Yayınlar
Koleksiyondaki öğeler
- MakaleAçık Erişim2019Scopus SJRQ1Side-Channel Analysis of Chaos-Based Substitution Box Structures
Acikkapi, Mehmet Sahin; Ozkaynak, Fatih; Ozer, Ahmet Bedri
There is a theoretically strong relationship between chaos and cryptology. In practice, one of the most successful applications of this relationship is chaos-based s-box structures. However, the performance metrics of chaos-based s-box designs are worse compared to those for s-box structure based on algebraic techniques used in modern encryption algorithms, such as the AES algorithm. What is the reason for using chaos-based s-box structures, even though they have worse cryptographic characteristics? Researchers claim that they may be an alternative defense against implementation attacks, especially side-channel analyses. However, no studies have supported or refuted this claim so far. In this paper, side-channel analyses have been performed for two different chaos-based s-box structures. These two s-box structures have been selected for having with the best and worst performance measurements for s-box structures previously proposed in the literature. The results were compared with the AES s-box structure. Analysis of the results showed that chaos-based s-box structures are more resistant against side-channel attacks. Therefore, chaos-based designs may be an alternative defense against implementation attacks, as alleged. However, both algebraic and chaos-based s-box designs have been observed to be insecure if the attacker has more than 30 plaintexts in the side channel analyses. These results show that implementation analysis studies are required in the chaos-based cryptology literature.
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İncele - MakaleYalnız künye2020Scopus SJRQ2Temporal and seasonal variations in phytoplankton community structure in Uzuncayir Dam Lake (Tunceli, Turkey)
Kutlu, Banu; Aydın, Rahmi; Danabas, Durali; Serdar, Osman
Seasonal variations in species composition and growth dynamics of phytoplankton in Uzuncayir Dam Lake (Tunceli, Turkey) were studied in relation to ecological factors by collecting horizontal water and phytoplankton samples for over a year. A total of 46 phytoplankton taxa were recorded, where Bacillariophyta was the most abundant in species number representing 24 taxa. Diatoms were the most conspicuous phytoplankton in terms of abundance as well as occurrence frequency. Charophyta, Chlorophyta, Cyanobacteria, Ochrophyta, Miozoa, and Euglenozoa were the least abundant. However, some Diatoms (Gyrosigma attenuatum, Hippodonta hungarica, Meridion circulare, Nitzschia clausii, Nitzschia frustulum, Pantocsekiella ocellata, Rhoicosphenia abbreviata), Charophytes (Cosmarium granatum, Mougeotiopsis calospora), Cyanobacteria (Leiblenia epiphytica, Planktothrix agardhii); Dinoflagellates (Ceratium hirundinella, Parvodinium africanum, Parvodinium inconspicuum, Peridinium cinctum), and Ochrophyta (Dinobryon pediforme) were also noticeable, with their occurrence in all seasons. Canonical correspondence analysis (CCA) and principal component analysis (PCA) were employed to analyze the relationship between occurrence and abundance of phytoplankton species as well as the ecological factors. The results showed that pH and the concentrations of NH4, NO3, and PO4 influenced seasonal occurrence and abundance of phytoplankton species in the lake. Uzuncayir Dam Lake may be classified as an oligotrophic lake with the mean value of nitrate 2.62 mg L−1 and phosphate 0.23 mg L−1 as supported by the occurrence of various phytoplankton groups. Findings related to pollution indices yielded that Uzuncayir Dam Lake is on the edge of the moderate state of organic pollution.
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İncele - MakaleAçık Erişim2018Scopus SJRQ2Quality changes of nugget prepared from fresh and smoked rainbow trout during chilled storage
Duman, Muhsine; Karaton Kuzgun, Nermin
Purpose: The purpose of this paper is to produce fish nugget from fresh or smoked fish and to investigate the quality characteristics of fish nuggets during refrigerated storage. Design/methodology/approach: The study was designed to evaluate the effect of fresh and smoked fish on the storage quality parameters of fish nuggets. The products were developed by incorporating optimum level of fresh and smoked separately and were vacuum packaged in low-density polyethylene pouches and assessed for various storage quality parameters under refrigerated (2±1°C) conditions for 27 days of storage. The products were evaluated for various chemical, microbiological and sensory parameters at regular interval of three day. Findings: Nuggets from smoked fish had lower (p<0.05) moisture, higher fat and crude protein compared to fresh fish nuggets. Total volatile basic nitrogen for fresh nugget samples exceeded the limit value of 30 mg N/100 g fish muscle on the 24 days of storage. At the end of storage period, TBA values were 2.8 mg malonaldehyde/kg for fresh nugget samples and 2.1 mg malonaldehyde/kg for smoked nugget samples. Microbial counts were found to be significantly (p<0.05) higher in fresh nugget than in smoked nugget samples. Sensory quality scores of smoked nuggets were significantly higher, than fresh nugget. The shelf life of fish nugget was found to be 24 days for fresh nuggets and 27 days for smoked nugget samples according to sensory assessment results. Originality/value: The paper has demonstrated that the smoked fish meat prouduce nuggets of better quality, as indicated by lower microbial counts and higher sensory attributes compared to fresh fish meat.
AtıfScopus7WoS8OpenAlex11İncele - MakaleYalnız künye2020Scopus SJRQ1Effects of Zn and ZnO Nanoparticles on Artemia salina and Daphnia magna Organisms: Toxicity, Accumulation and Elimination
Danabas, Durali; Ates, Mehmet; Ertit Tastan, Burcu; Cicek Cimen, Isil Canan; Unal, Ilkay; Aksu, Onder; Kutlu, Banu
In the study, Zn in the size of 40–60 nm and 80–100 nm and ZnO in the size of 10–30 nm were applied to A. salina and D. magna individuals in 7 groups with 3 repetitions. Measurements were made at 24th, 48th and 72nd hours and elimination values were examined at +24 h. LC50 values of NPs were determined and chemical analysis (metal accumulation and elimination), ion quantities which were given to the environment and the survival rates of organisms were determined after the exposure. According to the results of phase contrast microscopy, it was found that both experimental organisms absorbed the NPs in the medium level. In the toxicity results of D. magna, it can be said that Zn NP (40–60 nm) has a highly toxic effect only at 50 ppm concentration for 48 h and lethal dose can be accepted as of 5 ppm at the end of 72 h. In A. salina individuals, it is clearly seen that there is an increase in mortality in organisms parallel to the dose increase. Although all NPs were applied to organisms in low doses corresponding to environmental values, it was observed that toxic effect was in parallel with the increase in time. It is clearly known that there is the inverse proportion between the size of NPs and the toxic effect. The smaller the size of NPs is, the higher the toxic effect becomes When the results of Zn accumulation and elimination of A. salina and D. magna individuals exposed to the Zn and ZnO NPs were examined; it was found that accumulation and elimination occurred in parallel with the increase in concentration at each application hour and elimination. Intensive and possible misuse of nanoscale materials is one of the biggest threats to the environment and all living things worldwide.
AtıfScopus63WoS59OpenAlex71İncele - MakaleAçık Erişim2018Scopus SJRQ1An Agent-Based Pythagorean Fuzzy Approach for Demand Analysis with Incomplete Information
Baloglu, Ulas Baran; Demir, Yakup
Analyzing demand in environments with incomplete information is a challenging task. This paper proposes a novel agent-based Pythagorean fuzzy approach for analyzing this kind of demand. First, a Bayesian game is described with a large number of finite players, and this is followed by a Pythagorean fuzzy-based decision mechanism. Unlike the classical methods in the literature, the proposed method in this paper neither assumes nor forecasts the demand in a system. Instead, it tries to analyze the demand when there is limited availability of input data, or processing data are computationally expensive. The study ends with an application of the proposed system to an electricity grid. Electricity prices used as an incentive to construct an agent-based system that efficiently reduces the peak amounts in a smart grid by analyzing the demand. Test results provide evidence that the proposed approach is promising to design demand response systems.
AtıfScopus18WoS18OpenAlex19İncele - MakaleAçık Erişim2019Scopus SJRQ2The effect of water parameters and dissolved minerals on the hematological parameters of during breeding period catfish (Silurus glanis)
Küçükgül, Azime; Yüngül, Mücahit; Kahraman, Zuhal; Dörücü, Mustafa
In this study, the blood parameters of catfish (Silurus glanis Linnaeus, 1758) inhabiting Celik Lake (Adiyaman, Turkey) were investigated. The study was conducted between April 2013 and October 2013. After obtaining a blood sample from each catfish has been hematologically analyzed. Then, the water temperature, dissolved oxygen, pH, calcium, magnesium and nitrate values were determined at before breeding (April), breeding period (June-July) and after breeding of fish (October) and the impacts of these data on hematological values were investigated. According to this study, it was observed that the hematological values obtained at before breeding period, breeding and after the breeding period were affected by the water quality parameters.
AtıfScopus4WoS6OpenAlex5İncele - BildiriYalnız künye2020A risk assessment approach using both stochastic data and subjective judgments
Mete, Suleyman; Oz, Nurdan Ece; Gul, Muhammet; Serin, Faruk; Celik, Erkan
Risk assessment describes the overall process regarding identifying hazards and risk factors that have the potential to cause harm, analyzing and evaluating the risk associated with that hazard and determining appropriate ways to eliminate the hazard or control the risk. In the literature, lots of approaches are proposed to prioritize hazards and associated risks quantitatively. Fuzzy sets-based multi-criteria decision-making approaches are forefront that they have the ability in expressing the risks verbally based on decision-maker’s opinions and judgments. MCDA-based risk assessment approaches explain different types of uncertainties, which are generally modeled using stochastic analysis or fuzzy sets. The stochastic analysis is more suitable in modelling the probabilistic uncertainty. Therefore, in this study, a risk assessment approach using both stochastic data and subjective judgments is proposed, and a case study is also performed in a construction project. The VIKOR method is extended and a new risk assessment approach is developed where part of the data is stochastic. A three-year data is used to determine a fitted probability distribution of respected frequency. Evaluation of risks with respect to severity and probability parameters are then made by subjective judgments. In conclusion, a risk prioritization and potential action plan suggestion is performed.
AtıfScopus2OpenAlex3İncele - MakaleAçık Erişim2018Scopus SJRQ2Effect of brine and dry salting methods on the physicochemical and microbial quality of chub (Squalius cephalus Linnaeus, 1758)
Bonoco, Arzu; Kurt Kaya, Gülderen
The present study, looks at the physicochemical and microbiological quality changes that occur due to different salting techniques (20% salt concentration) of chub (Squalius cephalus) and when stored in 4 ± 0.5 °C. Samples of fish from each group was taken on the 15, 30, 45, 60, 90 and 120th day and was analyzed for nutritional component (crude protein, lipid, moisture, crude ash), pH value, salt content and the microbial flora (total mesophilic aerobic bacteria count, total coliform, total psychrophilic aerobic bacteria count, yeast and mould). Ot was determined that crude protein, lipid, crude ash and salt amounts in the group where dry salting method was applied were higher than the group where brine salting occurred, in addition protein and lipid values decreased as storage period was longer (P < 0.05). Ot was determined that there is an increase in total aerobic mesophilic, psycrophile bacteria and enumeration of yeast and mould as storage period increased, while coliform bacteria decreased (P < 0.05).
AtıfScopus21WoS15OpenAlex30İncele - MakaleYalnız künye2020Scopus SJRQ2“Home-buying behaviour model of Generation Y in Turkey”
Kayapinar Kaya, Sema; Ozdemir, Yasal; Dal, Murat
Purpose: The young population in Turkey is gradually increasing. Generation Y, which comprises the people born between 1980 and 1999 (Broadbridge et al., 2007) and free-spirited and tech-savvy, forms a large part of the population of the world, especially Turkey, and is of great importance to the housing sector for their home-buying preferences. In this study, housing preferences of students in Turkey’s two socio-economically different universities were comparatively analysed through quantitative methods. Design/methodology/approach: A survey was simultaneously distributed among students of two universities. The survey consists of six main factors: “reliability”, “economic opportunities”, “transportation opportunities”, “quality of life and social opportunities”, “quality standards”, and “technological opportunities”, with 25 statements. The questionnaire was developed through a comprehensive literature review and the opinions of university stakeholders. Findings: Results showed that the structure of the family and socio-economic differences affect home-buying preferences. The Mann–Whitney U test indicated that there was a meaningful difference of opinion between students of two universities. Munzur University students paid attention to economic opportunities when buying a home. Additionally, there was a meaningful relationship among the age groups in factors of “having a parking place” (p = 0.026) and “having a playground” (p = 0.026). As the age increases, students desire a playground around their future home. Research limitations/implications: The most important limitation of this study is the non-parametric data. Non-parametric data structure and the tests performed accordingly are less preferred than parametric data structure. For that reason, to what extent the results accurately represent Generation Y needs to be assessed through future study. Also, a certain number of sampling could be reached as purposive sampling was used. Originality/value: This study contributes to the literature in terms of comparatively analysing buying preferences of Generation Y through statistical methods and showing the relationship between these preferences and socio-economic features statistically. Due to the insufficient quantitative research on the literature, this quantitative study was carried future home-buying preferences of Generation Y university students, who will also be actively involved in the housing market. The purpose of this study investigates marketing factors that affect housing preferences of students in Turkey.
AtıfScopus9WoS7OpenAlex18İncele - MakaleYalnız künye2019Scopus SJRQ2The Evaluation of Imidacloprid Remediation in Soil Media by Two Bacterial Strains
Erguven, Gokhan Onder; Yildirim, Numan
Imidacloprid (C9H10ClN5O2) is used as the most recommended type of insecticide in vegetable farming worldwide. Two types of bacteria (Methylobacterium radiotolerans and Microbacterium arthrosphaerae) were isolated from a corn farming field in the Thrace region of Turkey, and then consortia of these bacteria were prepared from equal volumes of 107 CFU/ml for each bacterium type. Imidacloprid remediation studies were carried out during 18 days in soil test units. The water filtered from these soil test units was determined for chemical oxygen demand (COD) and biochemical oxygen demand (BOD5) to determine the optimum concentration of microorganisms to ascertain the best removal efficiency of Imidacloprid. COD removal rates were 98.7%, 96.4% and 51.6% with 80, 40, and 20 ml volumes of the consortia of bacteria, respectively, at the end of 18 days. The BOD5 removal rates were 88.4%, 78.6% and 49.9% in the same volumes of bacteria, respectively. As a result of this study, we have found that this bacterial consortium is very effective for the bioremediation of this insecticide at the two volumes of 40 and 80 ml, both being better than 20 ml.
AtıfScopus35WoS34OpenAlex37İncele - MakaleAçık Erişim2018Scopus SJRQ3Effects of conventional and organic rearing systems and hen age on oxidative stress parameters of blood and ovarian tissues in laying hens; [Konvansiyonel ve organik yetiştirme sistemleri ile tavuk yaşının yumurta tavuklarının kan ve yumurtalık dokusundaki oksidatif stres parametreleri üzerine etkisi]
Şimşek, Ülkü Gülcihan; Baykalir, Yasin; Erişir, Mine; Benzer, Fulya
In this study, effects of hen age and rearing systems on some oxidative stress parameters in serum and ovarian tissues of hens are investigated. For this purpose, total of 48 Bovans White commercial laying hybrids from two different rearing systems (conventional cage and organic) at 30 and 60 weeks of age were used. Serum and ovarian tissues of the hens were collected following slaughter process and malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GSH-Px) and catalase (CAT) levels of serum and ovarian tissues were determined. MDA levels of serum was found significantly higher in conventional system, both in 30 and 60 weeks old (P<0.05). GSH-Px activity was lower, conversely CAT activity was significantly higher in conventional system (P<0.05). Hen age didn’t affect MDA, GSH, GSH-Px and CAT levels of serum (P>0.05). In addition, there weren’t any significant interactions between rearing system and hen age in serum (P>0.05). MDA (P=0.010) and GSH (P<0.01) levels of ovarian tissue were found significantly higher in conventional system while GSH levels of ovarian tissue had increased in 60 weeks old (P<0.01). GSH-Px and CAT activity was similar between groups (P>0.05). Interaction between rearing system and hen age affected activity of CAT in ovarian tissue (P<0.05). As a result, conventional battery cages caused oxidative stress interrelated with increasing lipid peroxidation and MDA levels in laying hens. Antioxidant enzymes that play role in reduction of MDA were inadequate in this system. Oxidant/antioxidant balance can be established at 30 or 60 weeks of age by hen organism and therefore MDA levels of tissues would not be affected by age.
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2018Scopus SJRQ3Novel features of the nonlinear model arising in nano-ionic currents throughout microtubules
Celik, E.; Bulut, H.; Baskonus, H.M.
In this manuscript, the modified exp (-Ω(ξ))-expansion function method is implemented to find the new solutions to the nonlinear differential equation being the transmission line model. We obtain some new solutions to this model such as complex, exponential, trigonometric and hyperbolic functions. We plot the two- and three-dimensional surfaces of each solutions obtained in this manuscript.
AtıfScopus7OpenAlex9İncele - Derleme MakaleAçık Erişim2017Scopus SJRQ3Julius Caesar: Tyrannicide made unpopular
Öǧütcü, Murat
The late Elizabethan Period was marked by socio-economic discontent. Amid this, Shakespeare's Julius Caesar (1599) featured a prominent debate: whether or not tyrannicide could solve problems. Around 1599, Essex formulated a like-minded political revolution only to dismiss it until 1601. Yet, as providentialist and republican debates failed to provide solutions against misgovernment, the 1601 Essex rebellion also proved abortive. Essex was considered another regicide Brutus rather than a saviour. Contrary to the majority of apolitical or ahistorical critical analyses about tyranny in the play, a historicized analysis of Julius Caesar, therefore, illustrates how tyrannicide might have been perceived by Elizabethan playgoers.
AtıfScopus2OpenAlex2İncele - MakaleAçık Erişim2019Scopus SJRQ2A deep learning model for automated sleep stages classification using PSG signals
Yildirim, Ozal; Baloglu, Ulas Baran; Acharya, U Rajendra
Sleep disorder is a symptom of many neurological diseases that may significantly affect the quality of daily life. Traditional methods are time-consuming and involve the manual scoring of polysomnogram (PSG) signals obtained in a laboratory environment. However, the automated monitoring of sleep stages can help detect neurological disorders accurately as well. In this study, a flexible deep learning model is proposed using raw PSG signals. A one-dimensional convolutional neural network (1D-CNN) is developed using electroencephalogram (EEG) and electrooculogram (EOG) signals for the classification of sleep stages. The performance of the system is evaluated using two public databases (sleep-edf and sleep-edfx). The developed model yielded the highest accuracies of 98.06%, 94.64%, 92.36%, 91.22%, and 91.00% for two to six sleep classes, respectively, using the sleep-edf database. Further, the proposed model obtained the highest accuracies of 97.62%, 94.34%, 92.33%, 90.98%, and 89.54%, respectively for the same two to six sleep classes using the sleep-edfx dataset. The developed deep learning model is ready for clinical usage, and can be tested with big PSG data.
AtıfScopus255OpenAlex265İncele - MakaleAçık Erişim2019Scopus SJRQ2Automated Depression Detection Using Deep Representation and Sequence Learning with EEG Signals
Ay, Betul; Yildirim, Ozal; Talo, Muhammed; Baloglu, Ulas Baran; Aydin, Galip; Puthankattil, Subha D.; Acharya, U. Rajendra
Depression affects large number of people across the world today and it is considered as the global problem. It is a mood disorder which can be detected using electroencephalogram (EEG) signals. The manual detection of depression by analyzing the EEG signals requires lot of experience, tedious and time consuming. Hence, a fully automated depression diagnosis system developed using EEG signals will help the clinicians. Therefore, we propose a deep hybrid model developed using convolutional neural network (CNN) and long-short term memory (LSTM) architectures to detect depression using EEG signals. In the deep model, temporal properties of the signals are learned with CNN layers and the sequence learning process is provided through the LSTM layers. In this work, we have used EEG signals obtained from left and right hemispheres of the brain. Our work has provided 99.12% and 97.66% classification accuracies for the right and left hemisphere EEG signals respectively. Hence, we can conclude that the developed CNN-LSTM model is accurate and fast in detecting the depression using EEG signals. It can be employed in psychiatry wards of the hospitals to detect the depression using EEG signals accurately and thus aid the psychiatrists.
AtıfScopus279OpenAlex291İncele - MakaleAçık Erişim2020Scopus SJRQ2Evaluation of the role of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities in rams
Ozer Kaya, Seyma; Kandemir, Fatih Mehmet; Gur, Seyfettin; Erisir, Mine; Benzer, Fulya; Kaya, Emre; Turk, Gaffari; Sonmez, Mustafa
The purpose of this study is to investigate the effects of L-arginine on spermatological parameters, seminal plasma nitric oxide levels and arginase enzyme activities. Fertile rams that are 2–3 years old and weighing 50–60 kg were used as material. The semen was collected by artificial vagina at 1st, 4th, 24th, 48th, 72nd, 96th and 120th hours for the control group before L-arginine administration. For treatment groups, L-arginine was administered intraperitoneally at a dose of 5 mg kg−1 bw−1 and semen was collected at the time point described for the control group. Spermatological characteristics of semen samples (semen volume, pH, sperm motility, concentration and abnormal sperm rate), seminal plasma nitric oxide levels and arginase enzyme activities were determined. Increased seminal plasma nitric oxide level (p <.01), seminal plasma arginase activity (p <.01), semen volume (p <.05), semen mass activity (p <.05), sperm motility (p <.05) and concentration (p <.01) and decreased abnormal sperm rate (p <.05 and p <.01) were observed by L-arginine administration. In conclusion, it may be concluded that L-arginine application in rams during the breeding season may have positive effects on rams' reproductive performance.
AtıfScopus14WoS10OpenAlex11İncele - MakaleYalnız künye2020Scopus SJRQ4A comparison of morphometry features of the narrow-clawed crayfish (Astacus leptodactylus Eschscholtz, 1823) living in two different habitats
Yuksel, Fahrettin; Cilbiz, Mehmet; Demirol, Ferhat; Capkin, Kadir; Bektas, Zubeyde Hanoi; Gunduz, Fatih
Narrow-clawed crayfish (Astacus leptodactylus Eschscholtz, 1823) is native species to Turkey and the most important shellfish because of its commercial value and ecological role in ecosystem. The knowledge on bio-ecological features of narrow-clawed crayfish is limited. In this study, total length (TL), carapace length (CL), carapace width (CW), abdomen length (AL), abdomen width (AW), chela length (ChL) and chela width (ChW) of narrow-clawed crayfish were compared in two different habitats (Egirdir Lake and Keban Dam Lake). According to linear regression analysis, the highest relation was between TL and AL (R2=0.987) of the female in Egirdir Lake and the weakest relationship was between AW and ChL (R2=0.084) in Keban Dam Lake. Overall, the biometric features of A. leptodactylus populations in Egirdir Lake and Keban Dam Lake were different and these differences were significant in mid-length groups. These findings clearly demonstrated the impact of commercial catching on the length distribution of the crayfish stocks.
AtıfScopus5İncele - MakaleYalnız künye2021Scopus SJRQ4Balneotherapy Features of Natural Thermal Source from Pertek (Turkey-Tunceli) Due to Its Some Chemical, Radioactivity and Biological Parameters
Sönmez, Pinar Erecevit
It can also be defined as a discipline that reviews the factors of balneology or hydrotherapy, which are alternative treatment methods for public health, from chemical, biological and medical aspects. In this study, it was aimed to investigate whether the underground waters in the Pertek district of Tunceli province are suitable for balneology. Chemical, radioactivity analysis, microbiological quality, antimicrobial activities were determined in relation to natural groundwater and its ability to be a natural healing source was investigated. When the chemical content is examined, it was determined to be bromide amount is 0.24 mg / L, Iodine (I); 1.9 mg / L, sulfur (S); 0.02 mg / L, boron (B): 2676 µg / L, silicium (Si); 1.9 mg / L. With respect to the results, thermal water has the feature to be used in balneolotherapy. According to the results of the radioactivity analysis, alpha (α) is 0.15 Bq / L; Beta (β) is <0.30 Bq / L and radon (Rn) is <13.4 Bq / L tritium (T) content is <10 Bq / L (<83.33 TB) and it is included in both mineral and young water group. This ground water and they comply with the standards in terms of microbiology (Total bacteria, coliform, Escherichia coli). Its antibacterial, antifungal and antidermatophyte properties prove to be a healing source. We confirmed the effectiveness of this healing water to both protect and promote human health as a drinking cure and reach the newest and most effective treatment modalities by using related water in Health and Thermal Tourism.
- MakaleYayıncıda açık erişim2021Scopus SJRQ4Effects of magnesium biotinate supplementation on serum insulin, glucose and lipid parameters along with liver protein levels of lipid metabolism in rats
Sahin, Kazim; Orhan, Cemal; Kucuk, Osman; Erten, Fusun; Tuzcu, Mehmet; Sahin, Nurhan; Ojalvo, Sara Perez; Komorowski, James Richard
The objective of this study was to investigate the effects of a novel form of biotin (magnesium biotinate) on serum glucose, lipid profile, and hepatic lipid metabolism-related protein levels in rats. Forty-two rats were divided into six groups and fed a standard diet-based egg white powdered diet supplemented with either d-biotin at 0.01, 1, or 100 mg/kg BW or magnesium biotinate at 0.01, 1, or 100 mg/kg BW for 35 days. Neither form of biotin influenced (p > 0.05) serum glucose or insulin concentrations. Serum total cholesterol and triglyceride decreased with biotin from both sources (p < 0.05). Concentrations were lower with magnesium biotinate when comparing the 1 mg/kg dose (p < 0.05). Serum, liver, and brain biotin and liver cyclic guanosine monophosphate (cGMP) concentrations were greater when rats were treated with magnesium biotinate versus d-biotin, particularly when comparing the 1 and 100 mg/kg dose groups (p < 0.05). Both biotin forms decreased the liver SREBP-1c and FAS and increased AMPK-a1, ACC-1, ACC-2, PCC, and MCC levels (p < 0.05). The magnitudes of responses were more emphasized with magnesium biotinate. Magnesium biotinate, compared with a commercial d-biotin, is more effective in reducing serum lipid concentrations and regulating protein levels of lipid metabolism-related biomarkers.
AtıfScopus5WoS5OpenAlex5İncele - MakaleAçık Erişim2018Scopus SJRQ2On the bright and singular optical solitons to the (2 + 1)-dimensional NLS and the Hirota equations
Bulut, Hasan; Sulaiman, Tukur Abdulkadir; Baskonus, Haci Mehmet; Aktürk, Tolga
This study constructs bright and singular optical solitons the (2 + 1)-dimensional NLSE and the Hirota equation by utilizing the new sine-Gordon expansion method. The parametric conditions for the existence of valid solitons are given. We give the variations of solitary and periodic wave solutions that depend on the parameters. We present the 2D, 3D and contour graphs to represent the kind of solutions secured in this study.
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