Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2026Scopus SJRQ4/r/munzur/629
  Protective effects of Sodium Tetraborate on fatty acid profiles in rat hearts subject to Lead toxicity; [Efecto protector del tetraborato de sodio sobre los perfiles de ácidos grasos en el corazon de ratas, expuestas a toxicidad por plomo]

  Aydin, Sevinç

  This study was designed to observe the effects of sodium tetraborate on preventing lead metal toxicity damage to fatty acids in rat heart tissue. After the heart tissues were homogenized with Tris-HCl buffer, the separated pellet part was prepared for fatty acid analysis. The fatty acids in the obtained lipid extract were converted to methyl ester form and analyzed with SHIMADZU GC 2010 PLUS gas chromatography. When comparing the lead group with the lead + sodium tetraborate group, partial increases were observed in saturated fatty acid levels such as myristic acid (14:0), pentadecanoic acid (15:0), and palmitic acid (16:0), while varying increases were seen in some monounsaturated fatty acid levels such as palmitoleic acid (16:1, n-7), and oleic acid (18:1, n-9). Moreover, demonstrated varying levels of increases in all polyunsaturated fatty acids excluding the arachidonic acid (20:4, n-6) and adrenic acid (22:4, n-6) fatty acids. As the most notable fatty acid change in our study, arachidonic acid (20:4, n-6) fatty acid increasing in the lead group while decreasing in the sodium tetraborate group demonstrates that sodium tetraborate decreased the negative effects of oxidative stress on fatty acids. The results of this study provide supporting evidence for the potential use of sodium tetraborate in drug design to prevent the toxic effects of lead.

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• MakaleAçık Erişim2025Scopus SJRQ4/r/munzur/1905
  Protective effect of Momordica charantia against Hepatorenal toxicity induced by Potassium bromate (KBrO3) in rats; [Efecto protector de Momordica charantia contra la toxicidad hepatorrenal inducida por el bromato de potasio (KBrO3) en ratas]

  Karagözoğlu, Fatma; Uyar, Ahmet; Akkoyun, Hurrem Turan; Altun, Serdar; Akkoyun, Mahire Bayramoğlu; Aydin, Sevinç; Melek, Sule; Bengü, Aydın Şükrü; Ekin, Suat; Bakir, Ahmet

  This study aims to evaluate the effects of Momordica charantia on hepatorenal toxicity caused by potassium bromate (KBrO3) in rats. Wistar rats were divided into 4 groups as control, KBrO3, bitter melon (MC), and KBrO3+MC. Examining the antioxidant enzyme grade of the kidney tissues, it was found that the enzyme activities of catalase (CAT) (P<0.05), glutathione peroxidase (GSH–Px) (P<0.01), and superoxide dismutase (SOD) (P<0.01) decreased in the KBrO3 group in comparison to the control. There was a significant decrease (P<0.001) in glutathione (GSH) levels and an increase (P<0.01) in malondialdehyde (MDA) level in the KBrO3 group in comparison to the control. Examining the antioxidant enzyme activities in liver tissue, it was determined that CAT, GSH–Px, and SOD enzymes reduced significantly (P<0.05, P<0.01, and P<0.001, respectively) in the KBrO3 group in comparison to the control, and the enzyme activity of decreased CAT, GSH–Px, and SOD enzymes significantly elevated (P<0.01) in the MC group. There was a reduction in GSH level in the KBrO3 group in comparison to the control (P<0.01), while an increase was recorded in the KBrO3+MC group (P<0.05). MDA level in liver tissue increased in KBrO3 group in comparison to the control (P<0.01) and MC decreased the MDA level. Histopathological analysis results indicate severe degenerative and necrotic lesions in hepatorenal histoarchitecture of KBrO3 rats in comparison to the control. However, application of MC+KBrO3 significantly reduced the induced hepatorenal injury with a concomitant increase in histopathological lesions. From the immunohistochemical aspect, MC revealed apoptosis concomitant with the suppression of necrosis in the KBrO3-treated rats as demonstrated by the caspase-3 activity.

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  AtıfOpenAlex1

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• MakaleAçık Erişim2025Scopus SJRQ4/r/munzur/1478
  Protective Effect of Sumac and Terebinth Extracts Against the Negative Effects of Breast Cancer on Cardiac Tissues of in Rats; [Efecto protector de los extractos de zumaque y terebinto contra los efectos negativos del cáncer de mama en los tejidos cardíacos de ratas]

  Erişir, Figen Erdem; Aydın, Sevinç; Tuzcu, Zeynep; Yılmaz, Ökkeş

  Due to the toxic side effects of chemotherapeutic drugs used in breast cancer, interest in medicinal plants has increased in order to develop alternative cancer drugs. The experimental model of this study was created to observe the remedial impacts of the Terebinth (Pistacia terebinthus L.) and the Sumac (Rhus coriaria L.) plants against the negative effects of 7,12-Dimethylbenz[a]anthracene induced breast cancer on cardiac tissues in rats. For this purpose, the levels of malondialdehyde were analyzed the indicator of the oxidative stress breast cancer will cause on cardiac tissues, the catalase, glutathione transferase and superoxide dismutase enzymes, glutathione, which holds and important place among antioxidant impacts and proteins. At the end of the study, it was determined that there was an increase in malondialdehyde levels, a decrease in glutathione and protein amounts, and a decrease in antioxidant enzyme levels in rats treated with cancer-induced 7,12-Dimethylbenz[a]anthracene.

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• MakaleAçık Erişim2024/r/munzur/6292
  Allelopathic Effects of Essential Oils In Some Medicinal And Aromatic Plants on The Development of Oilseed Plants

  Aydın, Sevinç; Karaca Sanyürek, Nesrin; Yaman, Hümeyra; Yılmaz, Ömer

  Traditional methods used to increase plant productivity from the past to the present cause problems owing to their toxicological effects on organism resistance and living things. This has stipulated the creation of strategies to boost plant productivity without adversely affecting the health of living things. Essential oils secreted from various parts of plants stand out as, sustainable, and improvable alternatives and have been the subject of numerous types of research as they have many functional properties. The present research covers the investigation of the allelopathic effect of essential oils of Greek Oregano (Origanum vulgare L. subsp. hirtum), Lavandin (Lavandula x intermedia), and common sage (Salvia officinalis L.) on oilseed plants (Cephalaria syriaca L., Camelina sativa L.) at different ratios. Inhibitory effects of the essential oils obtained by hydrodistillation on the seeds of Cephalaria syriaca L. and Camelina sativa L. species at different concentrations were analyzed under sterile in vitro conditions. The inhibitory effects of essential oils and concentrations were analyzed using the Friedman test. The research revealed that essential oils were effective in weed control through their high inhibitory effect against Cephalaria syriaca L. seeds while reducing the germination power of Camelina sativa L.

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  AtıfOpenAlex2

  İncele
• Kitap BölümüYalnız künye2024/r/munzur/2056
  Effect of ecosystems and agricultural practices on Physalis peruviana phytochemicals

  Aydin, Sevinc

  As a result of the gradual decrease in natural resources and the increase in chronic diseases caused by unhealthy nutrition, the inclination among consumers toward food products that are both biologically active and beneficial, and environmentally friendly, is increasing. Therefore, environmental factors and agricultural practices that affect the amount of biologically active ingredients in these products have gained importance and become the subject of numerous scientific studies. Goldenberry (Physalis peruviana) is a yearly plant that is grown in mild climates, and it is a plant that is first planted in seed trays for primary development and then in the field for fruit production. Both its leaves, trunk, and roots have medicinal properties and its fruit is rich in components such as vitamins A and C, iron and phosphorus, flavonoid, and carotenoid which have made this plant, and particularly its fruit, more attractive. The amount and biological effect of these components, which are known as secondary metabolites, vary depending on the soil and the climate where this plant is grown and agricultural practices. With this compilation study, our aim is to summarize the studies that examined the positive or negative effects of environmental conditions that affect goldenberry cultivation and agricultural practices applied to increase the yield of the bioactive phytochemical ingredients of this plant, and thus to provide insight for relevant studies to be conducted.

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  AtıfScopus6·OpenAlex5

  İncele
• MakaleYayıncıda açık erişim2023Scopus SJRQ3/r/munzur/3085
  Vitamin content and MDA levels of certain white grape varieties from different altitudes in Turkey

  Akbaba, Emel; Aydın, Sevinç; Sanyürek, Nesrin Karaca; Çakır, Atilla; Erişir, Figen Erdem

  Grapevine (Vitis vinifera L.) is regarded as one of the world’s most important fruit crops in terms of acreage and commercial worth. Grapes are used to make not only wine but also fresh fruit, dried fruit, and juice. The quality of grapes or wine is significantly affected by environmental factors such as altitude, soil type, and climate. In this study, the 5 white grape varieties (Ağın beyazı, Tahannebi, Kabarcık, Şilfoni, and Besni) grown at different altitudes (800 m, 1000 m and 1200 m) in Turkey were investigated for their vitamin, and phytosterol concentrations as well as lipid peroxidation content. Şilfoni grape harvested at 800 m was found to possess the lowest lipid peroxidation content. High altitudes, were found to reduce lipid peroxidation contents in the Ağın beyazı, Tahannebi, and Kabarcık strains. The highest stigmasterol (98.34 μg/g), and beta-sitosterol (86.90 μg/g) concentrations were found within Şilfoni grape variety harvested at 800 m. The highest vitamin D-2 and D-3 levels were found in Ağın beyazı (1.39 μg/g) and Kabarcık (4.13 μg/g) grape varieties, both harvested at 1200 m. Kabarcık grape, however, revealed the highest concentrations of R-tocopherol (63.09 μg/g) and alpha-tocopherol (24.13 μg/g) at 1200 m within the samples. The highest vitamin K-2 level was determined within the Tahannebi grape (15.44 μg/g) from 1200 m. It was observed that the vitamin and phytosterol concentrations of white grape varieties tended to increase, while the lipid peroxidation values tended to decrease at high altitudes, especially at 1200 m. This study also exhibited a strong relationship among Vitamin D3, R-tocopherol, and alpha-tocopherol in the studied white grape cultivars.

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  AtıfScopus5·WoS5·OpenAlex3

  İncele
• MakaleYalnız künye2023Scopus SJRQ2/r/munzur/2396
  The protective effect of arbutin against potassium bromate-induced oxidative damage in the rat brain

  Akkoyun, H. Turan; Uyar, Ahmet; Bayramoglu Akkoyun, Mahire; Bengü, Aydın Şükrü; Melek, Şule; Karagözoğlu, Fatma; Aydın, Sevinç; Ekin, Suat; Erdem, Sinem Aslan

  This study aimed to investigate the protective effects of arbutin (ARB) against brain injury induced in rats with potassium bromate (KBrO3). The rats were divided into four groups as Group 1: Control (0.9% NaCl ml/kg/day p.), Group 2: KBrO3 (100 mg/kg (gavage), Group 3: ARB (50 mg/kg/day p.), and Group 4: KBrO3 + ARB (100 mg/kg (gavage) + 50 mg/kg/day p.). At the end of the fifth day of the study, the rats in all groups were killed, and their brain tissues were collected. In the collected brain tissues, malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) levels were measured, and routine histopathological examinations were made. The MDA levels in the group that was exposed to KBrO3 were significantly higher than those in the control group (p ˂ 0.001). In comparison to the KBrO3 group, the MDA levels in the KBrO3 + ARB group were significantly lower (p ˂ 0.001). It was observed that SOD and CAT enzyme activity levels were significantly lower in the KBrO3 group compared to the control group (p ˂ 0.001), while these levels were significantly higher in the KBrO3 + ARB group than in the KBrO3 group (p ˂ 0.001). Additionally, the group that was subjected to KBrO3 toxicity, as well as ARB administration, had much lower levels of histopathologic signs than the group that was subjected to KBrO3 toxicity only. Consequently, it was found that KBrO3 exposure led to injury in the brain tissues of the rats, and using ARB was effective in preventing this injury.

  AtıfScopus10

  İncele
• MakaleYalnız künye2023Scopus SJRQ3/r/munzur/1996
  Comprehensive Evaluation of the Relationships Between Grape Skin Color/Ripening Time and Antioxidative Capacity, Some Phytochemicals, and Fatty Acid Compositions of Their Seeds

  Çakır, Atilla; Odabaşıoğlu, Mehmet İlhan; Karaca Sanyürek, Nesrin; Aydın, Sevinç

  It has been proven that grapes, which are widely cultivated around the world, have positive health effects. However, the phytochemical composition of lesser-known local varieties of Vitis vinifera L., which has a very wide range of varieties, is still being studied. The aim of this study was to determine the effects of skin color and ripening time on the phytochemical compositions of grape seeds. As a plant material local grape varieties cultivated in Southeastern Anatolia (Turkey) were used. The results showed that grape skin color has an effect on vitamin K1, vitamin K2, vitamin D3, δ‑tocopherol, stigmasterol, ergosterol, myristic acid, oleic acid, trans-elaidic acid, and the monounsaturated fatty acid (MUFA) and saturated fatty acid (SFA) contents of seeds. The seeds of grape varieties with colored skins were richer in K2, D3, stigmasterol, oleic acid, trans-elaidic acid, and MUFAs, while the seeds of grape varieties with white skins were richer in K1, δ‑tocopherol, ergosterol, and SFAs. The ripening time of the grapes was found to have a partial effect on the fatty acid compositions of the seeds, but without any effect on linoleic acid contents. As the ripening time was delayed, there was an increase in oleic acid and MUFA contents of the seeds, while there was a decrease in SFA contents. In general, increased vitamin K1 contents of the seeds were parallel to decreases in vitamins K2, D2, and D3, as well as α‑tocopherol content and antioxidant activity. The seeds of grape varieties that have colored skins were found to have more suitable compound compositions for use in the production of functional foods that support human and animal health. In addition, it was concluded that grape berries that ripen late may be more favorable for grapeseed oil production.

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  AtıfScopus3·WoS4·OpenAlex3

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• MakaleAçık Erişim2022Scopus SJRQ2/r/munzur/2589
  Determination of trace element and fatty acid levels in tissues of mirror and scaly carp (Cyprinus carpio L., 1758) living in Keban Dam Reservoir (Elazig)

  Aydın, Sevinç; Akkoyun, H. Turan; Bayramoglu Akkoyun, Mahire; Bengu, Aydın Ş.; Ekin, Suat; Harlioğlu, Ayşe G.

  This study investigated the concentrations of some accumulated trace metals (iron, manganese, zinc and copper) and fatty acids in liver and muscle tissues of mirror and scaly carp varieties (Cyprinus carpio L., 1758) living in Keban Dam Reservoir (Elazig), which is the second-largest artificial lake in Turkey that hosts commercially valuable and preferred fish varieties for human consumption. The inductively coupled plasma mass spectrometry (ICP-MS) method was used to analyse the concentrations of trace elements. Fatty acid levels were measured in a gas chromatography mass spectrometry (GC–MS) device, using a flame ionization detector (FID). Considering the two fish varieties and tissues that were studied, the mean metal concentrations (μg g−1) were found in the following ranges: Fe 12.32–49.97, Mn 0.12–0.62, Zn 10.45–86.59 and Cu 2.74–11.86. Although the lowest levels were detected in the muscle tissue for all the metals examined, the levels in the liver tissue were significantly higher. According to the results of the analyses on fatty acid concentrations, the mean total saturated fatty acid levels in the muscle tissue of the scaly carp and mirror carp varieties were found to be 31.07 and 31.43 (%), respectively, whereas these values for the liver tissue were consecutively 22.36 and 22.08 (%). Successively, the mean total levels of unsaturated fatty acids were determined as 68.93 and 68.40 (%) in the muscle tissue and 77.64 and 77.92 in the liver tissue. This study, with the finding that the trace (metallic) element accumulation rates were below the upper limits of the tolerable range, and the examined fish varieties were rich in fatty acids, shows that mirror carp and scaly carp living in Keban Dam Reservoir are highly nutritious for human diets.

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  AtıfScopus1·OpenAlex2

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• MakaleAçık Erişim2022Scopus SJRQ3/r/munzur/2504
  SOME PHYTOCHEMICAL CONTENTS AND ANTIOXIDANT ACTIVITIES OF TWO PRANGOS LINDL. (UMBELLIFERA) SPECIES GROWN IN TURKEY

  Hayta, Şükrü; Aydin, Sevinç; Topdemir, Aykut

  The genus Prangos is a member of the Apiaceae family, and it has been a focus of the attention of researchers due to its high nutritional value and some special medical properties. In this study, the total phenolic and flavonoid contents and antioxidant activities of the leaf and fruit extracts of the Prangos ferulacea and Prangos uloptera species belonging to this genus were studied, and the properties of these two species were compared to each other. In the study, the Folin-Ciocalteu method was used for the analysis of the total phenolic content, methanolic formaldehyde was used for the total flavonoid content, and both analyses were carried out with a UV-VIS spectrophotometer device. The antioxidant activity of the specimens was measured based on the Trolox equivalent antioxidant capacity (TEAC) method. It was found that the P. ferulacea species had higher total phenolic and flavonoid content values than the P. uloptera species. The P. ferulacea species was also more effective in terms of antioxidant activity, which is known to be associated with these properties. When the fruit and leaf extracts of each species were compared, it was found that the total phenolic and flavonoid content of the fruit extract of the P. uloptera species was higher than that of its leaf extract, and the antioxidant activity of the fruit extract was also higher in proportion to these values. In the P. ferulacea species, as opposed to the case of P. uloptera, all values except for the total flavonoid values were higher in the leaf extract than the fruit extract.

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