Sürdürülebilir Kalkınma Amaçları

• 1

Yazarlar

• Aslan, Naim(2)
• Aksakal, Bunyamin(1)
• Arslan, Mehmet Enes(1)
• Dikici, Burak(1)
• Kadi, Abdurrahim(1)
• Kurt, Mustafa Şükrü(1)
• Topuz, Mehmet(1)
• Yazici, Ayşenur(1)
• Çobanoğlu, Şeymanur(1)
• Öner, Sena(1)

• Kitap BölümüAçık Erişim2023/r/munzur/2792
  Production technique–structure relationship in bioceramic-coated scaffold applications

  Aslan, Naim; Topuz, Mehmet; Aksakal, Bunyamin; Dikici, Burak

  It is well known that the surface of metal-based implants is very resistive in aggressive body environments due to the noble oxide layer naturally formed on their surfaces. However, their osseointegration properties are very low. By the way, specific cells attached are desired on the implant surface when the surface of an implant connects with tissue in many circumstances. Thus in parallel with technological developments, biomedical engineering focuses on the growth of new tissue on the implant surface or in the porosities of the implant. The bulk properties of metallic scaffolds, especially Young’s modulus, can be controlled by the porosity ratio of the scaffold but cannot form a bond between the implant and tissue interfaces. Thus the coating of scaffold walls with a bioactive material is required. In this chapter, bioceramic coating techniques of scaffolds, mechanical and corrosion behavior, biocompatibility, and interactions of surface/tissue interface, especially considering the last published reports, were reviewed, in detail.

  AtıfScopus4·OpenAlex4

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• MakaleYalnız künye2022Scopus SJRQ2/r/munzur/2796
  Structural, biocompatibility, and antibacterial properties of Ge–DLC nanocomposite for biomedical applications

  Arslan, Mehmet Enes; Kurt, Mustafa Şükrü; Aslan, Naim; Kadi, Abdurrahim; Öner, Sena; Çobanoğlu, Şeymanur; Yazici, Ayşenur

  Integrative production of new nanocomposites has been used to enhance favorable features of biomaterials for unlocking ultimate potential of different molecules. In the present study, advantageous properties of diamond like carbons (DLC) and germanium (Ge) like greater biocompatibility and antibacterial attributes were aimed to combined into a thin film. For this purpose, 400 nm DLC–Ge nanocomposite was coated on the borosilicate glasses via the magnetron sputtering and surface characteristics was analyzed by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS) and The Raman spectrum. Biocompatibility analysis were performed by 3-(4,5-Dimethylthiazol-2-yl) (MTT) cell viability assay and Hoechst 33258 fluorescent staining genotoxicity assessments on the human fibroblast cell line (HDFa). Finally, antibacterial properties of DLC–Ge nanocomposite coatings were investigated by Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923) bacterial attachment analysis. As a result of magnetron sputtering coating, nearly 400 nm thick DLC–Ge nanocomposite film showed a smooth, a non-porous, and a dense characteristic. Cell viability analysis showed that Ge–DLC coatings permits %95 cell surface growth of fibroblast cells. Also, there were no significant difference in aspect of nuclear abnormalities compared to the (−) control which showed nonmutagenic features of the thin film. Finally, antibacterial attachment analysis put forth that Ge–DLC coatings inhibits bacterial adhesion as %40 and %25 rates for P. aeruginosa and S. aureus bacterial strains, respectively. From these results, DLC–Ge nanocomposites could be proposed as a potential new biomaterial for various biomedical applications.

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  AtıfScopus20·WoS16·OpenAlex19

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