Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2018Scopus SJRQ3/r/munzur/5283
  The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats

  Parlak Ak, Tuba; Baykalır, Burcu Gül; Türkmen, Neşe Başak; Seven, Pinar Tatli; Seven, Ismail; Yaman, Mine

  This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.

  AtıfTR Dizin1

  İncele
• MakaleYalnız künye2018Scopus SJRQ3/r/munzur/4972
  Effects of conventional and organic rearing systems and hen age on oxidative stress parameters of blood and ovarian tissues in laying hens

  Benzer, Fulya; Baykalır, Yasin; Erişir, Mine; Şimşek, Ülkü Gülcihan

  Bu çalışmada yetiştirme sistemleri ve tavuk yaşının, tavukların serum ve yumurtalık dokusundaki bazı oksidatif stres parametreleri üzerine etkileri incelendi. Bu amaçla 30 ve 60 haftalık yaşta, iki farklı sistemden (konvansiyonel kafes ve organik) toplam 48 adet ticari yumurtacı hibrit olan Bovans White kullanıldı. Kesim işlemini takiben tavukların serum ve yumurtalık dokuları toplanarak, malondialdehid (MDA), glutatyon (GSH), glutatyon peroksidaz (GSH-Px) ve katalaz (CAT) düzeyleri belirlendi. Konvansiyonel kafeste yetiştirilen hem 30, hem de 60 haftalık tavukların serum MDA düzeyleri önemli derecede yüksek bulundu (P<0.05). Konvansiyonel kafeste GSH-Px aktivitesi düşük, aksine CAT aktivitesi önemli düzeyde yüksek tespit edildi (P<0.05). Tavuk yaşı serum MDA, GSH, GSH-Px ve CAT düzeylerini etkilemedi (P>0.05). Buna ek olarak, serumda, yetiştirme sistemi ve tavuk yaşı arasında önemli bir etkileşim bulunmadı (P>0.05). Konvansiyonel sistemdeki tavukların yumurtalık dokusunda MDA (P=0.010) ve GSH (P<0.01) seviyeleri önemli düzeyde yüksek bulunurken, GSH seviyesi 60 haftalık yaşta arttı (P<0.01). GSH-Px ve CAT aktiviteleri gruplar arasında benzer çıktı (P>0.05). Yetiştirme sistemi ve tavuk yaşı arasındaki etkileşim yumurtalık dokusunda CAT aktivitesini etkiledi (P<0.05). Sonuç olarak, konvansiyonel bataryalı kafesler, lipid peroksidasyon ve MDA düzeylerinin artmasıyla ilişkili olarak tavuklarda oksidatif strese neden oldu. Bu sistemde MDA'nın azalmasında rol oynayan antioksidan enzimler yetersiz kaldı. Oksidan/antioksidan dengesi 30 ve 60 haftalık yaşlarda tavuk organizması tarafından kurulabildi ve dolayısıyla dokuların MDA düzeyleri yaştan etkilenmedi

  AtıfTR Dizin2

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• MakaleAçık Erişim2018Scopus SJRQ3/r/munzur/3358
  The protective effects of propolis and flunixin meglumine on feed intake, antioxidant status and histological parameters in liver and kidney tissues against excess copper in rats; [Ratlarda bakır fazlalığına karşı yem tüketimi, antioksidan durum ve karaciğer ile böbrek dokularının histolojik parametreleri üzerine propolis ve fluniksin meglümin'in koruyucu etkileri]

  Tatli Seven, Pınar; Gül Baykalir, Burcu; Parlak Ak, Tuba; Seven, İsmail; Başak, Neşe; Yaman, Mine

  This experiment was conducted to determine the protective effects of flunixin meglumine and propolis on feed intake, antioxidant status and histological parameters in kidney and liver tissues in rats exposed to excessive copper. In this study individually housed thirty-six male Sprague-Dawley rats were used. Animals were randomly divided into six groups; control, copper sulphate (500 mg/kg BW/day, gavage), flunixin meglumine (2.2 mg/kg BW/day, ip), propolis (100 mg/kg BW/day, gavage), copper sulphate+flunixin meglumine (500 mg/kg BW/day of copper sulphate by gavage and 2.2 mg/kg BW/day of flunixin meglumine, ip) and copper sulphate+propolis (500 mg/kg BW/day of copper sulphate and 100 mg/kg BW/day of propolis by gavage). The study demonstrated that body weight change in the copper sulphate+propolis group significantly ameliorated in comparison with copper group (P<0.01). Propolis and flunixin meglumine administration significantly decreased MDA levels in the kidney and liver tissues, and serum TNF-α levels (P<0.001). Propolis supplementation to rats who were also treated with copper significantly increased the superoxide dismutase, catalase and reduced glutathione activities (P<0.001). Flunixin meglumine and propolis treatments decreased the copper-induced degenerative and necrotic changes with the apoptotic cells in the liver and kidney tissues. In conclusion, propolis appeared to ameliorate the adverse effects on feed intake, liver and kidney tissues seeing in the copper treatment and, apparently caused by the copper toxicity, by scavenging the free radicals and increasing activity of antioxidants.

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  AtıfScopus10·OpenAlex9

  İncele
• MakaleAçık Erişim2018Scopus SJRQ3/r/munzur/3208
  Effects of conventional and organic rearing systems and hen age on oxidative stress parameters of blood and ovarian tissues in laying hens; [Konvansiyonel ve organik yetiştirme sistemleri ile tavuk yaşının yumurta tavuklarının kan ve yumurtalık dokusundaki oksidatif stres parametreleri üzerine etkisi]

  Şimşek, Ülkü Gülcihan; Baykalir, Yasin; Erişir, Mine; Benzer, Fulya

  In this study, effects of hen age and rearing systems on some oxidative stress parameters in serum and ovarian tissues of hens are investigated. For this purpose, total of 48 Bovans White commercial laying hybrids from two different rearing systems (conventional cage and organic) at 30 and 60 weeks of age were used. Serum and ovarian tissues of the hens were collected following slaughter process and malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px) and catalase (CAT) levels of serum and ovarian tissues were determined. MDA levels of serum was found significantly higher in conventional system, both in 30 and 60 weeks old (P<0.05). GSH-Px activity was lower, conversely CAT activity was significantly higher in conventional system (P<0.05). Hen age didn’t affect MDA, GSH, GSH-Px and CAT levels of serum (P>0.05). In addition, there weren’t any significant interactions between rearing system and hen age in serum (P>0.05). MDA (P=0.010) and GSH (P<0.01) levels of ovarian tissue were found significantly higher in conventional system while GSH levels of ovarian tissue had increased in 60 weeks old (P<0.01). GSH-Px and CAT activity was similar between groups (P>0.05). Interaction between rearing system and hen age affected activity of CAT in ovarian tissue (P<0.05). As a result, conventional battery cages caused oxidative stress interrelated with increasing lipid peroxidation and MDA levels in laying hens. Antioxidant enzymes that play role in reduction of MDA were inadequate in this system. Oxidant/antioxidant balance can be established at 30 or 60 weeks of age by hen organism and therefore MDA levels of tissues would not be affected by age.

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  AtıfScopus5·WoS5·OpenAlex5

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