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Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats

MakaleYalnız künyeScopus SJRQ3
  • SDG 3 · Sağlık ve Kaliteli Yaşam

Özet

This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity.

Anahtar Kelimeler

curcuminDNA damagedoxorubicinoxidative stresstesticular toxicity
RDL Kalıcı Bağlantı (PID)
https://rdlopen.rawdatalibrary.net/r/munzur/3400Resmi atıflarda kullanılan kalıcı adres
DOI
https://doi.org/10.1002/jbt.22384Yayıncı resmi DOI adresi
İndeks kayıtları
ScopusScopusWeb of ScienceWeb of SciencePubMedPubMed
Kaydın indeks veri tabanlarındaki sayfası (aktarımda alınan kayıt numarasıyla). Erişim, indeksin kendi koşullarına bağlıdır.
Atıflar
Scopus
56
WoS
51
OpenAlex
68
Her kaynağın kendi saydığı toplam atıf; aktarım ve zenginleştirme sırasında alındı.
Tam Kayıt
AlanDeğerDil
dc.contributor.authorAksu, Emrah Hicazi
dc.contributor.authorKandemir, Fatih Mehmet
dc.contributor.authorYıldırım, Serkan
dc.contributor.authorKüçükler, Sefa
dc.contributor.authorDörtbudak, Muhammed Baheeddin
dc.contributor.authorÇağlayan, Cüneyt
dc.contributor.authorBenzer, Fulya
dc.date.accessioned2026-10-28T14:56:35.327331464Z
dc.date.available2026-10-28T14:56:35.327331464Z
dc.date.issued2019
dc.description.abstractThis study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity.
dc.description.sponsorshipFoundation of Scientific Research Projects, (YLMÜB016‐23)
dc.description.sponsorshipMunzur University
dc.identifier.articlenumbere22384
dc.identifier.doi10.1002/jbt.22384
dc.identifier.eissn1099-0461
dc.identifier.issn1095-6670
dc.identifier.issue10
dc.identifier.pmid31468665
dc.identifier.scopus2-s2.0-85071356423
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/munzur/3400
dc.identifier.volume33
dc.identifier.wosWOS:000484213300001
dc.language.isoen
dc.publisherJohn Wiley and Sons Inc.
dc.relation.ispartofJournal of Biochemical and Molecular Toxicology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectcurcumin
dc.subjectDNA damage
dc.subjectdoxorubicin
dc.subjectoxidative stress
dc.subjecttesticular toxicity
dc.subject.classificationBiochemistry & Molecular Biology
dc.subject.classificationToxicology
dc.subject.otherAnimals
dc.subject.otherAntibiotics, Antineoplastic
dc.subject.otherAntioxidants
dc.subject.otherCurcumin
dc.subject.otherDoxorubicin
dc.subject.otherMale
dc.subject.otherMalondialdehyde
dc.subject.otherOxidative Stress
dc.subject.otherPalliative Care
dc.subject.otherRats
dc.subject.otherRats, Wistar
dc.subject.otherTestis
dc.subject.other8 hydroxydeoxyguanosine
dc.subject.othercatalase
dc.subject.otherglutathione
dc.subject.othermalonaldehyde
dc.subject.othersodium chloride
dc.subject.othersuperoxide dismutase
dc.subject.otherantineoplastic antibiotic
dc.subject.otherantioxidant
dc.subject.otheradult
dc.subject.otheranimal experiment
dc.subject.otheranimal model
dc.subject.otheranimal tissue
dc.subject.otherArticle
dc.subject.otherbiochemical analysis
dc.subject.othercontrolled study
dc.subject.otherdegeneration
dc.subject.otherDNA damage
dc.subject.otherdrug efficacy
dc.subject.otherhistopathology
dc.subject.otherimmunohistochemistry
dc.subject.othernecrosis
dc.subject.othernonhuman
dc.subject.otherrat
dc.subject.otherreproductive toxicity
dc.subject.othersemen abnormality
dc.subject.otherseminiferous tubule
dc.subject.othersingle drug dose
dc.subject.otherspermatozoon motility
dc.subject.othertestis injury
dc.subject.otheranimal
dc.subject.otherdrug effect
dc.subject.othermetabolism
dc.subject.otherpalliative therapy
dc.subject.otherWistar rat
dc.titlePalliative effect of curcumin on doxorubicin-induced testicular damage in male rats
dc.typeArticle
rdl.citation.openalex68
rdl.citation.scopus56
rdl.citation.wos51
rdl.departmentDepartment of Reproduction and Artificial Insemination, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey
rdl.departmentDepartment of Biochemistry, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey
rdl.departmentDepartment of Pathology, Veterinary Medicine Faculty, Atatürk University, Erzurum, Turkey
rdl.departmentDepartment of Biochemistry, Veterinary Medicine Faculty, Bingöl University, Bingöl, Turkey
rdl.departmentDepartment of Food Engineering, Engineering Faculty, Munzur University, Tunceli, Turkey
rdl.oa.statusclosed
rdl.scopus.quartileQ3
rdl.sdgSDG03
rdl.source.indexSCOPUS
rdl.source.indexWOS
rdl.source.indexPUBMED
rdl.wos.indexScience Citation Index Expanded (SCI-EXPANDED)