Sürdürülebilir Kalkınma Amaçları
Yayınlar
- MakaleYalnız künye2026Scopus SJRQ3The relationship between muscle strength and oxygenation and activities of daily living in adolescents and young adults with pulmonary arterial hypertension
Dik, Jan; Topcuoglu, Ceyhun; Vardar-Yagli, Naciye; Goksuluk, Merve Basol; Aypar, Ebru; Alehan, Dursun; Saglam, Melda
Pulmonary arterial hypertension leads to dyspnoea, fatigue, and oxygen desaturation, limiting activities of daily living and functional capacity. This study aimed to evaluate the impact of pulmonary arterial hypertension on activities of daily living performance, functional capacity, peripheral muscle strength, oxygen dynamics, and energy expenditure. Eighteen adolescents and young adults with pulmonary arterial hypertension (10 females, 8 males; age 9–30 years) and 15 healthy controls (10 males, 5 females; age 9–30 years) were included. Peripheral muscle strength was assessed using a handheld dynamometer, functional capacity via the 6-minute walk test, and muscle oxygenation through near-infrared spectroscopy. Lower-limb endurance was evaluated with the 1-minute sit-to-stand test and activities of daily living performance with the Glittre Activities of Daily Living test. Compared to controls, the pulmonary arterial hypertension group had significantly lower 6-minute walk test distance (441.9 m versus 636.9 m; p < 0.001), reduced sit-to-stand repetitions (28 versus 42.1; p < 0.001), weaker peripheral strength, and lower minimum muscle oxygen saturation (24.9% versus 51.8%; p < 0.001). Glittre Activities of Daily Living test duration was longer (143 s versus 105 s; p < 0.001), with greater oxygen desaturation (−13% versus −1%; p < 0.001), higher dyspnoea scores using modified Borg scale (5 versus 1; p < 0.001), and blunted heart rate response (ΔHR [change in heart rate]: 32 versus 64; p = 0.011). These findings demonstrate that pulmonary arterial hypertension significantly impairs both cardiopulmonary and peripheral muscle function. Protecting muscle health and improving functional capacity should be prioritised to enhance quality of life in this population.
- BildiriYalnız künye2025Scopus SJRQ1Perceived learning after manual airway clearance techniques practice: peer learning vs. simulation-based learning
Cakmak-Onal, Aslihan; Aksel-Uylar, Aydan Asli; Saglam, Melda; Topcuoglu, Ceyhun; Vardar-Yagli, Naciye; Calik-Kutukcu, Ebru; Demirel, Aynur; Inal-Ince, Deniz
- MakaleYalnız künye2025Scopus SJRQ1Relationship between distance-saturation product of the 6-minute walk test and respiratory and peripheral muscle strength in renal transplant patients
Firat, Merve; Topcuoglu, Ceyhun; Aksel-Uylar, Aydan Asli; Saglam, Melda; Erdut, Arda; Yildirim, Tolga; Vardar-Yagli, Naciye
- MakaleAçık Erişim2025Scopus SJRQ1Effects of inspiratory muscle training on physical fitness in cystic fibrosis: a systematic review and meta-analysis
Aksel-Uylar, Aydan Asli; Topcuoglu, Ceyhun; Saglam, Melda; Vardar-Yagli, Naciye
Background: Cystic fibrosis (CF) is a multisystem disease primarily affecting the lungs. It impacts physical fitness due to increased bronchial secretions and exercise intolerance. Inspiratory muscle training (IMT) is recommended as a pulmonary rehabilitation approach. Therefore, we aimed to examine the effect of inspiratory muscle training on health-related physical fitness in CF. Methods: Articles were searched in five databases from inception to June 2025. All randomized controlled trials comparing IMT with a control group in individuals with cystic fibrosis were included. Four randomized controlled trials involving a total of 90 individuals with CF met the inclusion criteria. Results: A significant difference was found in the change in maximal work capacity, maximal minute ventilation, and exercise duration during the exercise test in the IMT group compared to the control group. However, no significant difference was observed in the change in maximal oxygen uptake, 6-minute walk test distance, and oxygen saturation during the 6-minute walk test between the IMT group and the control group. Conclusion: The therapeutic effectiveness of IMT for physical fitness is still uncertain. The evidence is not enough to assess how IMT can be used to enhance health-related physical fitness in CF. Further research should explore the optimal intensity and duration of IMT training needed to improve cardiorespiratory fitness. Additionally, future studies should evaluate how effective IMT is when examining its impact on health-related physical fitness.
