Sürdürülebilir Kalkınma Amaçları

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• MakaleYalnız künye2026Scopus SJRQ1/r/munzur/1137
  Enhancement of chlorogenic acid application on the quality, biochemical properties, and cold storage stability of sweet cherry fruit

  Gundogdu, Muttalip; Sen, Fatih; Aglar, Erdal; Kılıncer, Mustafa

  This study investigated the effects of chlorogenic acid (ChlA) applications on postharvest quality characteristics and biochemical components of sweet cherry (Prunus avium L. cv. ‘0900 Ziraat’) fruit. Fruits were treated with control, 0.5, 1.0, and 1.5 mM ChlA and stored at 4 ± 0.5 °C for 21 days. Storage significantly increased weight loss and decay rate while reducing respiration rate and biochemical quality. At the end of storage, the 1.5 mM ChlA treatment reduced weight loss from 8.32% in the control to 5.20% and decreased decay rate from 9.16% to 4.50%. ChlA applications also slowed changes in soluble solids content (SSC), titratable acidity (TA), and pH, contributing to a more stable chemical composition. The highest vitamin C content at the end of storage was recorded in the 1.5 mM ChlA treatment (11.71 mg 100 g⁻¹), compared with 9.97 mg 100 g⁻¹ in the control. Similarly, chlorogenic acid significantly delayed losses of organic acids and phenolic compounds; for example, quercetin content was maintained at 6.80 mg 100 g⁻¹ in 1.5 mM ChlA-treated fruit compared with 3.78 mg 100 g⁻¹ in the control after 21 days of storage. Principal component analysis (PCA) and correlation analysis revealed strong relationships among quality attributes and biochemical compounds and demonstrated the positive role of ChlA in preserving overall fruit quality. Overall, chlorogenic acid, particularly at 1.5 mM, effectively reduced postharvest quality losses and enhanced biochemical stability during cold storage.

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• MakaleAçık Erişim2026Scopus SJRQ1/r/munzur/600
  Ajuga vestita Boiss: a “natural gold mine” for the design of novel nutraceuticals and phytopharmaceuticals

  Cetiz, Mehmet Veysi; Zengin, Gokhan; Leyva-Jiménez, Francisco Javier; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, Maria; Custódio, Luísa; Rodrigues, Maria João; Pereira, Catarina G.; Lazarova, Irina; Balos, Mehmet Maruf

  Members of the Ajuga genus are of significant interest due to their traditional applications in various countries, and have therefore been the subject of phytochemical research investigating their natural bioactive compounds. The aim of this study was to determine the chemical composition and biological activities of various Ajuga vestita extracts (ethyl acetate, ethanol, ethanol/water and water). The biological effects assessed included antioxidant, enzyme inhibition and cytotoxic activities. The extracts were chemically profiled using ultra-high-performance liquid chromatography – electrospray ionization – quadrupole time-of-flight mass spectrometry (UHPLC-ESI-QTOF-MS), which identified 121 compounds, including iridoids, flavonoids, and phenolic acids. The ethanol/water extract exhibited superior radical scavenging activity (2,2-Diphenyl-1-picrylhydrazyl (DPPH): 43.13 mg Trolox equivalent (TE)/g; 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS): 45.37 mg TE/g) and reducing power (cupric reducing antioxidant capacity (CUPRAC): 103.43 mg TE/g; ferric reducing antioxidant power (FRAP): 45.29 mg TE/g). Regarding enzyme inhibition, the ethanol extract exhibited the greatest inhibition of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), glucosidase, and tyrosinase, whereas the ethyl acetate extract was most effective against amylase. Regarding cytotoxicity, the ethyl acetate extract exhibited the strongest effect, significantly reducing cell viability in all cell lines and having a particularly strong impact on murine bone marrow stromal (S17) cells, with viability at 30.8 ± 2.7% at a concentration of 100 µg/mL. By contrast, the aqueous extract exhibited low cytotoxicity, maintaining high cell viability (over 94% at 50 µg/mL and over 74% at 100 µg/mL). Additionally, network pharmacology, molecular docking and molecular dynamics simulations were employed to investigate the multi-target mechanisms and binding stability of A. vestita phytochemicals. These findings provide new, detailed insights into A. vestita and suggest its potential as a raw material for developing health-promoting nutraceutical and pharmaceutical products.

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• MakaleÖn baskısı açık2016Scopus SJRQ1/r/munzur/4028
  Determination of anthocyanins in cherry and cranberry by high-performance liquid chromatography-electrospray ionization-mass spectrometry

  Karaaslan, Nagihan M.; Yaman, Mehmet

  Anthocyanins are a group of widespread natural phenolic compounds in vegetables and fruits. The anthocyanins have a wide range of applications due to the antioxidant, anticancer and anti-inflammatory properties. In this study, anthocyanins (delphinidin-3-o-glucoside, cyanidin-3-o-glucoside, pelargonidin-3-o-glucoside and malvidin-3-o-glucoside) in cherry and cranberry were determined using high-performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS). The anthocyanins were separated using gradient elution and a reserved-phase analytical column before identification by high-performance liquid chromatography-electrospray ionization-mass spectrometry. A high-performance liquid chromatography-electrospray ionization-mass spectrometry method was optimized for the determination of anthocyanins in cherry and cranberry. Furthermore, in this study, we investigated extraction conditions of fruit samples as well as determination of optimum HPLC-ESI-MS conditions. This study is novel in terms of simultaneously examining both optimization of HPLC parameters and extraction conditions. Obtained optimum conditions were used for the determination as the quantitative and qualitative analysis of anthocyanins in cherry and cranberry. The content of anthocyanins on the basis of wet weight in cherry and cranberry samples was determined for delphinidin-3-o-glucoside < d.l. (detection limit) and < d.l., for cyanidin-3-o-glucoside varied from 3.5 +/- A 0.4 to 8.3 +/- A 1.1 mg kg(-1) (average 5.8 +/- A 0.8 mg kg(-1)) and 9.8 +/- A 1.4 to 18 +/- A 3.0 mg kg(-1) (average 13.2 +/- A 1.8 mg kg(-1)), for pelargonidin-3-o-glucoside < d.l. and varied from 136 +/- A 19 to 233 +/- A 35 mg kg(-1) (average 185.3 +/- A 28 mg kg(-1)), for malvidin-3-o-glucoside < d.l. and < d.l., respectively.

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  AtıfWoS25·OpenAlex29

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