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- MakaleAçık Erişim2024Scopus SJRQ3Evaluation of the Effect of Temperature on the Toxicity of Lambda-Cyhalothrin in Dreissena Polymorpha Using some Biochemical Biomarkers; [Vrednotenje vpliva temperature na toksičnost Lambda-cihalotrina v modelnem organizmu Dreissena Polymorpha z uporabo biokemijskih označevalcev]
Yildirim, Nuran Cikcikoglu; Serdar, Osman; Ketenalp, Zozan
Due to increasing climate change, it has become important to determine whether the dose-response relationship of organisms to some substances is affected by temperature. For this reason, in this study, it was aimed to reveal the effect of the temperature variable on the toxic response using the Dreissena polymorpha model organism and some of its biomarkers. For this purpose, acetylcholinesterase (AChE), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and malondialdehyde (MDA) levels in Dreissena polymorpha exposed to subletal concentrations of λ-cyhalothrin at different temperatures were measured using commercial ELISA kits. According to the results obtained, there was a statistically significant increase in MDA levels in the groups exposed to λ-cyhalothrin, while a decrease in GSH levels was found. AChE levels were inhibited especially in the groups exposed high concentrartion of λcyhalothrin. It was also found that the inhibition levels increased depending on the application times. While SOD enzyme activity decreased, CAT enzyme activity increased depending on the exposure concentration. It has been observed that different temperature have different effects on the toxicity of λ-cyhalothrin. It was observed that λ-cyhalothrin caused oxidative stress and neurotoxicity, and the toxicity of λ-cyhalothrin changed depending on the temperature.
- MakaleYalnız künye2024Scopus SJRQ3The RSM-CCD Optimization of Fenton Process for Industrial Wastewater Treatment and Determination of Treatment Efficiency Using Some Biochemical Responses in Dreissena polymorpha
Tanyol, Mehtap; Serdar, Osman; Ketenalp, Zozan; Yildirim, Nuran Cikcikoglu; Erguven, Gokhan Onder; Yildirim, Numan
The study investigated antioxidant biomarkers in Dreissena polymorpha to evaluate the efficiency of Fenton process (FP) in Organized Industrial Zone Wastewater (OIZW) treatment. Antioxidant enzymatic activities, including superoxide dismutase (SOD) and catalase (CAT), glutathione peroxidase (GPX), non-enzymatic antioxidants (GSH) and the indicator of lipid peroxidation (TBARS) were measured in D. polymorpha in response to treated OIZW by FP. The performance of the FP has been optimized with response surface methodology (RSM). The optimum conditions (reaction time, and H2O2 and Fe2+ concentration) for OIZW by the FP process were determined. The results showed that the highest COD removal efficiency (83.94 %) was obtained when as Fe2+ concentration=402.35 mg/L, H2O2 concentration=4100.30 mg/L, and reaction time=10.10 min (desirability=1.000). SOD and CAT enzyme was decreased in the 1/25 diluted OIZW group compared to control group. CAT and SOD enzyme activities were increased after treatment compared to control groups. No statistically significant changes were observed in GSH levels and GPx activities. TBARS levels were increased 1/25 diluted OIZW exposure groups compared to the control group. TBARS levels were decreased after treatment. The results revealed that antioxidant parameters are useful biomarkers for determining the treatment efficiency of the FP.
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İncele - MakaleAçık Erişim2024Scopus SJRQ3sThe Bioremediation of Industrial Effluents by Phanerochaete Chrysosporium: The COD, TOC Removal Efficiency and Biochemical Assessment for Dreissena Polymorpha
Serdar, Osman; Yıldırım, Numan; Onder Erguven, Gokhan; Ketenalp, Zozan; Cikcikoglu Yildirim, Nuran; Durmus, Barbaros
Bioremediation is one of the cheapest and easy method for biological treatment for most kind of industial wastewater. Bioremediation potential of the Phanerochaete chrysosporium for industrial wastewater from Industrial Zone Wastewater plant in Mardin, Turkey, was evaluated. The chemical oxygen demand (COD) and total organic carbon (TOC) reduction efficiencies of P. chrysoporium of on wastewater studied using biomarkers such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), Thiobarbituric Acid (TBARS) and reduced glutathione (GSH) levels in Dreissena polymorpha. The level of TBARS, a marker of lipid peroxidation was found to be high because of wastewater exposure after treatment. TBARS levels decreased (from 20.2 to 31.6 and from 20.8 to 37.5). GSH levels (from 52.3 to 15.9), CAT levels (from, 119.7 to 15.3 and from 91.1 to 13.4) SOD levels (from 3.8 to 0.9 and from 3.4 to 1.2) and GPX activity (from 177.2 to 104.4 and 174.2 to 100.5) decreased in the wastewater exposure groups during 24 and 96th hour compared to the control groups. GSH levels, CAT, SOD and GPX activity increased after treatment by P. chrysosporium. Results indicate that industrial wastewater caused oxidative stress in Dreissena polymorpha. The findings revealed that the highest removal efficiency for COD and TOC, at 86.3 % and 80.3 % respectively, occurred in the 1/20 diluted medium. P. chrysosporium has proven to be effective in the bioremediation of wastewater from the Industrial Zone Changes in biochemical parameters before and after bioremediation showed that antioxidant parameters such as CAT, SOD, GPx activities and GSH and TBARS levels can be used as biomarker to evaluate bioremediation efficiency.
AtıfScopus4WoS2OpenAlex4İncele - MakaleYalnız künye2023Scopus SJRQ2The potential ameliorative impacts of rare earth element cerium in dimethoate induced toxicity in freshwater mussel Dreissena polymorpha
Serdar, Osman; Ketenalp, Zozan; Cikcikoglu Yildirim, Nuran
The purpose of this study was to measure the antioxidant parameters to examine the potential ameliorative impacts of the rare earth element (REE) cerium (Ce) in dimethoate (DM) induced toxicity in Dreissena polymorpha. Lethal concentration 50 (LC50) of DM for 96 h was measured. The antioxidant effect of Ce was investigated by exposure of 1/2 of the LC50 value of DM together with 4, 20 and, 100 mg/L of Ce to D. polymorpha. The responses of the biomarkers were determined by measuring the superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malondialdehyde (MDA) levels. SOD, CAT, GPX and GSH levels were reduced (p < 0.05), while the MDA levels increased significantly (p < 0.05) in mussels exposed to DM. When DM was exposured together with Ce, it was observed that the MDA levels decreased, SOD, CAT, GPX and GSH levels increased during 24 and 96 h. The results of our study showed that Ce exerted a strong antioxidant effect on toxicity induced by DM. It has been shown that Ce may have a compensatory effect with the positive change in the antioxidant response of D. polymorpha to DM. This study is the first report about Ce and insecticide effects in bivalves.
AtıfScopus1WoS1OpenAlex1İncele - MakaleAçık Erişim2023Scopus SJRQ4Single and combined effects of dimethoate and malathion on oxidative stress biomarkers in the non-target freshwater mussel Dreissena polymorpha
Serdar, Osman; Yildirim, Numan; Yildirim, Nuran Cikcikoglu
This study evaluates the single and combined effects of dimethoate (DI) and malathion (MA) on oxidative stress biomarkers in the freshwater mussel Dreissena polymorpha, estimating the potential harm of these pesticides on aquatic ecosystems. Superoxide dismutase (SOD) and catalase (CAT) activities, and glutathione (GSH) and lipid peroxidation (TBARS) levels were determined in D. polymorpha exposed to sublethal concentrations of DI, MA and a combination of the two during 24 and 96 h periods. The results showed that the GSH levels were decreased but the TBARS levels were increased in all the exposure groups after 24 and 96 h compared to the control. It was observed that SOD activity decreased but CAT activity increased in all the DI exposure groups after 24 h compared to the control. At the end of 96 hours, it was observed that CAT and SOD activities increased again in some exposure groups compared to the control. Exposure time also had an effect on biomarkers in different levels. According to the results, the cytotoxicity of DI and MA combination depended on their concentrations. DI or/ and MA, in sub-lethal concentrations, induced oxidative damages in D. polymorpha. Combined exposure of the pesticides can alter their toxicity and may be evidence of increased toxicity and oxidative stress.
AtıfScopus3WoS3OpenAlex2İncele - MakaleAçık Erişim2022Scopus SJRQ2The Bioremediation Capacity of Sphingomonas melonis for Methomyl-Contaminated Soil Media: RSM Optimization and Biochemical Assessment by Dreissena polymorpha
Önder Erguven, Gokhan; Serdar, Osman; Tanyol, Mehtap; Cikcikoglu Yildirim, Nuran; Yildirim, Numan; Durmus, Barbaros
The bioremediation capacity of S. melonis for methomyl investigated with RSM. Oxidative stress and neurotoxic response determined in D. polymorpha. COD and TOC levels were measured. GSH, MDA levels and CAT, SOD, AChE activities in D. polymorpha exposed to before (group A) and after (group B) bioremediated media during 24 and 96 h were tested by using ELISA kit. AchE activity was decreased 24th h but increased during 96th h in group B compared with group A (p<0.05). MDA levels and CAT activities were decreased during 24 h and 96 h in group B compared with group A (p<0.05). GSH levels were increased during 24 h and 96 h in group B compared with group A (p<0.05). SOD activity did not show a significant change in group B (p<0.05). Methomyl could be effectively remediated by S. melonis and CAT, AChE activities and GSH, TBARS levels of D. polymorpha are useful biomarkers for evaluating the bioremediation capacity.
AtıfScopus5WoS6OpenAlex6İncele - MakaleYalnız künye2021Scopus SJRQ2The assessment of basic blue 41 textile dye decolorisation using the Fenton process: response surface methodology optimisation and toxicity evaluation
Tanyol, Mehtap; Cikcikoglu Yildirim, Nuran; Tatar, Sule; Serdar, Osman; Yildirim, Numan
The biochemical biomarkers (Catalase (CAT), glutathione s-transferase (GST), cytochrome P4501A1 (CYP1A1450) activities and glutathione (GSH), malondialdehyde (MDA) levels) of D. polymorpha exposed to the basic blue 41 (BB41) solutions for 24 and 96 h before and after the Fenton process (FTP) were evaluated to investigate the efficiency of the FTP. The optimum conditions for the removal of BB41 were set using central composite design (CCD), which is a response surface methodology (RSM) module in the Design-Expert® software. The optimal conditions were found to be 27.87 min, 3.49 mg/L, and 0.04 for reaction time, initial BB41 concentration, and Fe2+/H2O2 molar ratio, respectively, resulting in maximum (99%) removal efficiency. After FTP, the MDA and GSH levels decreased significantly during the 24 and 96 h. CAT activities were increased after treatment. No statistically significant changes were observed in the CYP1A1 levels after FTP. GST activities decreased during 24 h but increased during 96 h after FTP. CYP1A1450, catalase, GST activities and MDA, GSH levels of D. polymorpha are useful biomarkers to evaluate the efficiency of FTP. This study suggests that BB41 dye must be further treated after the FTP to minimise the ecotoxicological risk.
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