Sürdürülebilir Kalkınma Amaçları
Yazarlar
Yayınlar
- MakaleAçık Erişim2026Scopus SJRQ2Electrochemical analysis of tetracycline in drug formulations with glutardialdehyde-Fe2O3 modified glassy carbon electrode
Koçak, Berna; İpek, Yeliz
In this study, a glutardialdehyde-Fe2O3 modified glassy carbon electrode (GA2–Fe2O3/GCE) was used as a sensor for the electrochemical analysis of tetracycline (TC) in drug formulations. The electrochemical behavior of TC on GA2-Fe2O3/GCE was investigated using cyclic voltammetry (CV), while the quantitative determination was performed via differential pulse voltammetry (DPV). After optimizing the experimental conditions, the linear working range, limit of (LOD) detection, and limit of quantification (LOQ) of the GA2-Fe2O3/GCE electrode developed for the electrochemical analysis of TC were found to be 1.0 × 10−6–2.0 × 10−5 M and 2.0 × 10−5–9.9 × 10−6 M; 4.78 × 10−7 M; 1.59 × 10−6 M, respectively. In the sensor application study conducted on a Tetra® Gensenta tablet to demonstrate the applicability of the developed method, the linear working range, LOD, and LOQ values of the sensor were found to be 1.0 × 10−6–14.8 × 10−5 M; 5.72 × 10−7 M and 1.74 × 10−6 M, respectively. The applicability of the method was demonstrated through tablet recovery studies, and the tablet recovery ratio was determined to be 100.94%.
- MakaleYalnız künye2024Scopus SJRQ3Development of a novel rare earth element doped chitosan-graft-poly(hydroxyethyl methacrylate) composite for biomedical applications: synthesis, characterization, drug delivery, and antibacterial properties
Gürler, N.; Torǧut, G.; Yazdıç, F.C.; Karaman, A.; Karaaslan Ayhan, N.
The films of chitosan-graft-poly(hydroxyethyl methacrylate) polymer (Ch—g-poly(HEMA)) doped with the rare earth element (REE) lanthanum (La content of 0, 0.2, 0.4, and 0.8 wt.%) were fabricated. The films were characterized by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), thermogravimetric analysis (TGA), and powder X-ray diffraction (XRD) analysis. The films obtained were loaded with a model drug tetracycline by freezing/thawing method. The cumulative drug release properties of tetracycline were investigated. The release of tetracycline from the polymer matrix was carried out in phosphate-buffered saline (PBS) buffer (pH 7.4) at 37 °C. It was found that the REE-doped composite films had a retarding effect on tetracycline drug release compared to that of the undoped film. All tested composites regardless of the REE dopant content were found to be active against three Gram-positive and three Gram-negative bacterial strains used to assess the antimicrobial properties of the polymer composites. These findings demonstrated that lanthanum and tetracycline have a high affinity for the Ch—g-poly(HEMA) polymer and suggested a synergistic effect in the polymer—lanthanum—tetracycline system. The La3+-doped Ch—g-poly(HEMA) composite film can be used as drug carrier system in the biomedical field.
AtıfScopus4WoS4OpenAlex3
İncele - MakaleAçık Erişim2022Scopus SJRQ1Chitosan-graft-poly(N‑tert‑butylacrylamide) Copolymer: Synthesis, Characterization and Optimization of Tetracycline Removal Using RSM
Tanyol, Mehtap; Torğut, Gülben
In the present study, a graft copolymer was synthesized in accordance with the free radical method using N-tertiary butylacrylamide monomer on chitosan, which is an environmentally friendly polymer. The chemical structure and surface morphology of the newly synthesized graft copolymer were determined by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction. Moreover, the thermal behavior was analyzed by thermogravimetric analysis. The chitosan-graft-poly(N‑tert‑butylacrylamide) graft copolymer was used as an adsorbent for the rapid removal of tetracycline from aqueous solutions in order to investigate its applicability. Response surface methodology (RSM) was employed for the optimization of the study conditions, namely adsorbent dosage (0.01–0.04 g 100 mL−1), reaction time (10–90 min) and initial tetracycline concentration (10–100 mg 100 mL−1). The effects of these conditions on tetracycline uptake capacity were examined and the results were statistically analyzed. The RSM results showed that the maximum tetracycline uptake capacity of 104.81 mg g−1 was achieved under the following conditions: adsorbent dose of 0.03 mg 100 mL−1, reaction time of 51.12 min and initial tetracycline concentration of 97.99 mg L−1. ANOVA based on central composite design combined with RSM showed a good agreement between the experimental values and quadratic model estimates, thus resulting in a coefficient (R2) of 0.9118 for tetracycline uptake. The kinetics, isotherms, and thermodynamics of adsorption were examined, and results showed that equilibrium data fitted the Freundlich isotherm model, and the adsorption kinetics of tetracycline followed pseudo-second-order model. Thermodynamic parameters like the enthalpy − 10.39 kJ mol−1 (ΔH°), entropy 0.044 kJ mol−1 K−1 (ΔS°) and Gibbs free energy − 23.26 kJ mol−1 (ΔG°) were evaluated and also, ΔG° shows a negative values indicating that the adsorption process was exothermic and spontaneous. The findings demonstrated that the chitosan-graft-poly(N‑tert‑butylacrylamide) copolymer is an effective adsorbent for pharmaceutical wastewater treatment.
AtıfScopus11WoS12OpenAlex11İncele - MakaleAçık Erişim2020Scopus SJRQ3Removal of tetracycline antibiotic by Lemna gibba L. from aqueous solutions
Topal, Murat; Öbek, Erdal; Uslu Şenel, Gülşad; Arslan Topal, E. Işıl
In this study, the efficiency of Lemna gibba L. on tetracycline (TC) removal from the solutions prepared at various initial TC concentrations (50, 100 and 300 µg/L) was investigated. The study was conducted in the reactors planted with Lemna gibba L. plants. Lemna gibba L. plants in the reactors were harvested at various hydraulic retention times. Then, the concentrations of TC were determined by using LC/-MS-MS. The maximum removal efficiencies for the TC50, TC100 and TC300 in the planted reactors were 99.8 ± 4.1; 99.9 ± 4.9 and 99 ± 4.9%, respectively. The harvesting times for Lemna gibba L. at TC50, TC100 and TC300 concentrations were determined to be 12, 8 and 12 hours, respectively. First-, second- and pseudo-first-order kinetics are determined in the planted reactors (with Lemna gibba L.). According to the study results, second-order kinetics were obtained at TC50, TC100, TC300 concentrations. As a result, the Lemna gibba L. plant can be used as an alternative treatment method to other advanced treatment methods and it can be done with a cheap method by adapting to existing treatment plants. Lemna gibba L. plants can be used to remove pollutants by applying them to polluted lakes and water bodies.
AtıfScopus12OpenAlex11İncele - MakaleAçık Erişim2020Scopus SJRQ1Optimization of tetracycline removal with chitosan obtained from mussel shells using RSM
Topal, Murat; Arslan Topal, E. Işıl
In this study, the removal of tetracycline from aqueous solutions with chitosan obtained from mussel shells was optimized and investigated using responce surface methodology. For this aim, the central composite design was used to optimize the four variable factors (sorbent dosage (0.4–1.0 g), time (20−60 min), temparature (10−30 °C) and initial TC concentration (50−100 mg/L)) for the removal of TC from aqueous solutions by chitosan obtained from mussel shells. According to the RSM analysis results, optimum conditions for maximum TC removal efficiency were determined as 90.5 mg/L for initial TC concentration, 35.9 min for time, 29.9 °C for temperature and 0.4 g for sorbent dosage. It was observed that the tetracycline was crystallized on mussel shells. According to the results of XRD after adsorption, the content of mussel shells were observed as 60% calcite, 5.6% overite, 9.4% aragonite and calcium hydroxide 25%, respectively. As a result, experiments showed that chitosan obtained from mussel shells were a good adsorbant for tetracycline removal from aqueous solutions.
AtıfScopus53WoS52OpenAlex53İncele - MakaleAçık Erişim2017Investigation and monitoring of tetracycline and degradation products in waters of trout farm
Topal, Murat
In this study, tetracycline and degradation products were determined in the basins of a trout farm and in the stream carrying the waters of trout farm. Tetracycline (TC), 4-epitetracycline (ETC), 4-epianhydrotetracycline (EATC) and anhydrotetracycline (ATC) concentrations were determined under the detection limit in upstream of trout farm. The highest and lowest tetracycline concentrations detected in trout farm are 7.64 +/- 0.38 ppb and under detection limit, respectively. The highest and lowest 4-epitetracycline concentrations were 16.2 +/- 0.8 and 1.85 +/- 0.09 ppb, respectively while the highest and lowest 4-epianhydrotetracycline concentrations detected in trout farm were 25.8 +/- 1.3 and 6.12 +/- 0.30 ppb, respectively. The highest and lowest anhydrotetracycline concentrations detected in trout farm were 18.5 +/- 0.9 and 6.24 +/- 0.31 ppb, respectively. Mean tetracycline, 4-epitetracycline, 4-epianhydrotetracycline and anhydrotetracycline concentrations were 3.52 +/- 0.17; 5.30 +/- 0.26; 14.4 +/- 0.7 and 9.64 +/- 0.48 ppb in downstream of trout farm. When upstream and downstream were compared in terms of tetracycline and degradation products it could be said that Keban stream was affected as a result of activity of trout farm.
AtıfWoS1OpenAlex1İncele