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  • MakaleAçık Erişim2026Scopus SJRQ1
    Ellagic Acid Mitigates Lead (Pb)-Induced Toxicity in Cyprinus carpio: A Multi-Biomarker Assessment of Hematological, Immunological, and Oxidative Stress Responses Supported by Molecular Docking

    Eroglu, Mucahit; Cakmak, Mehmet Nuri; Pala, Aysegul; Uslu, Harun; Yonar, Serpil Mise; Ispir, Unal; Orhan, Cemal; Yonar, Muhammet Enis

    Lead (Pb) is a widespread environmental pollutant that induces systemic toxicity in aquatic organisms primarily through oxidative stress, hematological disruption, and immune dysfunction. This study investigated the protective effects of ellagic acid (EA) against Pb-induced toxicity in common carp (Cyprinus carpio) using a multi-biomarker approach and molecular docking. Fish were assigned to six experimental groups: control, EA-treated, Pb-I, Pb-I + EA, Pb-II, and Pb-II + EA. Fish in the Pb-I and Pb-II groups were exposed to 2.5 and 5 mg/L Pb, respectively, while EA was administered via diet at 100 mg/kg for 14 days. At the end of the exposure period, hematological indices, innate immune parameters, and oxidative stress biomarkers were assessed in blood, liver, kidney, and gill tissues. Pb exposure caused marked hematological impairment, suppressed immune responses, increased malondialdehyde levels, and disrupted antioxidant defense by reducing SOD, CAT, GSH-Px, and GSH levels while increasing GST activity. In contrast, dietary EA supplementation significantly mitigated Pb-induced alterations, improved hematological and immunological responses, reduced lipid peroxidation, restored antioxidant capacity, and normalized GST activity to control levels. Molecular docking analyses further showed that EA interacts with hemoglobin and immunoglobulin M, supporting its potential role in preserving oxygen transport and immune functions under Pb-induced stress. Overall, the findings demonstrate that Pb-induced toxicity involves coordinated disruption of redox homeostasis and immune function, whereas EA exerts a multi-target protective effect through biochemical and molecular mechanisms. This study provides mechanistic insight into chemical-biological interactions and supports the potential application of natural bioactive compounds in mitigating heavy metal-induced toxicity.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    Web of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    Determination of Oxidative Stress Responses Induced by the Combination of 4 Different Rare Earth Elements in Dreissena polymorpha; [Determinacija odgovorov na oksidativni stres, ki ga povzroča kombinacija 4 različnih redkih zemljinskih elementov v Dreissena polymorpha]

    Serdar, Osman; Aydin, Ayşe Nur

    Rare Earth Elements (REE), whose usage areas are increasing day by day, are increasing in the amount of mixing with the environment, causing changes in antioxidant enzyme activities by causing oxidative stress in living organisms. In this study, it was aimed to examine the oxidative stress responses induced by the mixture of 4 different REEs (terbium, gadolinium, Lanthanum, Praseodymium) in Dreissena polymorpha. For this purpose, sublethal concentration values were determined by literature review. Experimental application was carried out within 24 and 96 hours. In the analyzes performed to determine biomarker responses, samples taken from living organisms were weighed and homogenization processes were performed for the analysis of samples taken from the experimental groups, including the control group. After homogenization, samples were centrifuged at 4.000 rpm for 15 minutes. Supernatants were kept at -86 °C until measurements were made. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, and glutathione (GSH) and thiobarbituric acid reactive substances (TBARS) levels were determined using ELISA kits. Statistical analyses were performed using SPSS. One-way ANOVA (Duncan’s multiple range test; p < 0.05) was used for comparison of measured parameters among groups. As a result of the application, a decrease in CAT activity and GSH level and an increase in TBARS levels were observed after 96 hours compared to the control group, while no statistically significant difference was detected in SOD and GPx activities.

    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ4
    The microbiological and sensory quality of fish (Cyprinus carpio) meatballs prepared with different essential oils; [La calidad microbiológica y sensorial de las albóndigas de pescado (Cyprinus carpio) elaboradas con diferentes aceites esenciales]

    KARATON-KUZGUN, Nermin; ȘAHÎN, Seher

    In this study, the shelf life of fish meatballs made from common carp (Cyprinus carpio) and flavoured with lemon, ginger and mint essential oils was investigated under refrigeration conditions (4 ± 1 °C). In the study, fish mince obtained from common carp was mixed with breadcrumbs, cumin, salt, black pepper, allspice, garlic powder, sweet paprika and sunflower oil to form the experimental control group, whilst the remaining fish mince was mixed with essential oils to form four different groups. The fish meatballs were stored under refrigeration conditions, and microbiological and sensory analyses were conducted on the analysis days. As a result of these analyses, the shelf life of the fish meatballs was determined to be 20 days. Microbiologically, the limit value (6 log CFU/g) for total mesophilic aerobic bacteria was exceeded in Group control patty samples on the 10th day of storage, in Group ginger and mint patty samples on the 15th day, and in Group lemon patty samples on the 20th day. The evaluation of sensory analyses also revealed that the group of fish cake samples receiving the highest sensory approval was the group to which lemon essential oil had been added. It was concluded that offering fish-based meatballs created by adding essential oils which are natural additives in a variety of flavours would broaden the product range, further encourage consumption, and contribute to the shelf life of the resulting products.

    • SDG 2 · Açlığa Son
    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    Changes in common carp (Cyprinus carpio) sperm quality and membrane lipid composition related to cryopreservation by Tribulus terrestris; [Alterações na qualidade do esperma e na composição lipídica da membrana da carpa comum (Cyprinus carpio) relacionadas à criopreservação por Tribulus terrestris]

    Ölçülü, Abdullatif; Özçiçek, Esin; Kocabaş, Filiz Kutluyer; Kocabaş, Mehmet; Kızak, Volkan; Yilmaz, Ökkeş

    Docosahexaenoic acid (DHA) was the major polyunsaturated fatty acid (PUFA) in the sperm plasma membrane, and the levels of PUFAs decreased in treated groups during the cryopreservation process. The supplementation of TT (Tribulus terrestris) to Cyprinus carpio sperm at 200 µg∙L-1 positively affected the maintenance of motility parameters and FAs levels after the freeze-thaw cycle, and TT can be used as an herbal medicine instead of synthetic pharmaceuticals to improve the productive performance in aquaculture.

    • SDG 2 · Açlığa Son
    ScopusWeb of Scienceİncele
  • MakaleYayıncıda açık erişim2026Scopus SJRQ2
    Sperm cryopreservation of sex-reversed rainbow trout (Oncorhynchus mykiss): incorporation of amino acids and anti-oxidants to the extender media to improve the anti-oxidant system

    Kocabaş, Filiz Kutluyer; Kocabaş, Mehmet; Benzer, Fulya; Erişir, Mine

    Anti-oxidants are vital for protecting sperm and can mitigate the negative effects associated with cryopreservation. This study was conducted to evaluate the protective effects of adding anti-oxidants (vitamins and amino acids) to extender in sex-reversed rainbow trout (Oncorhynchus mykiss) sperm. The collected sperm was diluted at the ratio of 1: 5 by the extenders supplemented with different anti-oxidants including 1.00 mM of ascorbic acid and L-tryptophan, 2.00 mM of cysteine and α-tocopherol, and their combination. After dilution, the semen was aspirated into 0.50 mL straws, and the straws were placed on the tray, frozen for 10 min, and plunged into liquid nitrogen. Straws were thawed in a 30.00 ˚C water bath for 15 sec. The Sperm Class Analyzer System was used to evaluate sperm kinematics. The activity of anti-oxidant enzymes and lipid peroxidation were determined as oxidative stress indices. Our data indicated that the incorporation of anti-oxidants and amino acids increased sperm motility duration. The elevated activity of glutathione peroxidase, superoxide dismutase, and catalase in post-thaw samples indicates that the anti-oxidant system in sex-reversed rainbow trout sperm likely plays a crucial role in protecting membrane compounds from oxidation. In conclusion, the combination of 1.00 mM L-tryptophan and ascorbic acid to the extender media caused a prolonging effect in sperm motility after thawing and they have the potential to serve as effective agents for improving sperm cryosurvival.

    ScopusWeb of SciencePubMedİncele
  • MakaleYalnız künye2026Scopus SJRQ3
    Characteristics of the growth rate, fatty acid profile, and shell content of the freshwater snail Viviparus contectus (Millet, 1813)

    Kocabaş, Filiz Kutluyer; Kizak, Volkan; Özçiçek, Esin; Kocabaş, Mehmet; Yilmaz, Ökkeş

    Freshwater snails are a nutritious food source, providing vital amino acids, minerals, and protein with low lipid levels. Hence, the adaptation ability, growth rate, fatty acid (FA) profile, and shell content of Viviparus contectus were determined. Biometric measurements were recorded for 6 months. Over the 6-month cultivation period, specific growth rates were recorded as 0.32% · day-1 for shell length and 0.92% · day-1 for body weight. The FA profile of the freshwater snail included a total of 32 compounds with saturated, monounsaturated, and polyunsaturated FAs represented by 13, 10, and 9 types, respectively. Monounsaturated fatty acids (MUFAs) exhibited the highest concentration, followed by saturated fatty acids (SFAs) s at 35.14% and polyunsaturated fatty acids (PUFAs) at 14.57%. Stearic acid (C18:0), erucic acid (C22:1 n-9), and arachidonic acid (C20:4 n-6) were determined as the most abundant FAs within the saturated, monounsaturated, and polyunsaturated FAs classes, respectively. The energy-dispersive X-ray spectroscopy spectra analysis revealed that the shell powder composition consisted of the elements, such as carbon, oxygen, calcium, iron, manganese, and silicium. Overall, V. contectus showed a clear increase in growth over the cultivation period, and future studies are needed to obtain the best culture conditions and intensive production of the species.

    • SDG 2 · Açlığa Son
    • SDG 14 · Sudaki Yaşam
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2026Scopus SJRQ3
    Bioactive compounds in mucus and shell microstructure of the European ear snail (Radix auricularia)

    Kocabaş, Kutluyer; Kocabaş, M.; Kizak, V.; Korkmaz, B.

    Radix auricularia is a non-native and invasive freshwater snail species and it may have destructive impacts on biodiversity and ecosystem structure. In recent years, snail mucus, as a sticky substance, has garnered significant attention in the medical and cosmetic industries due to its content of numerous bioactive compounds. Despite frequently being discarded as waste due to the build-up of calcium carbonate crystals through biomineralization, shells of freshwater snail serve multiple functions in aquatic environments and have potential industrial applications. Hence, this study aims to identify bioactive compounds in the mucus and analyze the shell microstructure and mineralogy of the European ear snail (Radix auricularia). Bioactive constituents of mucus were characterized by Gas Chromatography-Mass Spectrometry (GC-FID-MS) analysis. We also conducted analyses on the organic matrix of shells from R. auricularia using X-ray diffraction (XRD) and Scanning Electron Microscope-Energy Dispersive Spectroscopy (SEM-EDS). Our results indicated that ten compounds are characterized by Eicosane (34.16%), 9-Octadecen-1-ol, (Z)-(11.86%) and N,N-Dimetylpalmitamide (5.55%) as the main components of mucus. The antioxidant potential, antifungal and anti-inflammatory properties of Eicosane was in notable quantity in the mucus. In addition, the elemental composition of shell powder comprised of carbon, aluminium, oxygen, calcium, iron, magnesium, silicium, manganese, sodium, sulphur and phosphorus. Aragonite emerged as the dominant mineralogy in the inorganic layer of their shells, as confirmed by XRD. Overall, individual compounds of mucus could be isolated and purified mucus compounds could have applications in pharmaceuticals and health sectors. The shells of R. auricularia offer potential for diverse applications and contribute to environmental sustainability as valuable biomaterials.

    ScopusWeb of Scienceİncele
  • MakaleAçık Erişim2026Scopus SJRQ2
    The Positive Effect of Antioxidants in Maintaining the Post-Cryopreserved Sperm Quality of Rainbow Trout Oncorhynchus mykiss (Walbaum, 1792)

    Handayani, Luvi S.; Rahayu, Sri R.; Razi, Nanda M.; Pane, Elya P.; Kocabas, Mehmet; Kocabas, Filiz Kutluyer; Hafizuddin, Hafizuddin; Fadli, Nur; Sulistiono, Sulistiono; Muchlisin, Zainal A.

    Rainbow trout aquaculture is challenging due to the restricted spawning seasons. Sperm cryopreservation technology can help ensure a successful spawning season, but its effectiveness is restricted by oxidative stress during freezing and thawing, which reduces the availability of male gametes. This study aimed to evaluate the effect of several types and concentrations of antioxidants on post-cryopreservation rainbow trout sperm quality. Subsequently, a factorial completely randomized design with three replications was applied, testing four types of antioxidants Ascorbic acid, Myo-inositol, Butylated hydroxytoluene (BHT), and Alpha-tocopherol at concentrations of 0, 20, 40, and 60 mM, respectively. The evaluation parameters included motility rate, sperm lifespan, and sperm motion characteristics using the Computer Assisted Sperm Analysis system. The results showed that the type and concentration of antioxidants significantly affected sperm motility and sperm lifespan (P<0.05). The treatment method carried out using 40 mM Ascorbic acid and 20 mM BHT led to the highest sperm motility of 46.67% and sperm lifespan of 34 seconds. Although both antioxidants showed similar effectiveness, BHT at a concentration of 20 mM is more recommended due to its lower toxicity and technical as well as economic efficiency considerations.

    • SDG 2 · Açlığa Son
    ScopusWeb of Scienceİncele
  • MakaleYalnız künye2026Scopus SJRQ1
    Hydrogeochemical controls on chromium speciation and potential human health risks in surface waters of an ultramafic mining watershed

    Kutlu, Banu; Baydar, Tarık; Yıldırım, Vesile; Konurhan, Zekeriya

    Accurate assessment of chromium contamination in mining-influenced watersheds requires distinguishing between the environmentally contrasting Cr(III) and Cr(VI) species, yet environmental monitoring and risk assessments still rely predominantly on total chromium concentrations. This study evaluated whether chromium speciation provides additional information beyond operational total chromium for assessing chromium occurrence and potential human health risks in an ultramafic, mining-influenced watershed. Surface-water samples were collected from 28 sampling stations across the Pülümür and Ovacık regions of the Eastern Anatolia Basin (Türkiye) between March 2025 and February 2026. Chromium speciation was determined using species-specific UV–Visible spectrophotometric methods and integrated with hydrochemical characterization, multivariate statistical analyses, mineralogical investigations (XRD, SEM–EDS, and FTIR), and deterministic and empirical-bootstrap human health risk assessments. Operational total chromium, defined as the sum of separately measured Cr(III) and Cr(VI), ranged from below the detection limit to 578.13 µg L−1. For contextual screening, this calculated value exceeded World Health Organization (WHO) drinking-water guideline for total chromium at 14 stations; however, it was not an independently measured total-Cr concentration. The highest Cr(VI) concentration occurred at a localized hotspot, whereas Cr(III) predominated throughout most of the watershed. Nevertheless, Cr(VI)-based screening thresholds were exceeded at multiple stations under the assumed untreated drinking-water ingestion scenario, indicating that operational total chromium alone did not consistently identify the spatial distribution of Cr(VI)-related potential risk. Screening-level hazard quotient (HQ) estimates were higher for children than for adults; however, direct untreated consumption of the sampled surface waters was not verified. Mining-influenced stations generally exhibited higher chromium concentrations, although the relative contributions of geogenic weathering and mining-related mobilization could not be quantitatively apportioned. Overall, chromium speciation provided additional environmentally and toxicologically relevant information beyond operational total chromium for evaluating chromium mobility and screening-level potential human health risks in this ultramafic watershed.

    • SDG 3 · Sağlık ve Kaliteli Yaşam
    • SDG 6 · Temiz Su ve Sanitasyon
    ScopusWeb of SciencePubMedİncele
  • MakaleAçık Erişim2026Scopus SJRQ3
    Oxidative Stress Responses induced by Yttrium in Gammarus pulex at Increasing Temperatures

    Aydın, Ayşe Nur; Serdar, Osman

    In parallel with the increase in the need for raw materials used in industry, the area and amount of use of Rare Earth Elements are also increasing. Yttrium (Y), which is used as a raw material source, is thought to form residues in the environment. Gammarus pulex individuals were selected as a model organism to investigate the effects of Yttrium on the environment and aquatic organisms. G. pulexes were exposed to Y at different temperatures (16, 18, and 20 °C) and concentrations (25, 100, and 500 µg/L) for 96 hours and samples were taken at 24 and 96 hours for biochemical analyses. For biomarker analysis, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, thiobarbituric acid (TBARS) and glutathione (GSH) levels were performed using CAYMAN ELISA kit. Study data revealed that SOD and CAT activities increased significantly with increasing temperature and exposure concentration, while GPx activity showed an irregular response; in contrast, no significant change was observed in TBARS levels at 16 °C, while the increase in TBARS and significant changes in GSH levels at 18 and 20 °C indicate that oxidative stress becomes more pronounced at high temperatures. Copyright Aydın,, A. N. & Serdar, O.

    ScopusWeb of Scienceİncele
Tam Kayıt
AlanDeğerDil
dc.date.accessioned2026-10-28T14:33:31.064400296Z
dc.date.available2026-10-28T14:33:31.064400296Z
dc.identifier.urihttps://rdlopen.rawdatalibrary.net/r/munzur/108
dc.rightsinfo:eu-repo/semantics/openAccess
dc.titleSu Ürünleri Fakültesitr
dc.titleFaculty of Fisheriesen
organization.identifier.codemunzur-su-urunleri
organization.unitTypefaculty
rdl.unit.alias\bsu urunleri fakultesi\b
rdl.unit.alias\bfac(ulty)? (of )?(fisher(ies|y)|aquatic products?)\b
rdl.unit.alias\bfisheries fac(ulty)?\b