Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Koçak, Berna(4)
- İpek, Yeliz(3)
- Keçeci, Ali(2)
- İpek, Yeliz.(1)
Yayınlar
- MakaleYalnız künye2025Scopus SJRQ3Eco-Friendly and Practical Electrochemical Determination of Lactic Acid in Milk Using Boron Doped Diamond Electrode
İpek, Yeliz.; Koçak, Berna; Keçeci, Ali
In this study, an economical, environmentally friendly, sensitive, selective, and rapid voltammetric quantitative analysis method was developed using a boron doped diamond electrode to determine lactic acid (LA). Two linear working ranges were determined for LA determination in phosphate buffer solution (PBS, pH of 2). The first linear working range (LR1) was between concentrations of 1.5 × 10−6–8 × 10−6 mol· L−1, with a detection limit of 1.3 × 10−6 mol·L−1, and the limit of quantification (LOQ) was found to be 4.4 µmol· L−1. The second linear working range (LR2) was determined in the concentration range of 8.0–89.2 µmol·L−1. LOD was calculated as 15.8 µmol·L−1, and the LOQ value was calculated as 52.6 µmol·L−1 in the LR2. Intraday repeatability of the BDD electrode for LA determination was (RSD) 6.8% in LR1 and 11.8% in LR2. The interday repeatabilities of the BDD electrode in LR1 and LR2 were calculated as 7.7% and 4.7%, respectively. The developed electrochemical sensor was successfully applied for the determination of LA in milk sample. The sensor exhibited a short response time of about 10 s in PBS at pH 2. The recovery values of LA in PBS and milk sample were 97.3% and 96.1%, respectively.
AtıfScopus2WoS2OpenAlex2
İncele - MakaleYalnız künye2023Scopus SJRQ3Nafion–Titanium (IV) Oxide-Graphene Modified Glassy Carbon Electrode (GCE) Based Electrochemical Sensor for the Voltammetric Determination of the β-blocker Bisoprolol Fumarate
Koçak, Berna; İpek, Yeliz
A Nafion–titanium (IV) oxide-graphene modified glassy carbon electrode (n-TiO2-GR/GCE) was used for the electrochemical determination of bisoprolol fumarate (BF). The modified electrode was prepared by depositing Nafion–titanium (IV) oxide-graphene onto the glassy carbon electrode by simple drop-casting. Differential pulse voltammetry (DPV) and square wave voltammetry (SWV) were used in the electrochemical determination of bisoprolol fumarate. The linear working range of bisoprolol fumarate for n-TiO2-GR/GCE DPV was from 3.0 × 10−7 to 5.0 × 10−6mol L−1 and the detection limit was 1.01 × 10−7mol L−1. In addition, with this developed method, the determination of bisoprolol fumarate in tablets was successfully performed with a recovery of 98.65%.
AtıfScopus3WoS2OpenAlex3İncele - MakaleYalnız künye2023Scopus SJRQ2A novel electrochemical sensor for metoprolol analysis based on glutardialdehyde–zinc oxide modified boron doped diamond electrode
Koçak, Berna; İpek, Yeliz; Keçeci, Ali
In this study, glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) was developed as a new electrochemical sensor for the rapid, sensitive and selective determination of metoprolol (MTP). By using boron doped diamond electrode (BDDE), glutardialdehyde modified boron doped diamond electrode (GA2/BDDE) and glutardialdehyde–zinc oxide modified boron doped diamond electrode (GA2–ZnO/BDDE) separately, the electrochemical behavior of MTP on the surfaces of these electrodes was determined by applying cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques. According to the results, the linear working range was 9.99 × 10−7–3.85 × 10−5 mol·L−1 and the limit of detection (LOD) was 7.53 × 10−8 mol·L−1 in pH 7 Britton–Robinson buffer solution. In addition, intraday reproducibility of peak current and peak potential were measured on the GA2–ZnO/BDDE surface and the results were calculated as 0.56 and 1 (RSD%), respectively. In order to investigate the reproducibility of GA2–ZnO/BDDE, 5 different modified electrodes were prepared with the same composition and conditions. The interday repeatability of the modified electrode was calculated as 3.13 (RSD%) and 1.05 (RSD%) for interday peak current and peak potential, respectively. The applicability of this method was confirmed by analysis of commercial drug tablets containing MTP as active ingredient. The mean recovery of the developed sensor was 95.6 % ± 1.7.
AtıfScopus14WoS12OpenAlex13İncele - MakaleAçık Erişim2022Scopus SJRQ3Electrochemical Detection of Ivermectin Used for the Treatment of COVID-19 with Glutardialdehyde-Modified Glassy Carbon Electrode
Koçak, Berna; İpek, Yeliz
In this study, the surface of the glassy carbon electrode was modified with glutardialdehyde. The modified glassy carbon electrode showed electrocatalytic activity against ivermectin. The glassy carbon electrode modified with glutardialdehyde showed high sensitivity, selectivity, and stability in the determination of ivermectin. The peak current of glutardialdehyde oxidation obtained by differential pulse voltammetry decreased inversely with the ivermectin concentration. Ivermectin inhibited the oxidation reaction of glutardialdehyde and caused a decrease in current. This change made the analysis of ivermectin electrochemically possible. In order to demonstrate the applicability of the developed method in real samples, recovery studies were carried out in tap water and urine. The highest sensitivity (0.45 µA/((µmol·L−1)(cm2))) was achieved with urine sample and the lowest detection limit as 2.66 × 10−6 mol·L−1 was obtained with BRT solution sample. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus14WoS13OpenAlex13
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