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- MakaleYayıncıda açık erişim2025Scopus SJRQ2COVID-19 Alters Respiratory Function Associations in High-Level Athletes
Kabak, Banu; Erdoğan, Murat; Tortu, Erkan; Deliceoğlu, Gökhan; Bulgay, Celal; Kızar, Oktay; Baydaş, Giyasettin; Szabo, Attila
Background and Objectives: Coronavirus disease 2019 (COVID-19) has affected multiple physiological systems, including respiratory function, which is critical for athletic performance. Although alterations in pulmonary dynamics have been observed in high-level athletes recovering from COVID-19, the effects on respiratory function remain unclear. In this context, the present study aimed to examine the impact of COVID-19 on the interrelationships among respiratory function parameters in high-level athletes. Materials and Methods: Sixty-eight high-level athletes participated in the present study, including 34 with a history of COVID-19 and 34 controls without prior infection. Respiratory function and respiratory muscle strength were assessed using a digital spirometer (Pony FX, Cosmed, Italy). Key variables included Forced Vital Capacity (FVC), Peak Expiratory Flow (PEF), Maximum Voluntary Ventilation (MVV), Forced Expiratory Volume in one second (FEV1), and Maximum Inspiratory/Expiratory Pressure (MIP/MEP). Results: High-level athletes with prior COVID-19 infection exhibited significant differences in the correlations (p < 0.05) between FVC and PEF, FVC and MVV, FEV1 and FEV1/FVC, and MIP and MVV compared to controls. Conclusions: These findings suggest that COVID-19 can disrupt the interrelationships among respiratory function parameters in high-level athletes, highlighting the need for further longitudinal investigations.
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İncele - MakaleYalnız künye2022Scopus SJRQ3Identification of Potential Inhibitors for Severe Acute Respiratory Syndrome-related Coronavirus 2 (SARS-CoV-2) Angiotensin-converting Enzyme 2 and the Main Protease from Anatolian Traditional Plants
Kılınç, Namık; Açar, Mikail; Tuncay, Salih; Karasakal, Ömer Faruk
Background: The 2019 novel coronavirus disease (COVID-19) has caused a global health catastrophe by affecting the human population around the globe. Unfortunately, there is no specific medi-cation or treatment currently available for COVID-19. Objective: It is extremely important to find effective drug treatment in order to put an end to this pandemic period and return to normal daily life. In this context and considering the urgency, rather than focusing on the discovery of novel compounds, it is critical to explore the effects of existing herbal agents with proven antiviral properties on the virus. Methods: Molecular docking studies were carried out employing three different methods, Glide extra precision (XP) docking, induced fit docking (IFD), and molecular mechanics/generalized born surface area (MM/GBSA), to determine the potential antiviral and antibacterial effects of 58 phytochemicals present in Rosmarinus officinalis, Thymbra spicata, Satureja thymbra, and Stachys lavandulifolia plants against the main protease (Mpro) and angiotensin-converting enzyme 2 (ACE2) enzymes. Results: 7 compounds stood out among all the molecules, showing very high binding affinities. Accord-ing to our findings, the substances chlorogenic acid, rosmarinic acid, and rosmanol exhibited extremely significant binding affinities for both Mpro and ACE2 enzymes. Furthermore, carnosic acid and alpha-cadinol showed potent anti-Mpro activity, whereas caffeic acid and carvacrol exhibited promising anti-ACE2 activity. Conclusion: Chlorogenic acid, rosmarinic acid, rosmanol, carnosic acid, alpha-cadinol, caffeic acid, and carvacrol compounds have been shown to be powerful anti-SARS-CoV-2 agents in docking simulations against Mpro and ACE2 enzymes, as well as ADME investigations.
AtıfScopus32WoS30OpenAlex31İncele - MakaleYalnız künye2021Scopus SJRQ3Determination of the estimated amounts of discarded face masks due to COVID 19 in Turkey
Topal, Murat; Topal, Emine Işıl Arslan
In this study, the estimated amounts of discarded face masks due to COVID 19 were investigated. In this context, the amount of waste face masks was determined separately according to the mask types used (nonwoven, meltblown, and 3-ply, pleated) and the importance of waste face masks was revealed. According to obtained data, the estimated total daily face mask use in Turkey is 72,351,638. The highest amounts of nonwoven, meltblown, and 3-ply face mask waste were determined as 26.88, 36.29, and 43.68 tonnes/day for İstanbul city, respectively. Total amounts of nonwoven, meltblown and 3-ply face mask waste in Turkey were calculated as 144.7, 195.35, and 235.14 tonnes/day, respectively. The top 5 provinces with the highest amount of waste masks are listed as follows; İstanbul (nonwoven=26.88, meltblown=36.29, 3ply=43.68 tonnes/day), Ankara (nonwoven=9.91, meltblown=13.38, 3ply=16.11 tonnes/day), İzmir (nonwoven=7.76, meltblown=10.47, 3ply=12.61 tonnes/day), Bursa (nonwoven=5.40, meltblown=7.29, 3ply=8.78 tonnes/day), and Antalya (nonwoven=4.45, meltblown=6.01, 3ply=7.23 tonnes/day), respectively. In Turkey, 91.3% of medical waste collected in health institutions in 2019 (90,920 tonnes) was sterilized and disposed of in storage areas (83,010 tonnes). 8.7% of medical waste was sent to incineration facilities and disposed (7,910 tonnes). Considering these values, 132, 178.35, and 214.7 tonnes/day of nonwoven, meltblown, and 3-ply face mask wastes can be disposed by sterilization and the remaining 12.7, 17, and 20.44 tonnes/day by incineration, respectively.
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