Sürdürülebilir Kalkınma Amaçları

• 2

Yazarlar

• Farooqi, Ammad Ahmad(2)
• Ozbey, Ulku(2)
• Ahmad, A(1)
• Alaaeddine, Nada(1)
• Aras, A.(1)
• Aras, Aliye(1)
• Attar, Rukset(1)
• Butt, Ghazala(1)
• Farooqi, A.A.(1)
• Khalid, S.(1)
• Khalid, Sumbul(1)
• Lin, X.(1)
• Ozbey, U.(1)
• Ozcelik, Beraat(1)
• Qadir, Muhammad Imran(1)
• Qureshi, M.Z.(1)
• Romero, M.A.(1)
• Tabassum, Sobia(1)
• Uteuliev, Yerzhan Sabitaliyevich(1)
• Yi, Liu(1)
• Yin, Ning(1)

• Kitap BölümüYalnız künye2019Scopus SJRQ2/r/munzur/3264
  TRAIL Mediated Signaling in Breast Cancer: Awakening Guardian Angel to Induce Apoptosis and Overcome Drug Resistance

  Yin, Ning; Yi, Liu; Khalid, Sumbul; Ozbey, Ulku; Uteuliev, Yerzhan Sabitaliyevich; Farooqi, Ammad Ahmad; Ahmad, A

  Sequencing technologies have allowed us to characterize highly heterogeneous molecular landscape of breast cancer with unprecedented details. Tremendous breakthroughs have been made in unraveling contributory role of signaling pathways in breast cancer development and progression. It is becoming progressively more understandable that deregulation of spatio-temporally controlled pathways underlie development of resistance against different drugs. TRAIL mediated signaling has attracted considerable appreciation because of its characteristically unique ability to target cancer cells while leaving normal cells intact. Discovery of TRAIL was considered as a paradigm shift in molecular oncology because of its conspicuous ability to selectively target cancer cells. There was an exponential growth in the number of high-quality reports which highlighted cancer targeting ability of TRAIL and scientists worked on the development of TRAIL-based therapeutics and death receptor targeting agonistic antibodies to treat cancer. However, later studies challenged simplistic view related to tumor targeting ability of TRAIL. Detailed mechanistic insights revealed that overexpression of anti-apoptotic proteins, inactivation of pro-apoptotic proteins and downregulation of death receptors were instrumental in impairing apoptosis in cancer cells. Therefore researchers started to give attention to identification of methodologies and strategies to overcome the stumbling blocks associated with TRAIL-based therapeutics. Subsequent studies gave us a clear picture of signaling cascade of TRAIL and how deregulation of different proteins abrogated apoptosis. In this chapter we have attempted to provide an overview of the TRAIL induced signaling, list of proteins frequently deregulated and modern approaches to strategically restore apoptosis in TRAIL–resistant breast cancers.

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  AtıfScopus6·WoS7·OpenAlex7

  İncele
• Derleme MakaleYayıncıda açık erişim2017Scopus SJRQ3/r/munzur/3844
  Regulation of signaling pathways by tanshinones in different cancers

  Lin, X.; Qureshi, M.Z.; Romero, M.A.; Khalid, S.; Aras, A.; Ozbey, U.; Farooqi, A.A.

  Past several years have witnessed dramatic leaps in our understanding of rewiring of gene expression at the translation level during cancer developmentthat provides linchpin support to the transformed phenotype. Most recent and ground-breaking developments in the field of molecular oncology aredriven by an explosion in technological advancements and have started to reveal previously unimagined regulatory mechanisms and how they intricately co-ordinate to modulate cancer progression, loss of apoptosis and development of resistance against different therapeutics. However, the insights gained from work in this natural product research have far-reaching impact because of rapidly increasing repertoire of medicinally and biologically efficient phytochemicals. How Tanshinones mediate targeting of JAK-STAT, ER stress associated signaling cascade,PI3K/AKT/mTOR pathway,autophagy, TRAIL pathway and microRNAs are being discovered and will prove to be helpful in getting a step closer to personalized medicine.

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  AtıfScopus12·OpenAlex12

  İncele
• Derleme MakaleAçık Erişim2017Scopus SJRQ3/r/munzur/658
  Regulation of signal transduction cascades by Pterostilbenes in different cancers: Is it a death knell for oncogenic pathways

  Butt, Ghazala; Attar, Rukset; Tabassum, Sobia; Aras, Aliye; Qadir, Muhammad Imran; Ozbey, Ulku; Alaaeddine, Nada; Ozcelik, Beraat; Farooqi, Ammad Ahmad

  Interdisciplinary research has revolutionized the field of medicine and we have witnessed exponential increase in the high-impact research in past few decades. However, the road to this burgeoning research field is obstacle-ridden because of intratumor heterogeneity, loss of apoptosis and dysregulation of spatio-temporally controlled signaling pathways. Ground-breaking findings obtained through genetic, genomic and proteomic studies have considerably improved our concepts related to the complexity of protein network and excitingly, discovery of miRNAs has added another layer of intricacy to quantitatively regulated gene networks. In this review, we chronicle the milestone achievements and discuss how Pterostilbenes effectively regulated different cellular pathways. We have provided detailed mechanistic insights related to regulation of JAK-STAT signaling, Notch pathway, Wnt mediated intracellular signaling by pterostilbene. Underlying mechanisms about regulation of PI3K/AKT and MAPK pathways by pterostilbene in different cancers. Regulation of Metastasis-associated protein 1 (MTA1) proteins and Human telomerase reverse transcriptase (hTERT) in cancer cells by pterostilbene. Pterostilbene has also been reported to modulate the expression of various oncogenic and tumor suppressor microRNAs in cancer cells. Better and sharper comprehension of the concepts associated with the modes of action of pterostilbene in different cancers will be useful in identification of cancers which can be efficiently targeted by pterostilbene.

  AtıfScopus15

  İncele