Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2020Scopus SJRQ2/r/munzur/3445
  Synthesis, and antimicrobial and anticancer activities of sodium acrylate copolymers

  Torğut, Gülben; Pıhtılı, Güzin; Erecevit Sönmez, Pınar; Erden, Yavuz; Kırbağ, Sevda

  This study was designed to synthesize poly(sodium acrylate-co-N-isopropylacrylamide) via aqueous free-radical polymerization using the 2,2′-azobisisobutyronitrile initiator system at 60°C. The structural characterization of the copolymer was determined by Fourier-transform infrared spectroscopy. The polymer was synthesized in two different ratios, namely, poly(NaAc-co-NIPA1:1) and poly(NaAc-co-NIPA2:1), to investigate whether it affects their antibacterial–antifungal activities and anti-tumour effects. When the antimicrobial activities of different proportions of the copolymer extracts prepared with pure water were examined using the agar disc diffusion sensitivity test (at 120 μL: 10.8 mg/µL), it was observed that they had effect at increasing rates against all the bacteria, yeasts and dermatophyte fungi such as Staphylococcus aureus COWAN 1, Staphylococcus cohnii ATCC 29974, Bacillus megaterium DSM 32, Bacillus subtilis ATCC 6633, Escherichia coli ATCC 25922, Klebsiella pneumoniae FMC 5, Pseudomonas aeruginosa DMS 50071 SCOTTA, Candida albicans FMC 17, Candida glabrata ATCC 66032, Trichophyton sp. and Epidermophyton sp. The results of this study revealed that the obtained copolymers have significant effects on the treatment of diseases. In addition, the anti-tumour activities of the poly(NaAc-co-NIPA1:1) copolymer on human breast (MCF-7) and ovarian cancer (A-2780) cell line were specified and it was determined that high doses of the copolymer showed anti-tumour effects on both types of cancer cell lines. Also, this article reviews its antimicrobial and anticancer activities that will be of help for future scientists.

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  AtıfScopus3·WoS3·OpenAlex6

  İncele
• MakaleYalnız künye2017/r/munzur/5383
  Probiyotik Maya Olarak Saccharomyces cerevisiae’nın Gelişimine Citrus limon (L.) Burm. f. (Limon)’un Bazı Fitokimyasal Etkileri

  Sönmez, Pınar Erecevit; Kırbağ, Sevda

  Bu çalışmada; besin olarak tüketilen Citrus limon (L.) Burm. f. (limon) ile muamele edilen Saccharomyces cerevisiae ekstraktlarının yağ asidi, vitamin, fitosterol, flavonoid ve resveratrol içerikleri ile antimikrobiyal aktiviteleri belirlenerek karşılaştırmalar yapıldı. Elde edilen sonuçlara göre; limon ekstraktındaki toplam yağ asidi düzeylerinin belirgin, vitamin ve fitosteroller içeriklerinin kısmi seviyelerde olduğu gözlendi. S. cerevisiae ile hazırlanan limon ekstraktlarının toplam yağ asidi düzeylerinin çok belirgin, vitamin içeriklerinin farklı miktarlarda arttığı, flavonoid içeriklerinin ise farklı oranlarda azaldığı saptandı. Çalışmada limonun değişen oranlarda antioksidan ve antimikrobiyal aktivitelere sahip olduğu görüldü. S. cerevisiae içeren limon ekstraktlarının ise antimikrobiyal aktiviteleri incelendiğinde yağ asidi ekstraktlarının tüm bakteri, maya ve dermatofit funguslarda değişen oranlarda etkili olduğu görülürken, vitamin ekstraktlarının Escherichia coli ATCC 25922, Klebsiella pneumoniae FMC 5 ve flavonoid ekstraktlarının ise Bacillus megaterium DSM 32, Staphylococcus aureus COWAN 1, Trichophyton sp. dışındaki tüm mikroorganizmalarda az miktarlarda antimikrobiyal aktivite gösterdiği saptandı. Sonuç olarak; besinsel lif kaynağı olan limonun, bu çalışmada kullanılan potansiyel probiyotik olarak kabul edilen S. cerevisiae için hem enerji kaynağı hemde olumlu yönde etkilerinin olduğu ve limondan elde edilen ekstraktlar içerisinde gelişen bu maya türünün faydalı bitkisel biyolojik bileşiklere değişen oranlarda etki gösterdiği saptandı

  AtıfTR Dizin2

  İncele
• MakaleAçık Erişim2017Scopus SJRQ3/r/munzur/3292
  Determining the phytochemical parameters of pisum sativum (Pease) and effects on the development of debaryomyces hansenii

  Erecevit, Pınar; Kırbağ, Sevda

  Objective: In this work; phytochemical parameters (fatty acid, vitamin, phytosterol, flavonoid and resveratrol contents, and antioxidant activities antimicrobial activities) of Pisum sativum (pease) extracts prepared with Debaryomyces hansenii were detected. P. sativum (pease) is known as one of the nutritional sources of prebiotics. Methods: Phytochemical contents of extracts were evaluated with device and assays like Shimadzu 17, Shimadzu brand HPLC, Spectrophotometer device and well agar methods respectively. Results: it was observed that total fatty acid, flavonoid, contents in pease extracts were at low levels and vitamin, and phytosterol contents were at changing. It was detected that total fatty acid, vitamin and phytosterol contents; at significant rates of pease extracts prepared with D. hansenii; however, flavonoid contents decreased at different rates. In the work, it was noticed that pease had increasingly antioxidant activities and antimicrobial activities at changing rates, acordingly at fatty acid, vitamin and phytosterol levels; at significant rates increased. On the other hand, flavonoid extracts demonstrated scarcely any antimicrobial activity. When antimicrobial activities of pease extracts containing D. hansenii were analyzed, they had effect at increasing rates of fatty acid, vitamin and phytosterol. On the other hand, it was demonstrated that flavonoid extracts did not have any antimicrobial activity against all of the microorganisms except Bacillus megaterium DSM 32. Conclusion: it was detected that pease which is known as prebiotic food, can be used in terms of proper prebiotic and the relationship of proper prebiotic-prebiotic (symbiotic) for the development of D. hansenii used in this study which is also accepted as probiotic yeast. It was observed that this yeast type developing in extracts obtained from pease affected other beneficial nutrients such as vitamins, minerals, phenolic compounds at varying rates.

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  AtıfScopus2·WoS1·OpenAlex2

  İncele