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- Yüksek Lisans TeziAçık Erişim2023Farklı su sıcaklıklarında gül ağacı (aniba rosaeodora) esansiyel yağının ve 2-fenoksietanolün japon balığı (Carassius auratus) üzerindeki anestezik etkileri
Barış Şahin
Bu tez çalışmasında, Japon balıklarında (Carassius auratus) gül ağacı (Aniba rosaeodora) esansiyel yağının ve 2-fenoksietanolün farklı su sıcaklıklarında anestezik etkilerinin incelenmesi amaçlanmıştır. 14°C ve 20°C su sıcaklıklarında anestezik denemeler gerçekleştirilmiştir. Gülağacı esansiyel yağı (ArEO) için 250, 300 ve 350 µl/lt, 2-fenoksietanol (2-PE) için 600, 700 ve 800 µl/lt konsantrasyonlar denenmiştir. Derin anestezi (AD) ve tam iyileşme (RF) birlikte dikkate alındığında 14°C su sıcaklığında ideal ArEO konsantrasyonu 300 µl/lt, 20°C su sıcaklığında ise 250 µl/lt olarak belirlenmiştir. 2-PE için her iki su sıcaklığında da ideal konsantrasyon 800 µl/lt olarak tespit edilmiştir. ArEO ve 2-PE konsantrasyonları arttıkça AD süreleri kısalmış, RF süreleri ise uzamıştır. Anestezik ajanların konsantrasyonları indüksiyon süreleri ile negatif, iyileşme süreleri ile pozitif korelasyon göstermiştir. 14ºC su sıcaklığında ArEO anestezik ajanında AD ve RF süreleri arasında zayıf negatif bir ilişki (R2=0,3093), 20ºC su sıcaklığında AD ve RF süreleri arasında negatif bir ilişki bulunmuştur (R2=0,5833). 14ºC ve 20ºC su sıcaklıklarında 2-PE anestezik maddesinde AD ve RF süreleri arasında negatif ilişki tespit edilmiştir (sırasıyla, R2=0,5092 ve R2=0,6357). ArEO AD süreleri ve ArEO konsantrasyonları arasında 14ºC ve 20ºC su sıcaklıklarında kuvvetli negatif bir ilişki (sırasıyla, R2=0,9937 ve R2=0,9615) vardır. 2-PE AD süreleri ve 2-PE konsantrasyonları arasında 14ºC ve 20ºC su sıcaklıklarında kuvvetli negatif bir ilişki (sırasıyla, R2=0,9982 ve R2=0,9996) bulunmuştur. ArEO RF süreleri ve ArEO konsantrasyonları arasında 14ºC ve 20ºC su sıcaklıklarında kuvvetli pozitif ilişki (sırasıyla, R2=0,9941 ve R2=0,8157) vardır. 2-PE RF süreleri ve 2-PE konsantrasyonları arasında 14ºC ve 20ºC su sıcaklıklarında kuvvetli pozitif ilişki (sırasıyla, R2=0,9435 ve R2=0,9807) bulunmuştur. Artan su sıcaklığının bir sonucu olarak her iki anestezik maddede anestezi ve iyileşme sürelerinin kısaldığı görülmüştür. ArEO ve 2-PE için indüksiyon ve iyileşme sürelerinde su sıcaklığı ve anestezik konsantrasyon interaksiyonu önemli bulunmuştur. Japon balıkları üzerinde ArEO ve 2-PE anesteziklerinin herhangi bir yan etkisi gözlemlenmemiştir. Sonuç olarak, ArEO anestezik ajan özelliklerini her iki su sıcaklığında da Japon balığında sağlamaktadır.
- MakaleYalnız künye2020Scopus SJRQ3Potential anesthetic properties of bay leaf (Laurus nobilis) essential oil compared with 2-phenoxyethanol on blue dolphin cichlid, cyrtocara moorii
Kizak, Volkan; Can, Erkan; Seyhaneyildiz Can, Şafak
The efficacy of Bay leaf (Laurus nobilis) essential oil (LnEO) as a herbal anesthetic agent was evaluated with 2-Phenoxyethanol (2-PE) in Blue Dolphin Cichlid, Cyrtocara moorii. Fish were exposed to different anesthetic concentrations and the lowest effective concentrations (LECs) were determined according to deep anesthesia (AD<3 min) and full recovery (RF<5 min) times. LnEO showed anesthetic properties, and all applied concentrations of both agents induced AD in C. moorii. The LECs of LnEO and 2-PE for C. moorii were determined as 800 µl L-1 (AD; RF → 183 ± 6.3 s; 191 ± 2.6 s) and 600 µl L-1 (AD; RF → 171 ± 3.2 s; 239 ± 4.9 s), respectively. Significant differences were found between anesthetic agents in terms of deep anesthesia and full recovery times for the same concentrations (p<0.05). Induction and recovery times decreased with increasing in LnEO concentrations. On the other hand, anesthesia times were decreased with increasing of 2-PE concentrations, while recovery times increased. Induction and recovery times for LnEO were significantly dependent on concentrations and positive relationships were recorded between AD and RF, whereas the relationship was negative in 2-PE. Bay leaf essential oil has not been used as an anesthetic agent in fish until now. Our results showed that LnEO was an effective anesthetic agent with some minor side effects on C. moorii.
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İncele - MakaleAçık Erişim2019Scopus SJRQ3Anesthetic and sedative efficacy of peppermint (Mentha piperita) and lavender (Lavandula angustifolia) essential oils in blue dolphin cichlid (Cyrtocara moorii)
Can, Erkan; Sümer, Esma
The use of different essential oils (Eos), which are considered as a good alternative to synthetic materials, is increasing day by day in fish species. Nevertheless, studies on the anesthetic effect of peppermint Eo (Mentha piperita; MPEo) and lavender Eo (Lavandula angustifolia; LAEo) are scarce. In the present study, the effective concentrations of three anesthetic materials (MPEo, LAEo, and MS-222) were previously determined in the concentrations range of 100–400 ppm in Cyrtocara moorii juveniles (4.92 ± 1.03 g and 7.13 ± 1.22 cm) with the criteria of appropriate induction time (AIt) and ready recovery time (RRt) (Trial 1). Afterwards, four different groups were established at three different sedative concentrations (10, 20, and 30 ppm and a control group without anesthetic additive) for transporting (Trial 2). The study concluded that MPEo and LAEo can be used as anesthetic and sedative agents in tropical fish species safely. The use of 100 µL L–1 (183.5 s AIt and 227.8 s RRt) and 300 µL L–1 (109.2 s AIt and 420.0 s RRt) MPEo and LAEo, respectively, was sufficient for deep anesthesia, whereas concentrations in the range of 10 to 30 µL L–1 are recommended for fish transport.
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İncele - MakaleYalnız künye2018Scopus SJRQ1Anesthetic potential of geranium (Pelargonium graveolens) oil for two cichlid species, Sciaenochromis fryeri and Labidochromis caeruleus
Can, Erkan; Kizak, Volkan; Seyhaneyildiz Can, Şafak; Özçiçek, Esin
The anesthetic potential of geranium oil (Pelargonium graveolens L.) was evaluated in two freshwater aquarium fish species, the electric blue hap (Sciaenochromis fryeri, 2.00 ± 0.61 g) and blue streak hap (Labidochromis caeruleus, 2.31 ± 0.52 g). Fish were exposed to nine concentrations of anesthetic (25, 50, 75, 100, 125, 150, 200, 250, 300 μl L−1). The induction time generally decreased significantly with increasing concentration of geranium oil for both of the fish species. The recovery time increased with the enhancing geranium oil concentration. Deep anesthesia took between 61.19 ± 7.25 s and 165.43 ± 6.78 s for S. fryeri and between 73.32 ± 8.92 s and 171.12 ± 10.74 s for L. caeruleus. Recovery occurred after 96 ± 6.87 s (L. caeruleus), with the longest being 291.45 ± 8.31 s (S. fryeri). The minimal effective concentration was 75 μl L−1 for deep anesthesia for both two species, and 50 μl L−1 was found as the minimal sedative concentration at the stage of loss of equilibrium. These findings suggested that geranium oil is a new potential anesthetic for two ornamental fish species.
AtıfScopus33WoS29OpenAlex34İncele - MakaleYalnız künye2018Scopus SJRQ1Evaluation of anesthetic potential of rosewood (Aniba rosaeodora) oil as a new anesthetic agent for goldfish (Carassius auratus)
Kizak, Volkan; Can, Erkan; Danabaş, Durali; Can, Şafak Seyhaneyildiz
The aim of this research was to investigate the efficacy of rosewood (Aniba rosaeodora) essential oil (EO) as a new herbal anesthetic compared with camphor (Cinnamomum camphora) EO and commonly used chemical agent 2-phenoxyethanol (2-PE) on goldfish (Carassius auratus). The anesthetic efficacies of these herbal EOs and 2-PE were evaluated in goldfish with mean body weight of 7.36 ± 0.77 g. Fish were exposed to each anesthetic concentrations and the lowest effective concentrations (LECs) were established according to deep anesthesia (AD < 3 min) and full recovery (RF < 5 min) times. RD and CP showed anesthetic characteristics and induced AD. The LECs for each anesthetic were established at 250 μl L−1 for RD (AD; RF → 171 ± 2.28 s; 297 ± 7.69 s), 250 μl L−1 for CP (AD; RF → 129 ± 4.18 s; 291 ± 2.81 s) and 700 μl L−1 for 2-PE (AD; RF → 177 ± 2.35 s; 214 ± 4.93 s). At concentrations of 50, 100, 150, 200 μl L−1 for RD, 50, 100, 150 μl L−1 for CP and 400, 500 μl L−1 for 2-PE failed to induce AD in goldfish. There were significantly differences found among RD, CP and 2-PE concentrations in terms of induction and recovery times (p < 0.05). The fastest AD and RF were obtained by 300 μl L−1 CP (120 ± 1.94 s) and 600 μl L−1 2-PE (190 ± 4.34 s), respectively. Fish exposed to 300 μl L−1 RD and 800 μl L−1 2-PE took slightly longer to achieve AD than 300 μl L−1 CP. Induction and recovery times for EOs and 2-PE were significantly dependent on concentrations. Negative relationships was recorded between AD and RF for all anesthetics. No mortality or adverse effects occurred and fish stayed calm during trials. Results showed that RD was found to be an effective anesthetic as well as CP for goldfish and can be used at least 3-fold lower concentrations than 2-PE. In conclusion, rosewood (Aniba rosaeodora) EO, as a new potential anesthetic for fish, proved to be an effective natural agent resulting in rapid induction and recovery.
AtıfScopus25WoS20OpenAlex23İncele - MakaleYalnız künye2018Scopus SJRQ3Anesthetic efficacy of cymbopogon citratus essential oil as a herbal agent in two ornamental fish species
Kizak, Volkan; Can, Erkan; Can, Şafak Seyhaneyildiz; Özçiçek, Esin
The efficacy of Cymbopogon citratus essential oil (CcEO) as a herbal anesthetic agent was evaluated for two ornamental fish species, Sciaenochromis fryeri and Labidochromis caeruleus. Fish were exposed to various essential oil concentrations and the lowest effective concentrations were determined according to deep anesthesia (AD<3 min) and full recovery (RF<10 min) times. CcEO showed anesthetic traits and induced AD in S. fryeri and L. caeruleus. The lowest effective concentrations was 200 µl/L for S. fryeri (AD; RF → 122 ± 1.8 s; 638 ± 8.9 s) and 200 µl/L for L. caeruleus (AD; RF → 139 ± 6.9 s; 625 ± 11.1 s). At concentration of 25 µl/L C. citratus essential oil did not induce AD in both of ornamental fish species. No significant differences were found between fish species in terms of induction and recovery times for same concentrations excluding AD time of 200 µl/L concentration. Although the fastest AD were obtained by 300 µl/L, recovery times were prolonged and fish did not full recover in 20 min. Induction and recovery times for CcEO were significantly dependent on concentrations and negative relationships were recorded between AD and RF. Neither mortality nor adverse effects were observed on two fish species. As a result, CcEO showed anesthetic properties for S. fryeri and L. caeruleus.
AtıfScopus8İncele - MakaleYalnız künye2017Scopus SJRQ3The efficacy of chamomile (Matricaria chamomilla) oil as a promising anaesthetic agent for two freshwater aquarium fish species
Can, Erkan; Kizak, Volkan; Özçiçek, Esin; Seyhaneyildiz Can, Şafak
The efficacy of anesthetic chamomile oil (from Matricaria chamomilla L.) was evaluated in two freshwater aquarium fish species, Electric Blue Hap (Sciaenochromis fryeri) and Yellow Princess (Labidochromis caeruleus). Fish were exposed to ten concentrations of anesthetic (0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1.0 ml/L). The optimal concentrations identified as 0.6 ml/L for deep anesthesia (A5) for both two species. The minimal sedative concentration at the stage of loss of equilibrium (A3) was found to be 0.3 ml/L. The induction time generally decreased significantly with increasing concentrations of chamomile oil for all treatment groups. Recovery time tended to increase with increased chamomile oil at concentrations lower than 0.7 ml/L, but after this concentration it decreased. Chamomile oil proved to be effective as an anesthetic for both ornamental fish species. These findings suggest that chamomile oil is a promising anesthetic agent for aquaculture. However, further studies should be focused on species based investigations on the effect of temperature, transfer of fish, and their effect on antioxidant and oxidant status, in order to gather further information.
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