Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ1Incorporating the HPLC-ESI-Q-TOF-MS profiles with the biochemical properties of eight Salvia species
Llorent-Martínez, Eulogio J.; Nilofar; Sinan, Kouadio Ibrahime; Darendelioglu, Ekrem; Bahsi, Muammer; Polat, Rıdvan; Cakilcioglu, Ugur; Orlando, Giustino; Ferrante, Claudio; Zengin, Gokhan
Salvia, a widely recognized genus globally esteemed for its traditional and medicinal applications, prompted our investigation into the methanol and water extracts of eight Salvia species native to Turkey. These species included S. aucheri, S. candidissima, S. divaricata, S. virgata, S. multicaulis, S. palestina, S. trichoclada, and S. cerino-pruinosa. Our study aimed to assess their biological properties and chemical composition. Utilizing HPLC-ESI-Q-TOF-MS, we identified chemical constituents in the extracts, while antioxidant (radical quenching, reducing power, and metal chelating) and enzyme inhibitory (amylase, glucosidase, tyrosinase, and cholinesterase) activities were evaluated for biological activities. One hundred thirty-one compounds were characterized in the tested extracts. Although many compounds belonging to different chemical families were identified, the main compounds in all the extracts were rosmarinic and sagerinic acids, along with several salvianolic acid isomers. Notably, the methanol extracts displayed superior antioxidant properties overall, with S. cerino-pruinosa exhibiting the highest activity among them, except for metal chelating. Similar to the antioxidant test results, the methanol extracts were more active than the water extracts in the enzyme inhibition tests. Multivariate analysis further highlighted the distinctiveness of the water extract of S. cerino-pruinosa. In conclusion, our findings underscore the biopharmaceutical potential of the tested Salvia species, suggesting their significance as sources of bioactive agents for health-promoting applications.
AtıfScopus17OpenAlex15
İncele - MakaleAçık Erişim2024Scopus SJRQ3Exploring Sorbus torminalis Leaves: Unveiling a Promising Natural Resource for Diverse Chemical and Biological Applications
Ak, Gunes; Tüfekci, Enis Fuat; Mustafa, Ahmed M.; Caprioli, Giovanni; Altunoglu, Yasemin Celik; Baloglu, Mehmet Cengiz; Cakılcıoglu, Ugur; Polat, Rıdvan; Darendelioglu, Ekrem; Zengin, Gokhan
Sorbus torminalis (L.) Crantz has a rich history of versatile applications spanning the fields of medicine and nutrition. It is noteworthy that the decoction obtained from S. torminalis leaves is a traditional treatment method against both diabetes and stomach disorders. Phytochemical profiling determined by HPLC/MS-MS. The effects of the extracts on cell viability were investigated using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) method against MDA-MB-231 cell line (human breast adenocarcinoma).The ethanol/water extract contained more concentration of total phenolic (91.41 mg gallic acid (GAE) equivalent /gr) and flavanoid (29.10 mg rutin (RE) equivalent/gr) in the tested extract (p<0.05). Resulting of HPLC analysis, the chemical constituents varied depending on the solvents and chlorogenic acid, hyperoside, isoquercetin, delphindin-3,5-diglucoside, procyanidin B2, epicatechin, neochlorogenic acid, 3,5-dicaffeoylquinic acid were identified in all extracts. Overall, ethanol, n-hexane and ethyl acetate extracts showed the highest inhibition for the tyrosinase enzyme. The effect of leaf extracts of S. torminalis on antimicrobial, biofilm inhibitory, and anticancer activities was examined. Based on outcomes of our study recognize this plant as a critical source of medically active chemicals for feasible phytopharmaceutical and nutraceutical applications, providing the first scientific insight into the detailed biological and chemical profiles of S. torminalis.
AtıfScopus7OpenAlex5
İncele - MakaleYalnız künye2023Scopus SJRQ2Chemical Characterization of Different Extracts from Artemisia annua and Their Antioxidant, Enzyme Inhibitory and Anti-Inflammatory Properties
Acquaviva, Alessandra; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Di Simone, Simonetta Cristina; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Cakilcioğlu, Ugur
Artemisia annua L. (Asteraceae Family) is an important plant in Asia that has been used for treating different diseases, including fever due to malaria, wounds, tubercolisis, scabues, pain, convulsions, diabetes, and inflammation. In this study we aimed to evaluate the effects of different polarity extracts (hexane, dichloromethane, ethyl acetate, ethanol, ethanol/water (70 %) and water) from A. annua against the burden of inflammation and oxidative stress occurring in colon tissue exposed to LPS. In parallel, chemical composition, antiradical, and enzyme inhibition effects against α-amylase, α-glucosidase, tyrosinase, and cholinesterases were evaluated. The water extract contained the highest content of the total phenolic with 34.59 mg gallic acid equivalent (GAE)/g extract, while the hexane had the highest content of the total flavonoid (20.06 mg rutin equivalent (RE)/g extract). In antioxidant assays, the polar extracts (ethanol, ethanol/water and water) exhibited stronger radical scavenging and reducing power abilities when compared to non-polar extracts. The hexane extract showed the best AChE, tyrosinase and glucosidase inhibitory effects. All extracts revealed effective anti-inflammatory agents, as demonstrated by the blunting effects on COX-2 and TNFα gene expression. These effects seemed to be not related to the only phenolic content. However, it is worthy of interest to highlight how the higher potency against LPS-induced gene expression was shown by the water extract; thus suggesting a potential phytotherapy application in the management of clinical symptoms related to inflammatory colon diseases, although future in vivo studies are needed to confirm such in vitro and ex vivo observations.
AtıfScopus45OpenAlex43İncele - MakaleAçık Erişim2022Scopus SJRQ2An ethnobotanical review on medicinal plants of the Lamiaceae family in Turkey
Selvi, Selami; Polat, Rıdvan; Çakilcioğlu, Uğur; Celep, Ferhat; Dirmenci, Tuncay; Ertuğ, Zafer Füsun
Medicinal plants have been used by humans for the treatment of various diseases for thousands of years from past to present. Members of the Lamiaceae family are among the most preferred medicinal plants due to the wide variety of secondary components they contain, particularly essential oils. In this review, Master’s and PhD theses and books based on ethnobotanical studies investigated between 1960 and 2021 as well as internationally recognized databases (PubMed, Scopus, Google Scholar, Web of Science, SciFinder, Springer and Elsevier) were used to determine the medicinal uses of Lamiaceae taxa among the people in Turkey. As a result of the study, it was found that a total of 221 taxa (192 species) belonging to 29 genera, 51 of which are endemic, have medicinal/therapeutic uses. The local names of these taxa, the usage which are used among the people, the diseases in which they are used, and the geographical regions given in the present study. The genera of taxa most commonly used for medicinal purposes by the local people are Salvia (37 taxa), Sideritis (25 taxa), Stachys (22 taxa), Thymus (16 taxa) and Origanum (13 taxa). It was observed that the most frequently used two methods while preparing these plants for use was infusion (61%), and decoction (24%). Studies conducted on National (TURK, BHP), Regional (EU) and International Pharmacopoeias (WHO) and various monographs (AHP, COMISSION E, EMA, ESCOP, PDR) have revealed that there are 29 taxa included in these pharmacopoeias and monographs whose purpose of use are similar to the diseases that local people are trying to treat. Diseases that people use plants for therapeutic purposes are grouped into 12 categories. It was determined that these plants were widely used for therapeutic purposes in gastric disorders as well as otolaryngology and respiratory system diseases. This review briefly discusses whether some taxa commonly used by the local people in the treatment of diseases can be useful in the treatment of the disease in question, in the light of scientific studies.
AtıfScopus101OpenAlex101TR Dizin21
İncele - MakaleYalnız künye2022Scopus SJRQ2Detailed Chemical Characterization and Biological Propensities of Malabaila lasiocarpa Extracts: An Endemic Plant to Turkey
Zengin, Gokhan; Zheleva-Dimitrova, Dimitrina; Babacan, Ebru Yüce; Polat, Rıdvan; Çakılcıoğlu, Uğur; Sadeer, Nabeelah Bibi; Costa, Emmanoel V.; Mahomoodally, Mohamad Fawzi; Naviglio, Daniele; Gallo, Monica
This study focused on the biological evaluation and chemical characterization of Malabaila lasiocarpa Boiss. (M. lasiocarpa) (Family: Apiaceae). The phytochemical profile, antioxidant, enzyme inhibitory of the methanolic, aqueous, dichloromethane, hexane extracts were investigated. Based on UHPLC-HRMS analyses, a total of 101 peaks were annotated or identified for the first time in M. lasiocarpa extracts. They include hydroxybenzoic, hydroxycinnamic, acylquinic acids and their glycosides, C- and O-glycosyl and O-diglycosyl flavonoids. In addition, 10 simple mono- and disubstituted coumarins together with 10 furanocoumarins were tentatively annotated. The methanolic extract possessing the highest phenolic (24.36±0.60 mg gallic acid equivalent/g extract) and flavonoid (69.15±0.37 mg rutin equivalent/g extract) content also exhibited the strongest radical scavenging potential against 2,2-diphenyl-1 picrylhydrazyl (21.73±0.42 mg Trolox equivalent/g extract, respectively), and highest reducing capacity (57.81±0.97 and 28.00±0.40 mg Trolox equivalent/g extract, for cupric reducing antioxidant capacity and ferric reducing antioxidant power, respectively). The dichloromethane extract substantially depressed the tyrosinase (73.92±5.37 mg kojic acid equivalent/g extract), α-amylase (0.63±0.01 mmol acarbose equivalent/g extract) and α-glucosidase (0.69±0.02 mmol acarbose equivalent/g extract) enzymes. This study has produced critical scientific data on M. lasiocarpa which are potential contenders for the development of novel phyto-pharmaceuticals.
AtıfScopus6OpenAlex5İncele - MakaleYalnız künye2022Scopus SJRQ2An ethno-veterinary study on plants used for the treatment of livestock diseases in Genç (Bingöl-Turkey)
Babacan, Ebru Yüce; Polat, Rıdvan; Güler, Osman; Moyan, Ayşe; Paksoy, Mehmet Yavuz; Çakılcıoğlu, Uğur
There are a very limited number of studies on plants traditionally used in animal diseases in Turkey. As a result, valuable information is getting lost. Traditional plant use in Genç District (Turkey) was recorded by semi-structured interviews with breeders and shepherds. The collected information was subjected to quantitative analysis using the informant consensus factor. It was recorded that a total of 53 plants from 24 families were used in the traditional treatment of animal diseases. 8 of these plants are endemic plants with a narrow distribution area and were recorded for the first time by us. The breeders stated that they applied such plants to animals with peace in mind as these plants had been used for human treatment as well. This study is the first ethnoveterinary study conducted in the province. Phytochemical studies need to be carried out on medicinal plants used in livestock around Bingöl Province. We believe that the use of this preliminary information obtained from ethnoveterinary studies by researchers will contribute to the production of natural animal medicines.
AtıfScopus32İncele - MakaleAçık Erişim2021Scopus SJRQ2An ethnoveterinary study on plants used for the treatment of livestock diseases in the province of Giresun (Turkey)
Güler, Osman; Polat, Rıdvan; Karaköse, Mustafa; Çakılcıoğlu, Uğur; Akbulut, Sefa
The lack of ethnoveterinary surveys in Turkey, results in losses in the veterinary phytopharmacology field. This is the first ethnoveterinary research in which statistical calculations about plants are done by informant consensus factor (ICF) method in the Blacksea Region of Turkey. To catalog, analyze, and disseminate the knowledge of plant use in ethnoveterinary practices in the province of Giresun (Turkey). Information was gathered through open and semi-structured interviews with local people, mainly elderly shepherds and farmers, in the Giresun province. The collected data was analyzed quantitatively using two indices, informant consensus factor (ICF). A total of 65 ethnoveterinary plants belonging to 38 families are used for the treatment of animal diseases. According to the local farmers, the most often mentioned species that used in the resarch area have high ethno-veterinary potential. Most of these plants are also used for some human conditions in the study area. There are large numbers of ethno-veterinary practices EVPs in southern Turkey with undocumented cumulative knowledge of the indigenous people. Unfortunately, some evidence of their slow disappearance has been found. The traditional knowledge in the treatment of livestock diseases of the Giresun districts needs further scientific evaluations by phytochemical and antimicrobial experimentation.
AtıfScopus65WoS54OpenAlex57İncele - MakaleAçık Erişim2021Scopus SJRQ1Chemical profiling and biological evaluation of nepeta baytopii extracts and essential oil: An endemic plant from turkey
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Aktumsek, Abdurrahman; Jekő, József; Cziáky, Zoltán; Rodrigues, Maria João; Custodio, Luisa; Polat, Rıdvan; Cakilcioglu, Ugur; Ayna, Adnan
Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.
AtıfScopus32OpenAlex32İncele - MakaleAçık Erişim2021Scopus SJRQ2Evaluation of chemical constituents and biological properties of two endemic Verbascum species
Zengin, Gokhan; Mahomoodally, Mohamad Fawzi; Sinan, Kouadio Ibrahime; Sadeer, Nabeelah; Maggi, Filippo; Caprioli, Giovanni; Angeloni, Simone; Mollica, Adriano; Stefanucci, Azzurra; Ak, Gunes
Members from the Verbascum genus are well appraised for their traditional uses against a variety of ailments including anti-inflammatory related disorders. This study thus attempts at validating the biological properties of two underexplored Verbascum members namely Verbascum euphraticum Benth. (V. euphraticum) and Verbascum oocarpum Murb. (V. oocarpum) in terms of their antioxidant and enzymatic inhibitory activities. Concentration of specific bioactive compounds was also established and molecular dynamic analysis were conducted on amassed data. Results showed that total phenolic and total flavonoid contents were higher for the methanolic extract of V. oocarpum compared to the methanolic extract of V. euphraticum. Phytochemical quantification revealed that the extraction solvents influenced the phytochemical composition of the extracts. Derivatives of phenolic acids such as 3-caffeoylquinic acid and 3,5-dicaffeoylquinic acid together with some phenolic acids i.e., gallic, vanillic, caffeic, syringic, p-coumaric and ferulic acid, have been detected in the extracts of both Verbascum species. Methanolic extracts of V. euphraticum and V. oocarpum yielded the highest total content of monitored compounds resulting in 162.758 and 3716.861 μg/g of dried weight extract, respectively. The methanolic extracts of both plants showed highest antioxidant potential while the ethyl acetate and hexane extracts were potent inhibitors of cholinesterase, α-amylase and α-glucosidase. Molecular dynamic results indicated that vanillic acid is able to make strong interactions with copper ions of tyrosinase, resulting into an effective anti-tyrosinase activity. In light of the above, both Verbascum species could be considered for future phytopharmaceutical development.
AtıfScopus36OpenAlex36İncele - MakaleYalnız künye2017Scopus SJRQ2Survey of wild food plants for human consumption in Bingöl (Turkey)
Polat, Rıdvan; Güner, Bülent; Babacan, Ebru Yüce; Çakılcıoğlu, Uğur
This study focused on the wild plants traditionally used for human consumption in Bingöl and its aim is to present data about the folk botanical knowledge and to give about their development in relation to plant resources and traditionally food culture. The information about the use of wild edible plants was collected from 6 different open-air-markets and 13 villages in the city during two-year period (2012-2013), through unstructured interviews. In this study, a total of 61 wild food plant taxa belonging to 25 families were established and also plant parts used, ethnographic data related to vernacular names, traditional use were recorded. Family Rosaceae is represented by the highest number of taxa (9), followed by Lamiaceae (8), Astaraceae (7), Apiaceae (6), Fabaceae (4) and Polygonaceae (3). The study showed that the plants used are either eaten raw, cooked by boiling in water, frying in oil or baked to be served as dishes such as stew, salad as hot drink. During this ethnobotanical research, it was verified that wild edible plants play an important role in diet in Bingöl. Furthermore, during our study Heracleum pastinacifolium C. Koch, Origanum acutidens (Hand.-Mazz.). Letsw, Prunus kurdica Fenzl ex Fritsch, Quercus petraea subsp. pinnatiloba (K. Koch) Menitsky has been recorded as endemic wild food plant taxa from Bingöl.
AtıfScopus43İncele - MakaleYalnız künye2016Giresun ilinde yayılış gösteren Hypericum L. (Hypericaceae) cinsinin mikromorfolojik ve anatomik özelliklerinin araştırılması
Cakilcioglu, Ugur; Selvi, Selami; Türkmen, Zafer; Hayta, Şükrü; Polat, Rıdvan
In this study the species Hypericum L. exhibiting distribution in and around Giresun were examined comparatively for micromorphological and anatomic characteristics. In anatomic examinations, cross sections from stems and leaves of the plants were examined and anatomic comparisons were made between the species. In micromorphological studies, epidermal surfaces of the stem and leaf and seed surface were examined. The micromorphological and anatomic characters were presented comparatively in tables. It was determined that the anatomic structure of the stem was almost identical in all species examined although the anatomic structure of the leaf was anatomically different. As a consequence it is seen that the characters such as structure of the stem and leaf, mesophyll type of the leaf, stoma configuration on the leaf surface (amphistomatic or hypostamatic), and canal types (type A, B and C) are the ones which will be used in systematic species discrimination.
AtıfTR Dizin2İncele - MakaleYalnız künye2015Investigations of ethnobotanical aspect of wild plants sold in Espiye (Giresun/Turkey) local markets
Cakilcioglu, Ugur; Gür, Fehmi; Denizhan Ulusan, Musa; Türkmen, Zafer; Polat, Rıdvan
Bu çalışma 2012-2013 dönemleri arasında Espiye yerel pazarlarında ticari amaçla satışı yapılan yabani bitkiler üzerine yapılmıştır. Alan çalışmaları bitkilerin yoğun olarak toplanıldığı ve satışlarının yapıldığı alanlarda yoğunlaşmıştır. Araştırmalar sonucunda yerel pazarlarda satışı yapılan etnobotanik kullanımı olan 32 bitki taksonu tespit edilmiştir. Etnobotanik veriler halk tıbbı, bitki çayı, baharat ve gıda olarak olarak kullanılan bitkilerle ilgili verileri içermektedir. Yörede yoğun olarak kullanımı olan bitki familyaları Lamiaceae (5 takson), Rosaceae (4 takson), Polygonaceae (3 takson), Apiaceae (2 takson) and Asteraceae (2 takson) olarak kayıt edilmiştir. Yöredeki satışı yapılan etnobotanik bitkilerden baharat ve gıda (24 takson), halk tıbbı (19 takson) bitki çayı (5 takson) vb. amaçlarla kullanıldığı görülmüştür. Ayrıca bu çalışma kapsamında bitkilerin yerel ve bilimsel adları, bitki familyaları, bitkilerin kullanılan kısımları ve kullanım şekilleri alfabetik sırasıyla tablo olarak sunulmuşur
AtıfTR Dizin7İncele