Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleAçık Erişim2025Scopus SJRQ4Protective Effect of Sumac and Terebinth Extracts Against the Negative Effects of Breast Cancer on Cardiac Tissues of in Rats; [Efecto protector de los extractos de zumaque y terebinto contra los efectos negativos del cáncer de mama en los tejidos cardíacos de ratas]
Erişir, Figen Erdem; Aydın, Sevinç; Tuzcu, Zeynep; Yılmaz, Ökkeş
Due to the toxic side effects of chemotherapeutic drugs used in breast cancer, interest in medicinal plants has increased in order to develop alternative cancer drugs. The experimental model of this study was created to observe the remedial impacts of the Terebinth (Pistacia terebinthus L.) and the Sumac (Rhus coriaria L.) plants against the negative effects of 7,12-Dimethylbenz[a]anthracene induced breast cancer on cardiac tissues in rats. For this purpose, the levels of malondialdehyde were analyzed the indicator of the oxidative stress breast cancer will cause on cardiac tissues, the catalase, glutathione transferase and superoxide dismutase enzymes, glutathione, which holds and important place among antioxidant impacts and proteins. At the end of the study, it was determined that there was an increase in malondialdehyde levels, a decrease in glutathione and protein amounts, and a decrease in antioxidant enzyme levels in rats treated with cancer-induced 7,12-Dimethylbenz[a]anthracene.
- MakaleAçık Erişim2025Scopus SJRQ1Effect of Ferula sp. on sperm cryotolerance, quality, and fatty acid composition in common carp (Cyprinus carpio)
Ölçülü, Abdullatif; Özçiçek, Esin; Kutluyer Kocabaş, Filiz; Kızak, Volkan; Kocabaş, Mehmet; Yılmaz, Ökkeş
Ferula sp. is a perennial herbaceous plant and is used in traditional medicine owing to their antimicrobial, antiviral, aphrodisiac and spermatogenic activities in the world. Hence, Ferula sp. was used in the present study for cryopreservation protocol as a herbal supplement. The impact of different concentrations [0 mM (Control), 30 µg L−1, 60 µg L−1, 90 µg L−1] of Ferula sp. extract on the quality and fatty acid (FAs) composition was assessed in fresh and cryopreserved sperm of Cyprinus carpio. Optimal supplementation of Ferula sp. at a concentration of 60 µg L−1 in the freezing extender significantly improved post-thawed sperm quality of C. carpio. Sperm motility parameters were assessed using the sperm class analyzer system. The fatty acid (FAs) content in sperm was analyzed using gas chromatography. The results revealed that the increases in motility rate (80.0 ± 3.54%) at 60 µg L−1 were increased significantly (p < 0.05). Significant differences in sperm parameters [(VCL: curvilinear velocity, VSL: straight line velocity, VAP: average path velocity, and BCF: beat cross frequency)] were observed between the different treatments (p < 0.05). The Monounsaturated fatty acids (MUFAs) showed a slight increase in comparison to fresh spermatozoa during cryopreservation. DHA (Docosahexaenoic acid), LA (Linoleic acid) and ARA (Arachidonic acid) were identified as the major PUFAs (polyunsaturated fatty acid) in the sperm plasma membrane, and however the total PUFAs reduced all treated compared to fresh sperm samples after post-thawing. Overall, the supplementation with Ferula sp. to extender at a concentration of 60 µg L−1 positively influenced the motility parameters and FAs levels during cryopreservation and, Ferula sp. may act as a promising protective substance for the conservation of valuable fish genetic resources.
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İncele - MakaleAçık Erişim2022Scopus SJRQ2Comparison of nutrient contents of wild and farmed rainbow trout (Oncorhynchus mykiss, Walbaum 1792) from Keban Dam Lake in Eastern Anatolia region of Turkey
Özçiçek, Esin; Can, Erkan; Yılmaz, Ökkeş
In this study, fatty acids, fat-soluble vitamins (A, D, E, K vitamins) and cholesterol contents of wild-caught and farm-raised rainbow trout (Oncorhynchus mykiss) were compared. The amounts of docosahexaenoic acid (22:6 n-3, DHA) in wild and farmed forms were 21.56%–18.14%, 18.79%–16.21% and 14.34%–11.49% in April, May and June, respectively. Vitamin E, which is one of the fat-soluble and antioxidant vitamins, showed highest level among the vitamins. Vitamin E levels in both wild and farmed fish were 5.11–4.26, 4.83–2.89 and 0.99–1.95 mg/100 g in April, May and June, respectively. The substantial difference between wild and farmed rainbow trout was found in May (p < 0.05). In conclusion, both wild and farmed rainbow trout from Keban Dam Lake (Pertek Region) can be considered as good sources of n-3 polyunsaturated fatty acids (PUFA). However, it was observed that the n-3 PUFA level in wild form was higher than the culture fish within the investigated monthly periods. On the other hand, farmed fish demonstrated higher levels of n-6 PUFA over the wild individuals.
AtıfScopus11WoS9OpenAlex8İncele - MakaleAçık Erişim2021Scopus SJRQ3The protective effects of lupine (Lupinus albus) fruit extract against to destructive effects of hyperglycemia in type I diabetic rats
Aydın, Sevinç; Kaya, Tubay; Erman, Orhan; Yılmaz, Ökkeş
Background: Lupinus albus is a member of the Fabaceae family. As a natural or cultivat-ed plant, Lupinus albus is distributed in Europe, the Balkans and Turkey, especially in Marmara and Aegean regions. The lupine is a nutritious and protective plant against diabetes. Objective: In the present study, the effects of Lupinus albus fruits on malondialdehyde (MDA), reduced glutathione (GSH), total protein, ADEK vitamins, and cholesterol values, which are the indi-cators of oxidative damage and antioxidant defense. In this regard, muscle, liver, renal, and brain tissues of STZ-induced type I diabetes rats were studied. Methods: The analyzes of ADEK vitamins and cholesterol levels in tissues were performed via Shimadzu HPLC device. The lipid peroxidation levels were measured at 532 nm in spectrophotome-ter. Determination of GSH was read at 412 nm against blank, and for the total protein levels Lowry method was applied. Results: According to the results obtained, it was determined that among the rats with induced type I diabetes, the group applied lupine fruit extract was found to have increased GSH level and decreased MDA levels in all the tissues. The protein values were increased in liver tissues but decreased in the other tissues. The level of vitamins was significantly increased in almost all the tissues in the diabetic group. Conclusion: In the present study, it was shown that the lupine reduced the devastating effects of type I diabetes by decreasing the fasting blood glucose and lipid peroxidation values and increasing the glutathione level in comparison to the diabetic group.
AtıfScopus4WoS4OpenAlex4İncele - MakaleAçık Erişim2018Scopus SJRQ3Determination of Lipid Peroxidation and Fatty Acid Compositions in the Caviars of Rainbow Trout and Carp
Gürel Inanlı, Ayşe; Emir Çoban, Özlem; Yılmaz, Ökkeş; Özpolat, Emine; Karaton Kuzgun, Nermin
In this study, roes obtained from carp (Cyprinus carpio carpio) that were caught in Keban Dam Lake (Turkey) and cultured rainbow trout (Oncorhynchus mykiss) were processed as caviar, and the products were stored at + 4 C°. Lipid peroxidation and the compositions of fatty acids of these products were assessed during production and storage period. The result of fatty analyses showed that palmitic acid (16:0), stearic acid (18:0), palmitoleic acid (16:1), oleic acid (18:1), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA), which are all essential fatty acids, were determined in the caviars of the roes obtained from rainbow trout and carp. According to results of chemical analyses, there were no significant differences in thiobarbituric acid reactive substances (TBARs) between rainbow trout and carp caviars (p > 0.05), but malondialdehyde (MDA) levels were found to be statistically significant (p < 0.01). It can be concluded that caviars obtained from both rainbow trout and carp roes are rich in fatty acids and take a part in a balanced and healthy diet.
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