Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2026Scopus SJRQ2/r/munzur/866
  Synthesis of Aminothiophene derivative complexes and electrochemical sensor application for carbofuran pesticide

  Taş, Abdurrahim; İpek, Yeliz; Adiguzel, Ragip

  In this study, a ligand named 2-amino-6-ethyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3‑carbonitrile (ATL), which is an aminothiophene ligand, was synthesized. ATL was used to synthesize ATL-Co(II), ATL-Cu(II), and ATL-Zn(II) complexes. The chemical structures of the complexes were elucidated by spectroscopic methods such as FT-IR, UV–visible, and LC-MS analysis, as well as TG-DTA analysis, magnetic susceptibility measurements, and elemental analysis. Finally, the electrochemical characterization of ATL and the electrochemical sensor application of its complexes was performed. In electrochemical sensor studies, a carbofuran pesticide sensor application was investigated. ATL exhibited an irreversible oxidation peak around 1.0 V. It was observed that ATL-Co(II), ATL-Cu(II), and ATL-Zn(II) complexes behaved similarly to ATL and exhibited an irreversible oxidation peak at the same potential. Carbofuran pesticide was added to the sensor medium using the standard addition method. The changes in peak current with different carbofuran concentrations constituted the data of the amperometric sensor application, and the changes in the peak potential constituted the data of the voltammetric sensor application. Linear working ranges, LOD, and LOQ values were calculated for ATL, ATL-Co(II), ATL-Cu(II), and ATL-Zn(II) complexes, separately. The widest operating range as a voltammetric sensor was achieved with the ATL: 20 μmol L−1 to 350 μmol L−1. The lowest LOD and LOQ values were achieved with the ATL-Co(II) complex for voltammetric detection as 8.8 μmol L−1 and 29.2 μmol L−1, respectively. The lowest LOD and LOQ values were achieved with the ATL-Co(II) complex as 1.6 μmol L−1 and 5.2 μmol L−1 with the amperometric technique, respectively.

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• MakaleAçık Erişim2025Scopus SJRQ2/r/munzur/952
  Synthesis and characterization of novel bis(thiosemicarbazone) complexes and investigation of their acetylcholinesterase and glutathione S-transferase activities with in silico and in vitro studies

  Donmez, Melike; Sekerci, Memet; Adiguzel, Ragip; Oğuz, Ercan; Türkan, Fikret; Yildiko, Umit; Colak, Naki

  In this study, firstly, bis(thiosemicarbazone) ligand [L: 2,2′-(2-(2-(4-methoxyphenyl)hydrazineylidene)cyclohexane-1,3-diylidene)bis(hydrazine-1-carbothioamide)] was synthesized by the condensation reaction of thiosemicarbazide and ketone compound (2-(2-(4-methoxyphenyl)hydrazone)cyclohexane-1,3-dione). The metal complexes were synthesized by the reaction of obtained ligand (L) with CuCl2·2H2O, NiCl2·6H2O, CoCl2·6H2O, and MnCl2·4H2O salts. The structures of synthesized ligand and their complexes were characterized using elemental analysis, IR, UV–Vis, 1H-NMR spectra, 13C-NMR spectra, magnetic susceptibility, mass spectra (LC–MS), thermogravimetry analysis-differential thermal analysis (TGA-DTA), and differential scanning calorimetry techniques. According to the results of the analysis, square plane geometry was suggested for Cu and Co complexes. However, the structures of Ni and Mn complexes were in agreement with octahedral geometry. Molecular docking analysis and pharmacological potential of the compound were evaluated to determine the inhibitory potential against acetylcholinesterase (AChE) and Glutathione-S-transferases (GST) enzymes. The compound exhibited strong binding/docking indices of − 5.708 and − 5.928 kcal/mol for the respective receptors. In addition, L–Ni(II) complex was found to be the most effective inhibitor for AChE enzyme with a Ki value of 0.519. However, with a Ki value of 1.119, L–Cu(II) complex was also found to be an effective inhibitor for the GST enzyme.

  AtıfScopus21·OpenAlex19

  İncele
• MakaleAçık Erişim2023Scopus SJRQ2/r/munzur/1842
  Preparation of composite supported phase change materials from inorganic-based microcapsules of cetyl alcohol and investigation of their phase change material (PCM) behaviors

  Karabulut, Serap; Sekerci, Memet; Adiguzel, Ragip; Karagoz Genc, Zuhal

  In this study, cetyl alcohol (CA) (CH3(CH2)15OH), which is a fatty alcohol, was microencapsulated by the coacervation method with the titanium-n-butoxide (TNBO). Firstly, at the beginning of the experimental process by thermal and structural analyses, the CA was determined as having a phase change material (PCM) property, then it was microencapsulated with TNBO. In the second step of the study, barite, boron nitride, marble powder, and fly ash were separately added to prepare a series of microencapsulated with TNBO. Lastly, structural and thermal properties of both microencapsulated PCM and composite supported microencapsulated PCMs (CSM-PCMs) have been analyzed by FTIR, DSC, TGA, and SEM devices. Surprisingly, the SEM image of CA turned from torn fiber structure into a particulate structure in the form of groundnut in the SEM images of the microencapsulated CA-Ti taken at different magnifications. After the thermal cycling test, the same analyses have been made before and after thermal cycling to compare the structural and thermal properties. It has been investigated whether to use as insulation material. It is concluded that the most suitable samples, compared with structural and thermal properties, are barite (B) and boron nitride (BN) with microencapsulated samples. The obtained results are shown that CATi-B and CATi-BN are CSM-PCMs and could be suggested in terms of thermal energy storage in buildings as promising PCMs.

  AtıfScopus3·WoS3·OpenAlex3

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• MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2808
  Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S-Transferase

  Buldurun, Kenan; Aras, Abdülmelik; Turan, Nevin; Turkan, Fikret; Adiguzel, Ragip; Bursal, Ercan

  In this study, several metal(II) complexes (Fe, Co, Zn, and Ru) of an azo dye ligand (ADL) that, apart from pyrazole ring (PR), include anisole having (−OCH3) group at the m-substitue of the phenyl (L: (E)-4-((3-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were prepared, characterized, and the biological activity studies were carried out. The structures of complexes were identified by elemental analysis, FTIR, UV-vis, mass spectra (Fe(II) and Co(II)), 1H-13C NMR spectra, and TGA-DTA. The azo ligand and its metal complexes were evaluated for their biological properties according to the enzyme inhibitory activities. The lowest Ki values of Co(II) complex against all three GST (19.48±2.17 μM), AChE (22.14±3.74 μM), and BChE (26.39±3.19 μM) enzymes were verified as the most effective enzyme inhibition. The biological activity results suggest that the obtained complexes have good potentials to be used in further analyses to explore new pharmaceutical agents.

  AtıfScopus20·WoS19·OpenAlex18

  İncele
• MakaleYalnız künye2021Scopus SJRQ2/r/munzur/2961
  Synthesis and in silico studies of Novel Ru(II) complexes of Schiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone compounds as potent Glutathione S-transferase and Cholinesterases Inhibitor

  Adiguzel, Ragip; Türkan, Fikret; Yildiko, Ümit; Aras, Abdülmelik; Evren, Enes; Onkol, Tijen

  Novel Ru(II) complexes of Shiff base derivatives of 3-[(4-amino-5-thioxo-1,2,4-triazole-3-yl)methyl]-2(3H)-benzoxazolone were synthesized. The ligands (1a-e) were confirmed by IR, 1H NMR, and 13C NMR spectra (only 1b and 1c). Structures of the synthesized Ru(II) complexes (2a-e) were illuminated by elemental analysis, IR, 1H NMR, 13C NMR, and mass spectra. As the biological studies, the inhibitory potency of the ligands and the novel synthesized complexes were evaluated against the glutathione S-transferase (GST), acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes in vitro conditions. Ki values in the range of 26.87-47.63 µM for AChE, 23.51-42.81 µM for BChE, and 33.14-51.73 µM for GST, respectively. The free binding energy of most active inhibitors against AChE, BChE, and GST enzymes were detected as -10.183 kcal/mol, -9.111 kcal/mol, and -6.097 kcal/mol, respectively. All compounds docked were observed to bind in the active site of the enzymes with similar binding orientation and binding interactions with the surrounding amino acids.

  AtıfScopus31·OpenAlex34

  İncele
• MakaleAçık Erişim2021Scopus SJRQ2/r/munzur/2465
  Investigation of spectroscopic, thermal, and biological properties of FeII, CoII, ZnII, and RuII complexes derived from azo dye ligand

  Turan, Nevin; Buldurun, Kenan; Adiguzel, Ragip; Aras, Abdülmelik; Turkan, Fikret; Bursal, Ercan

  In this study, the novel azo dye FeII, CoII, ZnII, and RuII complexes with an azo dye ligand (L: (E)-4-((4-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were synthesized. The structures of the complexes were characterized by FT-IR, elemental analysis, UV-Vis, mass spectra (FeII and CoII), NMR spectra (only diamagnetic ZnII and RuII), thermogravimetric and differential thermal analysis (TGA-DTA). All of the newly synthesized compounds were tested for their biochemical properties, including enzyme inhibitory and antioxidant activities. According to the in vitro ABTS, DPPH, CUPRAC, and FRAP antioxidant methods, the ligand and its metal complexes showed close antioxidant activities to the standards (BHA, BHT, ascorbic acid, and α-tocopherol). Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The best inhibition values (Ki) were observed for Ru(II) complex against GST (14.36 ± 2.16 µM), AChE (16.86 ± 2.74 µM), and BChE (14.12 ± 2.04 µM).

  AtıfScopus45·WoS45·OpenAlex45

  İncele
• MakaleAçık Erişim2020/r/munzur/6722
  A Computational Study on Some Pyridine-Substituted-Bis-1,2,4-Triazole Derivatives and Investigation of Their Catalytic Activities

  Çetın, Ahmet; Adiguzel, Ragip; Aktan, Ebru; Evren, Enes

  In this work were specified catalytic activity of pyridine-substituted-bis-1,2,4-triazole (PBTT) derivative ligands 5,5′-(pyridine-2,5-diyl)bis(4-ethyl-4H-1,2,4-triazole-3-thiol) (L1) and 5,5′-(pyridine-2,5-diyl)bis(4-phenyl-4H-1,2,4-triazole-3-thiol) (L2) in biaryl synthesis in situ-reaction condition. Catalytic activities are determined in terms of conversion percentages to derivatives of biaryl of aryl bromides by GC-MS. The highest catalytic effect for L1 ligand was measured as 61% with 4-bromobenzaldehyde. Apart from catalytic activity studies, some structural properties of related ligands were discussed by computational methods. As a result, the ground state geometries, frontier molecular orbitals (FMOs) and also the maps of molecular electrostatic potential (MEP) of L1 and L2 ligands were obtained using DFT/B3LYP/6-31+G(d) calculations. Additionally, the global reactivity descriptors were reached using the FMOs calculations.

  AtıfOpenAlex4·TR Dizin2

  İncele
• MakaleYayıncıda açık erişim2018Scopus SJRQ3/r/munzur/3766
  Spectral, thermal and antimicrobial properties of novel mixed ligand-metal complexes derived from saccharinate complexes and azo dye ligand

  Adiguzel, Ragip; Turan, Nevin; Buldurun, Kenan; Korkoca, Hanifi

  Background and Objective: Saccharin and saccharinate (sac) complexes and its anion have critical importance with biological, biochemical and pharmacological properties. The main objective of this study was to synthesize the novel mixed ligand complexes from the complexes [M(Sac)2(H2O)4]·2H2O [M: Mn(II), Co(II), Ni(II), Cu(II) and Cd(II)] with a second neutral ligand [L:(mmppa): 5-Methyl-4-(4-methylphenylazo)-2H-pyrazole-3-ylamine]. Methodology: The structures of the complexes were characterized by elemental analysis, magnetic susceptibility, FT-IR, mass and electronic spectral studies and thermal analysis. Antimicrobial (antibacterial and anticandidal) activities of the complexes were tested against Enterococcus faecalis ATCC 51299, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Candida albicans ATCC 64548. Results: According to the experimental results, it was determined that in Mn(II), Co(II) and Cd(II) complexes, two coordinated H2O molecules are replaced with two neutral ligands, on the other hand, in Ni(II) and Cu(II) complexes, all coordinated H2O molecules are replaced with four neutral ligands. It was established that the second neutral ligand was coordinated to the metal ions via nitrogen atom of-NH2 group in pyrazole ring. In antimicrobial activity, study was determined to occur significant inhibition zones (20-24 mm) against Candida albicans ATCC 64548 strain. Conclusion: As a result, mononuclear and monomeric structure in octahedral geometry including both saccharin and azo dye ligands were synthesized and their characterizations were accomplished. The result of this study shows that novel mixed ligand-saccharinate complexes can be utilized for the development of anticandidal agents.

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  AtıfScopus11·WoS10·OpenAlex11

  İncele
• MakaleAçık Erişim2016Scopus SJRQ3/r/munzur/4954
  Spectroscopic, Thermal and Antioxidant Properties of Novel Mixed Ligand-Metal Complexes Obtained from Saccharinate Complexes and Azo Dye Ligand (mnppa)

  Turan, Nevin; Adigüzel, Ragip; Buldurun, Kenan; Bursal, Ercan

  The novel mixed ligand-metal complexes with a general formula [M(Sac)(2)(H2O)(2)L-2]center dot nH(2)O) [M = Mn(II), Co(II), Ni(II), Cu(II) and Cd(II), L=5-Methly-4-(4-nitrophenylazo)-2H-pyrazole-3-ylamine (mnppa)] have been synthesized and characterized by elemental analyses, IR, UV-VIS, magnetic susceptibility mass spectra and thermogravimetry-differential thermal analysis (TGA-DTA). Each metal (II) ion is octahedral coordinated by two sac, two mnppa and two aqua ligands. The antioxidant properties of mixed ligand-metal complexes were determined by different in vitro methods such as ABTS, DPPH, FRAP and CUPRAC assays. The results of metal complexes were compared with standard antioxidant compounds.

  AtıfWoS30·OpenAlex30

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• MakaleYalnız künye2016Scopus SJRQ4/r/munzur/4303
  Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties

  Turan, Nevin; Savci, Ahmet; Buldurun, Kenan; Alan, Yusuf; Adigüzel, Ragip

  Fe(II) and Zn(II) complex series have been synthesized from Schiff base ligands derived from furan-2-carbaldehyde and thiophene-2-carbaldehyde. Elemental, infrared, ultra-violet- visible, NMR and thermal analysis, also mass spectroscopy and magnetic susceptibility measurements were performed to explain the structures of these synthesized ligands and their metal complexes. The formulas based on analytical, spectral, and magnetic studies, the complexes can be demonstrated as [M(L-1)(2)](H2O)(n), [M(L-2)(2)](H2O)(n), where M = Zn(II) and Fe(II). An octahedral geometry was suggested for the Zn(II) and Fe(II) complexes. The antioxidant, antiradical and antimicrobial properties of the Zn(II) and Fe(II) complexes were investigated using different in vitro assays. Some of the complexes showed reasonable amount of antioxidant and antimicrobial activity.

  AtıfWoS19·OpenAlex19

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