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Yayınlar
- MakaleAçık Erişim2022Scopus SJRQ2Synthesis and Characterization of Azo Dye Complexes as Potential Inhibitors of Acetylcholinesterase, Butyrylcholinesterase, and Glutathione S-Transferase
Buldurun, Kenan; Aras, Abdülmelik; Turan, Nevin; Turkan, Fikret; Adiguzel, Ragip; Bursal, Ercan
In this study, several metal(II) complexes (Fe, Co, Zn, and Ru) of an azo dye ligand (ADL) that, apart from pyrazole ring (PR), include anisole having (−OCH3) group at the m-substitue of the phenyl (L: (E)-4-((3-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were prepared, characterized, and the biological activity studies were carried out. The structures of complexes were identified by elemental analysis, FTIR, UV-vis, mass spectra (Fe(II) and Co(II)), 1H-13C NMR spectra, and TGA-DTA. The azo ligand and its metal complexes were evaluated for their biological properties according to the enzyme inhibitory activities. The lowest Ki values of Co(II) complex against all three GST (19.48±2.17 μM), AChE (22.14±3.74 μM), and BChE (26.39±3.19 μM) enzymes were verified as the most effective enzyme inhibition. The biological activity results suggest that the obtained complexes have good potentials to be used in further analyses to explore new pharmaceutical agents.
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İncele - MakaleAçık Erişim2021Scopus SJRQ2Investigation of spectroscopic, thermal, and biological properties of FeII, CoII, ZnII, and RuII complexes derived from azo dye ligand
Turan, Nevin; Buldurun, Kenan; Adiguzel, Ragip; Aras, Abdülmelik; Turkan, Fikret; Bursal, Ercan
In this study, the novel azo dye FeII, CoII, ZnII, and RuII complexes with an azo dye ligand (L: (E)-4-((4-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were synthesized. The structures of the complexes were characterized by FT-IR, elemental analysis, UV-Vis, mass spectra (FeII and CoII), NMR spectra (only diamagnetic ZnII and RuII), thermogravimetric and differential thermal analysis (TGA-DTA). All of the newly synthesized compounds were tested for their biochemical properties, including enzyme inhibitory and antioxidant activities. According to the in vitro ABTS, DPPH, CUPRAC, and FRAP antioxidant methods, the ligand and its metal complexes showed close antioxidant activities to the standards (BHA, BHT, ascorbic acid, and α-tocopherol). Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The best inhibition values (Ki) were observed for Ru(II) complex against GST (14.36 ± 2.16 µM), AChE (16.86 ± 2.74 µM), and BChE (14.12 ± 2.04 µM).
AtıfScopus45WoS45OpenAlex45İncele - MakaleYayıncıda açık erişim2018Scopus SJRQ3Spectral, thermal and antimicrobial properties of novel mixed ligand-metal complexes derived from saccharinate complexes and azo dye ligand
Adiguzel, Ragip; Turan, Nevin; Buldurun, Kenan; Korkoca, Hanifi
Background and Objective: Saccharin and saccharinate (sac) complexes and its anion have critical importance with biological, biochemical and pharmacological properties. The main objective of this study was to synthesize the novel mixed ligand complexes from the complexes [M(Sac)2(H2O)4]·2H2O [M: Mn(II), Co(II), Ni(II), Cu(II) and Cd(II)] with a second neutral ligand [L:(mmppa): 5-Methyl-4-(4-methylphenylazo)-2H-pyrazole-3-ylamine]. Methodology: The structures of the complexes were characterized by elemental analysis, magnetic susceptibility, FT-IR, mass and electronic spectral studies and thermal analysis. Antimicrobial (antibacterial and anticandidal) activities of the complexes were tested against Enterococcus faecalis ATCC 51299, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Candida albicans ATCC 64548. Results: According to the experimental results, it was determined that in Mn(II), Co(II) and Cd(II) complexes, two coordinated H2O molecules are replaced with two neutral ligands, on the other hand, in Ni(II) and Cu(II) complexes, all coordinated H2O molecules are replaced with four neutral ligands. It was established that the second neutral ligand was coordinated to the metal ions via nitrogen atom of-NH2 group in pyrazole ring. In antimicrobial activity, study was determined to occur significant inhibition zones (20-24 mm) against Candida albicans ATCC 64548 strain. Conclusion: As a result, mononuclear and monomeric structure in octahedral geometry including both saccharin and azo dye ligands were synthesized and their characterizations were accomplished. The result of this study shows that novel mixed ligand-saccharinate complexes can be utilized for the development of anticandidal agents.
AtıfScopus11WoS10OpenAlex11İncele - MakaleAçık Erişim2016Scopus SJRQ3Spectroscopic, Thermal and Antioxidant Properties of Novel Mixed Ligand-Metal Complexes Obtained from Saccharinate Complexes and Azo Dye Ligand (mnppa)
Turan, Nevin; Adigüzel, Ragip; Buldurun, Kenan; Bursal, Ercan
The novel mixed ligand-metal complexes with a general formula [M(Sac)(2)(H2O)(2)L-2]center dot nH(2)O) [M = Mn(II), Co(II), Ni(II), Cu(II) and Cd(II), L=5-Methly-4-(4-nitrophenylazo)-2H-pyrazole-3-ylamine (mnppa)] have been synthesized and characterized by elemental analyses, IR, UV-VIS, magnetic susceptibility mass spectra and thermogravimetry-differential thermal analysis (TGA-DTA). Each metal (II) ion is octahedral coordinated by two sac, two mnppa and two aqua ligands. The antioxidant properties of mixed ligand-metal complexes were determined by different in vitro methods such as ABTS, DPPH, FRAP and CUPRAC assays. The results of metal complexes were compared with standard antioxidant compounds.
AtıfWoS30OpenAlex30İncele - MakaleYalnız künye2016Scopus SJRQ4Synthesis and Chemical Structure Elucidation of Two Schiff Base Ligands, Their Iron(II) and Zinc(II) Complexes, and Antiradical, Antimicrobial, Antioxidant Properties
Turan, Nevin; Savci, Ahmet; Buldurun, Kenan; Alan, Yusuf; Adigüzel, Ragip
Fe(II) and Zn(II) complex series have been synthesized from Schiff base ligands derived from furan-2-carbaldehyde and thiophene-2-carbaldehyde. Elemental, infrared, ultra-violet- visible, NMR and thermal analysis, also mass spectroscopy and magnetic susceptibility measurements were performed to explain the structures of these synthesized ligands and their metal complexes. The formulas based on analytical, spectral, and magnetic studies, the complexes can be demonstrated as [M(L-1)(2)](H2O)(n), [M(L-2)(2)](H2O)(n), where M = Zn(II) and Fe(II). An octahedral geometry was suggested for the Zn(II) and Fe(II) complexes. The antioxidant, antiradical and antimicrobial properties of the Zn(II) and Fe(II) complexes were investigated using different in vitro assays. Some of the complexes showed reasonable amount of antioxidant and antimicrobial activity.
AtıfWoS19OpenAlex19İncele - MakaleAçık Erişim2015Scopus SJRQ2Synthesis, Structural Characterization and Biological Activity of Novel Cyclohexane-1,3-dione Ligands and Their Metal Complexes
Turan, Nevin; Körkoca, Hanifi; Adigüzel, Ragip; Çolak, Naki; Buldurun, Kenan
Some new Zn(II) and Cu(II) complexes [Cu(L-1)(OAc)(2)].H2O, [Cu(L-1)(NO3)H2O].NO3.3.5H(2)O, [Zn(L-1)(NO3)(2)].4.5H(2)O, [Zn(L-1)(OAc)(2)(H2O)(2)].3H(2)O, [Cu-2(L-2)(OAc)(4)].2H(2)O.2DMF, [Cu(L-2)(2)].2NO(3).1.5DMF.H2O, [Zn(L-2)(2)(NO3)(2)].DMF and [Zn-2(L-2)(OAc)(4)(H2O)(4)].5H(2)O; L-1 = 2-[2-(2-methoxyphenyl)hydrazono]cyclohexane-1,3-dione and L-2 = 2-[2-(3-nitrophenyl)hydrazono]cyclohexane-1,3-dione were synthesized and characterized by IR, H-1-NMR,C-13-NMR and ultraviolet (UV-Vis.) spectroscopy, elemental analysis, magnetic susceptibility, mass spectrometry and thermogravimetry-differential thermal analysis (TGA-DTA). The synthesized ligands and their complexes were tested for antibacterial activity against Escherichia coli ATCC 25922, Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 25923, and Salmonella typhimurium CCM 583. Some of complexes showed medium-level antibacterial activity against the test bacteria compared with ampicillin.
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İncele - MakaleYalnız künye2015Scopus SJRQ3Investigation of the Optical Properties of the Solutions of the Tetraaquabis(saccharinato)metal(II)dihydrate [Metal: Co(II) and NMI)] Complexes at Different Molarity and Volume of Stock Solutions
Adiguzel, Ragip; Gunduz, Bayram; Turan, Nevin; Topcu, Yildiray
We investigated the optical properties and the transmittance characterizations of the stock solutions of the Co (II) and Ni(II) complexes of Saccharin and determined the molar extinction coefficients at different molarity. The molar extinction coefficients (epsilon) values of the Co(II) and Ni(II) complexes in the first region decrease with increasing molarity, and the e values of the Co(II) and Ni(II) complexes at lower wavelength are higher than that of the values at higher wavelength. The absorption band edge values of the Co(II) complex shift from 3.584 to 3.139 eV with the increasing molarity, while the absorption band edge values of the Ni(II) complex shift from 3.574 to 3.493 eV with the increasing molarity. The plots of refractive index of the Co(II) and Ni(II) complexes consist of two anomalous (abnormal) dispersion regions and one normal dispersion region. The direct energy-gap of the Co(II) complex can be more decreased with molarity. The absorbance, molar extinction coefficients, refractive index values of the Co(II) and Ni(II) complexes decrease, while the average transmittance in the visible region, direct optical band-gap values of the Co(II) and Ni(II) complexes increase with increasing volume of DMF solvent or decreasing volume of the solutions of the Coal) and Ni(II) complexes.
AtıfWoS1İncele - MakaleYalnız künye2014Scopus SJRQ3Study of Structure and Spectral Characteristics of the Zinc(II) and Copper(II) Complexes With 5,5-Dimethyl-2-(2-(3-nitrophenyl) hydrazono)cyclohexane-1,3-dione and Their Effects on Optical Properties and the Developing of the Energy Band Gap and Investigation of Antibacterial Activity
Turan, Nevin; Gündüz, Bayram; Körkoca, Hanifi; Adigüzel, Ragip; Çolak, Naki; Buldurun, Kenan
A new chelating ligand, 5,5-dimethyl-2-(2-(3-nitrophenyl)hydrazono)cyclohexane-1,3-dione (L), and four transition metal complexes were synthesized. The ligand and its complexes were characterized by IR, H-1 and C-13-NMR spectra, elemental analyses, magnetic susceptibility, mass spectra, UV-Vis. and thermogravimetry-differential thermal analysis (TGA-DTA). The metal complexes showed different geometric structures. Antibacterial tests of the ligand and complexes were also done. The Zn(II) complexes showed antibacterial activity against Staphylococcus aureus ATCC-25923 at middle level. The optical properties of the ligand and its complexes were extensively investigated by optical measurements. The average transmittance value of the ligand was the highest value, while the average transmittance value of the [CuL2(NO3)(2)]center dot 6H(2)O complex was the lowest value. The optical band gap of the ligand, [(Zn)(2)L(OH)(4)]center dot 2DMF, [ZnL(NO3)(2)(H2O)(2)]center dot 5H(2)O, [CuL2(OAc)]center dot OAc center dot 3.5H(2)O and [CuL2(NO3)(2)]center dot 6H(2)O complexes were calculated and 3.121 eV, 2.180 eV, 1.551 eV, 2.489 eV and 1.556 eV values were found, respectively. The complexes decreased the optical band gap of the ligand. The optical band gap value of the [ZnL(NO3)(2)(H2O)(2)]center dot 5H(2)O complex is the lowest value. The optical band gap value of the ligand is the highest value. The complexes decrease the angle of incidence of the ligand, while complexes increase the angle of refraction of the ligand. The electric susceptibility of the ligand decreases with its complexes.
AtıfWoS28İncele - MakaleYalnız künye2011Scopus SJRQ3Synthesis and Characterization of Ni(II) and Cd(II) Complexes of 4-(4-Nitrophenylazo)-1H-pyrazole-3,5-diamine and 4-(4-Methylphenylazo)-1H-pyrazole-3,5-diamine
Adiguzel, Ragip; Esener, Hasan; Ergin, Zuhal; Aktan, Ebru; Turan, Nevin; Sekerci, Memet
In this study, the diazotized p-nitroaniline and p-methylaniline were coupled with malononitrile. The ring closure reaction of the obtained products with hydrazine monohydrate yielded 4-(4-methylphenylazo)-1H-pyrazole-3,5-diamine (L-1) and 4-(4-nitrophenylazo)-1H-pyrazole-3,5-diamine (L-2). The structure of the ligands has been elucidated by spectroscopic analyses. Then, novel Ni(II) and Cd(II) complexes of the ligands have been synthesized and the structures of these complexes determined by elemental analysis, spectrometric and TGA/DTA methods, molar conductance and magnetic susceptibility measurements. All the complexes were monomeric and diamagnetic. From the elemental analyses and mass spectra data, the complexes were proposed to the formulae [Ni-2(L-1)(2)(OH)(2)]center dot 2Cl center dot 8.5H(2)O, [Cd-2(L-1)(2)(OH)(2)]center dot 2Cl center dot DMF center dot 3H(2)O, [Ni(L-2)(2)]center dot 2Cl center dot 2DMF center dot 7H(2)O and [Cd-2(L-2)(2)(OH)(2)(H2O)(4)]center dot 2Cl center dot 1.5H(2)O. For the Cd(L-2) complex octahedral geometry was proposed, but the Ni(L-1), Ni(L-2) and Cd(L-1) complexes show four coordinated structure. The Ni(L-1), Cd(L-1) and Cd(L-2) complexes were found to be dinuclear. On the other hand the Ni(L-2) complex was found to be mononuclear. All the complexes were found to be (1:2) electrolytes.
AtıfWoS8İncele - MakaleAçık Erişim2011Scopus SJRQ2Synthesis and Characterization of Novel Mn(II), Co(III), Ni(II) and Cd(II) Complexes from 4-(2-nitrophenylazo)-1H-pyrazole-3,5-diamine
Esener, Hasan; Adiguzel, Ragip; Ergin, Zuhal; Aktan, Ebru; Turan, Nevin; Sekerci, Memet
In this study, the diazotized o-nitroaniline was coupled with malononitrile. The ring closure reaction of the obtained product with hydrazine monohydrate yielded 4-(2-nitrophenylazo)-1H-pyrazole-3,5-diamine (L). The structure of L has been elucidated by spectroscopic analyses. Then, novel Mn(II), Co(II), Ni(II) and Cd(II) complexes of L have been synthesized, and the structures of these complexes determined by elemental analysis, spectrometric and TGA/DTA methods, molar conductance and magnetic susceptibility measurements. All complexes were monomeric. Except Mn(II) complex, other complexes were diamagnetic. From the elemental analyses and mass spectra data, the complexes were proposed to the formulas [MnL2(CH3O)H2O]center dot Cl center dot CH3OH, [CoL2(CH3O)(2)]center dot Cl center dot 2.5CH(3)OH, [NiL2(CH3OH)(2)]center dot 6.5CH(3)OH and [Cd2L2(Cl)(2)(CH3O)(2)]center dot CH3OH center dot 1.5H(2)O. For Mn(II) and Co(III) complexes octahedral and for the Ni(II) complex square planar geometry were proposed, but the Cd(II) complex includes five coordinated structure. The Mn(II), Co(II) and Ni(II) complexes were found to be mononuclear and electrolytes. On the other hand Cd(II) complex was found to be dinuclear and non-electrolyte.
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