Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ4Protective effects of Sodium Tetraborate on fatty acid profiles in rat hearts subject to Lead toxicity; [Efecto protector del tetraborato de sodio sobre los perfiles de ácidos grasos en el corazon de ratas, expuestas a toxicidad por plomo]
Aydin, Sevinç
This study was designed to observe the effects of sodium tetraborate on preventing lead metal toxicity damage to fatty acids in rat heart tissue. After the heart tissues were homogenized with Tris-HCl buffer, the separated pellet part was prepared for fatty acid analysis. The fatty acids in the obtained lipid extract were converted to methyl ester form and analyzed with SHIMADZU GC 2010 PLUS gas chromatography. When comparing the lead group with the lead + sodium tetraborate group, partial increases were observed in saturated fatty acid levels such as myristic acid (14:0), pentadecanoic acid (15:0), and palmitic acid (16:0), while varying increases were seen in some monounsaturated fatty acid levels such as palmitoleic acid (16:1, n-7), and oleic acid (18:1, n-9). Moreover, demonstrated varying levels of increases in all polyunsaturated fatty acids excluding the arachidonic acid (20:4, n-6) and adrenic acid (22:4, n-6) fatty acids. As the most notable fatty acid change in our study, arachidonic acid (20:4, n-6) fatty acid increasing in the lead group while decreasing in the sodium tetraborate group demonstrates that sodium tetraborate decreased the negative effects of oxidative stress on fatty acids. The results of this study provide supporting evidence for the potential use of sodium tetraborate in drug design to prevent the toxic effects of lead.
- MakaleAçık Erişim2025Scopus SJRQ4Protective effect of Momordica charantia against Hepatorenal toxicity induced by Potassium bromate (KBrO3) in rats; [Efecto protector de Momordica charantia contra la toxicidad hepatorrenal inducida por el bromato de potasio (KBrO3) en ratas]
Karagözoğlu, Fatma; Uyar, Ahmet; Akkoyun, Hurrem Turan; Altun, Serdar; Akkoyun, Mahire Bayramoğlu; Aydin, Sevinç; Melek, Sule; Bengü, Aydın Şükrü; Ekin, Suat; Bakir, Ahmet
This study aims to evaluate the effects of Momordica charantia on hepatorenal toxicity caused by potassium bromate (KBrO3) in rats. Wistar rats were divided into 4 groups as control, KBrO3, bitter melon (MC), and KBrO3+MC. Examining the antioxidant enzyme grade of the kidney tissues, it was found that the enzyme activities of catalase (CAT) (P<0.05), glutathione peroxidase (GSH–Px) (P<0.01), and superoxide dismutase (SOD) (P<0.01) decreased in the KBrO3 group in comparison to the control. There was a significant decrease (P<0.001) in glutathione (GSH) levels and an increase (P<0.01) in malondialdehyde (MDA) level in the KBrO3 group in comparison to the control. Examining the antioxidant enzyme activities in liver tissue, it was determined that CAT, GSH–Px, and SOD enzymes reduced significantly (P<0.05, P<0.01, and P<0.001, respectively) in the KBrO3 group in comparison to the control, and the enzyme activity of decreased CAT, GSH–Px, and SOD enzymes significantly elevated (P<0.01) in the MC group. There was a reduction in GSH level in the KBrO3 group in comparison to the control (P<0.01), while an increase was recorded in the KBrO3+MC group (P<0.05). MDA level in liver tissue increased in KBrO3 group in comparison to the control (P<0.01) and MC decreased the MDA level. Histopathological analysis results indicate severe degenerative and necrotic lesions in hepatorenal histoarchitecture of KBrO3 rats in comparison to the control. However, application of MC+KBrO3 significantly reduced the induced hepatorenal injury with a concomitant increase in histopathological lesions. From the immunohistochemical aspect, MC revealed apoptosis concomitant with the suppression of necrosis in the KBrO3-treated rats as demonstrated by the caspase-3 activity.
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İncele - MakaleAçık Erişim2022Scopus SJRQ3SOME PHYTOCHEMICAL CONTENTS AND ANTIOXIDANT ACTIVITIES OF TWO PRANGOS LINDL. (UMBELLIFERA) SPECIES GROWN IN TURKEY
Hayta, Şükrü; Aydin, Sevinç; Topdemir, Aykut
The genus Prangos is a member of the Apiaceae family, and it has been a focus of the attention of researchers due to its high nutritional value and some special medical properties. In this study, the total phenolic and flavonoid contents and antioxidant activities of the leaf and fruit extracts of the Prangos ferulacea and Prangos uloptera species belonging to this genus were studied, and the properties of these two species were compared to each other. In the study, the Folin-Ciocalteu method was used for the analysis of the total phenolic content, methanolic formaldehyde was used for the total flavonoid content, and both analyses were carried out with a UV-VIS spectrophotometer device. The antioxidant activity of the specimens was measured based on the Trolox equivalent antioxidant capacity (TEAC) method. It was found that the P. ferulacea species had higher total phenolic and flavonoid content values than the P. uloptera species. The P. ferulacea species was also more effective in terms of antioxidant activity, which is known to be associated with these properties. When the fruit and leaf extracts of each species were compared, it was found that the total phenolic and flavonoid content of the fruit extract of the P. uloptera species was higher than that of its leaf extract, and the antioxidant activity of the fruit extract was also higher in proportion to these values. In the P. ferulacea species, as opposed to the case of P. uloptera, all values except for the total flavonoid values were higher in the leaf extract than the fruit extract.