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- MakaleAçık Erişim2025Scopus SJRQ3EFFECTS OF LACTOBACILLUS PLANTARUM ON THE AKT/ENOS CARDIAC PATHWAY IN RATS WITH FRUCTOSE-INDUCED METABOLIC SYNDROME
Kursun, Oznur Ece Durmaz; Yalim, Goknur; Demirel, Murside Ayse; Erten, Fusun; Sahin, Kazim; Akar, Fatma
Background. This study investigated the effects of Lactobacillus plantarum supplementation on the Akt/eNOS pathway in the cardiac tissue of rats subjected to a fructose-rich diet, which induced metabolic syndrome. Materials and methods. Twenty-two male Wistar albino rats were randomly assigned to three groups: (1) control, (2) fructose, and (3) fructose ± L. plantarum. Rats in the fructose group were administered a 20% fructose solution in their drinking water for 15 weeks. In the L. plantarum-treated group, the probiotic was administered via gastric gavage at a daily dose of 1×109 CFU/mL/100 g during the final six weeks of the study. Results. The administration of Lactobacillus plantarum resulted in a significant increase in the levels of Akt (p < 0.0001), IRS-1 (p = 0.0113), mTOR (p < 0.0001), eNOS (p < 0.0001), and SIRT1 (p = 0.0031) in the cardiac tissue of rats compared to the fructose group. Moreover, a marked reduction in iNOS, NF-κB, and TNF-α levels (p < 0.0001) was observed, highlighting the potential of L. plantarum to counteract the adverse effects of fructose consumption. Conclusion. The findings of this study suggest that L. plantarum has the potential to reduce inflammation in the heart, enhance insulin sensitivity via the Akt/eNOS pathway, and protect against cardiovascular diseases associated with metabolic syndrome.
- MakaleYayıncıda açık erişim2021Scopus SJRQ4Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats
Sahin, Kazim; Orhan, Cemal; Kucuk, Osman; Erten, Fusun; Tuzcu, Mehmet; Sahin, Nurhan; Ojalvo, Sara Perez; Komorowski, James Richard
The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-a1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers.
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