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Effects of Taurine on the Levels of PPARγ, IRS-1, HSP-27, HSP-72 and Histopathological Changes in Kidney of the Diabetic Rats

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Özet

The objective of this study was to investigate the effects of taurine on PPAR-γ, IRS-1, HSP-27, and HSP-72 levels along with the kidney histopathological changes in streptozotocin (STZ) induced diabetic rats. In the study, 40 Wistar albino male rats were divided into four groups. (i) Control group, (ii) Taurine, rats received taurine with drinking water (2%); (iii) STZ, rats were injected with STZ (60 mg/kg i.p. as single dose) and (iv) STZ+Taurine, rats received taurine and injected with STZ. After 8 weeks of the study, the Taurine group was found to be statistically indifferent to the control group in terms of PPAR-γ, IRS-1, HSP-27, and HSP-72 levels (P>0.05). However, PPAR-γ (P<0.01), IRS-1 and HSP-72 (P<0.001) levels decreased in the STZ group. HSP-27 (P<0.01) levels increased in the STZ group as compared with the control. On the other hand, there were histopathological changes in the STZ group. The intensity of histopathological changes induced by STZ was decreased in the STZ+Taurine group. As a result, the taurine supplementation may prevent and treat the kidney damage in diabetic rats

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Endokrinoloji ve MetabolizmaÜroloji ve NefrolojiBiyokimya ve Moleküler Biyoloji
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dc.contributor.authorTuzcu, Mehmet
dc.contributor.authorErten, Fusun
dc.contributor.authorGencoglu, Hasan
dc.date.accessioned2026-10-28T15:11:59.183689006Z
dc.date.available2026-10-28T15:11:59.183689006Z
dc.date.issued2020
dc.description.abstractThe objective of this study was to investigate the effects of taurine on PPAR-γ, IRS-1, HSP-27, and HSP-72 levels along with the kidney histopathological changes in streptozotocin (STZ) induced diabetic rats. In the study, 40 Wistar albino male rats were divided into four groups. (i) Control group, (ii) Taurine, rats received taurine with drinking water (2%); (iii) STZ, rats were injected with STZ (60 mg/kg i.p. as single dose) and (iv) STZ+Taurine, rats received taurine and injected with STZ. After 8 weeks of the study, the Taurine group was found to be statistically indifferent to the control group in terms of PPAR-γ, IRS-1, HSP-27, and HSP-72 levels (P>0.05). However, PPAR-γ (P<0.01), IRS-1 and HSP-72 (P<0.001) levels decreased in the STZ group. HSP-27 (P<0.01) levels increased in the STZ group as compared with the control. On the other hand, there were histopathological changes in the STZ group. The intensity of histopathological changes induced by STZ was decreased in the STZ+Taurine group. As a result, the taurine supplementation may prevent and treat the kidney damage in diabetic rats
dc.identifier.eissn2149-1712
dc.identifier.endpage145
dc.identifier.issn1308-9323
dc.identifier.issue3
dc.identifier.startpage139
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/munzur/6749
dc.identifier.volume34
dc.language.isotr
dc.relation.ispartofFırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectEndokrinoloji ve Metabolizma
dc.subjectÜroloji ve Nefroloji
dc.subjectBiyokimya ve Moleküler Biyoloji
dc.titleEffects of Taurine on the Levels of PPARγ, IRS-1, HSP-27, HSP-72 and Histopathological Changes in Kidney of the Diabetic Rats
dc.typeArticle
rdl.citation.trdizin0
rdl.source.indexTRDIZIN