Sürdürülebilir Kalkınma Amaçları

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• MakaleYayıncıda açık erişim2018Scopus SJRQ3/r/munzur/3766
  Spectral, thermal and antimicrobial properties of novel mixed ligand-metal complexes derived from saccharinate complexes and azo dye ligand

  Adiguzel, Ragip; Turan, Nevin; Buldurun, Kenan; Korkoca, Hanifi

  Background and Objective: Saccharin and saccharinate (sac) complexes and its anion have critical importance with biological, biochemical and pharmacological properties. The main objective of this study was to synthesize the novel mixed ligand complexes from the complexes [M(Sac)2(H2O)4]·2H2O [M: Mn(II), Co(II), Ni(II), Cu(II) and Cd(II)] with a second neutral ligand [L:(mmppa): 5-Methyl-4-(4-methylphenylazo)-2H-pyrazole-3-ylamine]. Methodology: The structures of the complexes were characterized by elemental analysis, magnetic susceptibility, FT-IR, mass and electronic spectral studies and thermal analysis. Antimicrobial (antibacterial and anticandidal) activities of the complexes were tested against Enterococcus faecalis ATCC 51299, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Candida albicans ATCC 64548. Results: According to the experimental results, it was determined that in Mn(II), Co(II) and Cd(II) complexes, two coordinated H2O molecules are replaced with two neutral ligands, on the other hand, in Ni(II) and Cu(II) complexes, all coordinated H2O molecules are replaced with four neutral ligands. It was established that the second neutral ligand was coordinated to the metal ions via nitrogen atom of-NH2 group in pyrazole ring. In antimicrobial activity, study was determined to occur significant inhibition zones (20-24 mm) against Candida albicans ATCC 64548 strain. Conclusion: As a result, mononuclear and monomeric structure in octahedral geometry including both saccharin and azo dye ligands were synthesized and their characterizations were accomplished. The result of this study shows that novel mixed ligand-saccharinate complexes can be utilized for the development of anticandidal agents.

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  AtıfScopus11·WoS10·OpenAlex11

  İncele
• MakaleAçık Erişim2016Scopus SJRQ3/r/munzur/4954
  Spectroscopic, Thermal and Antioxidant Properties of Novel Mixed Ligand-Metal Complexes Obtained from Saccharinate Complexes and Azo Dye Ligand (mnppa)

  Turan, Nevin; Adigüzel, Ragip; Buldurun, Kenan; Bursal, Ercan

  The novel mixed ligand-metal complexes with a general formula [M(Sac)(2)(H2O)(2)L-2]center dot nH(2)O) [M = Mn(II), Co(II), Ni(II), Cu(II) and Cd(II), L=5-Methly-4-(4-nitrophenylazo)-2H-pyrazole-3-ylamine (mnppa)] have been synthesized and characterized by elemental analyses, IR, UV-VIS, magnetic susceptibility mass spectra and thermogravimetry-differential thermal analysis (TGA-DTA). Each metal (II) ion is octahedral coordinated by two sac, two mnppa and two aqua ligands. The antioxidant properties of mixed ligand-metal complexes were determined by different in vitro methods such as ABTS, DPPH, FRAP and CUPRAC assays. The results of metal complexes were compared with standard antioxidant compounds.

  AtıfWoS30·OpenAlex30

  İncele
• MakaleAçık Erişim2012Scopus SJRQ2/r/munzur/4275
  Chemotherapeutic Agent-induced Nephrotoxicity in Rabbits: Protective Role of Grape Seed Extract

  Benzer, Fulya; Kandemir, Fatih Mehmet; Ceribasi, Songul; Ozkaraca, Mustafa; Yildirim, Nuran Cikcikoglu; Ozan, Sema Temizer

  Cisplatin (CP) is one of the most effective cancer chemotherapeutic agent used against various solid tumors. This study was designed to investigate the antioxidant effects of Grape Seed Extract (GSE) on CP induced oxidative damage in rabbit kidney. The material of study was consist of 18 male New Zealand rabbit. Animals were divided into 3 groups. The first group was administered a single intraperitoneal (i.p.) close of 0.9% saline. The second group of rabbits was treated with CP (a single i.p. dose of 5 mg kg(-1) body weight); The third group of rabbits was treated with GSE by gavage at the dose of 250 mg kg(-1) body weight for 6 consecutive days before and 6 consecutive days after a single i.p. CP injection. As a result of CP administration, kidney function tests; urea, BUN (Blood Urea Nitrogen) and creatinine levels were increased (p<0.001). It was observed that CP increase malondialdehide (MDA) levels, the most important indicator of oxidative damage and decreased the activity of catalasc (CAT). Administration of CP did not caused statically a change in glutathione (GSH) levels and glutathione peroxidase (GSH-P-x) activity (p>0.05). GSE treatment has high levels of MDA to compared to normal levels (p<0.001) but not an increase in CAT (p<0.05). In CP treatment group, severe acute tubular necrosis was seen. It was determined that in CP+GSE group mild degenerative changes were received instead of acute tubular necrosis. GSE has been found to be partially protective effect against CP induced biochemical and histopathological changes in rabbit kidney.

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  AtıfWoS7·OpenAlex7

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