Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ4Protective effect of Momordica charantia against Hepatorenal toxicity induced by Potassium bromate (KBrO3) in rats; [Efecto protector de Momordica charantia contra la toxicidad hepatorrenal inducida por el bromato de potasio (KBrO3) en ratas]
Karagözoğlu, Fatma; Uyar, Ahmet; Akkoyun, Hurrem Turan; Altun, Serdar; Akkoyun, Mahire Bayramoğlu; Aydin, Sevinç; Melek, Sule; Bengü, Aydın Şükrü; Ekin, Suat; Bakir, Ahmet
This study aims to evaluate the effects of Momordica charantia on hepatorenal toxicity caused by potassium bromate (KBrO3) in rats. Wistar rats were divided into 4 groups as control, KBrO3, bitter melon (MC), and KBrO3+MC. Examining the antioxidant enzyme grade of the kidney tissues, it was found that the enzyme activities of catalase (CAT) (P<0.05), glutathione peroxidase (GSH–Px) (P<0.01), and superoxide dismutase (SOD) (P<0.01) decreased in the KBrO3 group in comparison to the control. There was a significant decrease (P<0.001) in glutathione (GSH) levels and an increase (P<0.01) in malondialdehyde (MDA) level in the KBrO3 group in comparison to the control. Examining the antioxidant enzyme activities in liver tissue, it was determined that CAT, GSH–Px, and SOD enzymes reduced significantly (P<0.05, P<0.01, and P<0.001, respectively) in the KBrO3 group in comparison to the control, and the enzyme activity of decreased CAT, GSH–Px, and SOD enzymes significantly elevated (P<0.01) in the MC group. There was a reduction in GSH level in the KBrO3 group in comparison to the control (P<0.01), while an increase was recorded in the KBrO3+MC group (P<0.05). MDA level in liver tissue increased in KBrO3 group in comparison to the control (P<0.01) and MC decreased the MDA level. Histopathological analysis results indicate severe degenerative and necrotic lesions in hepatorenal histoarchitecture of KBrO3 rats in comparison to the control. However, application of MC+KBrO3 significantly reduced the induced hepatorenal injury with a concomitant increase in histopathological lesions. From the immunohistochemical aspect, MC revealed apoptosis concomitant with the suppression of necrosis in the KBrO3-treated rats as demonstrated by the caspase-3 activity.
AtıfOpenAlex1
İncele - MakaleYalnız künye2017Quercetin'in Koruyucu Etkisinin İncelendiği Ratlarda Alt Ekstremite İskemi-Reperfüzyon Hasarında TAS-TOS Düzeyleri
Akkoyun, Mahire Bayramoğlu; Arihan, Okan; Bengü, Aydın Şükrü; Aydın, Sevinç; Demir, Halit; Birinci, Ceyhun Birinci; Akkoyun, Hurrem Turan; Atçalı, Tuğçe
Objective: It was aimed to determine the protective effectiveness of quercetin in preventing lower extremity ischemia-reperfusion (I/R) injury. Material and Methods: 30 Sprague-Dawley male rats weighing 250-350 g were divided into three groups. Anaesthesia was applied to the first group of rats without ischemia-reperfusion process. To the second group two hours of ischemia and two hours of reperfusion, with the help of left lower extremities tourniquet , were applied. To the third group, 50mg/kg (ip) quercetin application was performed 45 minutes before the ischemia was initiated, two hours of ischemia and two hours of reperfusion application were carried out. At the end of the process, by taking the tissue samples, total antioxidant status (TAS) and total oxidant status (TOS) levels were evaluated. Results:When TAS was evaluated, it was determined that the decrease (p?0.001) occurring in I/R group in comparison with the control group was significant, the decrease (p?0.05) in I/R+Q group in comparison with control group, and again the increase (p?0.001) in I/R+Q group in comparison with I/R group was also significant. When the TOS amounts were evaluated, it was determined that the increase (p?0.001) occurring in I/R group in comparison with control group, the increase in I/R+Q group in comparison with control group (p?0.05), the decrease in I/R+Q group in comparison with I/R group was statistically significant. Conclusion: It has been determined that quercetin has protective effect and decrease the injury occurred in experimental Lower Extremity Ischemia-Reperfusion Injury in Rats.
