Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2022Scopus SJRQ2Age- and Sex-Specific Bioaccumulation of Selected Metals in Freshwater Mussel (Unio elangatulus eucirrus Bourguignat, 1860) Populating from Keban Dam Lake (Elazig, Turkey)
Danabaş, Durali; Kutluyer, Filiz; Ural, Mesut; Özçelik, Mehtap; Kocabaş, Mehmet
In aquatic life, environmental chemicals are accumulated by mussels due to their sentinel nature and filter-feeding characteristics. Herein, the present study focused on assessing the concentrations of Cu, Zn, Mg, Mn, Fe, Cd, Pb, Ca, K, and Na levels in freshwater mussels (Unio elangatulus eucirrus) depending on sex and age. For all trace metals, some important differences of bioaccumulations were determined depending on ages and sex. In details, the results indicated that an important age-related accumulation of Mg, Cd, Ca, and K was in females and all trace elements, except Cu, Mg, and K levels in males (p < 0.05). No statistical differences were determined in mean concentrations of Cu, Zn, Mg, and Na. There are statistical differences in Mg, Mn, Fe, and Ca levels between females and males in four aged mussels (p < 0.05). Lead levels were under detectable limits. Overall, metal levels and their toxicity in freshwater mussels should be closely monitored for health of the environment, animals, and humans, since mussels and fish species fed on them are consumed highly in the research region and around.
AtıfScopus5WoS6OpenAlex7
İncele - MakaleYalnız künye2020The Effect of Propolis on Oxidative Damage Induced by Whole Body Irradiation in Rat
Baykara, Murat; Erisir, Mine; Özçelik, Mehtap; Güler, Osman
The antioxidant and radioprotective effects of propolis against ionizing radiation induced oxidativedamage were investigated. Twenty one rats were divided in to 3 groups; 1 st group was the controlgroup; 2nd group was the irradiation group, physiological saline (i.p.)/ 3 days + 9 Gy gammairradiation; 3rd group was irradiation + Propolis group, propolis (i.p. 100 mg / kg BW) / 3 days + 9Gy gamma irradiation. As a result of irradiation, a significant increase was determined inmalondialdehyde (MDA) levels of liver, kidney, and brain tissues of the rats (P<0.001). There was asignificant decrease in glutathione peroxidase (GSH-Px) activity of all the tissues (P˂0.001) andsuperoxide dismutase (SOD) activity and glutathione (GSH) level in the liver (P˂0.01). Also, GSHlevel increased significantly in the kidney (P˂0.001) and ovarium tissues (P˂0.05). The MDA levelsthat increased in the liver as a result of irradiation, decreased significantly due the addition ofpropolis (P˂0.001); whereas, the MDA levels that increased in kidney and brain did not change. Inthe spleen and ovarium tissues, MDA levels decreased significantly as a result of addition ofpropolis compared to the irradiation group (P˂0.05). It was determined that GSH levels, thatdecreased in the liver (P˂0.01), and increased in the kidney due to addition of propolis, and GSHlevels, that decreased in the liver as a result of irradiation (P˂0.01) and increased in the kidney(P˂0.001), approached to the normal level (P˂0.001) and the GSH levels in the spleen and brainincreased compared to both the control and irradiation groups (P˂0.05). The addition of propoliscaused a decrease in the GSH-Px activities of heart, spleen, brain, and ovarium tissues comparedto both the control and irradiation groups (P˂0.001). Also, a decrease in the SOD activity of hearttissue compared to the control group was found (P˂0.05).
- MakaleAçık Erişim2020The Effect of N-Acetylcysteine on Oxidant/Antioxidant Status in Irradiated Rats
Baykara, Murat; Özçelik, Mehtap; Erisir, Mine; Guler, Osman
N-Acetylcysteine (NAC) is both a strong antioxidant and a glutathione precursor. The effect of NAC on the oxidant/antioxidant status of some tissues of the irradiated rats was investigated. Twenty one rats were assigned to 3 groups; the control group, the irradiation group, for which physiological saline solution was administered as i.p. for three days and then, 9 Gy gamma irradiation was applied, and 3rdirradiation + NAC group for which NAC was adminis-tered as i.p. for three days as 300 mg/kg body weight and then the same dose of irradiation was applied. Upon irradia-tion, the increase determined in malondialdehyde (MDA) was significant in the liver, kidney, and brain tissues of the rats (P˂0.05). While glutathione peroxidase (GSH-Px) activity decreased in all of the tissues and superoxide dismutase (SOD) activity only in the liver (P˂0.01), glutathione (GSH) levels significantly increased in the kidney and ovarium tissues (P˂0.001). While NAC administration returned the increased MDA levels in the kidney and brain as a result of irradiation to normal levels (P˂0.05), it was determined that it did not return the increased MDA levels in the liver tissue to the normal level (P˂0.001). While NAC addition led to a significant increase in GSH levels of the liver, heart, spleen, brain and ovarium tissues compared to both control and irradiation groups, it caused a significant decrease in the kid-ney tissue compared to irradiation group (P˂0.001). As a result of NAC addition, a significant decrease was determined in spleen GSH-Px activity, heart and ovarium SOD activity compared to control and irradiation groups (P˂0.05). It can be asserted that GSH increasing by the addition of NAC is the main antioxidant that has a role in decreasing oxidative stress occurring as a result of irradiation. In the examination of MDA values, it was found that the addition of NAC pro-tected the kidney and brain against the oxidative damage induced by irradiation but NAC addition could remain insuffi-cient for the liver.
AtıfOpenAlex2
İncele - MakaleYalnız künye2016Scopus SJRQ3-
Yıldırım, Nuran Cıkcıkoğlu; Özçelik, Mehtap; Benzer, Fulya
The effects of dietary antioxidants (vitamine E, vitamine C, Astaxhantin, ? carotene) on arginase activity and nitric oxide levels of hepatopancreas and muscle of freshwater crayfish (Actacus leptodactylus) were investigated during moulting.150 mg kg-1 vitamine E (VE), 200 mg kg-1vitamine C (VC), 200 mg kg-1 Astaxhantin and 200 mg kg-1 ? carotene were added to experimental diets. A. leptodactylus with these diets were fed with 2% of their total weight daily, in a day during 75 days. Arginase activity was increased in muscle of crayfish fed the diets VC, VE, astaxanthin and ? karoten but in hepatopancreas arginase activity was increased with ? carotene when compared to control. NO levels in muscle were decreased when compared to control but this decrease was not statically significant. NO levels in hepatopancreas of crayfish fed the diets VC and astaxanthin were higher than control groups. Our results demonstrated that dietary antioxidants affect the arginase activity and nitric oxide level of freshwater crayfish (Astacus leptodactylus, Esch. 1823) during moulting.
AtıfTR Dizin1İncele - MakaleAçık Erişim2016Scopus SJRQ3The Effects of Dietary Antioxidants on the Arginase Activity and Nitric Oxide Level of Narrow-Clawed Turkish Crayfish (Astacus leptodactylus, Esch 1823) in Moulting Period
Benzer, Fulya; Özçelik, Mehtap; Yildirim, Nuran Cikcikoglu
The effects of dietary antioxidants (vitamine E, vitamine C, Astaxhantin, beta carotene) on arginase activity and nitric oxide levels of hepatopancreas and muscle of freshwater crayfish (Actacus leptodactylus) were investigated during moulting. 150 mg kg(-1) vitamine E (VE), 200 mg kg(-1) vitamine C (VC), 200 mg kg(-1) Astaxhantin and 200 mg kg(-1) beta carotene were added to experimental diets. A. leptodactylus with these diets were fed with 2% of their total weight daily, in a day during 75 days. Arginase activity was increased in muscle of crayfish fed the diets VC, VE, astaxanthin and beta karoten but in hepatopancreas arginase activity was increased with beta carotene when compared to control. NO levels in muscle were decreased when compared to control but this decrease was not statically significant. NO levels in hepatopancreas of crayfish fed the diets VC and astaxanthin were higher than control groups. Our results demonstrated that dietary antioxidants affect the arginase activity and nitric oxide level of freshwater crayfish (Astacus leptodactylus, Esch. 1823) during moulting.
AtıfWoS3OpenAlex3İncele - MakaleYalnız künye2011Yoncanın toklularda kas ve kuyruk yağ dokularındaki retinol, a-tokoferol ve kolesterol düzeyleri üzerine etkisi
Seven, Pinar Tatli; Gürdoğan, Fuat; Benzer, Fulya; Erişir, Zeki; Seven, Ismail; Bahşi, Muammer; Özçelik, Mehtap; Kılınç, Ünal; Ökkeş; Yılmaz, Okkes
In this study, the effects of fresh, ensiled or dried alfalfa on retinol, a-tocopherol and cholesterol levels in yearling sheep were investigated. In the study, 40 Akkaraman male yearling sheep, 4 months of age and an average body weight of 21 kg, were used. All diets used in the present study were prepared as isonitrogenous and isoenergetic. The alfalfa forms used in rations composed the experimental groups. With regard to groups were fed with wheat straw as roughage was Control group (C-Group) or fed with fresh alfalfa was AF group, ensiled alfalfa was AS group and dried alfalfa was AD group. Retinol levels in muscular and tail adipose tissue were found to be higher in alfalfa feeding groups compared to control group. The highest a-tocopherol level in deltoideous muscle tissue was detected in AF group. Cholesterol levels in muscular and tail adipose tissue were found to be lower in alfalfa feeding groups compared to control group.As a conclusion it can be said that, decrasing cholesterol levels in yearling sheep by feeding with alfalfa, is extremely important for human beings that consume red meat, as it can reduce the risk of coronary heart diseases.