Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2023/r/munzur/6414
  The Antioxidant Capacities and Antimicrobial Activities of Some Salvia L. Seeds

  Ökkeş; Yılmaz, Okkes; Yilmaz; Kurşat, Murat; Kirbag, Sevda; Civelek, Şemsettin; Emre, Irfan; Sönmez, Pınar Erecevıt; Emre, Mustafa Yunus

  The goal of present study is to find the penolic contents, antioxidant activities and antimicrobial capacities in the seeds of five Salvia L. taxa two of which are endemics (Salvia euphratica var. leiocalycina and Salvia euphratica var. euphratica). The flavonoid and phenolic acid are determined by using HPLC while the antioxidant activities are determined based on different methods. Also, the antimicrobial activities of some Salvia species are determined by using the well agar method. The current study found that the studied Salvia species have low flavonoid. It has been found that Salvia euphratica var. euphratica has high vanillic acid, ferulic acid and rosmarinic acid among the studied taxa. Similarly, it has been found that Salvia euphratica var. euphratica has high DPPH and ABTS radical scavening capacity in all concentrations. It has been also found that Salvia euphratica var. euphratica has highest total phenolic content (372,63±0,87 µgGAE/mg) whilst Salvia tricholoda has low total phenolic content (46,41±1,71 µgGAE/mg). In addition, this study demonstrated that Salvia tricholoda has lowest metal chelating activity (37,35±0,51%). Furthermore, present study found that the lipid peroxidation levels of the studied Salvia taxa are between 18,21±0,37 mg/kg and 21,03±0,22 mg/kg while it has been found that the antibacterial properties of the Salvia taxa under study are altering.

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  AtıfOpenAlex1·TR Dizin1

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• MakaleAçık Erişim2023Scopus SJRQ2/r/munzur/1930
  Shape Memory Polymer-Based Nanocomposites Magnetically Enhanced with Fe3O4 Nanoparticles

  Pekdemir, Mustafa Ersin; Aydin, Derya; Selçuk Pekdemir, Sibel; Erecevit Sönmez, Pınar; Aksoy, Edanur

  This work aimed to investigate the effect of magnetic Fe3O4 nanoparticles (MNP), which are known to have a wide range of applications in recent years, on nanocomposite films prepared with shape memory polymers. Herein, PLA–PEG blend nanocomposite films were prepared by solution casting method using MNP at different ratios. PLA–PEG Blend/MNP nanocomposite films were characterized with Attenuated total reflection infrared spectroscopy (ATR-IR) to determine the –C=O stretching of PLA and Fe–O stretching signals of Fe3O4. The thermal stability, morphology, and magnetic behavior were studied by comparing the results among PLA–PEG blend, PLA–PEG blend/MNP nanocomposite with thermogravimetric analyses (TGA), differential scanning calorimetry (DSC), scanning electron microscopy (SEM), and a vibrating sample magnetometer (VSM), respectively. The effect of MNP on the shape memory properties of PLA/PEG blend was investigated. Moreover, the comparison of antimicrobial activity between PLA/PEG blend and PLA–PEG blend/MNP nanocomposite films were conducted by the disk diffusion method. The results showed that MNP increased the thermal stability of the PLA/PEG blend and the nanocomposites inhibited the growth of C.albicans microorganism. Graphical Abstract: [Figure not available: see fulltext.].

  AtıfScopus41·WoS39·OpenAlex42

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• MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2865
  Synthesis, characterization, and evaluation of antimicrobial performance of N-[3-(dimethylamino)propyl]methacrylamide based copolymer on pathogens

  Pıhtılı, Güzin; Erecevit Sönmez, Pınar; Biryan, Fatih; Torğut, Gülben

  In this study, poly{N-[3-(dimethylamino) propylmethacrylamide-co-acrylonitrile}; [P(DMAPMA-co-AcN)] copolymer was polymerized by free radical polymerization (FRP) in the presence of azobisisobutyronitrile (AIBN) initiator at 60°C. The structure of the synthesized polymer was characterized by the Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) methods. The bactericidal and fungicidal effects of the solutions prepared by adding methanol to this copolymer to prevent the growth of pathogenic bacteria, yeast, and fungi were evaluated by disk diffusion and broth microdilution method. Since the resistance of bacteria, yeast and fungi, which adversely affect human health, to antibiotics is an important issue, and there has not been any study on the antimicrobial properties of this copolymer, it has directed us to investigate its antimicrobial properties. According to antimicrobial susceptibility tests: The polymer solution showed a broad spectrum of antimicrobial action with 12.3–14.3 mm/inhibition zone diameter on Pseudomonas aeruginosa, Klepsiella pneumoniae, Enterococcus faecalis bacteria, Candida tropicalis, Epidermophyton floccosum yeast and fungi and showed a narrow spectrum of effect on inhibition of the growth of Candida albicans with 10.3 mm/inhibition zone diameter. No antimicrobial effects were observed on Staphylococcus aureus. The minimum inhibition concentration (MIC) value on the test microorganisms was determined as 125–31.25 μl. The data obtained prove that the polymer is in the same group as the interaction of bactericidal and fungicidal drugs. It is also important as a polymer with antimicrobial properties. This study aimed to produce a new polymer with antimicrobial properties. This polymer can be a new and yielding antimicrobial representative in different areas.

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  AtıfScopus1·WoS1·OpenAlex1

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• MakaleAçık Erişim2021/r/munzur/6648
  Nhibitory Property of Poly (AN-co-VP) Copolymer on Some Dermatophyte Fungiand Yeasts Causing Fungal Infections

  Torgut, Gulben; Kirbag, Sevda; Sönmez, Pınar Erecevıt; Pıhtılı, Güzin

  Antimicrobial susceptibility test for poly (AN-co-VP) copolymer, which we think could be an ideal drug in treatment interventions was evaluated with disk diffusion method and minimum inhibitor concentration. In the antimicrobial measurement data, it was determined that the poly (AN-co-VP) copolymer dissolved in pure water is a significant inhibitory property against the growth of yeast (on Candida spp. with 11.33±0.3 mm barrier area) and dermatophyte fungi (on Epidermophyton sp. and Trichophyton sp.with 12.33±0.3 mm barrier area) (p<0.001) and no inhibitory properties were observed in preventing the growth of all bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus megaterium). MIC limit values that prevent the growth of dermatophytes and yeasts supporting the disc diffusion method are 50-100 μL. This study is an alternative approach in order to limit the spread of superficial fungal infections they cause and eliminate these infections that tend to become chronic since this polymer extract has no inhibitory properties on bacteria but prevents the growth of yeast and dermatophytes.

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• MakaleYalnız künye2021/r/munzur/6605
  İnsanlarda Ciddi Hastalıklara Neden Olan Bakteri, Maya ve Dermatofit Mantarları Üzerinde Poly (DMAA-co-MMA) 'nin İnhibe Edici Etkisi

  Kirbag, Sevda; Sönmez, Pınar Erecevıt; Pıhtılı, Güzin

  Bu çalışmada insanlarda ciddi hastalıklara neden olan bakteri, maya ve dermatofit mantarları gibi mikroorganizmalar üzerindeki poli dimetilakrilamid-ko-metilmetakrilat’ın poli P (DMAA-co-MMA) diklorometan içeren çözeltilerinin inhibitör etkilerini araştırıldı. Disk difüzyon yöntemi ile incelenen bu çözelti, Bacillus megaterium ve Klebsiella pneumoniae dışındaki tüm bakterilerin (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus) ve dermatofit mantarlarının çoğalmasını engelleyerek antimikrobiyal özelliğe sahiptir. Antimikrobiyal duyarlılık verilerinde, diklorometan içinde çözünen poli P (DMAA-ko-MMA) maya ve dermatofit mantarlarının büyümesine karşı inhibe edici bir etkiye sahiptir (Candida spp. üzerinde 11.3mm / inhibisyon alanı - 12.3 mm / inhibisyon alanı) ve Epidermophyton sp. üzerinde 11.3 mm / inhibisyon alanı - Trichophyton sp. üzerinde 11.3 mm / inhibisyon alanı) (P &lt;0.001). Disk difüzyon yöntemini güçlendiren MIC (Minimal inhibisyon konsantrasyonu) sınır değerleri bakteriler, mayalar, dermatofitlerin büyümesini engelleyen en küçük değer olarak 50-100 μL'dir (10 mL de 4500- 9000 μg). Antimikrobiyal bileşik, gelecek bu alandaki çalışmaları aydınlatmak için büyük avantaj sağlayabilir. Çalışmada kullanılan polimer, iltihaplanma ve mantar enfeksiyonlarına neden olan mikroorganizmalar ile savaşan antimikrobiyal polimerlere umut verici yeni bir katkı sağlayacaktır.

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• MakaleAçık Erişim2021/r/munzur/5885
  Antibacterial and Antifungal Features of Centaurea urvillei DC. subsp. urvillei that is herboized in Turkey

  Cakilcioglu, Ugur; Sönmez, Pınar Erecevıt

  Although there are many studies on the activities of different species, the compounds and effects of Centaurea L., the largest genus of the Turkish flora, on human health, no relevant studies have been conducted on the antimicrobial properties of the usable parts (above ground leaves, flowers) of C. urvillei DC. subsp urvillei against pathogenic microorganisms.This study aimed to show whether it prevents the growth of these microorganisms that cause infectious diseases in humans on bacteria, yeast, dermatophytes that cause infectious diseases in humans via well agar and microdilution method by applying a methanol solution of the usable parts of C. urvillei DC. subsp. urvillei. Regarding the antimicrobial susceptibility results, the plant solution formed a generally sensitive inhibition zone (14.66 mm-11.66 mm inhibition zone-1 diameter) on inhibition of growth of yeast, dermatophyte isolates and other bacteria. This means that 40 mg dose of C. urvillei DC. subsp. urvillei has antibacterial and antifungal that can prevent the growth of all test microorganisms (Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212, Klepsiella pneumoniae clinical isolate, Candida albicans RSKK 02007, Candida glabrata RSKK 014019, Candida tropicalis RSKK 02011, Epidermophyton floccosum RSKK 14024, Trichophyton rubrum RSKK 03022) that cause disease. It is seen when we compared with the control group that there was no significant difference in bacteria, however, a significant difference was observed in yeast and dermatophytes (p

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  AtıfOpenAlex2·TR Dizin1

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• MakaleYalnız künye2021Scopus SJRQ4/r/munzur/3198
  Balneotherapy Features of Natural Thermal Source from Pertek (Turkey-Tunceli) Due to Its Some Chemical, Radioactivity and Biological Parameters

  Sönmez, Pinar Erecevit

  It can also be defined as a discipline that reviews the factors of balneology or hydrotherapy, which are alternative treatment methods for public health, from chemical, biological and medical aspects. In this study, it was aimed to investigate whether the underground waters in the Pertek district of Tunceli province are suitable for balneology. Chemical, radioactivity analysis, microbiological quality, antimicrobial activities were determined in relation to natural groundwater and its ability to be a natural healing source was investigated. When the chemical content is examined, it was determined to be bromide amount is 0.24 mg / L, Iodine (I); 1.9 mg / L, sulfur (S); 0.02 mg / L, boron (B): 2676 µg / L, silicium (Si); 1.9 mg / L. With respect to the results, thermal water has the feature to be used in balneolotherapy. According to the results of the radioactivity analysis, alpha (α) is 0.15 Bq / L; Beta (β) is <0.30 Bq / L and radon (Rn) is <13.4 Bq / L tritium (T) content is <10 Bq / L (<83.33 TB) and it is included in both mineral and young water group. This ground water and they comply with the standards in terms of microbiology (Total bacteria, coliform, Escherichia coli). Its antibacterial, antifungal and antidermatophyte properties prove to be a healing source. We confirmed the effectiveness of this healing water to both protect and promote human health as a drinking cure and reach the newest and most effective treatment modalities by using related water in Health and Thermal Tourism.

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• MakaleAçık Erişim2021/r/munzur/3018
  The antioxidant and antimicrobial capacities of phenolic profiles of some Salvia L. Seeds grown in Turkey

  Emre, Irfan; Kursat, Murat; Kirbag, Sevda; Erecevit, Pinar; Emre, Mustafa Yunus; Yilmaz, Okkes; Civelek, Semsettin

  The aim of current study is to show phenolics, antioxidant capacities and antimicrobial activities of seeds of five Salvia L. (S. frigida Boiss., S. candidissima subsp. candidissima Vahl., S. virgata Jacq., S. verticillata L. var. verticillata and S. russellii Benth.) taxa grown in Turkey. The flavonoid and phenolic acid contents were measured by using HPLC whilst the antioxidant capacities were determined by using different methods. In addition, agar well diffusion method was used to determine the antimicrobial activities of Salvia species in this study. It was found that S. frigida, S. verticillata var. verticillata and S. russellii have the highest catechin contents and S. frigida and S. verticillata var. verticillata have high rosmarinic acid while S. frigida, S. candidissima subsp. candidissima and S. verticillata var. verticillata have high vanilic acid. Also, it was determined that S. frigida and S. verticillata var. verticillata have high DPPH radical scavenging activities in 150 and 250 µL while S. frigida and S. verticillata var. verticillata have highest ABTS radical scavenging activity in all concentrations apart from 25 µL for S. frigida. Furthermore, S. frigida and S. verticillata var. verticillata have high total phenolic contents. On the other hand, Salvia species have similar lipid peroxidation inhibitions. However, the metal chelating activities of Salvia species are different. And also, it was demonstrated that Salvia taxa have antimicrobial activity.

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  AtıfScopus7·OpenAlex7·TR Dizin2

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• MakaleAçık Erişim2020/r/munzur/6729
  Screening of Antimicrobial Effect against Microorganisms Threatening to Human Health of the Endemic Plant; Centaurea saligna (C. Koch) Wagenitz from Turkey

  Cakilcioglu, Ugur; Sönmez, Pınar Erecevıt

  In this study, the antimicrobial effect researched on microorganisms threatening to human health of extract including methanol of Centaurea saligna that is endemic and used for therapy of many diseases. For disk diffusion method, this related extract is highly effective on the gram negative bacteria by its 20.3±0.5 mm inhibition area. Again to relation bacteria, gram positive bacteria are highly effective by 18.3±0.57 mm and 20.3±0.5 mm inhibition area. It has a effect against Candida species and Epidermophyton sp., the superficial skin infections are caused, by 9.6±0.5 mm and 13.6±1.5 mm inhibition area. On the other hand, for findings, this related extract is extremely effective against Trichophyton sp. that is one of dermatophyte fungi by 24.6±1.5 inhibition area. This natural extract shows its antimicrobial effect namely, by minimal inhibition value (MIC): 6.25 µL its lowest inhibition value against development of all the bacteria and dermatophyte fungi. This plant has a potential to be a natural antimicrobial agent to be used as a medicine for human health and life quality.

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  AtıfOpenAlex5·TR Dizin2

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• MakaleAçık Erişim2020/r/munzur/3651
  Reviewing Phlomis rigida Labill From Turkey as a Antimicrobial Efficacy

  Sönmez, Pınar Erecevit; Kirbağ, Sevda; Çakilcioğlu, Uğur

  This work researched the inhibitory properties of the extract of Phlomis rigida Labill plant including chloroform on gram-negative and positive bacteria, yeasts and dermatophyta; the related plant is used for therapeutic purpose in public. For the disk diffusion method, this extract is effective on Pseudomonas aeruginosa that is one of the negative bacterias by 11.33 ± 0.57 mm inhibition areas. Regarding other bacterias, the effect of the related extract is so low in avoiding the improvement of Escherichia coli, Staphylococcus aureus and Bacillus megaterium by 8.33 ± 0.57 mm inhibition area. It has highly effective on Trichopyton sp. and Candida albicans that are from dermatophytes fungis and yeast by 16.33 ± 0.57 mm inhibition area. About yeast and dermatophytes fungi it has a remarkable impact on Candida glabrata (14.33 ± 0.57 mm inhibition area), Epidermophyton sp. (12.33 ± 0.57 mm inhibition area). Antimicrobial activity of this natural extract against all the microorganisms that were tested by MIC method by concentrations vary by 100 uL and 6.25 uL. Acording to this; the results showed good inhibitory effect with 6.25 μL for C. albicans, Trichophyton sp. with 12.25 μL for C. glabrata. In the other hand it is effective with 25 μL for P. aeruginosa, Epidermophyton sp. with 50 μL for E. coli, S. aureus, B. megaterium. Being used plants for medical purposes as from since the early ages show that these plants can be used as alternatives of available antibiotics; including important medical components is the other reason for being an alternative at the same time. Concerning results, P. rigida can be utilized as a therapeutic drug for the healing of infections caused by microorganisms. In this study, we believe that the P. rigida is important in the search for new antibiotics and will contribute to the literature and the world of drug as it affects different types of microorganisms at the lowest level for the first time.

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  AtıfScopus4·OpenAlex6·TR Dizin1

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