly mitigated Pb-induced alterations, improved hematological and immunological responses, reduced lipid peroxidation, restored antioxidant capacity, and normalized GST activity to control levels. Molecular docking analyses further showed that EA interacts with hemoglobin and immunoglobulin M, supporting its potential role in preserving oxygen transport and immune functions under Pb-induced stress. Overall, the findings demonstrate that Pb-induced toxicity involves coordinated disruption of redox homeostasis and immune function, whereas EA exerts a multi-target protective effect through biochemical and molecular mechanisms. This study provides mechanistic insight into chemical-biological interactions and supports the potential application of natural bioactive compounds in mitigating heavy metal-induced toxicity.
- MakaleAçık Erişim2026Scopus SJRQ2Which implant for Pauwels type 2 femoral neck fractures: a biomechanical study
Aydın, Oğuz; Kazez, Muhammed; Say, Yakup; Belhan, Oktay
Objective: Femoral neck fractures (FNF) in young patients are relatively rare but can lead to severe complications if not treated appro-priately. Pauwels type 2 fractures, characterized by moderate inclination, require surgical stabilization. However, no consensus exists regarding the optimal implant that provides superior biomechanical stability. This study aims to compare the biomechanical properties of 3 different fixation systems for the surgical treatment of Pauwels type 2 FNF. Methods: A total of 21 bovine femurs of similar age and size were selected and divided into 3 fixation groups: dynamic hip screw (DHS), cannulated screws (CS), and major plate (MP). Each specimen underwent axial compression testing to assess the maximum load-bearing capacity, shear force resistance, and deformation characteristics of the fixation methods. Results: The results showed that the CS group exhibited the highest shear stress resistance, followed by the DHS group, while the MP group showed significantly lower mechanical strength and elongation (P <.05). Although DHS provided substantial stability, CS demon-strated superior overall mechanical performance. In contrast, the MP system showed significantly lower resistance compared to the other 2 fixation methods. Conclusion: This biomechanical study highlights the importance of implant selection in the management of Pauwels type 2 FNF. Although previous investigations have questioned the adequacy of CS fixation in highly unstable Pauwels type 3 fractures, the results suggest that CS may be a reliable and effective option for the relatively more stable Pauwels type 2 pattern. Because the tests were performed on bovine femur models, which do not fully reflect the structural characteristics of human bone, these findings should be interpreted with caution. Further biomechanical studies using human cadaveric specimens are required to confirm the applicability of these results to clinical practice.
- MakaleAçık Erişim2026Scopus SJRQ1Effects of Melatonin Formulations on Caffeine-Evoked Cortical Activity and Pentobarbital-Induced Sleep in Mice
Sahin, Nurhan; Yabas, Mehmet; Er, Besir; Erten, Fusun; Kursun, Oznur Ece Durmaz; Cikim, Ismail Gurkan; Kaplan, Berkan; Erek, Gozde; Ozmen, Busra; Orhan, Cemal
Melatonin has chronobiotic, antioxidant, anti-inflammatory, and neuromodulatory properties, and its oral effects may vary according to formulation. This study compared conventional melatonin with a lipid-multiparticulate (LMP) formulation in two acute pharmacological mouse paradigms. Eighty-four male BALB/c mice were assigned to caffeine-evoked cortical activity or pentobarbital-induced sedative-hypnotic experiments. Mice received caffeine (7.5 mg/kg, i.p.) alone or with standard or LMP-melatonin (10 or 20 mg/kg, oral). ECoG recorded cortical electrical activity under urethane anaesthesia. In a separate cohort, latency to and duration of pentobarbital-induced loss of the righting reflex were measured. Circulating neurochemical and redox markers, as well as neurotransmitter- and inflammation-related gene and protein expression, were evaluated. Caffeine increased spike frequency and altered ECoG amplitude, together with unfavorable changes in circulating neurochemical and redox markers and in neurotransmitter receptor- and inflammation-related outcomes. Both melatonin formulations attenuated several of these changes in a dose-dependent manner, with the strongest effects generally observed in the high-dose LMP-melatonin group. Compared with conventional melatonin, LMP-melatonin produced greater modulation of ECoG activity, circulating biochemical markers, neurotransmitter-receptor expression, and IL-6 and TNF-α-related outcomes. LMP-melatonin also produced a greater reduction in the latency to and a greater prolongation of the duration of pentobarbital-induced loss of the righting reflex. LMP-melatonin produced greater formulation-dependent effects than conventional melatonin on caffeine-evoked cortical electrical activity, pentobarbital-induced sedative-hypnotic responses, and selected biochemical and molecular outcomes. However, pharmacokinetic exposure, physiological sleep stages, sleep architecture, sleep quality, and direct measures of neuronal injury were not assessed. Therefore, the findings do not directly establish enhanced bioavailability, physiological sleep promotion, or neuroprotection.
- MakaleAçık Erişim2026Scopus SJRQ2Synergistic Effects of Caffeine and Paclitaxel in Breast Cancer Cells: Mechanistic Insights Into NF-κB and Nrf2 Signaling
Gencoglu, Hasan; Delioglu, Saime; Nergiz, Mehmet Akif; Metin, Rumeysa; Erten, Fusun; Tokmak, Muhammed; Orhan, Cemal; Sahin, Kazim
Breast cancer remains one of the most prevalent malignancies among women. Recent studies have explored the potential of phytochemicals such as caffeine as chemosensitizing agents in enhancing the efficacy of standard chemotherapeutics like paclitaxel. This study aimed to investigate the cytotoxic, apoptotic, inflammatory, and oxidative stress-related effects of caffeine alone and in combination with paclitaxel in MCF-7 cells. Cells were treated with various concentrations of caffeine (1–100 mM), paclitaxel (0–350 µg/mL), and their combinations for 24, 48, and 72 h. Cell viability was assessed using the MTS assay, and IC₅₀ values were calculated. The expression levels of Bax, Bcl-2, NF-κB, and Nrf2 proteins were analyzed by Western blotting. Both caffeine and paclitaxel induced time- and dose-dependent reductions in MCF-7 cell viability. The combination treatment showed synergistic cytotoxicity, with significantly lower IC₅₀ values compared to single-agent treatments. Western blot analysis showed that both treatments boosted pro-apoptotic Bax and decreased anti-apoptotic Bcl-2, with slightly less effect in the combination group. NF-κB levels increased considerably in caffeine and paclitaxel groups, but were lower in the combination group compared to paclitaxel alone, suggesting a possible reduction in inflammatory signaling. Nrf2 expression increased significantly with caffeine, suggesting oxidative stress responses. In MCF-7 cells, caffeine enhanced paclitaxel's pro-apoptotic and cytotoxic actions and modified inflammation and oxidative stress pathways in a complicated, dose-dependent manner. Cytotoxicity was synergistic; however, apoptotic and stress indicators may be antagonistic. In clinical circumstances, caffeine may be an adjuvant in breast cancer treatment, however mechanistic and in vivo investigations are needed.
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