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- MakaleAçık Erişim2026Scopus SJRQ1Biogenic amine profiling of fruit wines by high-performance liquid chromatography with fluorescence detection after OPA derivatisation: effect of fruit type
Tok, Fırat; Çetin, Burcu; Karaca Sanyürek, Nesrin
This study aimed to characterise the biogenic amine (BA) profiles of fruit wines produced from different raw materials and to investigate their association with pH and fruit type. Ten commercially available fruit wines, including pomegranate, black mulberry, sour cherry, strawberry, melon, blackberry, and blueberry, were analysed using HPLC with fluorescence detection (HPLC-FLD) following pre-column derivatisation with o-phthalaldehyde. Putrescine, tyramine (TYR), and histamine were identified as the predominant amines, with total BA concentrations ranging from 11.62 to 53.96 mg/L depending on the fruit type. The pH values of the wines (3.28-3.60) were inversely related to acidity and showed a strong positive correlation with total BA content (r = 0.97, p < .001). Among the detected compounds, TYR exhibited the highest sensitivity to pH variation. Multivariate analysis using principal component analysis clearly differentiated the samples into two distinct groups: low pH-low BA wines (pomegranate and blueberry) and high pH-high BA wines (blackberry and strawberry). The HPLC-FLD method demonstrated excellent analytical performance, with high chromatographic stability (retention time RSD < 1%) and reliable compound identification. Overall, the results indicate that BA formation in fruit wines is closely associated with both pH and fruit type, reflecting the combined effects of raw material composition and fermentation conditions. These findings provide valuable insights into the biochemical characterisation, quality assessment, and safety evaluation of fruit wines in oenological applications.
- Derleme MakaleYalnız künye2025Scopus SJRQ2Is sexual function impaired in patients with primary headaches? A systematic review of observational studies
Ataş, Kübra; Kaya Mutlu, Ebru
Introduction: Primary headaches, particularly migraine and tension-type headaches, as chronic and painful conditions, have a significant impact on individuals' health and overall quality of life, including aspects such as sexual health parameters. Objectives: The aim of this study was to review observational studies and to summarize the presence of sexual dysfunction in patients with primary headache and to discern whether it is more common in patients with primary headache than in healthy control subjects. Methods: Observational studies published between January 1, 2000, and May 21, 2023 were searched in Medline (PubMed), Web of Science, Scopus, and EBSCO. This review included 23 observational studies that evaluated sexual dysfunction with or without comparison with healthy control subjects. Results: As a result, the mean Female Sexual Function Index score, a score of <26.55 indicating sexual dysfunction, ranged from 19.25 ± 8.18 to 27.5 ± 7.5 in patients with primary headache. The prevalence of sexual dysfunction and erectile dysfunction was found to be between 10.7% and 93.75% in female patients and between 54.83% and 80% in male patients. Both migraineurs and tension-type headache sufferers had statistically significantly lower sexual function scores in females and lower erectile function scores in males compared with healthy control subjects. Conclusion: Sexual function is significantly affected in patients with primary headache, which is a chronic painful disorder. Therefore, it is very important to ask these patients about their sexual health and, if necessary, to seek support from a sexual health professional. Additionally, future studies may prioritize tension-type headaches and male patients due to the limited amount of research available on these subjects.
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İncele - DergiSexual Medicine Reviews
- DergiInternational Journal of Food Science and Technology