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- MakaleYalnız künye2020The Effect of Propolis on Oxidative Damage Induced by Whole Body Irradiation in Rat
Baykara, Murat; Erisir, Mine; Özçelik, Mehtap; Güler, Osman
The antioxidant and radioprotective effects of propolis against ionizing radiation induced oxidativedamage were investigated. Twenty one rats were divided in to 3 groups; 1 st group was the controlgroup; 2nd group was the irradiation group, physiological saline (i.p.)/ 3 days + 9 Gy gammairradiation; 3rd group was irradiation + Propolis group, propolis (i.p. 100 mg / kg BW) / 3 days + 9Gy gamma irradiation. As a result of irradiation, a significant increase was determined inmalondialdehyde (MDA) levels of liver, kidney, and brain tissues of the rats (P<0.001). There was asignificant decrease in glutathione peroxidase (GSH-Px) activity of all the tissues (P˂0.001) andsuperoxide dismutase (SOD) activity and glutathione (GSH) level in the liver (P˂0.01). Also, GSHlevel increased significantly in the kidney (P˂0.001) and ovarium tissues (P˂0.05). The MDA levelsthat increased in the liver as a result of irradiation, decreased significantly due the addition ofpropolis (P˂0.001); whereas, the MDA levels that increased in kidney and brain did not change. Inthe spleen and ovarium tissues, MDA levels decreased significantly as a result of addition ofpropolis compared to the irradiation group (P˂0.05). It was determined that GSH levels, thatdecreased in the liver (P˂0.01), and increased in the kidney due to addition of propolis, and GSHlevels, that decreased in the liver as a result of irradiation (P˂0.01) and increased in the kidney(P˂0.001), approached to the normal level (P˂0.001) and the GSH levels in the spleen and brainincreased compared to both the control and irradiation groups (P˂0.05). The addition of propoliscaused a decrease in the GSH-Px activities of heart, spleen, brain, and ovarium tissues comparedto both the control and irradiation groups (P˂0.001). Also, a decrease in the SOD activity of hearttissue compared to the control group was found (P˂0.05).
