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• Korunur, Sibel(1)
• Yilmaz, Ali(1)
• Zengin, Bilgin(1)

• MakaleAçık Erişim2019Scopus SJRQ4/r/munzur/3608
  Investigation of relaxation times in 5-fluorouracil and human serum albumin mixtures

  Korunur, Sibel; Zengin, Bilgin; Yilmaz, Ali

  Background: Human serum albumin (HSA) is often selected as a subject of any study because albumin is the most abundant protein in human blood plasma. NMR is recognized as a valuable method to determine the structure of proteins-ligand and protein-drug complexes. Objective - Aim of the study: In this study, protein drug interactions were investigated using 5-Fluorouracil anticancer drug and human serum albumin protein. Materials and methods: In this context 400 MHz NMR spectrometry was used and NMR relaxation rates in drug-albumin complex were investigated with respect to increase albumin concentration and increase in 5-Fluoro-uracil (5-FU)-albumin solution temperature. Results: The results of this study indicated that 5-FU had a weak association with albumin, and it easily dissociated from the protein to which it was attached. Conclusion: The obtained results also gave us useful information about molecular dynamics of drug-albumin interactions.

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