Sürdürülebilir Kalkınma Amaçları

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• MakaleAçık Erişim2026Scopus SJRQ3/r/munzur/1531
  Determination of Oxidative Stress Responses Induced by the Combination of 4 Different Rare Earth Elements in Dreissena polymorpha; [Determinacija odgovorov na oksidativni stres, ki ga povzroča kombinacija 4 različnih redkih zemljinskih elementov v Dreissena polymorpha]

  Serdar, Osman; Aydin, Ayşe Nur

  Rare Earth Elements (REE), whose usage areas are increasing day by day, are increasing in the amount of mixing with the environment, causing changes in antioxidant enzyme activities by causing oxidative stress in living organisms. In this study, it was aimed to examine the oxidative stress responses induced by the mixture of 4 different REEs (terbium, gadolinium, Lanthanum, Praseodymium) in Dreissena polymorpha. For this purpose, sublethal concentration values were determined by literature review. Experimental application was carried out within 24 and 96 hours. In the analyzes performed to determine biomarker responses, samples taken from living organisms were weighed and homogenization processes were performed for the analysis of samples taken from the experimental groups, including the control group. After homogenization, samples were centrifuged at 4.000 rpm for 15 minutes. Supernatants were kept at -86 °C until measurements were made. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, and glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. Statistical analyses were performed using SPSS. One-way ANOVA (Duncan’s multiple range test; p < 0.05) was used for comparison of measured parameters among groups. As a result of the application, a decrease in CAT activity and GSH level and an increase in TBARS levels were observed after 96 hours compared to the control group, while no statistically significant difference was detected in SOD and GPx activities.

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• MakaleAçık Erişim2026Scopus SJRQ3/r/munzur/1125
  Oxidative Stress Responses induced by Yttrium in Gammarus pulex at Increasing Temperatures

  Aydın, Ayşe Nur; Serdar, Osman

  In parallel with the increase in the need for raw materials used in industry, the area and amount of use of Rare Earth Elements are also increasing. Yttrium (Y), which is used as a raw material source, is thought to form residues in the environment. Gammarus pulex individuals were selected as a model organism to investigate the effects of Yttrium on the environment and aquatic organisms. G. pulexes were exposed to Y at different temperatures (16, 18, and 20 °C) and concentrations (25, 100, and 500 µg/L) for 96 hours and samples were taken at 24 and 96 hours for biochemical analyses. For biomarker analysis, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, thiobarbituric acid (TBARS) and glutathione (GSH) levels were performed using CAYMAN ELISA kit. Study data revealed that SOD and CAT activities increased significantly with increasing temperature and exposure concentration, while GPx activity showed an irregular response; in contrast, no significant change was observed in TBARS levels at 16 °C, while the increase in TBARS and significant changes in GSH levels at 18 and 20 °C indicate that oxidative stress becomes more pronounced at high temperatures. Copyright Aydın,, A. N. & Serdar, O.

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• MakaleAçık Erişim2026Scopus SJRQ4/r/munzur/1104
  Oxidative Stress Response to Zinc Oxide, Copper Oxide and Iron (III) Oxide in Gammarus pulex; [Gammarus pulex'te Çinko Oksit, Bakır Oksit ve Demir (III) Oksit'e Karşı Oksidatif Stres Tepkisi]

  Aydin, Ayşe Nur; Çiçek Çi̇Men, Işıl Canan; Serdar, Osman

  Nanoparticles (NPs) are increasingly used across various fields of science and technology, including food science from crop harvesting to final food consumption. With their widespread application in daily life, the environmental effects of nanoparticles have become an important area of academic investigation. In this study, Gammarus pulex species was selected as research material/bioindicator species to investigate the effects of zinc oxide (ZnO), copper oxide (CuO), and iron(III) oxide (Fe2O3) on aquatic life. To conduct the experiments, separate setups were established for each of the nanoparticles (ZnO, CuO, and α-Fe2O3). Following ten organisms for each concentration group (10, 20, and 40 ppm) with corresponding control groups, exposures were performed for 24 and 96 hours. Samples were collected at both time points and biochemical analyses were conducted using homogenization procedures. The results were evaluated statistically. According to the findings, SOD activity increased significantly after exposure to ZnO, CuO, and Fe2O3. CAT activity did not show any change under ZnO NP exposure, whereas a decrease was observed under CuO and Fe2O3 NP exposures. However, a significant increase in TBARS levels and a significant increase in GSH levels were observed following nanoparticle exposure. Based on the study data, exposure to ZnO, CuO, and Fe2O3 appears to induce oxidative stress in G. pulex.

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• MakaleYalnız künye2026Scopus SJRQ1/r/munzur/988
  Determination of microplastic contamination and phthalate ester migration in canned and frozen packaged seafood: A probabilistic human health risk assessment via Monte Carlo simulation

  Macit, Arife; Köktürk, Mine; Serdar, Osman; Alak, Gonca

  This research was designed to identify the levels of microplastics (MP) and phthalate esters (PAE) in canned and frozen packaged fish and to assess the human health risks associated with these pollutants. Analyses were carried out on a total of 25 sample groups, including 10 different canned tuna samples, 9 different packaged seafood products, and 6 different packaging materials. Microplastics were characterized and polymer identification was performed using μ-Raman and ATR-FTIR spectroscopy, while PAEs were determined by GC–MS/MS. The obtained data were used to calculate estimated daily intake (EDI), hazard index (HI), hazard quotient (HQ), and cancer risk (CR), and uncertainty was assessed using Monte Carlo simulation. The findings revealed that both microplastic and phthalate exposure were higher in the frozen fish group than in canned products. The highest MP concentrations were recorded in packaged Whiting B (0.73 ± 0.25 items/g) and oil-added canned tuna (0.57 ± 0.15 items/g). Regarding PAEs, while DEHP and DBP were generally prominent, significant peak concentrations of BBP and DNOP were also identified, reaching 1.91 ± 0.01 ppm for BBP in canned tuna with sunflower oil and 1.84 ± 0.01 ppm in packaged whiting. Furthermore, higher exposure was observed in males for most PAEs. HQ and HI values were below 1 (maximum HI: 1.57 × 10−2 for males consuming frozen seafood), while CR values remained within an acceptable range (4.74 × 10−7 to 3.49 × 10−6). In conclusion, health risks related to processed fish consumption appear generally low; however, processing and packaging may contribute to contamination and warrant further investigation.

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• MakaleAçık Erişim2026Scopus SJRQ2/r/munzur/954
  Protective Effect of Propolis Against Oxidative Damage Caused by Cyfluthrin Insecticide on Gammarus pulex

  Serdar, Osman

  This study aimed to investigate both the protective and therapeutic effects of propolis (PP) against pesticide-induced oxidative stress in aquatic environments. For this purpose, Gammarus pulex was exposed to 0.00 (control), 0.05, 0.1, and 0.2 ppm concentrations of cyfluthrin (CYF) to determine its toxic effects. To evaluate the protective effect of PP, 5 ppm of PP was added to each pesticide concentration. Samples were collected from all experimental groups after 24 and 96 hours under appropriate conditions. SOD activity decreased under CYF exposure but increased significantly after PP supplementation. Although CAT activity did not show significant changes with CYF alone, it increased in the presence of PP. GPx activity remained statistically unchanged under CYF exposure but increased following PP treatment. CYF exposure led to decreased GSH levels; however, PP did not significantly alter GSH levels. TBARS levels increased due to CYF, and this increase was alleviated by PP application.

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• MakaleYalnız künye2026Scopus SJRQ1/r/munzur/619
  Evaluation of rainbow trout response to the optimal anesthetic concentration of citronella oil (Cymbopogon nardus) predicted by artificial neural network

  Minaz, Mert; Félix, Luís M.; Er, Akif; Köse, Özay; Ak, Kübra; Alparslan, Cem; Serdar, Osman; Aydın, Baki; Kurtul, Irmak; Hoseini, Seyyed Morteza

  Anesthesia practices in aquaculture are important for preventing potential stress in fish. For this purpose, interest in natural anesthetic agents as substitute for currently used synthetic anesthetics has increased. In this context, the present study demonstrated the anesthetic efficacy of citronella oil (Cymbopogon nardus) in rainbow trout (Oncorhynchus mykiss) individuals. Based on an artificial neural network (ANN) model derived from preliminary studies, the optimal anesthetic concentration for rainbow trout individuals was estimated as 90 μL L−1. Validation of the concentration predicted by ANN revealed no time-dependent hematological or histological effects on fish to citronella oil. Furthermore, biochemical tests revealed that the partial post-anesthesia increase in ALT and AST values was transient and negligible in light of histological findings. Although oxidative stress was observed during the acute period, the enzymatic activity of SOD and CAT effectively reduced the oxidative damage, demonstrating their role in protecting the fish from oxidative stress. The antioxidant activity observed was temporary, returning to baseline levels without any accompanying tissue damage at the tested concentration. Behavioral monitoring further indicated a swift reduction in motor activity followed by a smooth recovery process, with no evident signs of stress or avoidance behaviour. Overall, these results position citronella oil as a promising natural anesthetic for rainbow trout under the studied parameters. That said, further studies involving various solvents, temperature ranges, and fish species are necessary to comprehensively establish its efficacy and safety.

  AtıfScopus4

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• MakaleAçık Erişim2025/r/munzur/6211
  Determination of Toxic Effect of Gamma Cyhalothrin in Dreissena polymorpha by Some Biomarkers

  Parlak Ak, Tuba; Aydın, Ayşe Nur; Serdar, Osman

  In this study, the effects of pesticides on the freshwater mussel Dreissena polymorpha, a non-target organism, were aimed to be determined through biochemical responses. For this purpose, first, the acute toxicity value (LC50) of Gamma Cyhalothrin (GCH) pesticide on D. polymorpha was determined by standard static method and the LC50 value was calculated as 13.64 mg/L using probit analysis. Then, superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) activities, malondialdehyde (MDA) and glutathione (GSH) level responses of D. polymorpha organism exposed to GCH sublethal concentrations for 24 and 96 hours were determined. In addition to biochemical biomarkers, histopathological responses were evaluated. In conclusion, this study demonstrated the abilities of GCH pesticides to induce oxidative stress. Moreover, MDA, GSH levels, SOD, CAT, GPx activities and histopathological responses could be used as an effective biomarker in D. polymorpha.

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• MakaleAçık Erişim2025/r/munzur/6205
  Determination of Oxidative Stress Responses in Dreissena polymorpha Exposed to Rare Earth Elements (Terbium, Lanthanum, Gadolinium and Praseodymium) with Temperature

  Serdar, Osman; Aydın, Ayşe Nur

  The continuous development of industry pushes people to search for new resources, and for this reason, the usage areas of Rare Earth Elements (REEs) are increasing day by day. Increasing concentrations of REEs, as a result of increased use, create pollution in the environment and harm living organisms. This pollution interacts with increasing temperature and causes more negative synergistic effects of the pollutant in the environment and in the living body. In this study, sublethal concentration values were determined by literature review and the concentration value was determined as 125 mg/L. In the present study tt was aimed to investigate some oxidative stress and antioxidant responses of Terbium, Lanthanum, Gadolinium and Praseodymium REEs in Dreissena polymorpha at 125 mg/L concentration at 3 different temperatures (16, 18, 20 0C) with biomarkers. For this purpose, 24 and 96 hour experimental trial design was created and 7 D. polymorpha were used in each trial group, and the application experiments were carried out with 3 replications. The samples at the end of the experimental phase were stored at -80 degrees Celsius until they were analyzed. In this study, Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) enzyme activities and glutathione (GSH) and Thiobarbituric acid (TBARS) level biomarker responses were determined by ELISA test microplate reader. CAYMAN brand SOD (Catalog No 706002), CAT Catalog No 707002) and GPx (Catalog No 703102), GSH (Catalog No 703002) and TBARS (Catalog No 10009055) were used in the study. SPSS 24.0 package program one-way ANOVA (Duncan 0.05) was used for the evaluation of biochemical analyzes. According to the study data, statistically significant decreases were observed in SOD and CAT activities in the oxidative stress responses of REEs on D. Polymorpha with increasing temperature, while there was no significant change in GPx activities. It was determined that there were increases in TBARS levels and decreases in GSH levels. It is thought that the temperature factor, application concentration and application time are effective in the formation of these changes. It can be said that temperature change and pollutants cause oxidative stress in organisms and cause cell damage.

  AtıfOpenAlex3·TR Dizin1

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• MakaleYayıncıda açık erişim2025Scopus SJRQ2/r/munzur/2267
  Determination of Toxic Effects of Copper in Navicula cryptocephala var. veneta by Biomarkers and Bioaccumulation Quantification

  Aydın, Ayşe Nur; Serdar, Osman; Ölçülü, Abdüllatif; Çimen, Işıl Canan Çiçek; Ak, Tuba Parlak; Derman, Taner; Sevim, Ayşegül; Yıldırım, Nuran Cikcikoğlu

  As a result of the increased use of metals such as copper (Cu), copper pollution in the environment is also increasing. In order to investigate the effect of copper mixed into the water environment and on aquatic biota, the microalga Navicula cryptocephala var. veneta was chosen as a model organism. N. cryptocephala var. veneta it was aimed to determine the accumulation and elimination amounts and some biomarker responses. Metal accumulation amounts in the organisms used in the study. The amount of metal accumulated in relation to the wet weight mass of the samples was determined using Atomic Absorption Spectophotometry (AAS) mass spectrometry. In the bioassays conducted within the scope of the study, lipid peroxidation (TBARS) and reduced glutathione (GSH) levels, superoxide dismutase (SOD) enzyme activity, glutathione peroxidase (GSH-Px) enzyme activity and catalase (CAT) enzyme activity were determined with an ELISA microplate reader at 24, 48, 72, 96 and 120 hours. According to the study data, it was observed that Cu metal accumulated in Navicula cryptocephala var. veneta and caused oxidative stress in the organism, affecting the organism by causing changes in TBARS, GSH levels and antioxidant enzymes SOD, CAT and GPx activities. Additionally, it was observed that different elimination levels occurred in the application groups.

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  AtıfScopus1·OpenAlex1

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• MakaleAçık Erişim2025Scopus SJRQ4/r/munzur/2235
  Comparison between traditional models and artificial neural networks as estimators of the growth of the Tigris scraper Capoeta umbla (Teleostei: Cyprinidae) in the Munzur River, Turkey; [Comparación entre modelos tradicionales y redes neuronales artificiales como estimadores del crecimiento del raspador del Tigris Capoeta umbla (Teleostei: Cyprinidae) en el río Munzur, Turquía]

  Ozcan, Ebru Ifakat; Serdar, Osman

  In this study, a comparison of traditional growth methods (lengthweight relationships and von Bertalanffy growth function) with artificial neural networks in growth models was carried out in the growth of 783 specimens of Capoeta umbla from the Munzur River, Turkey from September 2019 to May 2021. The lengthweight relationships of C. umbla W = 0.0085L3.013 R2=0.943 was determined for all individuals. The ages of the specimens were from 0 to 11 years old. The von Bertalanffy growth function was Lt = 46.15 [1-e-0.139 (t + 2.57)] and Wt = 856.32 [1-e-0.139 (t + 2.57)]3.013 for all individuals. Ф’ value was 2.471 all individuals. The training stopped and the best validation performance was fixed at 8.1473 × 10-5 at epoch 42. The validation checks were reached as 6, at epoch 48 and the gradient = 5.6566 × 10-5, at epoch 48. The target output R value was 0.98584 for training, 0.98969 for validation, 0.98757 for testing and 0.9868 for all. The calculated MAPE values were 0.140 and 0.578 for artificial neural networks, 1.168 and 2.726 for length–weight relationships, 5.721 and 4.013 for von Bertalanffy growth function, respectively. The calculated SSE values for length and weight were 0.0128 and 30.864 for artificial neural networks, 1.3985 and 350.786 for length–weight relationships. The results of the present show that artificial neural networks can be superior estimators than length–weight relationships and von Bertalanffy growth function. Therefore, artificial neural networks models are an effective tool to describe body weight and length in fish.

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