Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2024/r/munzur/4950
  Investigation of Flower, Leaf, and Stem Parts of Three Gundelia Species Growth in the Eastern Anatolia Region of Türkiye from a Biochemical Perspective

  Yilmaz, Fatih; Türkoglu, Ismail; Kirmizikaya Özmen, Gorkem; Yüce Babacan, Ebru; Yilmaz, Okkes

  13 species of Gundelia species plants are endemic in T & uuml;rkiye and are frequently used by the public for both nutrition and medicinal objectives. In this study, three parts (flower, leaf, and stem) of three species of Gundelia ( G.dersim , G.glabra, and G.munzurensis) were biochemically investigated. DPPH and ABTS analyses for antioxidant activity were performed on methanol extracts of plant parts. As a result of both analyses in parallel, the flower part of G.munzurensis had the highest %Inhibition value (DPPH:91.85 +/- 0.78; ABTS:97.38 +/- 0) (P<0.001). In total phenolic (29.09 mg GAE/g) and total flavonoid (5.59 mg CE/g) measurements, the highest amount was found statistically quite significant (P<0.001) in the leaf part of G.munzurensis. Gallic, vanillic, ferulic, romantic, and cinnamic acids, which are phenolic acids and of the flavonoids, rutin, catechin, naringin, and naringenin, were determined in all plant parts. Vitamin D3, alpha-tocopherol, ergosterol, stigmasterol, and beta-sterol were detected in parts of all plant species. While palmitic (16:0), palmitoleic (16:1), stearic (18:0), oleic (18:1), linoleic (18:2), and linolenic (18:3) fatty acids as the main fatty acids were detected in all parts of the three Gundelia species, lauric (12:0), tridecanoic (13:0), myristic (14:0), pentadecanoic (15:0), cis-10-pentadecanoic (15:1), heptadecanoic (17:0), cis-10heptadecanoic (17:1), and eicosanoid (21:0) acids were also identified at different concentrations. Considering the biochemical properties of Gundelia species, it shows that they can be consumed as food and also used pharmacologically.

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  AtıfOpenAlex1

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• MakaleAçık Erişim2023Scopus SJRQ1/r/munzur/2270
  Yield and Composition of the Essential Oil of the Opopanax Genus in Turkey

  Babacan, Ebru Yüce; Demirpolat, Azize; Çakılcıoğlu, Uğur; Bagcı, Eyüp

  The genus Opopanax W. Koch (Apiaceae) is represented by four species in Turkey. The composition of the essential oil of Opopanax genus members (Apiaceae) growing in Turkey was investigated in this study. GC-MS was used to analyze the composition of Opopanax essential oil samples that were taken from their natural environments. The Clevenger apparatus was used to hydrodistill the plant’s aerial parts, and the yields were determined to be between 0.2% v/w (for O. siifolius) and 0.4% (for O. hispidus, O. chironium, and O. persicus). The results and the chemical data provided some information and clues on the chemotaxonomy of the genus Opopanax. In this study, γ-elemene, butanoic acid octyl ester, and cylopropane were the main compounds identified in the essential oils of O. chironium, O. hispidus, and O. persicus. In particular, hexynyl n-valerate was most abundant in the essential oil of O. chironium, cyclopropane in that of O. hispidus, γ-elemene in that of O. persicus, and n-hexadecanoic acid/palmitic acid in that of O. siifolius. In a chemotaxonomic approach, the essential oil analysis of the Opopanax species revealed that these species conformed in a cluster analysis with their morphological classification. The constituents of the essential oils of all examined in the genus Opopanax were determined in this study, which is the most thorough one to date. This study provides new information about the composition of the essential oils of the investigated species.

  AtıfScopus4·WoS4

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• MakaleAçık Erişim2023Scopus SJRQ1/r/munzur/1707
  Orbitrap Mass Spectrometry-Based Profiling of Secondary Metabolites in Two Unexplored Eminium Species and Bioactivity Potential

  Babacan, Ebru Yuce; Zheleva-Dimitrova, Dimitrina; Gevrenova, Reneta; Bouyahya, Abdelhakim; Balos, Mehmet Maruf; Cakilcioglu, Ugur; Sinan, Kouadio Ibrahime; Zengin, Gokhan

  The study aimed at the metabolite profiling and evaluation of antioxidant and enzyme inhibitory properties of methanol extracts from flowers, leaves, and tubers of unexplored Eminium intortum (Banks & Sol.) Kuntze and E. spiculatum (Blume) Schott (Araceae). A total of 83 metabolites, including 19 phenolic acids, 46 flavonoids, 11 amino, and 7 fatty acids were identified by UHPLC-HRMS in the studied extracts for the first time. E. intortum flower and leaf extracts had the highest total phenolic and flavonoid contents (50.82 ± 0.71 mg GAE/g and 65.08 ± 0.38 RE/g, respectively). Significant radical scavenging activity (32.20 ± 1.26 and 54.34 ± 0.53 mg TE/g for DPPH and ABTS) and reducing power (88.27 ± 1.49 and 33.13 ± 0.68 mg TE/g for CUPRAC and FRAP) were observed in leaf extracts. E. intortum flowers showed the maximum anticholinesterase activity (2.72 ± 0.03 mg GALAE/g). E. spiculatum leaves and tubers exhibited the highest inhibition towards α-glucosidase (0.99 ± 0.02 ACAE/g) and tirosinase (50.73 ± 2.29 mg KAE/g), respectively. A multivariate analysis revealed that O-hydroxycinnamoylglycosyl-C-flavonoid glycosides mostly accounted for the discrimination of both species. Thus, E. intortum and E. spiculatum can be considered as potential candidates for designing functional ingredients in the pharmaceutical and nutraceutical industries.

  AtıfScopus15·OpenAlex11

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• MakaleYalnız künye2022/r/munzur/4576
  ESSENTIAL OIL COMPOSITION OF ENDEMIC Hypericum ekerii FROM TURKEY AND CHEMOTAXONOMIC COMPARISONS

  Yuce-Babacan, Ebru; Demirpolat, Azize

  In our study, chemotaxonomic comparisons and essential oil composition of Hypericum ekeriNtice&Aytac (Hypericaceae) endemic to Turkey was studied for the first time. The composition of the essential oils of Hypericum ekerii was investigated and 45compounds were determined in total. GC and GC-MS analysis result showed a-pinene 18.73%, limonene 7.28%, caryophyllene oxide 6.71% and b-caryophyllene 6.47% as the majorcomponents. Based on the major chemical components, clusterinvestigated was applied for all the Hypericum species on Drosanthesection studied. With H. ekerii and all Drosanthesection species were grouped based on the presence of a specific compound and a dendrogram was created, and this section grouped the species into clusters. The chemical distribution of essential oil compounds in the genus pattern were discussed in means of natural products, major components and chemotaxonomy.

  İncele
• MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2836
  Detailed Chemical Characterization and Biological Propensities of Malabaila lasiocarpa Extracts: An Endemic Plant to Turkey

  Zengin, Gokhan; Zheleva-Dimitrova, Dimitrina; Babacan, Ebru Yüce; Polat, Rıdvan; Çakılcıoğlu, Uğur; Sadeer, Nabeelah Bibi; Costa, Emmanoel V.; Mahomoodally, Mohamad Fawzi; Naviglio, Daniele; Gallo, Monica

  This study focused on the biological evaluation and chemical characterization of Malabaila lasiocarpa Boiss. (M. lasiocarpa) (Family: Apiaceae). The phytochemical profile, antioxidant, enzyme inhibitory of the methanolic, aqueous, dichloromethane, hexane extracts were investigated. Based on UHPLC-HRMS analyses, a total of 101 peaks were annotated or identified for the first time in M. lasiocarpa extracts. They include hydroxybenzoic, hydroxycinnamic, acylquinic acids and their glycosides, C- and O-glycosyl and O-diglycosyl flavonoids. In addition, 10 simple mono- and disubstituted coumarins together with 10 furanocoumarins were tentatively annotated. The methanolic extract possessing the highest phenolic (24.36±0.60 mg gallic acid equivalent/g extract) and flavonoid (69.15±0.37 mg rutin equivalent/g extract) content also exhibited the strongest radical scavenging potential against 2,2-diphenyl-1 picrylhydrazyl (21.73±0.42 mg Trolox equivalent/g extract, respectively), and highest reducing capacity (57.81±0.97 and 28.00±0.40 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively). The dichloromethane extract substantially depressed the tyrosinase (73.92±5.37 mg kojic acid equivalent/g extract), α-amylase (0.63±0.01 mmol acarbose equivalent/g extract) and α-glucosidase (0.69±0.02 mmol acarbose equivalent/g extract) enzymes. This study has produced critical scientific data on M. lasiocarpa which are potential contenders for the development of novel phyto-pharmaceuticals.

  AtıfScopus6·OpenAlex5

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• MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2679
  An ethno-veterinary study on plants used for the treatment of livestock diseases in Genç (Bingöl-Turkey)

  Babacan, Ebru Yüce; Polat, Rıdvan; Güler, Osman; Moyan, Ayşe; Paksoy, Mehmet Yavuz; Çakılcıoğlu, Uğur

  There are a very limited number of studies on plants traditionally used in animal diseases in Turkey. As a result, valuable information is getting lost. Traditional plant use in Genç District (Turkey) was recorded by semi-structured interviews with breeders and shepherds. The collected information was subjected to quantitative analysis using the informant consensus factor. It was recorded that a total of 53 plants from 24 families were used in the traditional treatment of animal diseases. 8 of these plants are endemic plants with a narrow distribution area and were recorded for the first time by us. The breeders stated that they applied such plants to animals with peace in mind as these plants had been used for human treatment as well. This study is the first ethnoveterinary study conducted in the province. Phytochemical studies need to be carried out on medicinal plants used in livestock around Bingöl Province. We believe that the use of this preliminary information obtained from ethnoveterinary studies by researchers will contribute to the production of natural animal medicines.

  AtıfScopus32

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• MakaleYalnız künye2021Scopus SJRQ2/r/munzur/2847
  Two Medicinal Plants (Alkanna trichophila and Convolvulus galaticus) from Turkey: Chemical Characterization and Biological Perspectives

  Mahomoodally, Mohamad Fawzi; Zengin, Gokhan; Sinan, Kouadio Ibrahime; Ak, Gunes; Sadeer, Nabeelah Bibi; Angeloni, Simone; Mustafa, Ahmed M.; Caprioli, Giovanni; Maggi, Filippo; Cakilcioglu, Ugur

  The aim of the present study was to quantify selected phenolic compounds, determine antioxidant activity and enzyme inhibitory effects of the aerial parts of Alkanna trichophylla Hub.-Mor. (A. trichophylla) and Convolvulus galaticus Rost.ex Choisy (C. galaticus) extracts prepared by homogenizer-assisted extraction (HAE), maceration (MAC) and infusion techniques. This is the first time such study has been designed to validate the phytochemical composition and bioactivity of these plants. Multivariate analysis was conducted on collected data. Rutin and caffeoylquinic acid derivatives were the most significant compounds in A. trichophylla and C. galaticus, respectively. The highest antioxidant activity of A. trichophylla was mostly exhibited by HAE/methanolic extracts as determined by DPPH, ABTS, FRAP (51.39, 112.70 and 145.73 mg TE/g, respectively) and phosphomolybdenum (2.05 mmol TE/g) assays. However, significant antioxidant activities varied within the extracts of C. galaticus. HAE/methanolic extract of A. trichophylla significantly depressed AChE (2.70 mg GALAE/g), BChE (5.53 mg GALAE/g) and tyrosinase (26.34 mg KAE/g) activities and that of C. galaticus inhibited AChE (2.04 mg GALAE/g), tyrosinase (31.25 mg KAE/g) and α-amylase (0.53 mmol ACAE/g) activities significantly. We concluded that HAE was the most efficient extraction technique as high yield of compounds and promising bioactivities were recorded from extracts prepared. Multivariate analysis showed that types of solvents influenced recovery of compounds and biological activities. This research study can be used as one methodological starting point for further investigation on these plants as all results are clearly promising and open the door to further research challenges such as cytotoxicity evaluation, molecular docking analysis, and more screening of pharmacological actions.

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  AtıfScopus12·OpenAlex10

  İncele
• MakaleYalnız künye2020Scopus SJRQ2/r/munzur/3477
  A comparative assessment of biological activities of Gundelia dersim Miller and Gundelia glabra Vitek, Yüce & Ergin extracts and their chemical characterization via HPLC-ESI-TOF-MS

  de la Luz Cádiz-Gurrea, María; Zengin, Gokhan; Leyva-Jiménez, Francisco Javier; Fernández-Ochoa, Álvaro; Sinan, Kouadio Ibrahime; Cakilcioglu, Ugur; Babacan, Ebru Yuce; Mahomoodally, Mohamad Fawzi; Picot-Allain, Carene; Xiao, Jianbo

  Plants from the Gundelia genus have been well appraised as both food and remedies. The members of the Gundelia genus are widely used as foods in several countries including Turkey. This study presents a comparative assessment of two poorly studied Gundelia species (G. glabra Miller and G. dersim Vitek, Yüce & Ergin). The effect of conventional (infusion, maceration, and Soxhlet extraction) and non-conventional (homogeniser and ultrasound assisted extraction) methods of extraction of bioactive secondary metabolites from the selected Gundelia species was also assessed. A total of 68 different compounds were detected by high-performance liquid chromatography coupled to electrospray ionization and time-of-flight mass spectrometry (HPLC-ESI-TOF-MS) technique. Non-conventional extraction techniques do not guarantee higher antioxidant activity. As such, G. dersim (91.27, 138.87, 182.28, and 125.65 mg TE [Trolox equivalent]/g dried extract, for 2,2-diphenyl-1-picrylhydrazyl (DPPH), 2,2′-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), cupric reducing antioxidant capacity (CUPRAC), and ferric reducing antioxidant power (FRAP) assays, respectively).The highest α-glucosidase inhibition was recorded for the extracts obtained by ultrasonication. In the multivariate analysis, the extracts from Gundelia species were separated based on their biological activities. The presented findings could be one methodological starting point for designing novel products from two Gundelia species.

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  AtıfScopus12·OpenAlex13

  İncele
• MakaleAçık Erişim2019Scopus SJRQ4/r/munzur/4257
  MICROMORPHOLOGICAL AND ANATOMICAL INVESTIGATION ON SIX SPECIES OF ONOSMA L. (BORAGINACEAE) FROM TURKEY

  Selvi, Selami; Polat, Ridvan; Babacan, Ebru Yuce; Rahman, M. Oliur; Çakilcioglu, Ugur

  Micromorphology and anatomy of six Onosma L. species, viz. O. argentata Hub.Mor., O. neglecta Riedl, O. proballanthera Rech. f, O. rechingeri Riedl, O. sericea Willd. and O. stenoloba Hausskn. ex Riedl from Turky were investigated. Stem anatomy revealed that cuticle layer ranged from 0.6 mu m in O. argentata to 1.7 mu m in O. proballanthera. Parenchymatous cells of O. neglecta and O. stenoloba possessed more intense starch than the other species studied. In leaf anatomy, the longest palisade parenchyma was found in O. neglecta, while the smallest was noted in O. argentata. Mesophyll structure of O. argentata, O. sericea and O. rechingeri was equifacial (isobilateral), while O. neglecta, O. proballanthera and O. stenoloba presented bifacial (dorsiventral) structure. Rugose nutlet ornamentation was observed in O. argentata, O. neglecta and O. sericea, whereas reticulate type was found in O. proballanthera, O. rechingeri and O. stenoloba. Onosma stenoloba could easily be distinguished from other species by its aesterotrichous indumentum, and in contrary, other species possessed haplotrichous type of indumentum. Micromorphological features of nutlet surface, anatomical features of epidermal surface (trichomes and stomata), and lamina mesophyll structure (dorsiventral and isobilateral) could be useful in solving taxonomic problem of the genus.

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  AtıfWoS7·OpenAlex12

  İncele
• MakaleYalnız künye2017Scopus SJRQ3/r/munzur/4415
  &ITHYPERICUM EKERII&IT (HYPERICACEAE), A NEW SPECIES FROM TURKEY

  Babacan, Ebru Yuce; Aytaç, Zeki; Pinar, Munevver

  Hypericum ekerii Yuce & Aytac sp. nov. (Hypericaceae) is described and illustrated from Duzgun Baba Mountain in Eastern Anatolia, Turkey. The new taxon grows on volcanic rocks in Tunceli Province. It is closely related to H. capitatum Choisy s.l. an Irano-Turanian element of Anatolia. Diagnostic morphological characters were discussed. The pollen characters of threetaxa were examined by scanning electron microscopy (SEM).

  AtıfWoS20

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