Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Acquaviva, Alessandra(1)
- Balos, Maruf(1)
- Bouyahya, Abdelhakim(1)
- Brunetti, Luigi(1)
- Cakilcioğlu, Ugur(1)
- Chiavaroli, Annalisa(1)
- Di Simone, Simonetta Cristina(1)
- Ferrante, Claudio(1)
- Guler, Osman(1)
- Leone, Sheila(1)
- Libero, Maria Loreta(1)
- Menghini, Luigi(1)
- Nilofar(1)
- Orlando, Giustino(1)
- Recinella, Lucia(1)
- Uba, Abdullahi Ibrahim(1)
- Zengin, Gokhan(1)
Yayınlar
- MakaleAçık Erişim2023Scopus SJRQ1Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Acquaviva, Alessandra; Di Simone, Simonetta Cristina; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Guler, Osman
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
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