Sürdürülebilir Kalkınma Amaçları

• 9
• 5

• MakaleAçık Erişim2023/r/munzur/6414
  The Antioxidant Capacities and Antimicrobial Activities of Some Salvia L. Seeds

  Ökkeş; Yılmaz, Okkes; Yilmaz; Kurşat, Murat; Kirbag, Sevda; Civelek, Şemsettin; Emre, Irfan; Sönmez, Pınar Erecevıt; Emre, Mustafa Yunus

  The goal of present study is to find the penolic contents, antioxidant activities and antimicrobial capacities in the seeds of five Salvia L. taxa two of which are endemics (Salvia euphratica var. leiocalycina and Salvia euphratica var. euphratica). The flavonoid and phenolic acid are determined by using HPLC while the antioxidant activities are determined based on different methods. Also, the antimicrobial activities of some Salvia species are determined by using the well agar method. The current study found that the studied Salvia species have low flavonoid. It has been found that Salvia euphratica var. euphratica has high vanillic acid, ferulic acid and rosmarinic acid among the studied taxa. Similarly, it has been found that Salvia euphratica var. euphratica has high DPPH and ABTS radical scavening capacity in all concentrations. It has been also found that Salvia euphratica var. euphratica has highest total phenolic content (372,63±0,87 µgGAE/mg) whilst Salvia tricholoda has low total phenolic content (46,41±1,71 µgGAE/mg). In addition, this study demonstrated that Salvia tricholoda has lowest metal chelating activity (37,35±0,51%). Furthermore, present study found that the lipid peroxidation levels of the studied Salvia taxa are between 18,21±0,37 mg/kg and 21,03±0,22 mg/kg while it has been found that the antibacterial properties of the Salvia taxa under study are altering.

  • 
  • 
  AtıfOpenAlex1·TR Dizin1

  İncele
• MakaleAçık Erişim2023Scopus SJRQ2/r/munzur/2944
  B2O3 reinforced polylactic acid/thermoplastic polyethylene glycol shape memory composites

  Pekdemir, Mustafa Ersin; Kök, Mediha; Kanca, Muhammed Sait; Özen Öner, Ecem; Pekdemir, Sibel; Inci, Şule; Kirbağ, Sevda; Tatar, Beyhan

  Recently, there has been a great demand for boron-containing compounds (BCCs) with unique biological properties. The demand for the use of these compounds not alone but as additives in composite materials is increasing day by day. In this study, the effect of adding B2O3 compound to the blend of PLA and PEG polymers, which is an important biocompatible shape memory polymer, was investigated. In order to examine the effect of increasing B2O3 additive on the thermal properties of PLA-PEG blend, it was determined by using a Differential Scanning Calorimetry (DSC) and thermogravimetric analyzer (TGA), and it was seen that while the melting temperature of PEG decreased, the melting temperature of PLA increased. In addition, when the thermal stability of the composites was examined, increasing of thermal stability was observed with the addition of B2O3 and a three-step degradation occurred. It was determined that the B2O3/PLA-PEG composite was homogeneous by taking X-ray measurements and SEM measurements. The antimicrobial property of the PLA-PEG blend improved with the increasing B2O3 contribution were observed from the antimicrobial activity measurements of the composite against 4 different bacteria. However, it was determined that the PLA-PEG blend preserved its shape memory effect with increasing diboron trioxide contribution.

  AtıfScopus13·OpenAlex16

  İncele
• MakaleAçık Erişim2021/r/munzur/3018
  The antioxidant and antimicrobial capacities of phenolic profiles of some Salvia L. Seeds grown in Turkey

  Emre, Irfan; Kursat, Murat; Kirbag, Sevda; Erecevit, Pinar; Emre, Mustafa Yunus; Yilmaz, Okkes; Civelek, Semsettin

  The aim of current study is to show phenolics, antioxidant capacities and antimicrobial activities of seeds of five Salvia L. (S. frigida Boiss., S. candidissima subsp. candidissima Vahl., S. virgata Jacq., S. verticillata L. var. verticillata and S. russellii Benth.) taxa grown in Turkey. The flavonoid and phenolic acid contents were measured by using HPLC whilst the antioxidant capacities were determined by using different methods. In addition, agar well diffusion method was used to determine the antimicrobial activities of Salvia species in this study. It was found that S. frigida, S. verticillata var. verticillata and S. russellii have the highest catechin contents and S. frigida and S. verticillata var. verticillata have high rosmarinic acid while S. frigida, S. candidissima subsp. candidissima and S. verticillata var. verticillata have high vanilic acid. Also, it was determined that S. frigida and S. verticillata var. verticillata have high DPPH radical scavenging activities in 150 and 250 µL while S. frigida and S. verticillata var. verticillata have highest ABTS radical scavenging activity in all concentrations apart from 25 µL for S. frigida. Furthermore, S. frigida and S. verticillata var. verticillata have high total phenolic contents. On the other hand, Salvia species have similar lipid peroxidation inhibitions. However, the metal chelating activities of Salvia species are different. And also, it was demonstrated that Salvia taxa have antimicrobial activity.

  • 
  • 
  AtıfScopus7·OpenAlex7·TR Dizin2

  İncele
• MakaleAçık Erişim2020/r/munzur/3651
  Reviewing Phlomis rigida Labill From Turkey as a Antimicrobial Efficacy

  Sönmez, Pınar Erecevit; Kirbağ, Sevda; Çakilcioğlu, Uğur

  This work researched the inhibitory properties of the extract of Phlomis rigida Labill plant including chloroform on gram-negative and positive bacteria, yeasts and dermatophyta; the related plant is used for therapeutic purpose in public. For the disk diffusion method, this extract is effective on Pseudomonas aeruginosa that is one of the negative bacterias by 11.33 ± 0.57 mm inhibition areas. Regarding other bacterias, the effect of the related extract is so low in avoiding the improvement of Escherichia coli, Staphylococcus aureus and Bacillus megaterium by 8.33 ± 0.57 mm inhibition area. It has highly effective on Trichopyton sp. and Candida albicans that are from dermatophytes fungis and yeast by 16.33 ± 0.57 mm inhibition area. About yeast and dermatophytes fungi it has a remarkable impact on Candida glabrata (14.33 ± 0.57 mm inhibition area), Epidermophyton sp. (12.33 ± 0.57 mm inhibition area). Antimicrobial activity of this natural extract against all the microorganisms that were tested by MIC method by concentrations vary by 100 uL and 6.25 uL. Acording to this; the results showed good inhibitory effect with 6.25 μL for C. albicans, Trichophyton sp. with 12.25 μL for C. glabrata. In the other hand it is effective with 25 μL for P. aeruginosa, Epidermophyton sp. with 50 μL for E. coli, S. aureus, B. megaterium. Being used plants for medical purposes as from since the early ages show that these plants can be used as alternatives of available antibiotics; including important medical components is the other reason for being an alternative at the same time. Concerning results, P. rigida can be utilized as a therapeutic drug for the healing of infections caused by microorganisms. In this study, we believe that the P. rigida is important in the search for new antibiotics and will contribute to the literature and the world of drug as it affects different types of microorganisms at the lowest level for the first time.

  • 
  AtıfScopus4·OpenAlex6·TR Dizin1

  İncele
• MakaleAçık Erişim2020Scopus SJRQ2/r/munzur/3445
  Synthesis, and antimicrobial and anticancer activities of sodium acrylate copolymers

  Torğut, Gülben; Pıhtılı, Güzin; Erecevit Sönmez, Pınar; Erden, Yavuz; Kırbağ, Sevda

  This study was designed to synthesize poly(sodium acrylate-co-N-isopropylacrylamide) via aqueous free-radical polymerization using the 2,2′-azobisisobutyronitrile initiator system at 60°C. The structural characterization of the copolymer was determined by Fourier-transform infrared spectroscopy. The polymer was synthesized in two different ratios, namely, poly(NaAc-co-NIPA1:1) and poly(NaAc-co-NIPA2:1), to investigate whether it affects their antibacterial–antifungal activities and anti-tumour effects. When the antimicrobial activities of different proportions of the copolymer extracts prepared with pure water were examined using the agar disc diffusion sensitivity test (at 120 μL: 10.8 mg/µL), it was observed that they had effect at increasing rates against all the bacteria, yeasts and dermatophyte fungi such as Staphylococcus aureus COWAN 1, Staphylococcus cohnii ATCC 29974, Bacillus megaterium DSM 32, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae FMC 5, Pseudomonas aeruginosa DMS 50071 SCOTTA, Candida albicans FMC 17, Candida glabrata ATCC 66032, Trichophyton sp. and Epidermophyton sp. The results of this study revealed that the obtained copolymers have significant effects on the treatment of diseases. In addition, the anti-tumour activities of the poly(NaAc-co-NIPA1:1) copolymer on human breast (MCF-7) and ovarian cancer (A-2780) cell line were specified and it was determined that high doses of the copolymer showed anti-tumour effects on both types of cancer cell lines. Also, this article reviews its antimicrobial and anticancer activities that will be of help for future scientists.

  • 
  AtıfScopus3·WoS3·OpenAlex6

  İncele
• MakaleYalnız künye2020Scopus SJRQ4/r/munzur/3178
  Quality changes and storage life of common carp (Cyprinus carpio) with the use of Ginger (Zingiber officinale) essential oil

  Sönmez, Pınar Erecevi t; Kuzgun, Nermin Karaton; Kirbağ, Sevda

  Ginger (Zingiber officinale) essential oil is considered safe. In this study, ginger (Zingiber officinale) essential oil was used to extend storage life of common carp (Cyprinus carpio) and detect its protective effects. The following tests were performed to assess the shelf life of carp (C:control) treated with ginger essential oil (G). The microbiota growth of the carp, sensory properties, pH, TVB TBA values, the shelf life of the carp changed positively by adding ginger oil in different concentrations to the carp (C1, C2, C3: 0.1%, 0.25%, 0.5%ginger essential oil was added to carp samples). On the other hand; ginger essential oil has a positive effect on TVB-N and TBA values of carp fillets. With reference to the results of microbiota growth, carp sample (C: control) showed the highest value (P < 0.05) on the 6th storage day. The results show the importance of the use of Zingiber officinale essential oil to prevent food spoilage.

  • 
  • 
  AtıfScopus2·WoS1

  İncele
• MakaleAçık Erişim2019Scopus SJRQ3/r/munzur/3434
  Antifungal and antibacterial effect of dodder (Cuscuta campestris) used for hepatitis treatment of mothers and newborn infants in Province Mardin in Turkey; [Türkiye'de Mardin ilindeki annelerin ve yenidoğan bebeklerin sarılık tedavisinde kullanılan küsküt'ün (Cuscuta campestris) antifungal ve antibakteriyel etkileri]

  Erecevit Sönmez, Pınar; Kirbağ, Sevda; İnci, Şule

  Dodder is a plant used for the hepatitis treatment in new born infants in and around Mardin. The aim of this research to determine the antifungal and antibacterial effects of traditionally used dooder is known as a regional folk remedy. Thus and so, the efficacy of the drug has been demonstrated by the inclusion of natural therapeutic antimicrobial agents such as anti-inflammatory and wound healing, including infectious diseases. The antimicrobial effects of these plant was analyzed against bacteria, yeast and dermatopyta fungi by the agar disc diffusion method. The nominal concentration of the plant to prevent from the development of microorganisms was detected with the broth microdulitions method. It was determined that it had sensitive and moderately sensitive antimicrobial effect against all of microrganisms (13-19.66 mm/inhibition zone), growth of tested microrganisms were inhibited at 50-6.25 µL.It is though that this natural herbal resource can light the way for treatment of several diseases and direct the next studies because of having the potential for being used as a new antimicrobial agent.

  • 
  AtıfScopus7·OpenAlex8·TR Dizin5

  İncele
• MakaleAçık Erişim2017Scopus SJRQ3/r/munzur/3292
  Determining the phytochemical parameters of pisum sativum (Pease) and effects on the development of debaryomyces hansenii

  Erecevit, Pınar; Kırbağ, Sevda

  Objective: In this work; phytochemical parameters (fatty acid, vitamin, phytosterol, flavonoid and resveratrol contents, and antioxidant activities antimicrobial activities) of Pisum sativum (pease) extracts prepared with Debaryomyces hansenii were detected. P. sativum (pease) is known as one of the nutritional sources of prebiotics. Methods: Phytochemical contents of extracts were evaluated with device and assays like Shimadzu 17, Shimadzu brand HPLC, Spectrophotometer device and well agar methods respectively. Results: it was observed that total fatty acid, flavonoid, contents in pease extracts were at low levels and vitamin, and phytosterol contents were at changing. It was detected that total fatty acid, vitamin and phytosterol contents; at significant rates of pease extracts prepared with D. hansenii; however, flavonoid contents decreased at different rates. In the work, it was noticed that pease had increasingly antioxidant activities and antimicrobial activities at changing rates, acordingly at fatty acid, vitamin and phytosterol levels; at significant rates increased. On the other hand, flavonoid extracts demonstrated scarcely any antimicrobial activity. When antimicrobial activities of pease extracts containing D. hansenii were analyzed, they had effect at increasing rates of fatty acid, vitamin and phytosterol. On the other hand, it was demonstrated that flavonoid extracts did not have any antimicrobial activity against all of the microorganisms except Bacillus megaterium DSM 32. Conclusion: it was detected that pease which is known as prebiotic food, can be used in terms of proper prebiotic and the relationship of proper prebiotic-prebiotic (symbiotic) for the development of D. hansenii used in this study which is also accepted as probiotic yeast. It was observed that this yeast type developing in extracts obtained from pease affected other beneficial nutrients such as vitamins, minerals, phenolic compounds at varying rates.

  • 
  AtıfScopus2·WoS1·OpenAlex2

  İncele
• MakaleAçık Erişim2014Scopus SJRQ4/r/munzur/3938
  Antimicrobial Activity of the Methanol Extracts and Essential Oil with the Composition of Endemic Origanum acutidens (Lamiaceae)

  Gulec, Azime Kucukgul; Erecevit, Pinar; Yuce, Ebru; Arslan, Ali; Bagci, Eyup; Kirbag, Sevda

  The chemical composition of hydro distilled essential oil from Origanum acutidens (Hand. and Mazz.) Ietswaart was collected from Tunceli (Turkey) were analyzed by GC and GC-MS. Essential oil and methanol extract of Origanum acutidens were tested against Yersinia ruckeri (ATCC 29473), Aeromonas hydrophila (ATCC 607920), Lactococcus garviae (ATCC 43921) Staphylococcus aureus (ATCC 29213) fish pathogenic bacterial strains. The analysis of the essential oil of Origanum acutidens showed the presence of 6 components accounting for 93.8 % of the total amount. Calvacrol (61.8 %), p-cymene (15.5 %) and thymol (12.7 %) that possessed antimicrobial activity were found as the major component. The final concentrations of the methanol extract and the essential oil were determined by using disk diffusion assay. Mean inhibition zones of bacterial strains for Origanum acutidens essential oil varied from 28.0 +/- 1.2 and 36.7 +/- 0.7 mm. The inhibition zones of methanol extract (10 mu L and 20 mu L) of Origanum acutidens against bacterial strains were in the range 8.7 +/- 0.7 - 11.0 +/- 0.6 mm and 12.7 +/- 0.67 - 22.7 +/- 1.3 mm, respectively. Our results suggest that both the methanol extract and the essential oil of Origanum acutidens may be valuable as potential antibacterial agents against the major fish pathogens.

  • 
  AtıfWoS7·OpenAlex12

  İncele
• MakaleAçık Erişim2013Scopus SJRQ3/r/munzur/4059
  Determination of phytochemical characteristics of the extract of Zea mays with Saccharomyces boulardii

  Erecevit, Pinar; Kirbag, Sevda; Yilmaz, Okkes

  Fatty acid, vitamin, phytosterol, flavonoid, and resveratrol contents and antimicrobial activities of Zea mays L. (corn) extracts treated with Saccharomyces boulardii were determined and compared. The total fatty acid, vitamin, and phytosterol contents in corn extract were at certain levels. It was detected that total fatty acid levels and vitamin contents of corn extracts prepared with Saccharomyces boulardii increased; however, flavonoid contents decreased at different rates. In addition to this, it was observed that naringin, resveratrol, and myricetin flavonoids were present in the extracts that contained S. boulardii. In the study, it was noticed that Z. mays L. (corn) had antioxidant and antimicrobial activities at different rates. It was observed that S. boulardii developing in extracts obtained from plants affected bioactive compounds at different rates.

  • 
  • 
  AtıfWoS3·OpenAlex4

  İncele