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- MakaleYalnız künye2026Scopus SJRQ2Comparative phytochemical characterization and bioactivity evaluation of hemp (Cannabis sativa L.) root extracts using green extraction technologies
Korkmaz, Nesrin; Yaman, Cennet; Güçlü, Ebru; Doğan, Üzeyir; İmamoğlu, Rızvan; Aslan korkmaz, Şengül
This study investigates the largely untapped therapeutic potential of industrial hemp (Cannabis sativa L.) roots, which are usually discarded as agricultural byproducts. The phytochemical composition and biological activities of extracts obtained using Soxhlet, ultrasound-assisted extraction (UAE), and supercritical CO₂ (SC-CO₂) techniques were comparatively evaluated. Compounds were characterized using FTIR, GC–MS, LC–MS, and ICP-MS. SC-CO₂ extraction yielded the most chemically diverse profile, particularly enriched in fatty acids and triterpenoids. In vitro assays demonstrated that SC-CO₂ and Soxhlet extracts significantly promoted fibroblast migration and reduced inflammatory responses compared to UAE extracts. Gene and protein expression analyses further supported these bioactivities. In conclusion, this study highlights the phytopharmaceutical potential of hemp root extracts obtained using alternative extraction techniques, including supercritical CO₂ extraction. While SC-CO₂ extraction enabled the recovery of a chemically diverse extract, the present study focuses on comparative phytochemical and bioactivity outcomes rather than a quantitative assessment of environmental sustainability. The findings support further investigation of hemp roots, currently treated as an underutilized biomass, for potential applications in natural product research.
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İncele - MakaleYalnız künye2026Scopus SJRQ3Green revolution in nanotechnology: phytogenic CuO nanoparticles for biomedical and pharmaceutical applications
Ceylan, Yusuf; Korkmaz, Nesrin; Kaçan, Fatma N.; Aydin, Ali; Korkmaz, Şengül A.; Yildirim, Ebru Ş.
Copper oxide nanoparticles (CuO NPs) were synthesized using a green approach with Vitis vinifera L. extract, a plant rich in secondary metabolites that act as natural reducing agents. The obtained CuO NPs were characterized by XRD, EDX, and STEM analyses. FT-IR analysis revealed the presence of functional groups originating from plant biomolecules and confirmed the formation of Cu–O bonds, indicating the successful synthesis and stabilization of CuO NPs. XRD confirmed distinctive CuO diffraction peaks at 32.38°, 35.35°, 38.61°, 40.75°, 48.79°, 51.90°, 57.66°, 61.38°, 65.94°, and 75.12°. STEM imaging showed predominantly spherical, well-dispersed nanoparticles with an average size of 23–38 nm. Antibacterial analysis revealed a minimum inhibitory concentration (MIC) of 4 µg mL−1 against Escherichia coli ATCC 25922. In anticancer assays, the CuO NPs demonstrated notable cytotoxicity at both low concentrations and even at levels below the control group in A549, Calu-1, and Saos-2 cancer cell lines, highlighting their strong biomedical potential.
AtıfScopus1WoS1OpenAlex1İncele - MakaleYalnız künye2018Scopus SJRQ1In vitro biological properties and predicted DNA-BSA interaction of three new dicyanidoargentate(I)-based complexes: synthesis and characterization
Karadag, Ahmet; Korkmaz, Nesrin; Aydin, Ali; Tekin, Saban; Yanar, Yusuf; Yerlif, Yusuf; Korkmaz, Sengul Aslan
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