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- MakaleYayıncıda açık erişim2026Scopus SJRQ1Phenolic Profiling of Some Bryophyte Species: In Vitro and In Silico Assessment of Their Antimicrobial Potentials
Çambay, Zafer; Uslu, Harun; Coteli, Ebru; Göktaş, Bünyamin; Özdemir Bayçinar, Kevser; Emre, Mustafa Yunus; Güngören, Muhammed; Alataş, Mevlüt
This study explores the phytochemical composition and antimicrobial potential of Palustriella commutata, Philonotis calcarea, Cinclidotus riparius, Rhynchostegium riparioides, Plagiomnium ellipticum, and Porella platyphylla, with a focus on bryophyte species phenolic constituents and biological activities. HPLC analysis identified seven phenolic acids (4-hydroxybenzoic acid, 2,5-dihydroxybenzoic acid, 3,4-dihydroxybenzoic acid, caffeic acid, vanillic acid, syringic acid, and p-coumaric acid) across all species in varying concentrations. In in vitro antimicrobial tests, the bryophyte extracts used showed significant activity against Pseudomonas aeruginosa (ATCC 9027), while exhibiting relatively lower inhibition against Staphylococcus aureus (ATCC 25923). The study showed that all species extracts exhibited comparable activity to erythromycin against P. aeruginosa, while Cinclidotus riparius and Plagiomnium ellipticum extracts showed no activity against S. aureus, and the remaining species exhibited lower activity compared to erythromycin. Molecular docking studies demonstrated strong binding affinities of these phenolics to the active site of the target macromolecule (PDB ID: 3FRQ), suggesting meaningful interactions with residues such as ARG122 and ASN123, similar to erythromycin binding patterns. The findings indicate that bryophyte-derived phenolic compounds possess significant antimicrobial potential and may serve as promising candidates for the development of novel bioactive agents. This study provides a broad framework for the insufficiently researched antimicrobial potential of bryophytes by establishing direct links between species-specific phenolic fingerprints, experimentally observed antibacterial activities, and predicted receptor-level interactions. Further complementary biological studies are needed to confirm and expand upon these results.
- MakaleAçık Erişim2023The Antioxidant Capacities and Antimicrobial Activities of Some Salvia L. Seeds
Ökkeş; Yılmaz, Okkes; Yilmaz; Kurşat, Murat; Kirbag, Sevda; Civelek, Şemsettin; Emre, Irfan; Sönmez, Pınar Erecevıt; Emre, Mustafa Yunus
The goal of present study is to find the penolic contents, antioxidant activities and antimicrobial capacities in the seeds of five Salvia L. taxa two of which are endemics (Salvia euphratica var. leiocalycina and Salvia euphratica var. euphratica). The flavonoid and phenolic acid are determined by using HPLC while the antioxidant activities are determined based on different methods. Also, the antimicrobial activities of some Salvia species are determined by using the well agar method. The current study found that the studied Salvia species have low flavonoid. It has been found that Salvia euphratica var. euphratica has high vanillic acid, ferulic acid and rosmarinic acid among the studied taxa. Similarly, it has been found that Salvia euphratica var. euphratica has high DPPH and ABTS radical scavening capacity in all concentrations. It has been also found that Salvia euphratica var. euphratica has highest total phenolic content (372,63±0,87 µgGAE/mg) whilst Salvia tricholoda has low total phenolic content (46,41±1,71 µgGAE/mg). In addition, this study demonstrated that Salvia tricholoda has lowest metal chelating activity (37,35±0,51%). Furthermore, present study found that the lipid peroxidation levels of the studied Salvia taxa are between 18,21±0,37 mg/kg and 21,03±0,22 mg/kg while it has been found that the antibacterial properties of the Salvia taxa under study are altering.
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İncele - MakaleAçık Erişim2021The antioxidant and antimicrobial capacities of phenolic profiles of some Salvia L. Seeds grown in Turkey
Emre, Irfan; Kursat, Murat; Kirbag, Sevda; Erecevit, Pinar; Emre, Mustafa Yunus; Yilmaz, Okkes; Civelek, Semsettin
The aim of current study is to show phenolics, antioxidant capacities and antimicrobial activities of seeds of five Salvia L. (S. frigida Boiss., S. candidissima subsp. candidissima Vahl., S. virgata Jacq., S. verticillata L. var. verticillata and S. russellii Benth.) taxa grown in Turkey. The flavonoid and phenolic acid contents were measured by using HPLC whilst the antioxidant capacities were determined by using different methods. In addition, agar well diffusion method was used to determine the antimicrobial activities of Salvia species in this study. It was found that S. frigida, S. verticillata var. verticillata and S. russellii have the highest catechin contents and S. frigida and S. verticillata var. verticillata have high rosmarinic acid while S. frigida, S. candidissima subsp. candidissima and S. verticillata var. verticillata have high vanilic acid. Also, it was determined that S. frigida and S. verticillata var. verticillata have high DPPH radical scavenging activities in 150 and 250 µL while S. frigida and S. verticillata var. verticillata have highest ABTS radical scavenging activity in all concentrations apart from 25 µL for S. frigida. Furthermore, S. frigida and S. verticillata var. verticillata have high total phenolic contents. On the other hand, Salvia species have similar lipid peroxidation inhibitions. However, the metal chelating activities of Salvia species are different. And also, it was demonstrated that Salvia taxa have antimicrobial activity.
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