Sürdürülebilir Kalkınma Amaçları
Yazarlar
- Tasar, Neslihan(3)
- Cakilcioglu, Ugur(2)
- Kiran, Yasar(2)
- Ak, Gunes(1)
- Açar, Mikail(1)
- Balos, Maruf(1)
- Baser, Birol(1)
- Custódio, Luísa(1)
- Dogan, Gulden(1)
- Doğan, Gülden(1)
- Erdogan, Tugce(1)
- Fernández-Ochoa, Álvaro(1)
- Gonenc, Tuba(1)
- Hayta, Sukru(1)
- Jiménez, Francisco-Javier Leyva(1)
- Kiran, Yaşar(1)
- Kivcak, Bijen(1)
- Oliur Rahman, M.(1)
- Pereira, Catarina G.(1)
- Rodrigues, Maria João(1)
- Soomro, Sanam Iram(1)
- Taşar, Neslihan(1)
- Uba, Abdullahi Ibrahim(1)
- Zengin, Gokhan(1)
- de la Luz Cádiz-Gurrea, María(1)
- Çakilcioğlu, Uğur(1)
Yayınlar
- MakaleAçık Erişim2024Scopus SJRQ2Cytotoxic, antioxidant, and enzyme inhibitory activities of Centaurea stapfiana extracts and their HPLC-ESI-QTOF-MS profiles: Insights into an unexplored Centaurea species
Zengin, Gokhan; Fernández-Ochoa, Álvaro; de la Luz Cádiz-Gurrea, María; Jiménez, Francisco-Javier Leyva; Uba, Abdullahi Ibrahim; Ak, Gunes; Soomro, Sanam Iram; Balos, Maruf; Cakilcioglu, Ugur; Rodrigues, Maria João
The members of the genus Centaurea have a great interest in pharmaceutical and nutraceutical fields due to their biological potential. Based on this information, we aimed to evaluate the biological properties (antioxidant, enzyme inhibition and cytotoxicity) and chemical profile of the extract of Centaurea stapfiana, an unstudied species. The highest total phenolic content was found in the ethanol/water extract with 32.17 mg GAE/g. A total of 102 of them were identified by HPLC-ESI-QTOF-MS analysis. These compounds were mainly hydroxybenzoic acid and hydroxycinnamic acid as well as flavonoids. In the antioxidant tests, the ethanol/water extract had the best free radical scavenging and reducing ability. However, in the enzyme inhibition test, the ethanol extract was the most active. The extracts were also tested on two tumour cell lines (RAW 264.7 and HepG2) and one non-tumour cell line (S17). The ethanol extract showed the promising effect on HepG2 (cell viability: 28.6 % at 50 g/ml). Furthermore, we examined the interactions between the compounds and enzymatic and cellular targets. A good interaction was found between quercetin-3-xylosyl-(1- > 6)-glucoside and iNOS. In summary, our results suggest that C. stapfiana can be considered as a versatile raw material for the development of health-promoting applications in the pharmaceutical and cosmeceutical fields.
AtıfScopus13OpenAlex14
İncele - MakaleAçık Erişim2022Scopus SJRQ2A statistical overview to the chromosome characteristics of some Centaurea L. taxa distributed in the Eastern Anatolia (Turkey)
Açar, Mikail; Taşar, Neslihan
This study performed statistical analyses based on chromosome micromor-phology of 18 Centaurea taxa, two of which are endemic. ANOVA, Correlation analy-sis, Discriminant analysis and Cluster analysis were performed to determine the relationships between taxa based on chromosomal features. In addition, according to the data obtained from these analyses, the relationships between taxa and sections were tried to be interpreted. As a result of the analyses, the taxa C. drabifolia Sm. floccosa (Boiss.) Wagenitz & Greuter, C. kotschyi (Boiss. & Heldr.) Hayek var. floccosa (Boiss.) Wagenitz and C. behen L. and C. polypodiifolia Boiss pseudobehen (Boiss.) Wagen-itz were located close to each other. These taxa are located in the same sections in the morphological classification. Besides, in the Discriminant analysis, the taxa of Acrocen-tron, Microlophus, Cheirolepis sections were closely located compared to all other taxa. However, results were not seen to cover all taxa of the sections. This study revealed various chromosomal characteristics of some Centaurea taxa distributed in the Eastern Anatolia. It also performed statistical analyses on these data. While determining the relationships between taxa according to chromosomal characteristics, comparing chromosomal formulas and indices collectively and evaluating the relationships was found to be relatively consistent with morphological classification.
AtıfScopus3WoS3OpenAlex3İncele - MakaleAçık Erişim2018Scopus SJRQ3Morphological, anatomical and cytological investigations on three taxa of Centaurea L. (Asteraceae) from Turkey
Tasar, Neslihan; Doğan, Gülden; Kiran, Yaşar; Oliur Rahman, M.; Çakilcioğlu, Uğur
Morphological, anatomical and cytological features of three Turkish taxa of Centaurea L., viz. C. polypodiifolia Boiss. var. polypodiifolia, C. urvillei DC. subsp. urvillei and C. urvillei subsp. armata Wagenitz were investigated. Stem anatomy revealed the presence of a thick cuticle layer outside the stem, and epidermis with dense hairs was observed in the lower part. Investigation on leaf anatomy showed that different types of hairs on the outside of the leaf were very intense. Palisade parenchyma was observed below the upper and lower epidermis. In Centaurea polypodiifolia var. polypodiifolia, chromosome number was found to be 2n=16, while in C. urvillei subsp. urvillei and C. urvillei subsp. armata 2n=20. Total karyotype length of C. polypodiifolia var. polypodiifolia, C. urvillei subsp. urvillei and C. urvillei subsp. armata was 22.9 μm, 37.84 μm and 40.01 μm, respectively. Among the investigated taxa the karyotype asymmetry index was found lowest in C. urvillei subsp. armata. Satellite was detected in C. urvillei subsp. urvillei and subsp. armata, while it was absent in C. polypodiifolia Boiss. var. polypodiifolia.
AtıfScopus15WoS17OpenAlex9İncele - MakaleAçık Erişim2018Scopus SJRQ3Karyological investigation on seven centaurea L. (Asteraceae) Taxa from Turkey
Tasar, Neslihan; Dogan, Gulden; Kiran, Yasar
The somatic chromosome numbers and karyotypes were examined in seven species of genus Centaurea L. distributed in Turkey. The chromosome numbers were determined as 2n=2x=16 in C. behen L. and C. solstitialis L.; 2n=2x=18 in C. cynarocephala Wagenitz and C. agregata Fisch. & Mey. ex DC. ssp. agregata; 2n=2x=20 in C. iberica Trev. ex Sprengel; 2n=2x=26 in C. balsamita Lam.; 2n=4x=36 in C. virgata Lam. All of the chromosomes had centromeres at median point (M), median region (m), and submedian region (sm). Satellite chromosomes (sat-chromosomes) were observed only in C. virgata. The findings for each of the analyzed taxa are compared each other and with the results of previous studies.
AtıfScopus5WoS3OpenAlex1İncele - MakaleAçık Erişim2017Scopus SJRQ3Comparative morphological, karyological and palynological investigations of three endemic Centaurea L. species (Asteraceae) in Turkey
Hayta, Sukru; Tasar, Neslihan; Kiran, Yasar; Baser, Birol
Centaurea derderiifolia Wagenitz., Centaurea drabifolia Sm. subsp. floccosa (Boiss.) Wagenitz & Greuter and Centaurea kotschyi (Boiss. & Heldr.) Hayek var. floccosa (Boiss.) Wagenitz, which are endemic taxa from Turkey belonging to Centaurea sect. Cheirolepis, were subjected to morphological, karyological and palynological investigations. The somatic chromosome numbers, pollen morphology and detailed morphometric properties were examined. The somatic chromosome numbers were determined as 2n = 2x = 36 in C. derderiifolia, C. kotschyi var. floccosa, and C. drabifolia subsp. floccosa. Karyotype analysis indicated that chromosomes of these Centaurea taxa generally have median region (m), submedian region (sm) and rarely median point (M) karyotypes. The pollen morphology of these endemic taxa of the genus Centaurea was investigated by light and scanning electron microscopy. The pollen grains of the examined species are mainly isopolar and radially symmetric, subprolate, tricolporate. Tectum ornamentation is scabrate and scabrate-perforate, amb triangular. The pollen grains of all taxa studied are 3-zonocolporate. The colpus is usually long, acute at ends and with smooth membrane. Pollen grains belonging to Cheirolepis section reveal homogeneity in their characters.
AtıfWoS7OpenAlex4İncele - MakaleAçık Erişim2014Scopus SJRQ3Fatty Acid Composition of the Aerial Parts of Some Centaurea Species in Elazig, Turkey
Erdogan, Tugce; Gonenc, Tuba; Cakilcioglu, Ugur; Kivcak, Bijen
Purpose: To evaluate the fatty acid composition of six Centaurea species, viz, Centaurea behen, C. saligna, C. depressa, C. urvillei subsp. urvillei, C. urvillei subsp. hayekiana and C. aggregata subsp. aggregata, from Elazig, Turkey. Methods: Fatty acid methyl esters (FAMEs) of the oil extracts of four Centaurea species were prepared. The fatty acid compositions of Centaurea species were analyzed by gas chromatography (GC). Results: Saturated fatty acids (SFAs) in Centaurea species and subspecies ranged from 24.61 - 50.92% of their total fatty acid content, while monounsaturated fatty acids (MUFAs) were in the range of 3.40 - 37.96% and polyunsaturated fatty acids (PUFAs) 12.21 - 20.57%. Palmitic acid C 16: 0, oleic acid C 18:1 omega 9 and linoleic acid C 18:1 omega 3 were the major fatty acids in all the species. Oleic acid was the main constituent of C. urvillei subps. urvillei and C. agrregata subsp. aggregata with a content of 26.92 and 50.92%, respectively. Conclusion: The oil extracted from Centaurea species is a good source of essential fatty acids.
AtıfWoS18OpenAlex20İncele