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- MakaleYalnız künye2017Scopus SJRQ2Marine Fungi Against Aquaculture Pathogens and Induction of the Activity via Co-Culture
Özkaya, Ferhat Can; Peker, Zerife; Camas, Mustafa; Camas, Anil Sazak; Altunok, Muhammet
Ethyl acetate extracts from 70 strains of marine-derived fungi, isolated from sponges, were screened against four fish pathogenic bacteria. Sixteen of the fungal isolates exhibited antibacterial activity against at least one pathogen. All the strains showed antibacterial activity against Vagococcus salmoninarum. Three isolates showed strong inhibition against all test pathogens and they may therefore be remarkable as a broad-spectrum antimicrobial. Nine isolates showed antibacterial activity against Lactococcus garvieae, six were against Vibrio anguillarum, and four isolates inhibited the growth of Yersinia ruckeri. Co-culture of the fungus with the mix of the pathogen bacteria led to the induction of bioactivity in two isolates. Aspergillus iizukae produced strong and broad-spectrum antibacterial activity against pathogens with minimum inhibitory concentrations of 0.8-406 mu gmL(-1). The screening results confirmed the sponge associated fungi as a source of environmentally friendly antimicrobials that may contribute the sustainable development of aquaculture. In addition, co-culture technique is a promising strategy to increase antimicrobial activity that can stimulate the production of novel compounds, and increases the antimicrobial activities of marine derived fungi.
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