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Calculation of Dynamic Properties of Drug-Added Aqueous Solutions with T1 and T2 Relaxation Times; [İlaç Katkılı Sulu Çözeltilerin Dinamik Özelliklerinin T1 ve T2 Rölaksasyon Zamanları ile Hesaplanması]

MakaleAçık Erişim

Özet

The development of modern spectroscopic methods has facilitated and accelerated structure analysis. The NMR method is the most popular way to perform structural analysis of compounds with very complex structures. D2O is a solvent that is frequently used in NMR analysis of both chemical molecules and many biological molecules such as drugs, proteins, and enzymes. In this paper, the study of residual water in proton drug-added protein solutions was carried out via NMR relaxation. The spin-lattice (T1) and the spin-spin relaxation (T2) times of residual water in drug-added protein solutions were studied depending on temperature by Avance Bruker 400 MHz1H-NMR Spectrometer, and activation energies (E! ) and rotational correlation times (τ" and τ# ) have been determined for T1 and T2 relaxation times.

Anahtar Kelimeler

Activation energyD<sub>2</sub>OFlurouacilProton NMRRelaxation times
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/munzur/2521Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.37094/adyujsci.1200682Yayıncı resmi DOI adresi
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dc.contributor.authorKorunur, Sibel
dc.date.accessioned2026-10-28T14:55:28.681398473Z
dc.date.available2026-10-28T14:55:28.681398473Z
dc.date.issued2022
dc.description.abstractThe development of modern spectroscopic methods has facilitated and accelerated structure analysis. The NMR method is the most popular way to perform structural analysis of compounds with very complex structures. D2O is a solvent that is frequently used in NMR analysis of both chemical molecules and many biological molecules such as drugs, proteins, and enzymes. In this paper, the study of residual water in proton drug-added protein solutions was carried out via NMR relaxation. The spin-lattice (T1) and the spin-spin relaxation (T2) times of residual water in drug-added protein solutions were studied depending on temperature by Avance Bruker 400 MHz1H-NMR Spectrometer, and activation energies (E! ) and rotational correlation times (τ" and τ# ) have been determined for T1 and T2 relaxation times.
dc.identifier.doi10.37094/adyujsci.1200682
dc.identifier.eissn2146-586X
dc.identifier.endpage314
dc.identifier.issn2147-1630
dc.identifier.issue2
dc.identifier.scopus2-s2.0-85159478960
dc.identifier.startpage299
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/munzur/2521
dc.identifier.volume12
dc.language.isoen
dc.publisherAdiyaman University
dc.relation.ispartofAdiyaman University Journal of Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectActivation energy
dc.subjectD<sub>2</sub>O
dc.subjectFlurouacil
dc.subjectProton NMR
dc.subjectRelaxation times
dc.titleCalculation of Dynamic Properties of Drug-Added Aqueous Solutions with T1 and T2 Relaxation Times; [İlaç Katkılı Sulu Çözeltilerin Dinamik Özelliklerinin T1 ve T2 Rölaksasyon Zamanları ile Hesaplanması]
dc.typeArticle
rdl.citation.openalex0
rdl.citation.scopus0
rdl.citation.trdizin0
rdl.oa.statusgold
rdl.oa.urlhttps://dergipark.org.tr/en/download/article-file/2756607
rdl.source.indexSCOPUS
rdl.source.indexTRDIZIN