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Koleksiyondaki öğeler
- MakaleAçık Erişim2024Scopus SJRQ3Toxicity assessment of advanced biological wastewater treatment plant effluent by integrated biomarker response in zebra mussels (Dreissenapolymorpha)
Serdar, Osman; Ketenalp, Zozan; Yildirim, Nuran Cikcikoglu
In this study, zebra mussels (Dreissena polymorpha) were exposed to advanced biological wastewater treatment plant effluent (ABWTPE) for 96 h. At the end of the 96th hour, antioxidant parameters such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione S-transferase (GST), malondialdehyde (MDA) and glutathione (GSH) were examined. The objective of the study was to identify biomarkers that are useful for assessing the potential toxic effects of ABWTPE in freshwater environments. We observed an increase in GPX, SOD activity and MDA levels, and a decrease in CAT, GST activity and GSH levels. The results obtained in our study showed that the measured biochemical parameters (GSH, MDA, SOD, CAT, GPX and GST) are useful biomarkers in determining the possible toxicity of ABWTPE in aquatic environments.
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İncele - MakaleYalnız künye2023Scopus SJRQ3Comprehensive Evaluation of the Relationships Between Grape Skin Color/Ripening Time and Antioxidative Capacity, Some Phytochemicals, and Fatty Acid Compositions of Their Seeds
Çakır, Atilla; Odabaşıoğlu, Mehmet İlhan; Karaca Sanyürek, Nesrin; Aydın, Sevinç
It has been proven that grapes, which are widely cultivated around the world, have positive health effects. However, the phytochemical composition of lesser-known local varieties of Vitis vinifera L., which has a very wide range of varieties, is still being studied. The aim of this study was to determine the effects of skin color and ripening time on the phytochemical compositions of grape seeds. As a plant material local grape varieties cultivated in Southeastern Anatolia (Turkey) were used. The results showed that grape skin color has an effect on vitamin K1, vitamin K2, vitamin D3, δ‑tocopherol, stigmasterol, ergosterol, myristic acid, oleic acid, trans-elaidic acid, and the monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA) contents of seeds. The seeds of grape varieties with colored skins were richer in K2, D3, stigmasterol, oleic acid, trans-elaidic acid, and MUFAs, while the seeds of grape varieties with white skins were richer in K1, δ‑tocopherol, ergosterol, and SFAs. The ripening time of the grapes was found to have a partial effect on the fatty acid compositions of the seeds, but without any effect on linoleic acid contents. As the ripening time was delayed, there was an increase in oleic acid and MUFA contents of the seeds, while there was a decrease in SFA contents. In general, increased vitamin K1 contents of the seeds were parallel to decreases in vitamins K2, D2, and D3, as well as α‑tocopherol content and antioxidant activity. The seeds of grape varieties that have colored skins were found to have more suitable compound compositions for use in the production of functional foods that support human and animal health. In addition, it was concluded that grape berries that ripen late may be more favorable for grapeseed oil production.
AtıfScopus3WoS4OpenAlex3İncele - MakaleYalnız künye2024Scopus SJRQ1Preparation and characterization of the highly efficient tetraphenylimidazole substituted Phthalocyanine/ZnO composite and investigation of its effect on the photocatalytic degradation of Rhodamine B and 2,4,6-trichlorophenol
Karaoğlu, Kaan; Yüzüak, Gizem Durak; Yüzüak, Ercüment; Turan, Hanife; Akçay, Hakkı Türker
Growing concerns about industrial waste-induced environmental degradation have driven research towards sustainable solutions. Photocatalytic degradation, fueled by light and avoiding harmful chemicals, offers a promising avenue due to its minimal environmental impact. ZnO, TiO₂, and their derivatives are particularly effective and widely studied photocatalysts. This study aims to prepare new composite materials bearing phthalocyanine and investigate the photocatalytic properties on the degradation of Rhodamine B dye and 2,4,6-trichlorophenol (TCP) as the model compounds. In the initial step, ZnO materials were synthesized using the solvothermal method. Subsequently, a novel Zn(II) complex, including peripherally tetra phenyl imidazole substituted phthalocyanine, was successfully prepared. The composite catalysts were prepared from ZnO materials produced with the tetraphenyl imidazole phthalocyanine Zn(II) complex, called TFI-Zn. The were characterized using instrumental techniques. The photocatalytic characteristics of the composite materials developed were further examined under varying quantities of catalyst and Rhodamine B, variable pH conditions, and varying intensities of UV-A light. In addition, the reusability of the catalyst was investigated. With the new composite photocatalyst prepared within the scope of this study, 98% degradation efficiency and 8.0 × 10−4 min−1 degradation rate was obtained on Rhodamine B solution in 40 min. The newly developed photocatalyst displayed remarkable catalytic activity that remained virtually unchanged for five consecutive cycles, indicating excellent reusability and operational stability. The photocatalytic degradation performance of ZnO-TFI-Zn (1) was also examined on TCP and 90% degradation activity was obtained at the end of 80 min.
AtıfScopus7WoS7OpenAlex7İncele - MakaleYalnız künye2025Scopus SJRQ2Tailoring ZrWNb-Based Refractory High Entropy Alloys: A Multidirectional Characterization Through Elemental, Physical, Thermodynamic, and Nuclear Radiation Attenuation Properties
Güler, Ömer; Özkul, İskender; Almisned, Ghada; Sen Baykal, Duygu; Alkarrani, Hessa; Kilic, G.; Mesbahi, A.; Tekin, H.O.
This study explores the development and characterization of 18 novel ZrWNb[(X)(Y)] (where XY are Hf, Ta, Mo, V, Ti) refractory high entropy alloys (RHEAs) designed to enhance mechanical robustness, thermodynamic stability, and radiation shielding effectiveness. Through a rigorous analysis, we evaluated the elastic modulus, entropy, and enthalpy of mixing, atomic size difference, valence electron concentration, and the omega parameter to understand the alloys’ phase behavior and structural integrity. Our findings revealed a broad range of elastic modulus values, indicating diverse mechanical adaptability suitable for high-stress applications. The thermodynamic assessment highlighted several RHEAs with favorable phase stability, particularly ZrWNbTaHf and ZrWNbTiTaHf, which are poised for high-performance usage due to their balanced mixing entropy and enthalpy. This study also benchmarks the RHEAs against conventional alloys, with sample R1 exhibiting the lowest fast neutron effective removal cross section, underscoring its superior neutron shielding capabilities. Additionally, R1 demonstrated exceptional photon attenuation, as evidenced by its competitive half-value layer performance across an extensive energy spectrum. Collectively, these results position R1 as a standout candidate, offering a significant advancement in materials science for applications demanding stringent radiation shielding, such as in nuclear reactor environments and space exploration.
AtıfScopus4OpenAlex5İncele - MakaleYalnız künye2023Scopus SJRQ1Energy, exergy and cost analysis of different hemispherical solar distillers: A comparative study
Hadi Attia, Mohammed El; Hussein, Ahmed Kadhim; Radhakrishnan, Ganesh; Vaithilingam, Sivakumar; Younis, Obai; Akkurt, Nevzat
The experimental study of the results of reflective aluminum foils, metal sheets, and phosphate granules on the productivity and efficiency of hemispherical solar stills was given throughout this work under the solar conditions of the city of El-Oued (Algeria). Solar stills were designed, manufactured, and tested in August 2020. A standard hemispherical solar still was made of wood and coated with black silicon. It was considered a traditional solar still. Although it was compared to traditional solar stills, it was improved by covering its side walls with reflective aluminum foil, zinc metal sheets, and copper sheets. It had been found that the productivity of the modified still was 8.67%, 29.08%, and 42.35%, respectively, on top of that of the traditional solar still. This could be due to the activity of the foils and metals, which reflect more radiation and store energy, increasing the temperature of the salt water in the basin. In the second experiment, three modified solar stills in line with aluminum foil and phosphate granules (30 g/L), zinc metal sheet and phosphate granules, and copper metal sheet and phosphate granules were collectively used. It had been found that the productivity of the modified solar still with aluminum foil and phosphate granules (the improvement rate is 30.61%) was on the far side of that with zinc metal sheets and phosphate granules (the improvement rate is 49.961%) and copper metal sheets and phosphate granules (the improvement rate is 62.24%).
AtıfScopus37OpenAlex34İncele - MakaleAçık Erişim2023Scopus SJRQ1Screening for Chemical Characterization and Pharmacological Properties of Different Extracts from Nepeta italica
Acquaviva, Alessandra; Di Simone, Simonetta Cristina; Nilofar; Bouyahya, Abdelhakim; Zengin, Gokhan; Recinella, Lucia; Leone, Sheila; Brunetti, Luigi; Uba, Abdullahi Ibrahim; Guler, Osman
Plants from the Nepeta genus have been proved to possess different pharmacological properties, among which are antimicrobial, antioxidant, anti-inflammatory, analgesic, and cytotoxic effects. Nepeta italica is a medicinal plant traditionally used for its analgesic effects, and in the present study, the phytochemical composition and biological effects of hexane, dichloromethane (DCM), ethyl acetate (EA), ethanol, ethanol-water, and water extracts of the aerial parts were investigated for determining phenolic composition, antioxidant effects, and anti-inflammatory effects in isolated mouse colon specimens exposed to lipopolysaccharide (LPS). Polar extracts were the richest in terms of phenolic compounds, especially rosmarinic acid. In parallel, ethanol, ethanol-water, and water extracts were also the most effective as scavenging/reducing and enzyme inhibition agents, especially towards cholinesterases and α-glucosidase, and in inhibiting the LPS-induced cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNFα) gene expression in mouse colon. This poses the basis for future in vivo investigations for confirming the protective effects of polar extracts of N. italica against inflammatory bowel diseases.
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İncele - BildiriAçık Erişim2025Investigation of Mechanical Properties of Hot Mix Asphalt Modified with Elvaloy and Polyphosphoric Acid
Yilmaz, Mehmet; Yalcin, Beyza Furtana
In order for the bituminous hot mix layers to resist the increased traffic load and volume as well as the adverse environmental conditions for a long time without being deformed, the bituminous binder used in the mixture has been commonly modified with the Styrene-Butadiene-Styrene (SBS) polymer. The high demand for SBS makes it difficult to supply and therefore brings on the use of alternative additives. In this study, the combined use of Elvaloy and phosphoric acid (PPA) was investigated. Additionally, the effects on the mechanical properties of bituminous mixtures were examined. Modified binders were prepared using Elvaloy/PPA additives mixed under specified conditions. Hot mix asphalt (HMA) samples prepared with these binders were subjected to Marshall stability and flow, indirect tensile stiffness modulus, and indirect tensile fatigue tests to comprehensively evaluate the effects of modified bi nders on the mechanical properties of bituminous hot mixtures. As a result, the bituminous hot mix tests revealed that asphalt mixtures improved their mechanical properties at the specified ratios.
- MakaleAçık Erişim2023Scopus SJRQ1Analysis of unsteady thermo-solutal MoS2-EO Brinkman electro-conductive reactive nanofluid transport in a hybrid rotating Hall MHD generator
Shamshuddin, M.D.; Bég, O. Anwar; Akkurt, Nevzat; Leonard, Henry J.; Bég, Tasveer A.
MHD rotating generators offer a plausible renewable energy mechanism. New designs are emerging in which nanotechnology is contributing. Such systems are increasingly deploying more complex functional fluid materials such as base fluids containing magnetic nanoparticles which constitute electromagnetic nanofluids and can be tuned to enhance efficiencies. Motivated by these developments, a mathematical model is presented for the combined effects of Hall current, heat source, chemical reaction and radiative flux on the unsteady rotating thermo-solutal magnetohydrodynamic transport of a Molybdenum disulphide (MoS 2)-EO oil electroconductive Brinkman nanofluid to study the boundary layer characteristics in the vicinity of the side wall of an MHD generator system. The governing dimensional conservation equations are scaled using appropriate transformations into a system of dimensionless coupled partial differential equations. Under appropriate initial and boundary conditions, solutions are derived using the Laplace Transform Method (LTM) and complex variables. The physical impacts of the magnetic, nanoscale, thermal and species control parameters on primary and secondary velocity, temperature and concentration are visualized graphically. The judicious doping of the base fluid with MoS 2 nanoparticles is shown to achieve superior thermal performance for MHD rotating energy generators.
AtıfScopus38OpenAlex24İncele - Kitap BölümüYalnız künye2024Assessment of critical raw materials by addressing sustainable development goals using fuzzy MCDM approach
Göçmen-Polat, Elifcan
Critical raw materials (CRMs), constituting the first step of the industry, are vital to meet sustainable development. With increasing digital technology and green transition efforts under the scope of twin transformation, demand for CRMs has increased, and supply interruption is expected in the future. All countries should plan the supply chain of CRMs in the context of the green and digital transition. The sustainable development goals (SDGs) have presented a reference based on sustainability metrics. In the chapter, hesitant-fuzzy analytical hierarchy process-based order preference technique based on similarity to ideal solutions (HF-AHP based TOPSIS) has been developed to evaluate the critical raw materials in the context of sustainability. Most relevant goals with the CRMs are obtained as SDG 1, SDG 3, SDG 5, SDG 6, SDG 7, SDG 8, SDG 9, SDG 11, SDG 17. The findings show how raw materials have important strengths and weaknesses in sustainable development. Policies recommended for the most important CRMs are effective road maps in the context of twin transformation.
AtıfScopus4OpenAlex6İncele - Kitap BölümüYalnız künye2024Otherness and censorship in the theatre of Turkey (1960s-70s)
Çelik, Duygu
This chapter delves into the relationship between censorship and 'otherness', examining three plays across distinct political epochs from the multi-party period of 1945-60 to the post-coup regimes of 1960 and 1971, marked by democratic transitions and restricted liberties Musa Anter's Birîna Reş (1959), recognised as the first Kurdish play on Republican history, encountered state prohibition and confiscation in 1965. Erol Toy's Pir Sultan Abdal (1968), centered on the Alevi folk poet, faced a ban exclusively in Tunceli, a city predominantly inhabited by Alevis, amidst violent events resulting in a civilian's death. Deprem ve Zulüm (1977), a collaborative piece by the Revolutionary Ankara Art Theatre, explores the aftermath of a 1976 earthquake in Van, a Kurdish-dominated city. These plays share a commonality in addressing the concept of the 'Other' and were censored under the accusation of promoting separatism, thereby violating constitutional norms. By scrutinising these cases, the chapter aims to unravel the dynamics between artistic expression, political climates, and the imposition of censorship, shedding light on how the theme of 'otherness' becomes entangled in the suppression of voices across diverse socio-political contexts.
- MakaleAçık Erişim2023Scopus SJRQ3Production of SBS Reinforced Polyester Composite: Characterization of Physical and Chemical Properties
Şahal, Hakan; Aydoğmuş, Ercan
In this study, dissolved styrene butadiene styrene (SBS) copolymer is homogeneously reinforced into orthophthalic unsaturated polyester (UP) resin. Polyester composite production is carried out with the help of methyl ethyl ketone peroxide (MEKP) and cobalt octoate (Co Oc) catalysts. The density, Shore D hardness, thermal conductivity coefficient, thermal stability, morphological surface structure, and chemical bond structure of the obtained composite have been examined. According to the results, SBS reinforcement decreases the density of the composite and increases the thermal conductivity coefficient. The addition of SBS at different weight ratios (1%, 3%, 5%, 7%, and 10% w/w) reduces both the hardness and thermal stability of the polyester composite. According to the test and analysis results, 5 wt.% SBS reinforced polyester composite production is determined as the optimum ratio. 7 wt.% and above SBS reinforcement negatively affect the physical and chemical properties of the obtained composite. For example, when 10 wt. % SBS reinforced composite is examined by scanning electron microscope (SEM), and irregular pores are observed in the surface morphology. Also, it is understood by Fourier transform infrared spectroscopy (FTIR) that there is a physical interaction between SBS and polyester and that no chemical bond is formed. The thermal decomposition behavior of the composite has been determined according to the decrease in the activation energy. As SBS ratio increases, it is understood that the thermal stability of the product obtained with the decrease in the activation energy of the polyester composite weakens.
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İncele - BildiriAçık Erişim2024A New Approach to Detecting Free Parking Spaces Based on YOLOv6 and Keyframe Detection with Video Analytics
Yilmazer, Merve; Karakose, Mehmet; Tanberk, Senem; Arslan, Samed
With urbanization and population growth, automobile use has also increased. As a result of this, there is a need to expand parking management and inspection systems to ensure safe and efficient use of parking areas. A new deep learning-based method has been proposed as an alternative to traditional systems to control free spaces in parking areas monitored by CCTV security cameras. A large amount of video data needs to be processed for parking areas recorded with video cameras 24 hours a day, 365 days a year. Repeating frames in videos cause overlearning in deep learning models. It also increases memory and computation cost. For this reason, keyframe detection based on sampling was first performed on the sample video of the Dragon Lake Parking (DLP) dataset and a summary of the dataset was obtained. Then, empty parking areas were detected by YOLOv6 deep neural network. It has been observed that the model can detect empty parking areas at a rate of 96.6% mAP.
AtıfScopus7OpenAlex5İncele - MakaleYalnız künye2024Scopus SJRQ1Resistance to magnesium sulphate attack of binary and ternary cementless self-compacting alkali-activated mortar
Şahin Yön, Merve; Karataş, Mehmet
The aim of this study is to investigate the effect of sulphate on self-compacting alkali-activated mortars (SCAAMs) produced using volcanic scoria (V), boron waste (B) and granulated blast furnace slag (G) together with alkali activators. Thus, the production of cement-free alkali-active mortar by recycling waste and reducing the CO2 effect increases the importance of this study. The fact that the waste material is provided free of charge and that V is readily available from nature provides economic advantages in the production of these mortars. In this experimental study, magnesium sulphate solution was utilized to define the sulphate resistance of SCAAMs. In binary SCAAMs, B was used with G in a ratio of NS:NH = 3.0, with an increase from 5 % to 15 %; in ternary mixtures, B was used together with G and V in the same proportions, in a ratio of NS:NH = 1.0. The tests involved immersion in 5 % magnesium sulphate solution for 1, 3 and 6 months. Mass development, compressive strength, visual inspection and microstructural changes were investigated. In general, the binary SCAAMs performed better in magnesium sulphate solution than the ternary SCAAMs, except in the 6th month. Considering the samples with the highest B content, a 100 % loss of compressive strength occurred in the B15G85 sample under the influence of sulphate for 6 months, while a loss of compressive strength of about 15 % occurred in the B15G40V45 sample. The results showed that the increase in B content caused a severe deterioration of the sulphate effect in the samples over time and that the V additive had a positive effect on the sulphate resistance.
AtıfScopus26WoS23OpenAlex19İncele - MakaleAçık Erişim2023Scopus SJRQ1Lutein/Zeaxanthin Isomers and Quercetagetin Combination Safeguards the Retina from Photo-Oxidative Damage by Modulating Neuroplasticity Markers and the Nrf2 Pathway
Sahin, Emre; Orhan, Cemal; Sahin, Nurhan; Padigaru, Muralidhara; Morde, Abhijeet; Lal, Mohan; Dhavan, Nanasaheb; Erten, Fusun; Bilgic, Ahmet Alp; Ozercan, Ibrahim Hanifi
Exposure to light-emitting diode (LED) light is a primary cause of retinal damage, resulting in vision loss. Several plant-derived substances, such as lutein and quercetagetin (QCG), show promise in supporting eye health. In this study, the impact of lutein/zeaxanthin (L/Z, Lutemax 2020) and QCG were evaluated individually and together in a rat model of LED-induced retinal damage. A total of 63 Wistar rats were allocated into nine groups (n = 7). For 28 days, the rats received L/Z (10 or 20 mg/kg BW), quercetin (QC, 20 mg/kg BW), QCG (10 or 20 mg/kg BW), or a mixture of different lutein and QCG dosages, after which they were exposed to LED light for 48 h. LED exposure led to a spike in serum malondialdehyde (MDA) and inflammatory cytokines, as well as an increase in retinal NF-κB, ICAM, GFAP, and MCP-1 levels (p < 0.0001 for all). It also reduced serum antioxidant enzyme activities and retinal Nrf2, HO-1, GAP43, NCAM, and outer nuclear layer (ONL) thickness (p < 0.0001 for all). However, administering L/Z and QCG, particularly a 1:1 combination of L/Z and QCG at 20 mg/kg, effectively reversed these changes. The treatment suppressed NF-κB, ICAM, GFAP, and MCP-1 while enhancing Nrf2, HO-1, GAP43, and NCAM and preventing ONL thickness reduction in LED-induced retinal damage rats. In conclusion, while LED light exposure caused retinal damage, treatment with L/Z, QC, and QCG, particularly a combined L/Z and QCG regimen, exhibited protective effects on the retina. This is possibly due to the modulation of neuroplasticity markers and nuclear transcription factors in the rats’ retinal cells.
AtıfScopus22OpenAlex22İncele - MakaleAçık Erişim2025Scopus SJRQ2Dual-effect of Holmium(III) oxide and Boron Carbide reinforcement on physical, microstructural evolution and gamma-ray shielding performance of 316L-SS
Yayla, Nihal; Albayrak, M. Gökhan; Güler, Ömer; Almisned, Ghada; Sen Baykal, Duygu; Alkarrani, Hessa; Kilic, Gokhan; Tekin, Huseyin Ozan
This study provides one of the first comprehensive evaluations of 316L stainless steel composites reinforced with 10 wt.% B4C and varying concentrations of Ho2O3, proposing a new compositional design for simultaneous structural enhancement and dual gamma-neutron shielding optimization. XRD analysis confirmed the predominance of the austenitic phase with minor martensitic peaks at higher Ho2O3levels. SEM and EDX results revealed uniform dispersion and improved densification with increasing oxide content. The 316L-B4C-20%Ho2O3composite exhibited the highest mass attenuation coefficient (0.8953 cm2/g) and linear attenuation coefficient (6.73 cm−1) at 0.1 MeV, demonstrating superior gamma-ray shielding capability. The effective electron density increased from 2.86 × 1023to 5.82 × 1023electrons/cm³, while the energy absorption buildup factor (EABF) showed a consistent decrease with higher oxide concentrations. Although a slight reduction in fast neutron removal cross-section was observed, the composite maintained satisfactory neutron attenuation performance. Overall, the findings indicate that the 316L-B4C-20%Ho2O3system offers a promising balance between structural stability and dual radiation protection, making it a strong candidate for next-generation nuclear shielding materials.
AtıfScopus1İncele - MakaleAçık Erişim2023Scopus SJRQ4New Approaches to Predict the Sperm Quality by the Spermatozoal miRNA Content in Fish: A Review
Kocabaş, Filiz Kutluyer; Kocabaş, Mehmet
The survival of the progeny and fertilization success depend on high-quality mature spermatozoa containing DNA and coding and non-coding RNAs besides the female gamete quality. Sperm cells and gonads in fish contain different RNA classes. It is possible that the development of fish could be affected by miRNA and/or other non-coding RNAs being abundant in Teleost fish and having important functions. Studies about the presence of miRNA in some fish species (e.g. Danio rerio, Salmo salar, Carassius auratus, Cyprinus carpio) showed that sperm motility is regulated by miRNA. Nevertheless, limited knowledge and several hypotheses have been presented about classes and content of RNAs in fish spermatozoa. More research about the effects of miRNA on fish reproduction and sperm quality are needed for population, aquatic ecosystems, and broodstock management, and the evaluation of molecular sperm quality parameters with miRNA could be used together with traditional techniques.
AtıfScopus4İncele - MakaleYalnız künye2023Scopus SJRQ2Novel electrochemical sensor of nebivolol drug used for treatment of hypertension and chronic heart failure
İpek, Yeliz; Koçak, Berna
Nebivolol is a beta-blocker used to treat high blood pressure and heart failure. Nebivolol is a cardiovascular drug in the group of selective beta-blockers (with selective action on the cardiovascular system). It prevents the increase in heart rate and controls the pumping power of the heart. It also has a dilating effect on blood vessels and helps to lower blood pressure with this effect. The ability to analyze nebivolol quickly, simply, economically and reliably is of high importance in two cases. The first is to adjust the drug dosage to be used by the patients, and the second is to provide fast intervention in the drug production process as a result of fast and accurate quality control in drug production and to provide quality control of produced tablets. Since, the boric acid has a good catalytic activity and enhances the peak current intensity, a boric acid‒glutardialdehyde-modified glassy carbon electrode was designed for investigation of electrochemical behavior and quantitative determination of nebivolol (NBV) in this study. Electrochemical reaction peak and the peak current intensity changes with changing NBV concentration provide detection of NBV. The role of glutardialdehyde was to immobilize the boric acid on the electrode surface with its crosslinking ability. The designed electrode was achieved by dropping boric acid‒glutardialdehyde mixture on glassy carbon electrode and drying it at room conditions. By using boric acid‒glutardialdehyde-modified glassy carbon electrode (BA‒GA2/GCE), quantitative analysis of the active drug ingredient (NBV), which is widely used in the treatment of hypertension and chronic heart failure, was carried out sensitively, selectively and at low detection limits with low cost. This electrode exhibited good repeatability and stability for detection of the oxidation peak of NBV. In addition, the working ranges and detection limits of NBV were determined in the optimum experimental conditions. SWV technique was used and according to the results obtained, LOD values for NBV in BR buffer (pH 9) and in urine samples were 1.0 × 10−7 mol L−1 and 4.12 × 10−7 mol L−1, respectively. The feasibility of the developed novel sensor was demonstrated by performing recovery studies with tablet and urine samples containing NBV. The recovery results were 93.10% and 58.16% for urine and tablet samples, respectively. Graphical abstract: [Figure not available: see fulltext.]
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2024Scopus SJRQ1Impact of a Novel Valerian Extract on Sleep Quality, Relaxation, and GABA/Serotonin Receptor Activity in a Murine Model
Sahin, Kazim; Gencoglu, Hasan; Korkusuz, Ahmet Kayhan; Orhan, Cemal; Aldatmaz, İsmail Ertuğ; Erten, Fusun; Er, Besir; Morde, Abhijeet; Padigaru, Muralidhara; Kilic, Ertugrul
Insomnia is a major global health issue, highlighting the need for treatments that are both effective and safe. Valerian extract, a traditional remedy for sleep problems, offers potential therapeutic options. This research examined the potential sleep-enhancing effects of VA (Valerian Pdr%2) in mice. The study evaluated sleep quality by comparing the impact of the VA extract against melatonin on brain activity, using electrocorticography (ECoG) to assess changes in brain waves. For this purpose, the study utilized two experimental models on BALB/c mice to explore the effects of caffeine-induced insomnia and pentobarbital-induced sleep. In the first model, 25 mice were assigned to five groups to test the effects of caffeine (caffeine, 7.5 mg/kg i.p) alone, caffeine with melatonin (2 mg/kg), or caffeine with different doses of valerian extract (100 or 300 mg/kg) given orally on brain activity, assessed via electrocorticography (ECoG) and further analyses on the receptor proteins and neurotransmitters. In the second model, a different set of 25 mice were divided into five groups to examine the impact of pentobarbital (42 mg/kg) alone, with melatonin, or with the valerian extract on sleep induction, observing the effects 45 min after administration. The study found that ECoG frequencies were lower in groups treated with melatonin and two doses of valerian extract (100 and 300 mg/kg), with 300 mg/kg showing the most significant effect in reducing frequencies compared to the caffeine control group, indicating enhanced sleep quality (p < 0.05). This was supported by increased levels of serotonin, melatonin, and dopamine and higher levels of certain brain receptors in the melatonin and valerian extract groups (p < 0.05). Modulatory efficacy for the apoptotic markers in the brain was also noted (p < 0.05). Additionally, melatonin and both doses of VA increased sleep duration and reduced sleep onset time compared to the pentobarbital control, which was particularly notable with high doses. In conclusion, the findings suggest that high doses (300 mg/kg) of valerian extract enhance both the quantity and quality of sleep through the GABAergic pathway and effectively increase sleep duration while reducing the time to fall asleep in a pentobarbital-induced sleep model in mice.
AtıfScopus19OpenAlex19İncele - BildiriYalnız künye2024An Analysis of Dependence Relationships Between Covid-19 Pandemic and Environmental Conditions Cases Study in Indonesia, England, and Türkiye
Handhayani, Teny; Caglar, Durdane Kocacoban
This study explores the causal relationships between environmental conditions and Coronavirus disease 2019 (COVID-19) using Bayesian networks in three geographically distinct cities: Jakarta (Indonesia), London (England), and Istanbul (Türkiye). The datasets collected from these cities span from January 2020 to October 2022, encompassing a variety of environmental variables (Particulate Matter (PM2.5), temperature, humidity, precipitation, wind speed, and Ultraviolet (UV) index) and COVID-19 variables (new cases, deaths, and population density). By using the PC algorithm and Greedy Equivalence Search (GES) to generate causal graphs, and applying the Intersection-Validation (InterVal) method to derive agreement graphs, this research reveals significant geographical differences in how environmental factors influence COVID-19 dynamics. The Peter-Clark (PC) algorithm identifies conditional dependencies, while GES optimizes the structure of the causal graph. The study highlights the significant impact of temperature, UV index, and humidity on COVID-19 dynamics, emphasizing the importance of localized public health strategies tailored to specific environmental conditions. These findings contribute to the understanding of environmental influences on COVID-19 and offer valuable insights for future research and policy-making aimed at mitigating the impact of pandemics in diverse geographical settings.
AtıfScopus3OpenAlex2İncele - MakaleAçık Erişim2024Scopus SJRQ1Fabrication and structural, physical, and nuclear radiation shielding properties for Oxide Dispersion-Strengthened (ODS) alloys through Erbium (III) oxide, Samarium (III) oxide, and Praseodymium (III) oxide into 316L matrix
Güler, Seval Hale; Güler, Ömer; Kavaz, E.; ALMisned, Ghada; Albayrak, M. Gökhan; Issa, Bashar; Tekin, H.O.
We report a comprehensive investigation on customization process of Oxide Dispersion-Strengthened alloys through Sm2O3, Pr2O3, and Er2O3 incorporation into 316L stainless steel matrix in terms of a desired enhancement in structural, physical, and nuclear radiation shielding properties. Oxide powders are incorporated into 316L stainless steel powder all with the same purity of 99.5%. These were Erbium oxide (Er2O3), Praseodymium oxide (Pr2O3), and Samarium oxide (Sm2O3). First, X-Ray diffraction and Scanning Electron Microscope/Energy-dispersive X-ray spectroscopy analyses are conducted in order to investigate their physical and structural properties. Next, two different experimental setups are employed using a133Ba and 241Am/Be sources for the measurements of gamma-ray and neutron transmission properties of Oxide Dispersion-Strengthened alloys. The maximum density increment is achieved through Er2O3 compared to other reinforced oxides. The detector counting value reached its minimum level when a 5% Er2O3 oxide dispersion was introduced into the 316L SS matrix. Similarly, the most significant degree of photon absorption, the highest values of mass attenuation coefficient, lowest half value layer, and most effective atomic number, were all attained by the same sample. Based on the findings derived from the investigation, it can be concluded that incorporating Er2O3 oxide into 316L steel can be considered as a viable option in terms of enhancing the critical properties of Oxide Dispersion-Strengthened alloys for extreme conditions such as nuclear reactors and other similar fields, where the behavioral attributes of the utilized materials are at utmost importance.
AtıfScopus22OpenAlex25İncele
