Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2025/r/munzur/4863
  Antigenotoxic Effects of Stachys viscosa (Lamiaceae), a potential medicinal plant in Drosophila melanogaster

  Karabulut, Aygul Kilic; Açar, Mikail

  This research aimed to examine the anti-genotoxic properties of Stachys viscosa, a plant of the Lamiaceae family, which has medicinal and aromatic properties and is widely used in cosmetics, food, and pharmaceutical industries. The Drosophila wing somatic mutation and recombination test (SMART), an in vivo tool for evaluating somatic mutation and recombination, was employed. The antigenotoxic effect of the S. viscosa plant against mitomycin C (MMC) mutagen was investigated. The study evaluated doses of 5 mg, 15 mg, 45 mg, and 60 mg of S. viscosa, concluding that doses of 45 mg and 60 mg effectively mitigated DNA damage induced by MMC. At doses of 45 mg and 65 mg, the total number of spots caused by MMC was suppressed by 8.21% and 13.17%, respectively. The data collected indicate that the S. viscosa plant possesses certain anti-genotoxic properties.

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  AtıfWoS2·OpenAlex2

  İncele
• MakaleAçık Erişim2022/r/munzur/6507
  Investigation of Antigenotoxic Effects of Althaea officinalis L. in Drosophila Melanogaster

  Karabulut, Aygul Kılıç

  In this study, the antigenotoxic effect of Althaea officinalis L., which is a medicinal plant and is widely used in the treatment of many diseases, was studied. For this reason, the Drosophila wing spot test (SMART), an in vivo test that measures somatic mutation and recombination, was used. The antigenotoxic effect of A. officinalis against the mitomycin C (MMC) mutagen was investigated. After application studies, it was determined that 5 mg, 15 mg and 45 mg doses of dried herba of A. officinalis, could suppress DNA damage caused by MMC. As a result of the application of 5mg, 15mg and 45mg doses it was determined that the total number of spots induced by MMC was inhibited by 3.66%, 1.83% and 2.03%, respectively. According to the data obtained, it is thought that A. officinalis contains some antigenotoxic factors.

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