Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2019Scopus SJRQ2Regulation of signaling pathways by β-elemene in cancer progression and metastasis
Qureshi, Muhammad Z.; Attar, Rukset; Romero, Mirna A.; Sabitaliyevich, Uteuliyev Y.; Nurmurzayevich, Sadykov B.; Ozturk, Ozlem; Wakim, Lara H.; Lin, Xiukun; Ozbey, Ulku; Yelekenova, Armida Bakhytbekovna
Entry of β-elemene into various phases of clinical trials advocates its significance as a premium candidate likely to gain access to mainstream medicine. Based on the insights gleaned from decades of research, it seems increasingly transparent that β-elemene has shown significant ability to modulate multiple cell signaling pathways in different cancers. We partition this multicomponent review into how β-elemene strategically modulates various signal transduction cascades. We have individually summarized regulation of tumor necrosis factor related apoptosis-inducing ligand, signal transducers and activators of transcription, transforming growth factor/SMAD, NOTCH, and mammalian target of rapamycin pathways by β-elemene. Last, we will discuss the results of clinical trials of β-elemene and how effectively we can use these findings to stratify patients who can benefit most from β-elemene.
AtıfScopus33OpenAlex33
İncele - MakaleAçık Erişim2018Scopus SJRQ3Maslinic acid as an effective anticancer agent
Lin, Xiukun; Ozbey, Ulku; Uteuliyev, Yerzhan Sabitaliyevich; Attar, Rukset; Ozcelik, Beraat; Zhang, Yuanyan; Guo, Mingyue; Liu, Minghua; Alhewairini, Saleh S.; Farooqi, Ammad Ahmad
Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid) is a naturally occurring pentacyclic triterpenic compound. Maslinic acid is gradually gaining attention as an excellent pharmacologically active product because of its premium biological properties. In this review we will focus on chemopreventive properties of Maslinic acid against different cancers. Seemingly, available data is limited and we have yet to unravel how Maslinic acid therapeutically targeted oncogenic cell signal transduction cascades in different cancers. Moreover, there are visible knowledge gaps about the ability of Maslinic acid to modulate oncogenic and tumor suppressor microRNAs in various cancers.
AtıfScopus20OpenAlex17İncele